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Dementias

Section edited by Marwan Sabbagh

This section focuses on neurodegeneration. Topics of interest include, but are not limited to, Alzheimer’s disease, Parkinson’s Disease, frontotemporal dementias, Lewy body dementia, vascular dementia, mild cognitive impairment and basic aspects of neurodegenerative diseases and prion diseases.

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  1. Content type: Research article

    Posterior cortical atrophy (PCA) is a group of clinical syndromes characterized by visuospatial and visuoperceptual impairment, with memory relatively preserved. Although PCA is pathologically almost identical...

    Authors: Jieying Li, Liyong Wu, Yi Tang, Aihong Zhou, Fen Wang, Yi Xing and Jianping Jia

    Citation: BMC Neurology 2018 18:65

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  2. Content type: Research article

    This study aimed to i) examine the frequency of C9orf72 expansions in a cohort of patients with the behavioural variant frontotemporal dementia (bvFTD) phenocopy syndrome, ii) observe outcomes in a group of pheno...

    Authors: E. Devenney, T. Swinn, E. Mioshi, M. Hornberger, K. E. Dawson, S. Mead, J. B. Rowe and J. R. Hodges

    Citation: BMC Neurology 2018 18:56

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  3. Content type: Case report

    Creutzfeldt-Jakob disease is a rare and fatal neurodegenerative disorder that affects mammals and humans. The prevalence of this disease in the United States is 0.5 to 1 per million inhabitants. So far in Ecua...

    Authors: Germaine Eleanor Torres Herrán, Andrés Damián Ortega Herrera, Braulio Martinez Burbano, Marcos Serrano-Dueñas, María Angélica Ortiz Yepez, Raúl Alberto Barrera Madera, Luis Alfredo Masabanda Campaña, Guillermo David Baño Jiménez, Denny Maritza Santos Saltos and Edgar Patricio Correa Díaz

    Citation: BMC Neurology 2018 18:55

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    The Correction to this article has been published in BMC Neurology 2018 18:84

  4. Content type: Case report

    Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease. Common first symptoms are dementia, cerebellar ataxia, visual disturbance, and psychiatric symptoms. Seizure as the first symptom of CJD is...

    Authors: Keita Miyake, Takashi Hara, Etsuko Oshima, Kiyohiro Kawada, Hideki Ishizu, Yuko Yamauchi, Katsuya Satoh, Tetsuyuki Kitamoto, Shintaro Takenoshita, Seishi Terada and Norihito Yamada

    Citation: BMC Neurology 2018 18:54

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  5. Content type: Study protocol

    Type 2 diabetes mellitus is associated with cognitive dysfunction and an increased risk of dementia. Linagliptin is a glucose-lowering agent of the dipeptidyl peptidase-IV (DPP-IV) inhibitor class that is of p...

    Authors: Geert Jan Biessels, Jolien Janssen, Esther van den Berg, Bernard Zinman, Mark A. Espeland, Michaela Mattheus and Odd Erik Johansen

    Citation: BMC Neurology 2018 18:7

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  6. Content type: Research article

    Alzheimer’s disease (AD) is an important, progressive neurodegenerative disease, with a complex genetic architecture. A key goal of biomedical research is to seek out disease risk genes, and to elucidate the f...

    Authors: Xiaoyan Huang, Hankui Liu, Xinming Li, Liping Guan, Jiankang Li, Laurent Christian Asker M. Tellier, Huanming Yang, Jian Wang and Jianguo Zhang

    Citation: BMC Neurology 2018 18:5

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  7. Content type: Research article

    Long non-coding RNA (LncRNA) have been reported to be involved in the pathogenesis of neurodegenerative diseases, but whether it can serve as a biomarker for Alzheimer disease (AD) is not yet known.

    Authors: Liang Feng, Yu-Ting Liao, Jin-Cai He, Cheng-Long Xie, Si-Yan Chen, Hui-Hui Fan, Zhi-Peng Su and Zhen Wang

    Citation: BMC Neurology 2018 18:4

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  8. Content type: Case report

    Enlarged perivascular spaces (PVS) are common magnetic resonance imaging (MRI) findings, whereas widespread enlarged PVS are extremely rare. Although most patients with widespread enlarged PVS remain asymptoma...

    Authors: Daisuke Taniguchi, Hideki Shimura, Masao Watanabe, Nobutaka Hattori and Takao Urabe

    Citation: BMC Neurology 2017 17:210

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  9. Content type: Research article

    The clinical features of Alzheimer’s disease (AD) are related to brain network degeneration, and hyperhomocysteinemia is related to greater white matter hyperintensities. We investigated the changes in four di...

    Authors: Chen-Chang Lee, Shih-Wei Hsu, Chi-Wei Huang, Wen-Neng Chang, Sz-Fan Chen, Ming-Kung Wu, Chiung-Chih Chang, Lain-Chyr Hwang and Po-Chou Chen

    Citation: BMC Neurology 2017 17:192

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  10. Content type: Case report

    Progranulin gene (GRN) mutations are major causes of frontotemporal lobar degeneration. To date, 68 pathogenic GRN mutations have been identified. However, very few of these mutations have been reported in Asians...

    Authors: Takashi Hosaka, Kazuhiro Ishii, Takeshi Miura, Naomi Mezaki, Kensaku Kasuga, Takeshi Ikeuchi and Akira Tamaoka

    Citation: BMC Neurology 2017 17:182

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  11. Content type: Debate

    Cerebral amyloid angiopathy (CAA) is characterized by the deposition of ß-amyloid peptides (Aß) in and surrounding the wall of microvasculature in the central nervous system, together with parenchymal amyloid ...

    Authors: Jian-Ming Li, Li-Ling Huang, Fei Liu, Bei-Sha Tang and Xiao-Xin Yan

    Citation: BMC Neurology 2017 17:163

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  12. Content type: Research article

    The causes of behavioral and psychological symptoms of dementia (BPSD) vary according to the dementia subtype and associated neuropathology. The present study aimed to (i) compare BPSD between patients with su...

    Authors: Min-Chien Tu, Wen-Hui Huang, Yen-Hsuan Hsu, Chung-Ping Lo, Jie Fu Deng and Ching-Feng Huang

    Citation: BMC Neurology 2017 17:144

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    The Correction to this article has been published in BMC Neurology 2017 17:189

  13. Content type: Research article

    The mini-mental state examination (MMSE) was adapted by individual countries according to their languages and cultures, though it has not been systematically compared. The objective of this study was to compar...

    Authors: Yong S. Shim, Dong Won Yang, Hee-Jin Kim, Young Ho Park and SangYun Kim

    Citation: BMC Neurology 2017 17:141

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  14. Content type: Research article

    Vascular cognitive impairment (VCI) is a heterogeneous entity with multiple aetiologies, all linked to underlying vascular disease. Among these, VCI related to subcortical small vessel disease (SSVD) is emergi...

    Authors: A. Wallin, E. Kapaki, M. Boban, S. Engelborghs, D. M. Hermann, B. Huisa, M. Jonsson, M. G. Kramberger, L. Lossi, B. Malojcic, S. Mehrabian, A. Merighi, E. B. Mukaetova-Ladinska, G. P. Paraskevas, B. O. Popescu, R. Ravid…

    Citation: BMC Neurology 2017 17:102

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  15. Content type: Research article

    To analyze voxel-wise correlation between cerebral blood flow (CBF) measured using ASL-MRI and cognition in patients with Alzheimer’s disease (AD).

    Authors: Tomohiro Kaneta, Omi Katsuse, Takamasa Hirano, Matsuyoshi Ogawa, Ayako Shihikura-Hino, Keisuke Yoshida, Toshinari Odawara, Yoshio Hirayasu and Tomio Inoue

    Citation: BMC Neurology 2017 17:91

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  16. Content type: Case report

    Dementia with Lewy bodies (DLB) is the second most frequent diagnosis of progressive degenerative dementia in older people. Delusions are common features in DLB and, among them, Capgras syndrome represents the...

    Authors: Paolo Solla, Gioia Mura, Antonino Cannas, Gianluca Floris, Davide Fonti, Gianni Orofino, Mauro Giovanni Carta and Francesco Marrosu

    Citation: BMC Neurology 2017 17:78

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  17. Content type: Study protocol

    Increasing age is the biggest risk factor for dementia, of which Alzheimer’s disease is the commonest cause. The pathological changes underpinning Alzheimer’s disease are thought to develop at least a decade p...

    Authors: Christopher A. Lane, Thomas D. Parker, Dave M. Cash, Kirsty Macpherson, Elizabeth Donnachie, Heidi Murray-Smith, Anna Barnes, Suzie Barker, Daniel G. Beasley, Jose Bras, David Brown, Ninon Burgos, Michelle Byford, M. Jorge Cardoso, Ana Carvalho, Jessica Collins…

    Citation: BMC Neurology 2017 17:75

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  18. Content type: Commentary

    Traditional approaches to clinical research have, as yet, failed to provide effective treatments for vascular dementia (VaD). Novel approaches to collation and synthesis of data may allow for time and cost eff...

    Authors: Fergus N. Doubal, Myzoon Ali, G. David Batty, Andreas Charidimou, Maria Eriksdotter, Martin Hofmann-Apitius, Yun-Hee Kim, Deborah A. Levine, Gillian Mead, Hermann A. M. Mucke, Craig W. Ritchie, Charlotte J. Roberts, Tom C. Russ, Robert Stewart, William Whiteley and Terence J. Quinn

    Citation: BMC Neurology 2017 17:72

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  19. Content type: Research article

    Alzheimer’s disease (AD) is a globally prevalent neurodegenerative condition, clinically characterized by progressive memory loss and gradual impairment of cognitive functions. Bapineuzumab is a fully humanize...

    Authors: Abdelrahman Ibrahim Abushouk, Ahmed Elmaraezy, Amro Aglan, Reham Salama, Samar Fouda, Rana Fouda and Ammar M. AlSafadi

    Citation: BMC Neurology 2017 17:66

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