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Dementias

This section focuses on neurodegeneration. Topics of interest include, but are not limited to, Alzheimer's disease, Parkinson's Disease, frontotemporal dementias, Lewy body dementia, vascular dementia, mild cognitive impairment and basic aspects of neurodegenerative diseases and prion diseases.

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  1. The association between cytomegalovirus (CMV) and dementia remains controversial. Previous studies have suggested that CMV serostatus, as assessed by serum immunoglobulin G, plays a role in neurodegeneration w...

    Authors: Kyoung Hwa Lee, Da Eun Kwon, Kyung Do Han, Yeonju La and Sang Hoon Han

    Citation: BMC Neurology 2020 20:216

    Content type: Research article

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  2. Pisa syndrome (PS) is characterized by an abnormally sustained posture, with flexion of the body and head to one side and slight rotation of the trunk. Although PS most commonly arises as an adverse effect of ...

    Authors: Yu Mimura, Shin Kurose, Taketo Takata, Hajime Tabuchi, Masaru Mimura and Michitaka Funayama

    Citation: BMC Neurology 2020 20:183

    Content type: Case report

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  3. Mild cognitive impairment (MCI) is an intermediate stage between normal aging and dementia. Studies on MCI progression are important for Alzheimer’s disease (AD) prevention. 18F fluoro-deoxy-glucose positron e...

    Authors: Lirong Teng, Yongchao Li, Yu Zhao, Tao Hu, Zhe Zhang, Zhijun Yao and Bin Hu

    Citation: BMC Neurology 2020 20:148

    Content type: Research article

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  4. Presently, for patients presenting with suspected Normal Pressure Hydrocephalus (NPH) who undergo temporary drainage of cerebrospinal fluid (CSF) there is no defined model to differentiate chance improvement f...

    Authors: Alexander Davis, Sevil Yasar, Iris Emerman, Seema Gulyani, Kristina Khingelova, Aruna Rao, Lacie Manthripragada, Mark Luciano and Abhay Moghekar

    Citation: BMC Neurology 2020 20:140

    Content type: Research article

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  5. Patients with Alzheimer’s disease dementia (ADD) are thought to exhibit taste disorders; however, this has not been extensively studied. We investigated gustatory functions and factors affecting taste in patie...

    Authors: Minoru Kouzuki, Junya Ichikawa, Daiki Shirasagi, Fumiya Katsube, Yuuki Kobashi, Hideki Matsumoto, Huichia Chao, Shintaro Yoshida and Katsuya Urakami

    Citation: BMC Neurology 2020 20:110

    Content type: Research article

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  6. Dementia and cognitive decline are serious social and economic burdens. An increase in the population of older people, as well as longer lifespans mean that numbers of dementia cases are exponentially rising. ...

    Authors: Katrin Müller, Stephanie Fröhlich, Andresa M. C. Germano, Jyothsna Kondragunta, Maria Fernanda del Carmen Agoitia Hurtado, Julian Rudisch, Daniel Schmidt, Gangolf Hirtz, Peter Stollmann and Claudia Voelcker-Rehage

    Citation: BMC Neurology 2020 20:84

    Content type: Study protocol

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  7. Subtle cognitive decline (SCD) may represent a very early stage of objective cognitive impairment before mild cognitive impairment (MCI), with less neuronal damage and more functional reservation. Detecting in...

    Authors: Feng-Feng Pan, Lin Huang, Ke-liang Chen, Qian-hua Zhao and Qi-hao Guo

    Citation: BMC Neurology 2020 20:78

    Content type: Research article

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  8. We investigated the potential associations between cerebro-spinal fluid (CSF) levels of phosphorylated tau (P-tau) and total tau (T-tau) with short-term response to cholinesterase inhibitor (ChEI) treatment, l...

    Authors: Carina Wattmo, Kaj Blennow and Oskar Hansson

    Citation: BMC Neurology 2020 20:10

    Content type: Research article

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  9. Frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are associated with divergent differences in grey matter volume, white matter diffusion, and functional connectivity. However, it is unknown at what d...

    Authors: Rogier A. Feis, Mark J. R. J. Bouts, Elise G. P. Dopper, Nicola Filippini, Verena Heise, Aaron J. Trachtenberg, John C. van Swieten, Mark A. van Buchem, Jeroen van der Grond, Clare E. Mackay and Serge A. R. B. Rombouts

    Citation: BMC Neurology 2019 19:343

    Content type: Research article

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  10. Early consultation is important to delay the onset of dementia. The present study aimed to explore the reasons for delaying a consultation of dementia while focusing on the differences in the perception of cog...

    Authors: Nobue Nakahori, Michikazu Sekine, Masaaki Yamada, Takashi Tatsuse, Hideki Kido and Michio Suzuki

    Citation: BMC Neurology 2019 19:338

    Content type: Research article

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  11. Mild Cognitive Impairment (MCI) carries a high risk of progression to Alzheimer’s disease (AD) dementia. Previous clinical trials testing whether cholinesterase inhibitors can slow the rate of progression from...

    Authors: Joy L. Taylor, Benjamin C. Hambro, Nicole D. Strossman, Priyanka Bhatt, Beatriz Hernandez, J. Wesson Ashford, Jauhtai Joseph Cheng, Michael Iv, Maheen M. Adamson, Laura C. Lazzeroni and Margaret Windy McNerney

    Citation: BMC Neurology 2019 19:326

    Content type: Study protocol

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  12. Neologisms are commonly encountered in patients with acute cerebrovascular diseases, particularly in those with Wernicke’s aphasia. However, few studies have investigated primary progressive aphasia with neolo...

    Authors: Hiroyuki Watanabe, Manabu Ikeda and Etsuro Mori

    Citation: BMC Neurology 2019 19:299

    Content type: Case report

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  13. To determine whether items of the Chinese version of the Montreal Cognitive Assessment Basic (MoCA-BC) could discriminate among cognitively normal controls (NC), and those with mild cognitive impairment (MCI),...

    Authors: Yan-Rong Zhang, Yun-Long Ding, Ke-liang Chen, Yan Liu, Can Wei, Ting-ting Zhai, Wen-Juan Wang and Wan-Li Dong

    Citation: BMC Neurology 2019 19:269

    Content type: Research article

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  14. As investigations of disease modifying drugs aim to slow down progression of Alzheimer’ disease (AD) biomarkers to reliably track disease progression gain more importance. This is especially important as clini...

    Authors: Marion Ortner, René Drost, Dennis Heddderich, Oliver Goldhardt, Felix Müller-Sarnowski, Janine Diehl-Schmid, Hans Förstl, Igor Yakushev and Timo Grimmer

    Citation: BMC Neurology 2019 19:264

    Content type: Research article

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    The Correction to this article has been published in BMC Neurology 2020 20:80

  15. Activated Vitamin D has anti-inflammatory properties and adequate 25-hydroxyvitamin D [25(OH)D] concentrations may be important for neurocognitive function and protection against neurologic injury. We examined...

    Authors: Oluwaseun E. Fashanu, Di Zhao, Andrea L. C. Schneider, Andreea M. Rawlings, A. Richey Sharrett, Pamela L. Lutsey, Rebecca F. Gottesman, Alden L. Gross, Eliseo Guallar, Alvaro Alonso, Thomas H. Mosley and Erin D. Michos

    Citation: BMC Neurology 2019 19:244

    Content type: Research article

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  16. Neurodegeneration with brain iron accumulation (NBIA) is characterized by pathological iron accumulation in the subcortical nuclei and the cortex. As age-related iron accumulation studies in these structures a...

    Authors: Marlous C. M. van der Weijden, Peter Jan van Laar, Roald A. Lambrechts, Dineke S. Verbeek and Marina A. J. Tijssen

    Citation: BMC Neurology 2019 19:233

    Content type: Research article

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  17. Hip fracture represents a substantial acute inflammatory trauma, which may constitute a significant insult to the degenerating brain. Research suggests that an injury of this kind can affect memory and thinkin...

    Authors: Nick Leavey, Simon P. Hammond, Lee Shepstone, Jane Cross, Henrik Zetterberg, Colm Cunningham, Alasdair MacLullich, Leiv Otto Watne, Anne Marie Minihane, Clive Ballard, Anne-Brita Knapskog, Roanna Hall, Gregory Howard, Matt Hammond and Chris Fox

    Citation: BMC Neurology 2019 19:223

    Content type: Study protocol

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  18. THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine o...

    Authors: Hee Jin Kim, Hanna Cho, Seongbeom Park, Hyemin Jang, Young Hoon Ryu, Jae Yong Choi, Seung Hwan Moon, Seung Jun Oh, Minyoung Oh, Duk L. Na, Chul Hyoung Lyoo, Eun-Joo Kim, William W. Seeley, Jae Seung Kim, Kyung Chan Choi and Sang Won Seo

    Citation: BMC Neurology 2019 19:211

    Content type: Case report

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  19. Subcortical ischemic vascular dementia (SIVD) is very common among the older people, but has no approved treatment. Preclinical trials show that remote ischemic conditioning (RIC) reduces recurrence of ischemi...

    Authors: Zhangyuan Liao, Yali Bu, Meijie Li, Ranran Han, Nan Zhang, Junwei Hao and Wei Jiang

    Citation: BMC Neurology 2019 19:206

    Content type: Research article

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  20. Previous studies have shown that obstructive sleep apnea (OSA) is associated with a higher risk of cognitive impairment or dementia in the elderly, leading to deleterious health effects and decreasing quality ...

    Authors: Talha Mubashir, Lusine Abrahamyan, Ayan Niazi, Deween Piyasena, Abdul A. Arif, Jean Wong, Ricardo S. Osorio, Clodagh M. Ryan and Frances Chung

    Citation: BMC Neurology 2019 19:195

    Content type: Research article

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  21. Cognitive dysfunction is highly prevalent in Parkinson’s disease (PD) and a large proportion of patients eventually develops PD-related dementia. Currently, no effective treatment is available. Cognitive train...

    Authors: Tim D. van Balkom, Henk W. Berendse, Ysbrand D. van der Werf, Jos W. R. Twisk, Iris Zijlstra, Rob H. Hagen, Tanja Berk, Chris Vriend and Odile A. van den Heuvel

    Citation: BMC Neurology 2019 19:179

    Content type: Study protocol

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  22. Cholinesterase inhibitors remain the first line therapy for people with mild to moderate Alzheimer’s disease (AD). Response is modest and difficult to predict from pre-treatment characteristics. We hypothesise...

    Authors: Peter J. Connelly, Fiona Adams, Ziad I. Tayar and Faisel Khan

    Citation: BMC Neurology 2019 19:88

    Content type: Research article

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  23. Aging is often associated with behavioral impairments, but some people age more gracefully than others. Why? One factor that may play a role is individual differences in the distinctiveness of neural represent...

    Authors: Holly Gagnon, Molly Simmonite, Kaitlin Cassady, Jordan Chamberlain, Erin Freiburger, Poortata Lalwani, Shannon Kelley, Bradley Foerster, Denise C. Park, Myria Petrou, Rachael D. Seidler, Stephan F. Taylor, Daniel H. Weissman and Thad A. Polk

    Citation: BMC Neurology 2019 19:61

    Content type: Study protocol

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  24. Although patients with dementia frequently experience neuropsychological symptoms (NPS) such as agitation, which profoundly impacts patients, caregivers, and the healthcare system, few studies have evaluated t...

    Authors: Myrlene Sanon Aigbogun, Robert Stellhorn, Ann Hartry, Ross A. Baker and Howard Fillit

    Citation: BMC Neurology 2019 19:33

    Content type: Research article

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  25. Anti leucine-rich glioma inactivated 1 (LGI1) encephalitis is a rare autoimmune encephalitis (AE), characterized by acute or subacute cognitive impairment, faciobrachial dystonic seizures, psychiatric disturba...

    Authors: Xuanting Li, Junliang Yuan, Lei Liu and Wenli Hu

    Citation: BMC Neurology 2019 19:19

    Content type: Case report

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  26. To determine the association of prior traumatic brain injury (TBI) with subsequent diagnosis of neurodegeneration disease.

    Authors: Chi-Hsien Huang, Chi-Wei Lin, Yi-Che Lee, Chih-Yuan Huang, Ru-Yi Huang, Yi-Cheng Tai, Kuo-Wei Wang, San-Nan Yang, Yuan-Ting Sun and Hao-kuang Wang

    Citation: BMC Neurology 2018 18:184

    Content type: Research article

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  27. Neurodegenerative processes in the elderly damage the brain, leading to progressive, incapacitating cognitive, behavioral, and motor dysfunctions which culminate in dementia. Fully manifest dementia is likely ...

    Authors: Lorenzo Pasquini, Jorge Llibre Guerra, Martin Prince, Kia-Chong Chua and A. Matthew Prina

    Citation: BMC Neurology 2018 18:163

    Content type: Research article

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  28. Peripheral diagnostics for Alzheimer’s disease (AD) continue to be developed. Diagnostics capable of detecting AD before the onset of symptoms are particularly desirable, and, given the fact that early detecti...

    Authors: Marwan N Sabbagh, Jiong Shi, Moonhee Lee, Lisa Arnold, Yazan Al-Hasan, Jennifer Heim and Patrick McGeer

    Citation: BMC Neurology 2018 18:155

    Content type: Research article

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  29. There is evidence that uric acid may have antioxidant and neuroprotective effects and might therefore alter the risk for neurodegenerative diseases such as dementia. So far, the relation between serum uric aci...

    Authors: Bettina Engel, Willy Gomm, Karl Broich, Wolfgang Maier, Klaus Weckbecker and Britta Haenisch

    Citation: BMC Neurology 2018 18:131

    Content type: Research article

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  30. Dysphagia and other eating and drinking difficulties are common in progressive neurological diseases. Mealtimes can become a major source of difficulty and anxiety for patients and their families. Decisions ab...

    Authors: Gemma Clarke, Elizabeth Fistein, Anthony Holland, Jake Tobin, Sam Barclay and Stephen Barclay

    Citation: BMC Neurology 2018 18:115

    Content type: Research article

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  31. Semantic variant primary progressive aphasia (svPPA) is a subtype of primary progressive aphasia characterized by two-way anomia and disturbance in word comprehension, with focal atrophy in the left temporal l...

    Authors: Ryota Kobayashi, Hiroshi Hayashi, Shinobu Kawakatsu, Aiko Ishiki, Nobuyuki Okamura, Hiroyuki Arai and Koichi Otani

    Citation: BMC Neurology 2018 18:109

    Content type: Case report

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  32. Mild cognitive impairment is an early stage of Alzheimer’s disease. Increasing evidence has indicated that cognitive training could improve cognitive abilities of MCI patients in multiple cognitive domains, ma...

    Authors: Yiqi Lin, Binyin Li, Huidong Tang, Qun Xu, Yuncheng Wu, Qi Cheng, Chunbo Li, Shifu Xiao, Lu Shen, Weiguo Tang, Hui Yu, Naying He, Huawei Lin, Fuhua Yan, Wenwei Cao, Shilin Yang…

    Citation: BMC Neurology 2018 18:103

    Content type: Study protocol

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  33. Recently, most reports of Leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis are from Europe and the US, while the short term outcome and clinical characteristics of Chinese patients are rarely rep...

    Authors: Weishuai Li, Si Wu, Qingping Meng, Xiaotian Zhang, Yang Guo, Lin Cong, Shuyan Cong and Dongming Zheng

    Citation: BMC Neurology 2018 18:96

    Content type: Research article

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  34. Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are incurable, progressive and fatal neurodegenerative diseases with patients variably affected clinically by motor, behavior, and cognitiv...

    Authors: Vivek Majumder, Jenna M. Gregory, Marcelo A. Barria, Alison Green and Suvankar Pal

    Citation: BMC Neurology 2018 18:90

    Content type: Research article

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  35. Posterior cortical atrophy (PCA) is a group of clinical syndromes characterized by visuospatial and visuoperceptual impairment, with memory relatively preserved. Although PCA is pathologically almost identical...

    Authors: Jieying Li, Liyong Wu, Yi Tang, Aihong Zhou, Fen Wang, Yi Xing and Jianping Jia

    Citation: BMC Neurology 2018 18:65

    Content type: Research article

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  36. This study aimed to i) examine the frequency of C9orf72 expansions in a cohort of patients with the behavioural variant frontotemporal dementia (bvFTD) phenocopy syndrome, ii) observe outcomes in a group of pheno...

    Authors: E. Devenney, T. Swinn, E. Mioshi, M. Hornberger, K. E. Dawson, S. Mead, J. B. Rowe and J. R. Hodges

    Citation: BMC Neurology 2018 18:56

    Content type: Research article

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  37. Creutzfeldt-Jakob disease is a rare and fatal neurodegenerative disorder that affects mammals and humans. The prevalence of this disease in the United States is 0.5 to 1 per million inhabitants. So far in Ecua...

    Authors: Germaine Eleanor Torres Herrán, Andrés Damián Ortega Herrera, Braulio Martinez Burbano, Marcos Serrano-Dueñas, María Angélica Ortiz Yepez, Raúl Alberto Barrera Madera, Luis Alfredo Masabanda Campaña, Guillermo David Baño Jiménez, Denny Maritza Santos Saltos and Edgar Patricio Correa Díaz

    Citation: BMC Neurology 2018 18:55

    Content type: Case report

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    The Correction to this article has been published in BMC Neurology 2018 18:84

  38. Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease. Common first symptoms are dementia, cerebellar ataxia, visual disturbance, and psychiatric symptoms. Seizure as the first symptom of CJD is...

    Authors: Keita Miyake, Takashi Hara, Etsuko Oshima, Kiyohiro Kawada, Hideki Ishizu, Yuko Yamauchi, Katsuya Satoh, Tetsuyuki Kitamoto, Shintaro Takenoshita, Seishi Terada and Norihito Yamada

    Citation: BMC Neurology 2018 18:54

    Content type: Case report

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  39. Type 2 diabetes mellitus is associated with cognitive dysfunction and an increased risk of dementia. Linagliptin is a glucose-lowering agent of the dipeptidyl peptidase-IV (DPP-IV) inhibitor class that is of p...

    Authors: Geert Jan Biessels, Jolien Janssen, Esther van den Berg, Bernard Zinman, Mark A. Espeland, Michaela Mattheus and Odd Erik Johansen

    Citation: BMC Neurology 2018 18:7

    Content type: Study protocol

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  40. Alzheimer’s disease (AD) is an important, progressive neurodegenerative disease, with a complex genetic architecture. A key goal of biomedical research is to seek out disease risk genes, and to elucidate the f...

    Authors: Xiaoyan Huang, Hankui Liu, Xinming Li, Liping Guan, Jiankang Li, Laurent Christian Asker M. Tellier, Huanming Yang, Jian Wang and Jianguo Zhang

    Citation: BMC Neurology 2018 18:5

    Content type: Research article

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  41. Long non-coding RNA (LncRNA) have been reported to be involved in the pathogenesis of neurodegenerative diseases, but whether it can serve as a biomarker for Alzheimer disease (AD) is not yet known.

    Authors: Liang Feng, Yu-Ting Liao, Jin-Cai He, Cheng-Long Xie, Si-Yan Chen, Hui-Hui Fan, Zhi-Peng Su and Zhen Wang

    Citation: BMC Neurology 2018 18:4

    Content type: Research article

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  42. Enlarged perivascular spaces (PVS) are common magnetic resonance imaging (MRI) findings, whereas widespread enlarged PVS are extremely rare. Although most patients with widespread enlarged PVS remain asymptoma...

    Authors: Daisuke Taniguchi, Hideki Shimura, Masao Watanabe, Nobutaka Hattori and Takao Urabe

    Citation: BMC Neurology 2017 17:210

    Content type: Case report

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  43. The clinical features of Alzheimer’s disease (AD) are related to brain network degeneration, and hyperhomocysteinemia is related to greater white matter hyperintensities. We investigated the changes in four di...

    Authors: Chen-Chang Lee, Shih-Wei Hsu, Chi-Wei Huang, Wen-Neng Chang, Sz-Fan Chen, Ming-Kung Wu, Chiung-Chih Chang, Lain-Chyr Hwang and Po-Chou Chen

    Citation: BMC Neurology 2017 17:192

    Content type: Research article

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  44. Progranulin gene (GRN) mutations are major causes of frontotemporal lobar degeneration. To date, 68 pathogenic GRN mutations have been identified. However, very few of these mutations have been reported in Asians...

    Authors: Takashi Hosaka, Kazuhiro Ishii, Takeshi Miura, Naomi Mezaki, Kensaku Kasuga, Takeshi Ikeuchi and Akira Tamaoka

    Citation: BMC Neurology 2017 17:182

    Content type: Case report

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  45. Cerebral amyloid angiopathy (CAA) is characterized by the deposition of ß-amyloid peptides (Aß) in and surrounding the wall of microvasculature in the central nervous system, together with parenchymal amyloid ...

    Authors: Jian-Ming Li, Li-Ling Huang, Fei Liu, Bei-Sha Tang and Xiao-Xin Yan

    Citation: BMC Neurology 2017 17:163

    Content type: Debate

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  46. The causes of behavioral and psychological symptoms of dementia (BPSD) vary according to the dementia subtype and associated neuropathology. The present study aimed to (i) compare BPSD between patients with su...

    Authors: Min-Chien Tu, Wen-Hui Huang, Yen-Hsuan Hsu, Chung-Ping Lo, Jie Fu Deng and Ching-Feng Huang

    Citation: BMC Neurology 2017 17:144

    Content type: Research article

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    The Correction to this article has been published in BMC Neurology 2017 17:189