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Cerebrovascular disease and stroke

Section edited by Erwin Stolz and Szatmari Szabolcs

This section is dedicated to covering all aspects of stroke and cerebrovascular diseases. Topics of interest include, but are not limited to, ischemic stroke, spontaneous intracranial bleeding, sinus thrombosis, carotid or vertebral artery disease, cerebrovascular physiology, and neuroimaging related to cerebrovascular diseases.

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  1. Content type: Case report

    Structural anomaly of the cervical spine or craniocervical junction has been reported as one of the rare causes of ischemic stroke. We report a case of a young patient with recurrent posterior circulation infa...

    Authors: Seung-Hoon Song, Hong Gee Roh, Hahn Young Kim, Jin Woo Choi, Won-Jin Moon, Woo Jin Choe and Ileok Jung

    Citation: BMC Neurology 2014 14:252

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  2. Content type: Research article

    Recovering useful hand function after stroke is a major scientific challenge for patients with limited motor recovery. We hypothesized that sequential training beginning with proximal bilateral followed by uni...

    Authors: Sandy McCombe Waller, Jill Whitall, Toye Jenkins, Laurence S Magder, Daniel F Hanley, Andrew Goldberg and Andreas R Luft

    Citation: BMC Neurology 2014 14:236

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  3. Content type: Research article

    Fatigue is common in stroke survivors. Lesion location may influence the risk of poststroke fatigue (PSF) but it is uncertain whether location has an impact on the prognosis of PSF. This study examined the ass...

    Authors: Wai Kwong Tang, Yang Kun Chen, Hua Jun Liang, Winnie Chiu Wing Chu, Vincent Chung Tony Mok, Gabor S Ungvari and Ka Sing Wong

    Citation: BMC Neurology 2014 14:234

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  4. Content type: Research article

    Although it is preferable that all patients with a recent Transient Ischemic Attack (TIA) undergo acute carotid imaging, there are centers with limited access to such acute examinations. It is controversial wh...

    Authors: Elias Johansson, Jakob Bjellerup and Per Wester

    Citation: BMC Neurology 2014 14:223

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  5. Content type: Research article

    Vascular cognitive impairment-no dementia (VCIND) refers to the early or mild cognitive impairment induced by cerebral vascular injury. Research shows that serum total homocysteine (tHcy) level is an independe...

    Authors: Bo Jiang, Yumei Chen, Guoen Yao, Cunshan Yao, Hongmei Zhao, Xiangdong Jia, Yunyan Zhang, Junling Ge, Enchao Qiu and Chengyun Ding

    Citation: BMC Neurology 2014 14:217

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  6. Content type: Research article

    Acute ischemic stroke (AIS) is one of the leading causes of death and adult disability worldwide. In the present study, we aimed to develop a web-based risk model for predicting dynamic functional status at di...

    Authors: Ruijun Ji, Wanliang Du, Haipeng Shen, Yuesong Pan, Penglian Wang, Gaifen Liu, Yilong Wang, Hao Li, Xingquan Zhao and Yongjun Wang

    Citation: BMC Neurology 2014 14:214

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  7. Content type: Case report

    The specificity of computed tomography (CT) for subarachnoid haemorrhage (SAH) is very high. However, physicians should be aware of rare false positive findings, also referred to as "pseudo-SAH". We present an...

    Authors: Maximilian Patzig, Christoph Laub, Hendrik Janssen, Lorenz Ertl and Gunther Fesl

    Citation: BMC Neurology 2014 14:219

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  8. Content type: Study protocol

    10-40% of patients with acute ischemic stroke (AIS) suffer an early neurological deterioration (END), which may influence their long term prognosis. Multiple definitions of END exist, even in recently publishe...

    Authors: Bernt Harald Helleberg, Hanne Ellekjær, Gitta Rohweder and Bent Indredavik

    Citation: BMC Neurology 2014 14:201

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  9. Content type: Research article

    Fatigue, slowness, apathy and decrease in level of activity are common long-term complaints after a subarachnoid haemorrhage (SAH). They resemble the symptoms frequently found in patients with endocrine dysfun...

    Authors: Ladbon Khajeh, Karin Blijdorp, Sebastian JCMM Neggers, Gerard M Ribbers, Diederik WJ Dippel and Fop van Kooten

    Citation: BMC Neurology 2014 14:205

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  10. Content type: Study protocol

    Following stroke, many people have difficulty activating their paretic muscles quickly and with sufficient power to regain their balance by taking quick and effective steps. Reduced dynamic balance and mobilit...

    Authors: Kimberly J Miller, Michael A Hunt, Courtney L Pollock, Dianne Bryant and S Jayne Garland

    Citation: BMC Neurology 2014 14:187

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  11. Content type: Study protocol

    The choice of surgical or conservative treatment for patients with spontaneous intracerebral hemorrhage is controversial. Some minimally invasive treatments have been applied to hematoma evacuation and could i...

    Authors: Jun Zheng, Hao Li, Rui Guo, Sen Lin, Xin Hu, Wei Dong, Lu Ma, Yuan Fang, Anqi Xiao, Ming Liu and Chao You

    Citation: BMC Neurology 2014 14:206

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  12. Content type: Research article

    Cardioembolic stroke (CES) due to atrial fibrillation (AF) is associated with high stroke mortality. Oral anticoagulation (OAC) reduces stroke mortality, however, the impact of OAC-administration during hospit...

    Authors: Frederick Palm, Martin Kraus, Anton Safer, Joachim Wolf, Heiko Becher and Armin J Grau

    Citation: BMC Neurology 2014 14:199

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  13. Content type: Research article

    Mood disorders are commonly seen in those with cerebrovascular disease. Literature to-date has tended to focus on depression and on patients with stroke, with relatively little known about post-stroke anxiety ...

    Authors: Niall M Broomfield, Terence J Quinn, Azmil H Abdul-Rahim, Matthew R Walters and Jonathan J Evans

    Citation: BMC Neurology 2014 14:198

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  14. Content type: Research article

    Despite clear evidence for the effectiveness of oral anticoagulation (OA) in patients with atrial fibrillation (AF), there is evidence for the underutilisation of this therapy in the secondary stroke preventio...

    Authors: Christian Tanislav, Sonja Milde, Sabine Schwartzkopff, Nicole Sieweke, Heidrun Helga Krämer, Martin Juenemann, Björn Misselwitz and Manfred Kaps

    Citation: BMC Neurology 2014 14:195

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  15. Content type: Research article

    In experimental studies, the apolipoprotein D (APOD) and the sigma receptor type 1 (SIGMAR1) have been related to processes of brain damage, repair and plasticity.

    Authors: Håkan Lövkvist, Ann-Cathrin Jönsson, Holger Luthman, Katarina Jood, Christina Jern, Tadeusz Wieloch and Arne Lindgren

    Citation: BMC Neurology 2014 14:191

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  16. Content type: Study protocol

    Novel virtual reality rehabilitation systems provide the potential to increase intensity and offer challenging and motivating tasks. The efficacy of virtual reality systems to improve arm motor function early ...

    Authors: Iris Brunner, Jan S Skouen, Håkon Hofstad, Liv I Strand, Frank Becker, Anne-Marthe Sanders, Hanne Pallesen, Tove Kristensen, Marc Michielsen and Geert Verheyden

    Citation: BMC Neurology 2014 14:186

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  17. Content type: Case report

    Reports of occurrence of deep vein thrombosis during intensive sport are scarce. While a few cases have been described in the cerebral territory, these are only in the context of traumatism or anabolic agent c...

    Authors: Sébastien Richard, Jean-Christophe Lacour, Birgit Frotscher, Ana Enea, Gioia Mione and Xavier Ducrocq

    Citation: BMC Neurology 2014 14:182

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  18. Content type: Research article

    The investigation of glycated hemoglobin (HbA1c) as a diagnostic tool for abnormal glycometabolism is lack in acute ischemic stroke patients in China and worldwide. This paper was aimed to determine whether Hb...

    Authors: Shuolin Wu, Yuzhi Shi, Yuesong Pan, Jingjing Li, Qian Jia, Ning Zhang, Xingquan Zhao, Gaifen Liu, Yilong Wang, Yongjun Wang and Chunxue Wang

    Citation: BMC Neurology 2014 14:177

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  19. Content type: Case report

    Following carotid revascularization, an abrupt increase in cerebral blood flow may disrupt the blood-brain barrier, resulting in reperfusion injury. This damage to the blood-brain barrier may be reflected by s...

    Authors: Hyun-Ji Cho, Young Jin Kim, Joon Hwa Lee, Jin Woo Choi, Won-Jin Moon, Hong Gee Roh, Young Il Chun and Hahn Young Kim

    Citation: BMC Neurology 2014 14:178

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  20. Content type: Study protocol

    The failures of recent studies intended to prevent cerebral vasospasm have moved the focus of research into delayed cerebral ischemia away from cerebral artery constriction towards other mechanisms. Recent acc...

    Authors: Satoru Takeuchi, Kentaro Mori, Hirohiko Arimoto, Kazuya Fujii, Kimihiro Nagatani, Satoshi Tomura, Naoki Otani, Hideo Osada and Kojiro Wada

    Citation: BMC Neurology 2014 14:176

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  21. Content type: Research article

    There is uncertainty surrounding the differences in outcomes after intracerebral haemorrhage (ICH) between men and women. This study aimed to investigate the sex differences in clinical characteristics, severi...

    Authors: Junshan Zhou, Yingdong Zhang, Hisatomi Arima, Yanxia Zhao, Hongdong Zhao, Danni Zheng, Youyong Tian, Yukai Liu, Qing Huang and Jie Yang

    Citation: BMC Neurology 2014 14:172

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  22. Content type: Research article

    A key treatment for acute ischaemic stroke is thrombolysis (rtPA). However, treatment is not devoid of side effects and patients are carefully selected. AVERT (A Very Early Rehabilitation Trial), a large, ongo...

    Authors: Linnéa Muhl, Jenny Kulin, Marie Dagonnier, Leonid Churilov, Helen Dewey, Thomas Lindén and Julie Bernhardt

    Citation: BMC Neurology 2014 14:163

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  23. Content type: Research article

    There is increasing evidence for the beneficial effects of exercise training in stroke survivors. In order to reach the desired training effects, exercise training principles must be considered as this ensures...

    Authors: Bernadette C Ammann, Ruud H Knols, Pierrette Baschung, Rob A de Bie and Eling D de Bruin

    Citation: BMC Neurology 2014 14:167

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  24. Content type: Research article

    Intracranial Atherosclerotic Disease (ICAD) is the most frequent etiology of stroke with high prevalence among Asians. Despite this, early determinants of ICAD have not been described from this region.

    Authors: Ayeesha Kamran Kamal, Farzin Majeed, Omrana Pasha, Hasan Rehman, Muhammad Islam, Iqbal Azam, Muhammad Saleem Ilyas, Munawar Hussain, Kamran Masood, Bilal Ahmed, Sumaira Nazir, Zafar Sajjad and Scott E Kasner

    Citation: BMC Neurology 2014 14:155

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  25. Content type: Case report

    Cerebral cavernous malformations are relatively rare vascular disorders that may affect any part of the central nervous system. This presentation has been associated with heterozygous mutations in CCM1/KRIT1, CCM...

    Authors: Silvia Lanfranconi, Dario Ronchi, Naghia Ahmed, Vittorio Civelli, Paola Basilico, Nereo Bresolin, Giacomo Pietro Comi and Stefania Corti

    Citation: BMC Neurology 2014 14:158

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  26. Content type: Case report

    Osteogenesis imperfecta (OI) is a heterogeneous group of inherited disorders that occur owing to the abnormalities in type 1 collagen, and is characterized by increased bone fragility and other extraskeletal m...

    Authors: Toshio Hirohata, Satoru Miyawaki, Akiko Mizutani, Takayuki Iwakami, So Yamada, Hajime Nishido, Yasutaka Suzuki, Shinya Miyamoto, Katsumi Hoya, Mineko Murakami and Akira Matsuno

    Citation: BMC Neurology 2014 14:150

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  27. Content type: Research article

    Hypertensive putaminal haemorrhage comprises major part of intra-cerebral haemorrhages, with particularly high morbidity and mortality. However, the optimal treatments for these individuals remain controversial.

    Authors: Hao Liu, Yunhui Zen, Jin Li, Xiang Wang, Hao Li, Jianguo Xu and Chao You

    Citation: BMC Neurology 2014 14:141

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  28. Content type: Research article

    Subarachnoid hemorrhage (SAH) is mainly caused by ruptured cerebral aneurysms but in up to 15% of patients with SAH no bleeding source could be identified. Our objective was to analyze patient characteristics,...

    Authors: Juergen Konczalla, Johannes Platz, Patrick Schuss, Hartmut Vatter, Volker Seifert and Erdem Güresir

    Citation: BMC Neurology 2014 14:140

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  29. Content type: Research article

    Women die of stroke more often than men. After menopause, the incidence of ischemic stroke increases rapidly. Elevated fibrinogen levels and smoking have been associated with an increased risk of stroke. In ge...

    Authors: Mika Martiskainen, Niku Oksala, Tarja Pohjasvaara, Markku Kaste, Anni Oksala, Pekka J Karhunen and Timo Erkinjuntti

    Citation: BMC Neurology 2014 14:137

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  30. Content type: Study protocol

    Successful treatment options for cancer result in more young long-term survivors prone for long-term complications. Carotid artery vasculopathy is a potential long-term complication after radiotherapy of the n...

    Authors: Joyce Wilbers, Arnoud C Kappelle, Roy PC Kessels, Stefan CA Steens, Frederick JA Meijer, Johannes H Kaanders, Roy AM Haast, Laura E Versteeg, Anil M Tuladhar, Chris L de Korte, Hendrik HG Hansen, Frank J Hoebers, Willem Boogerd, Erik D van Werkhoven, Marlies E Nowee, Guus Hart…

    Citation: BMC Neurology 2014 14:132

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  31. Content type: Research article

    Previous research has suggested that vitamin D and sunlight are related to cardiovascular outcomes, but associations between sunlight and risk factors have not been investigated. We examined whether increased ...

    Authors: Shia T Kent, Mary Cushman, George Howard, Suzanne E Judd, William L Crosson, Mohammad Z Al-Hamdan and Leslie A McClure

    Citation: BMC Neurology 2014 14:133

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  32. Content type: Research article

    The modified version of the Postural Assessment Scale for Stroke Patients (SwePASS) is a new ordinal outcome measurement designed to assess postural control in patients with stroke. Before implementation of Sw...

    Authors: Carina U Persson, Katharina S Sunnerhagen and Åsa Lundgren-Nilsson

    Citation: BMC Neurology 2014 14:134

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  33. Content type: Research article

    Responsiveness of a measurement tool is its ability to detect change over time. The aim of this study was to determine the responsiveness and floor/ceiling effects of the ten-metre walk test (10mWT), Step Test...

    Authors: Katharine Scrivener, Karl Schurr and Catherine Sherrington

    Citation: BMC Neurology 2014 14:129

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  34. Content type: Research article

    Chronic renal insufficiency, diagnosed using creatinine based estimated glomerular filtration rate (GFR) or microalbumiuria, has been associated with the presence of cerebral microbleeds (CMBs). Cystatin C has...

    Authors: Mi-Young Oh, Hyon Lee, Joon Soon Kim, Wi-Sun Ryu, Seung-Hoon Lee, Sang-Bae Ko, Chulho Kim, Chang Hun Kim and Byung-Woo Yoon

    Citation: BMC Neurology 2014 14:127

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  35. Content type: Research article

    Small changes of bilirubin and liver enzymes are often detected during the acute phase of stroke, but their origin and significance are still poorly understood.

    Authors: Antonio Muscari, Andrea Collini, Elisa Fabbri, Marco Giovagnoli, Chiara Napoli, Valentina Rossi, Luca Vizioli, Andrea Bonfiglioli, Donatella Magalotti, Giovanni M Puddu and Marco Zoli

    Citation: BMC Neurology 2014 14:122

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  36. Content type: Research article

    No study on the characteristics of injury of the corticospinal tract (CST) or corticoreticular pathway (CRP) in patients with putaminal hemorrhage has been reported. In this study, using diffusion tensor tract...

    Authors: Jin Sun Yoo, Byung Yeon Choi, Chul Hoon Chang, Young Jin Jung, Seong Ho Kim and Sung Ho Jang

    Citation: BMC Neurology 2014 14:121

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  37. Content type: Study protocol

    Alteplase is the only approved thrombolytic agent for acute ischaemic stroke. The overall benefit from alteplase is substantial, but some evidence indicates that alteplase also has negative effects on the isch...

    Authors: Nicola Logallo, Christopher E Kvistad, Aliona Nacu, Halvor Naess, Ulrike Waje-Andreassen, Jörg Asmuss, Anne Hege Aamodt, Christian Lund, Martin W Kurz, Ole Morten Rønning, Rolf Salvesen, Titto T Idicula and Lars Thomassen

    Citation: BMC Neurology 2014 14:106

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  38. Content type: Study protocol

    The treatment of large (10-25 mm) or giant (≥25 mm) cerebral aneurysms remains technically challenging, with a much higher complication and recanalization rate than that is observed for smaller aneurysms. The ...

    Authors: Yu Zhou, Peng-Fei Yang, Yi-Bin Fang, Yi Xu, Bo Hong, Wen-Yuan Zhao, Qiang Li, Rui Zhao, Qing-Hai Huang and Jian-Min Liu

    Citation: BMC Neurology 2014 14:97

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  39. Content type: Research article

    A proportion of patients with acute ischemic stroke have elevated cardiac troponin levels and ECG changes suggestive of cardiac injury, but the etiology is unclear. The aims of this study were to assess the fr...

    Authors: Kashif Waqar Faiz, Bente Thommessen, Gunnar Einvik, Pål Haugar Brekke, Torbjørn Omland and Ole Morten Rønning

    Citation: BMC Neurology 2014 14:96

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  40. Content type: Research article

    Quality of life (QoL) assessment is important when monitoring over time the recovery of stroke-survivors living at home. This study explores the associations between QoL and socioeconomic factors, functional i...

    Authors: Michèle Baumann, Etienne Le Bihan, Kénora Chau and Nearkasen Chau

    Citation: BMC Neurology 2014 14:92

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  41. Content type: Research article

    Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disturbance in which patients enact their dreams while in REM sleep. The behavior is typically violent in association with violent dream conten...

    Authors: Wai Kwong Tang, Dirk M Hermann, Yang Kun Chen, Hua Jun Liang, Xiang Xin Liu, Winnie Chui Wing Chu, Anil T Ahuja, Jill Abrigo, Vincent Mok, Gabor S Ungvari and Ka Sing Wong

    Citation: BMC Neurology 2014 14:88

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  42. Content type: Study protocol

    Poor-grade aneurysmal subarachnoid hemorrhage (aSAH) is associated with very high mortality and morbidity. Our limited knowledge on predictors of long-term outcome in poor-grade patients with aSAH definitively...

    Authors: Bing Zhao, Xianxi Tan, Hua Yang, Kuang Zheng, Zequn Li, Ye Xiong and Ming Zhong

    Citation: BMC Neurology 2014 14:86

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  43. Content type: Research article

    The effects of performing a minimally invasive procedure at different stages after intracerebral hemorrhage on perihematomal MMP-9 expression and blood–brain barrier (BBB) permeability were evaluated.

    Authors: Guofeng Wu, Jing Shi, Fan Wang, Likun Wang, Anrong Feng and Siying Ren

    Citation: BMC Neurology 2014 14:85

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  44. Content type: Research article

    Stenosis of the internal carotid artery has been associated with cognitive impairment and decline. However, studies testing the effect of carotid revascularisation on cognition have had conflicting results. Th...

    Authors: Aysun Altinbas, Jeroen Hendrikse, Ale Algra, Martine JE van Zandvoort, Martin M Brown, Leo H Bonati, Gert Jan de Borst, L Jaap Kappelle and H Bart van der Worp

    Citation: BMC Neurology 2014 14:84

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  45. Content type: Research article

    Acute non-traumatic focal subarachnoid haemorrhage (fSAH) is a rare transient ischaemic attack (TIA)-mimic. MRI is considered to be indispensable by some authors in order to avoid misdiagnosis, and subsequent ...

    Authors: Lorenz Ertl, Dominik Morhard, Maria Deckert-Schmitz, Jennifer Linn and Gernot Schulte-Altedorneburg

    Citation: BMC Neurology 2014 14:80

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  46. Content type: Research article

    The relationship between circulating microRNA-223 and pathogenesis of acute ischemic stroke is unknown. Here we investigated the roles and possible targets of circulating microRNA-223 in human ischemic stroke ...

    Authors: Yang Wang, Yu Zhang, Jun Huang, Xiaoyan Chen, Xiang Gu, Yongting Wang, Lili Zeng and Guo-Yuan Yang

    Citation: BMC Neurology 2014 14:77

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  47. Content type: Case report

    Takayasu arteritis (TA) is an idiopathic large-vessel vasculitis that can result in significant morbidity and mortality secondary to progressive stenosis and occlusion. Monitoring disease progression is crucia...

    Authors: Timothy E O’Connor, Haley E Carpenter, Sharatchandra Bidari, Michael F Waters and Vishnumurthy Shushrutha Hedna

    Citation: BMC Neurology 2014 14:62

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  48. Content type: Research article

    Women have been reported to show more frequent recanalization and better recovery after intravenous (IV) recombinant tissue plasminogen activator (rt-PA) treatment for acute stroke compared with men. To invest...

    Authors: Fawaz Al-hussain, Muhammad S Hussain, Carlos Molina, Ken Uchino, Ashfaq Shuaib, Andrew M Demchuk, Andrei V Alexandrov and Maher Saqqur

    Citation: BMC Neurology 2014 14:60

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