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Section edited by Marwan Sabbagh

This section focuses on neurodegeneration. Topics of interest include, but are not limited to, Alzheimer’s disease, Parkinson’s Disease, frontotemporal dementias, Lewy body dementia, vascular dementia, mild cognitive impairment and basic aspects of neurodegenerative diseases and prion diseases.

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  1. Content type: Research article

    Neurodegeneration with brain iron accumulation (NBIA) is characterized by pathological iron accumulation in the subcortical nuclei and the cortex. As age-related iron accumulation studies in these structures a...

    Authors: Marlous C. M. van der Weijden, Peter Jan van Laar, Roald A. Lambrechts, Dineke S. Verbeek and Marina A. J. Tijssen

    Citation: BMC Neurology 2019 19:233

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  2. Content type: Study protocol

    Hip fracture represents a substantial acute inflammatory trauma, which may constitute a significant insult to the degenerating brain. Research suggests that an injury of this kind can affect memory and thinkin...

    Authors: Nick Leavey, Simon P. Hammond, Lee Shepstone, Jane Cross, Henrik Zetterberg, Colm Cunningham, Alasdair MacLullich, Leiv Otto Watne, Anne Marie Minihane, Clive Ballard, Anne-Brita Knapskog, Roanna Hall, Gregory Howard, Matt Hammond and Chris Fox

    Citation: BMC Neurology 2019 19:223

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  3. Content type: Case report

    THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine o...

    Authors: Hee Jin Kim, Hanna Cho, Seongbeom Park, Hyemin Jang, Young Hoon Ryu, Jae Yong Choi, Seung Hwan Moon, Seung Jun Oh, Minyoung Oh, Duk L. Na, Chul Hyoung Lyoo, Eun-Joo Kim, William W. Seeley, Jae Seung Kim, Kyung Chan Choi and Sang Won Seo

    Citation: BMC Neurology 2019 19:211

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  4. Content type: Research article

    Subcortical ischemic vascular dementia (SIVD) is very common among the older people, but has no approved treatment. Preclinical trials show that remote ischemic conditioning (RIC) reduces recurrence of ischemi...

    Authors: Zhangyuan Liao, Yali Bu, Meijie Li, Ranran Han, Nan Zhang, Junwei Hao and Wei Jiang

    Citation: BMC Neurology 2019 19:206

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  5. Content type: Research article

    Previous studies have shown that obstructive sleep apnea (OSA) is associated with a higher risk of cognitive impairment or dementia in the elderly, leading to deleterious health effects and decreasing quality ...

    Authors: Talha Mubashir, Lusine Abrahamyan, Ayan Niazi, Deween Piyasena, Abdul A. Arif, Jean Wong, Ricardo S. Osorio, Clodagh M. Ryan and Frances Chung

    Citation: BMC Neurology 2019 19:195

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  6. Content type: Study protocol

    Cognitive dysfunction is highly prevalent in Parkinson’s disease (PD) and a large proportion of patients eventually develops PD-related dementia. Currently, no effective treatment is available. Cognitive train...

    Authors: Tim D. van Balkom, Henk W. Berendse, Ysbrand D. van der Werf, Jos W. R. Twisk, Iris Zijlstra, Rob H. Hagen, Tanja Berk, Chris Vriend and Odile A. van den Heuvel

    Citation: BMC Neurology 2019 19:179

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  7. Content type: Research article

    Cholinesterase inhibitors remain the first line therapy for people with mild to moderate Alzheimer’s disease (AD). Response is modest and difficult to predict from pre-treatment characteristics. We hypothesise...

    Authors: Peter J. Connelly, Fiona Adams, Ziad I. Tayar and Faisel Khan

    Citation: BMC Neurology 2019 19:88

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  8. Content type: Study protocol

    Aging is often associated with behavioral impairments, but some people age more gracefully than others. Why? One factor that may play a role is individual differences in the distinctiveness of neural represent...

    Authors: Holly Gagnon, Molly Simmonite, Kaitlin Cassady, Jordan Chamberlain, Erin Freiburger, Poortata Lalwani, Shannon Kelley, Bradley Foerster, Denise C. Park, Myria Petrou, Rachael D. Seidler, Stephan F. Taylor, Daniel H. Weissman and Thad A. Polk

    Citation: BMC Neurology 2019 19:61

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  9. Content type: Research article

    Although patients with dementia frequently experience neuropsychological symptoms (NPS) such as agitation, which profoundly impacts patients, caregivers, and the healthcare system, few studies have evaluated t...

    Authors: Myrlene Sanon Aigbogun, Robert Stellhorn, Ann Hartry, Ross A. Baker and Howard Fillit

    Citation: BMC Neurology 2019 19:33

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  10. Content type: Case report

    Anti leucine-rich glioma inactivated 1 (LGI1) encephalitis is a rare autoimmune encephalitis (AE), characterized by acute or subacute cognitive impairment, faciobrachial dystonic seizures, psychiatric disturba...

    Authors: Xuanting Li, Junliang Yuan, Lei Liu and Wenli Hu

    Citation: BMC Neurology 2019 19:19

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  11. Content type: Research article

    To determine the association of prior traumatic brain injury (TBI) with subsequent diagnosis of neurodegeneration disease.

    Authors: Chi-Hsien Huang, Chi-Wei Lin, Yi-Che Lee, Chih-Yuan Huang, Ru-Yi Huang, Yi-Cheng Tai, Kuo-Wei Wang, San-Nan Yang, Yuan-Ting Sun and Hao-kuang Wang

    Citation: BMC Neurology 2018 18:184

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  12. Content type: Research article

    Neurodegenerative processes in the elderly damage the brain, leading to progressive, incapacitating cognitive, behavioral, and motor dysfunctions which culminate in dementia. Fully manifest dementia is likely ...

    Authors: Lorenzo Pasquini, Jorge Llibre Guerra, Martin Prince, Kia-Chong Chua and A. Matthew Prina

    Citation: BMC Neurology 2018 18:163

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  13. Content type: Research article

    Peripheral diagnostics for Alzheimer’s disease (AD) continue to be developed. Diagnostics capable of detecting AD before the onset of symptoms are particularly desirable, and, given the fact that early detecti...

    Authors: Marwan N Sabbagh, Jiong Shi, Moonhee Lee, Lisa Arnold, Yazan Al-Hasan, Jennifer Heim and Patrick McGeer

    Citation: BMC Neurology 2018 18:155

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  14. Content type: Research article

    There is evidence that uric acid may have antioxidant and neuroprotective effects and might therefore alter the risk for neurodegenerative diseases such as dementia. So far, the relation between serum uric aci...

    Authors: Bettina Engel, Willy Gomm, Karl Broich, Wolfgang Maier, Klaus Weckbecker and Britta Haenisch

    Citation: BMC Neurology 2018 18:131

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  15. Content type: Research article

    Dysphagia and other eating and drinking difficulties are common in progressive neurological diseases. Mealtimes can become a major source of difficulty and anxiety for patients and their families. Decisions ab...

    Authors: Gemma Clarke, Elizabeth Fistein, Anthony Holland, Jake Tobin, Sam Barclay and Stephen Barclay

    Citation: BMC Neurology 2018 18:115

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  16. Content type: Case report

    Semantic variant primary progressive aphasia (svPPA) is a subtype of primary progressive aphasia characterized by two-way anomia and disturbance in word comprehension, with focal atrophy in the left temporal l...

    Authors: Ryota Kobayashi, Hiroshi Hayashi, Shinobu Kawakatsu, Aiko Ishiki, Nobuyuki Okamura, Hiroyuki Arai and Koichi Otani

    Citation: BMC Neurology 2018 18:109

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  17. Content type: Study protocol

    Mild cognitive impairment is an early stage of Alzheimer’s disease. Increasing evidence has indicated that cognitive training could improve cognitive abilities of MCI patients in multiple cognitive domains, ma...

    Authors: Yiqi Lin, Binyin Li, Huidong Tang, Qun Xu, Yuncheng Wu, Qi Cheng, Chunbo Li, Shifu Xiao, Lu Shen, Weiguo Tang, Hui Yu, Naying He, Huawei Lin, Fuhua Yan, Wenwei Cao, Shilin Yang…

    Citation: BMC Neurology 2018 18:103

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  18. Content type: Research article

    Recently, most reports of Leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis are from Europe and the US, while the short term outcome and clinical characteristics of Chinese patients are rarely rep...

    Authors: Weishuai Li, Si Wu, Qingping Meng, Xiaotian Zhang, Yang Guo, Lin Cong, Shuyan Cong and Dongming Zheng

    Citation: BMC Neurology 2018 18:96

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  19. Content type: Research article

    Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are incurable, progressive and fatal neurodegenerative diseases with patients variably affected clinically by motor, behavior, and cognitiv...

    Authors: Vivek Majumder, Jenna M. Gregory, Marcelo A. Barria, Alison Green and Suvankar Pal

    Citation: BMC Neurology 2018 18:90

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  20. Content type: Research article

    Posterior cortical atrophy (PCA) is a group of clinical syndromes characterized by visuospatial and visuoperceptual impairment, with memory relatively preserved. Although PCA is pathologically almost identical...

    Authors: Jieying Li, Liyong Wu, Yi Tang, Aihong Zhou, Fen Wang, Yi Xing and Jianping Jia

    Citation: BMC Neurology 2018 18:65

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  21. Content type: Research article

    This study aimed to i) examine the frequency of C9orf72 expansions in a cohort of patients with the behavioural variant frontotemporal dementia (bvFTD) phenocopy syndrome, ii) observe outcomes in a group of pheno...

    Authors: E. Devenney, T. Swinn, E. Mioshi, M. Hornberger, K. E. Dawson, S. Mead, J. B. Rowe and J. R. Hodges

    Citation: BMC Neurology 2018 18:56

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  22. Content type: Case report

    Creutzfeldt-Jakob disease is a rare and fatal neurodegenerative disorder that affects mammals and humans. The prevalence of this disease in the United States is 0.5 to 1 per million inhabitants. So far in Ecua...

    Authors: Germaine Eleanor Torres Herrán, Andrés Damián Ortega Herrera, Braulio Martinez Burbano, Marcos Serrano-Dueñas, María Angélica Ortiz Yepez, Raúl Alberto Barrera Madera, Luis Alfredo Masabanda Campaña, Guillermo David Baño Jiménez, Denny Maritza Santos Saltos and Edgar Patricio Correa Díaz

    Citation: BMC Neurology 2018 18:55

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    The Correction to this article has been published in BMC Neurology 2018 18:84

  23. Content type: Case report

    Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease. Common first symptoms are dementia, cerebellar ataxia, visual disturbance, and psychiatric symptoms. Seizure as the first symptom of CJD is...

    Authors: Keita Miyake, Takashi Hara, Etsuko Oshima, Kiyohiro Kawada, Hideki Ishizu, Yuko Yamauchi, Katsuya Satoh, Tetsuyuki Kitamoto, Shintaro Takenoshita, Seishi Terada and Norihito Yamada

    Citation: BMC Neurology 2018 18:54

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  24. Content type: Study protocol

    Type 2 diabetes mellitus is associated with cognitive dysfunction and an increased risk of dementia. Linagliptin is a glucose-lowering agent of the dipeptidyl peptidase-IV (DPP-IV) inhibitor class that is of p...

    Authors: Geert Jan Biessels, Jolien Janssen, Esther van den Berg, Bernard Zinman, Mark A. Espeland, Michaela Mattheus and Odd Erik Johansen

    Citation: BMC Neurology 2018 18:7

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  25. Content type: Research article

    Alzheimer’s disease (AD) is an important, progressive neurodegenerative disease, with a complex genetic architecture. A key goal of biomedical research is to seek out disease risk genes, and to elucidate the f...

    Authors: Xiaoyan Huang, Hankui Liu, Xinming Li, Liping Guan, Jiankang Li, Laurent Christian Asker M. Tellier, Huanming Yang, Jian Wang and Jianguo Zhang

    Citation: BMC Neurology 2018 18:5

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  26. Content type: Research article

    Long non-coding RNA (LncRNA) have been reported to be involved in the pathogenesis of neurodegenerative diseases, but whether it can serve as a biomarker for Alzheimer disease (AD) is not yet known.

    Authors: Liang Feng, Yu-Ting Liao, Jin-Cai He, Cheng-Long Xie, Si-Yan Chen, Hui-Hui Fan, Zhi-Peng Su and Zhen Wang

    Citation: BMC Neurology 2018 18:4

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  27. Content type: Case report

    Enlarged perivascular spaces (PVS) are common magnetic resonance imaging (MRI) findings, whereas widespread enlarged PVS are extremely rare. Although most patients with widespread enlarged PVS remain asymptoma...

    Authors: Daisuke Taniguchi, Hideki Shimura, Masao Watanabe, Nobutaka Hattori and Takao Urabe

    Citation: BMC Neurology 2017 17:210

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  28. Content type: Research article

    The clinical features of Alzheimer’s disease (AD) are related to brain network degeneration, and hyperhomocysteinemia is related to greater white matter hyperintensities. We investigated the changes in four di...

    Authors: Chen-Chang Lee, Shih-Wei Hsu, Chi-Wei Huang, Wen-Neng Chang, Sz-Fan Chen, Ming-Kung Wu, Chiung-Chih Chang, Lain-Chyr Hwang and Po-Chou Chen

    Citation: BMC Neurology 2017 17:192

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  29. Content type: Case report

    Progranulin gene (GRN) mutations are major causes of frontotemporal lobar degeneration. To date, 68 pathogenic GRN mutations have been identified. However, very few of these mutations have been reported in Asians...

    Authors: Takashi Hosaka, Kazuhiro Ishii, Takeshi Miura, Naomi Mezaki, Kensaku Kasuga, Takeshi Ikeuchi and Akira Tamaoka

    Citation: BMC Neurology 2017 17:182

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  30. Content type: Debate

    Cerebral amyloid angiopathy (CAA) is characterized by the deposition of ß-amyloid peptides (Aß) in and surrounding the wall of microvasculature in the central nervous system, together with parenchymal amyloid ...

    Authors: Jian-Ming Li, Li-Ling Huang, Fei Liu, Bei-Sha Tang and Xiao-Xin Yan

    Citation: BMC Neurology 2017 17:163

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  31. Content type: Research article

    The causes of behavioral and psychological symptoms of dementia (BPSD) vary according to the dementia subtype and associated neuropathology. The present study aimed to (i) compare BPSD between patients with su...

    Authors: Min-Chien Tu, Wen-Hui Huang, Yen-Hsuan Hsu, Chung-Ping Lo, Jie Fu Deng and Ching-Feng Huang

    Citation: BMC Neurology 2017 17:144

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    The Correction to this article has been published in BMC Neurology 2017 17:189

  32. Content type: Research article

    The mini-mental state examination (MMSE) was adapted by individual countries according to their languages and cultures, though it has not been systematically compared. The objective of this study was to compar...

    Authors: Yong S. Shim, Dong Won Yang, Hee-Jin Kim, Young Ho Park and SangYun Kim

    Citation: BMC Neurology 2017 17:141

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  33. Content type: Research article

    Vascular cognitive impairment (VCI) is a heterogeneous entity with multiple aetiologies, all linked to underlying vascular disease. Among these, VCI related to subcortical small vessel disease (SSVD) is emergi...

    Authors: A. Wallin, E. Kapaki, M. Boban, S. Engelborghs, D. M. Hermann, B. Huisa, M. Jonsson, M. G. Kramberger, L. Lossi, B. Malojcic, S. Mehrabian, A. Merighi, E. B. Mukaetova-Ladinska, G. P. Paraskevas, B. O. Popescu, R. Ravid…

    Citation: BMC Neurology 2017 17:102

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  34. Content type: Research article

    To analyze voxel-wise correlation between cerebral blood flow (CBF) measured using ASL-MRI and cognition in patients with Alzheimer’s disease (AD).

    Authors: Tomohiro Kaneta, Omi Katsuse, Takamasa Hirano, Matsuyoshi Ogawa, Ayako Shihikura-Hino, Keisuke Yoshida, Toshinari Odawara, Yoshio Hirayasu and Tomio Inoue

    Citation: BMC Neurology 2017 17:91

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  35. Content type: Case report

    Dementia with Lewy bodies (DLB) is the second most frequent diagnosis of progressive degenerative dementia in older people. Delusions are common features in DLB and, among them, Capgras syndrome represents the...

    Authors: Paolo Solla, Gioia Mura, Antonino Cannas, Gianluca Floris, Davide Fonti, Gianni Orofino, Mauro Giovanni Carta and Francesco Marrosu

    Citation: BMC Neurology 2017 17:78

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  36. Content type: Study protocol

    Increasing age is the biggest risk factor for dementia, of which Alzheimer’s disease is the commonest cause. The pathological changes underpinning Alzheimer’s disease are thought to develop at least a decade p...

    Authors: Christopher A. Lane, Thomas D. Parker, Dave M. Cash, Kirsty Macpherson, Elizabeth Donnachie, Heidi Murray-Smith, Anna Barnes, Suzie Barker, Daniel G. Beasley, Jose Bras, David Brown, Ninon Burgos, Michelle Byford, M. Jorge Cardoso, Ana Carvalho, Jessica Collins…

    Citation: BMC Neurology 2017 17:75

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  37. Content type: Commentary

    Traditional approaches to clinical research have, as yet, failed to provide effective treatments for vascular dementia (VaD). Novel approaches to collation and synthesis of data may allow for time and cost eff...

    Authors: Fergus N. Doubal, Myzoon Ali, G. David Batty, Andreas Charidimou, Maria Eriksdotter, Martin Hofmann-Apitius, Yun-Hee Kim, Deborah A. Levine, Gillian Mead, Hermann A. M. Mucke, Craig W. Ritchie, Charlotte J. Roberts, Tom C. Russ, Robert Stewart, William Whiteley and Terence J. Quinn

    Citation: BMC Neurology 2017 17:72

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  38. Content type: Research article

    Alzheimer’s disease (AD) is a globally prevalent neurodegenerative condition, clinically characterized by progressive memory loss and gradual impairment of cognitive functions. Bapineuzumab is a fully humanize...

    Authors: Abdelrahman Ibrahim Abushouk, Ahmed Elmaraezy, Amro Aglan, Reham Salama, Samar Fouda, Rana Fouda and Ammar M. AlSafadi

    Citation: BMC Neurology 2017 17:66

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  39. Content type: Research article

    Alzheimer’s disease (AD) is the most common type of dementia. International multilateral cost-of-illness (COI) studies have revealed that the cost of treating this disease is huge, which places a significant b...

    Authors: Fangyu Li, Shuoqi Chen, Cuibai Wei and Jianping Jia

    Citation: BMC Neurology 2017 17:15

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  40. Content type: Research article

    Recent research suggests that several pathogenetic factors, including aging, genetics, inflammation, dyslipidemia, diabetes, and infectious diseases, influence cognitive decline (CD) risk. However, no definiti...

    Authors: Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Fumitaro Miyatani, Masaki Kondo, Aiko Tamura, Takashi Kasai, Yoichi Ohshima, Tomokatsu Yoshida, Takahiko Tokuda, Ikuko Mizuta, Shigeto Mizuno, Kei Yamada, Kazuo Takeda…

    Citation: BMC Neurology 2016 16:253

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  41. Content type: Database

    Heterogeneous disease trajectories of mild cognitive impairment (MCI) and dementia are frequently encountered in clinical practice, but there is still insufficient knowledge to understand the reasons and mecha...

    Authors: Weiqi Liao, Renske E. G. Hamel, Marcel G. M. Olde Rikkert, Saskia M. Oosterveld, Pauline Aalten, Frans R. J. Verhey, Philip Scheltens, Nicole Sistermans, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Inez H. G. B. Ramakers and René J. F. Melis

    Citation: BMC Neurology 2016 16:242

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  42. Content type: Case report

    Creutzfeldt - Jakob disease (CJD) is a rapidly progressive and fatal neurodegenerative prion disease. MRI findings are included in diagnostic criteria for probable CJD, giving a sensitivity and specificity mor...

    Authors: Edgaras Dirzius, Renata Balnyte, Vesta Steibliene, Rymante Gleizniene, Inga Gudinaviciene, Andrius Radziunas and Kestutis Petrikonis

    Citation: BMC Neurology 2016 16:234

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  43. Content type: Research article

    The smell sense reduction was considered to represent the potentially warning of early stage of neurodegenerative disorders. The Shanghai Aging Study provided us a unique opportunity to explore the association...

    Authors: Xiaoniu Liang, Ding Ding, Qianhua Zhao, Qihao Guo, Jianfeng Luo and Zhen Hong

    Citation: BMC Neurology 2016 16:199

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  44. Content type: Research article

    Caregivers of care-recipients with mild cognitive impairment (MCI) or dementia experience high caregiver burden; however, the psychiatric burden of caregivers of care-recipients with subjective cognitive decli...

    Authors: Xiaoniu Liang, Qihao Guo, Jianfeng Luo, Fang Li, Ding Ding, Qianhua Zhao and Zhen Hong

    Citation: BMC Neurology 2016 16:191

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  45. Content type: Research article

    Older adults with dementia are at an increased risk of falls, however, little is known about risk factors for recurrent injurious falls (a subsequent fall after the first fall has occurred) among this group. T...

    Authors: Lynn B. Meuleners, Michelle L. Fraser, Max K. Bulsara, Kyle Chow and Jonathon Q. Ng

    Citation: BMC Neurology 2016 16:188

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