Skip to main content

Dementias

This section focuses on neurodegeneration. Topics of interest include, but are not limited to, Alzheimer's disease, Parkinson's Disease, frontotemporal dementias, Lewy body dementia, vascular dementia, mild cognitive impairment and basic aspects of neurodegenerative diseases and prion diseases.

Page 1 of 4

  1. Brain age is a biomarker that predicts chronological age using neuroimaging features. Deviations of this predicted age from chronological age is considered a sign of age-related brain changes, or commonly refe...

    Authors: Jo Wrigglesworth, Phillip Ward, Ian H. Harding, Dinuli Nilaweera, Zimu Wu, Robyn L. Woods and Joanne Ryan

    Citation: BMC Neurology 2021 21:312

    Content type: Research article

    Published on:

  2. Dementia is one of the greatest global health and social care challenges of the twenty-first century. The etiology and pathogenesis of Alzheimer’s disease (AD) as the most common type of dementia remain unknow...

    Authors: Lingling Wang, Ping Li, Ming Hou, Xiumin Zhang, Xiaolin Cao and Hongyan Li

    Citation: BMC Neurology 2021 21:271

    Content type: Research article

    Published on:

  3. Inherited prion diseases are rare autosomal dominant disorders associated with diverse clinical presentations. All are associated with mutation of the gene that encodes prion protein (PRNP). Homozygous mutations ...

    Authors: Ahamad Hassan, Tracy Campbell, Lee Darwent, Hans Odd, Alison Green, John Collinge and Simon Mead

    Citation: BMC Neurology 2021 21:248

    Content type: Case report

    Published on:

  5. Blood-brain barrier (BBB) breakdown, as an early biomarker for vascular mild cognitive impairment (vMCI), has only been validated by a few studies. The aim of this study was to investigate whether compromised ...

    Authors: Man Li, Yue Li, Long Zuo, Wenli Hu and Tao Jiang

    Citation: BMC Neurology 2021 21:159

    Content type: Research article

    Published on:

  6. The retinal and cerebral microvasculature share similar embryological origins and physiological characteristics. Improved imaging technologies provide opportunistic non-invasive assessment of retinal microvasc...

    Authors: R. A. O’Neill, A. P. Maxwell, E. N. Paterson, F. Kee, I. Young, R. E. Hogg, S. Cruise, S. Murphy, B. McGuinness and G. J. McKay

    Citation: BMC Neurology 2021 21:112

    Content type: Research article

    Published on:

  7. To explore the correlation between the volume of putamen and brain cognitive impairment in patients with HIV and to predict the feasibility of early-stage HIV brain cognitive impairment through radiomics.

    Authors: Yu Qi, Man Xu, Wei Wang, Yuan-Yuan Wang, Jiao-Jiao Liu, Hai-Xia Ren, Ming-Ming Liu, Rui-Li Li and Hong-Jun Li

    Citation: BMC Neurology 2021 21:106

    Content type: Research article

    Published on:

  8. Screening for cognitive impairment (CI) is often hampered by lack of consensus as to which screening instrument to use. The aim is to assess the consistence and applicability of different CI screening tools.

    Authors: Lixia Lu, Lin Chen, Weiwen Wu, Yang Wang, Zhenbao Liu, Jun Xu, Qianhong Yang, Jun Zhao, Liangxian Liu and Hui Yu

    Citation: BMC Neurology 2021 21:95

    Content type: Research article

    Published on:

  9. Gait impairments are common in patients with Alzheimer’s disease. Cholinesterase inhibitors are used to treat the symptoms of patients with Alzheimer’s disease, but they have not been shown to reduce the sever...

    Authors: Hideki Shimura, Aiba Saiko, Akito Hayashi, Nobutaka Hattori and Takao Urabe

    Citation: BMC Neurology 2021 21:61

    Content type: Research article

    Published on:

  11. Glucocerebrosidase (GBA) heterozygous variants are the most important genetic risk factor for the development of alpha-synucleinopathies (i.e., Parkinson’s disease and Dementia with Lewy Bodies). Herein, we repor...

    Authors: Marina Picillo, Sara Scannapieco, Alessandro Iavarone, Monia Ginevrino, Enza Maria Valente and Paolo Barone

    Citation: BMC Neurology 2021 21:17

    Content type: Case report

    Published on:

  12. Parkinson’s disease (PD), frequently accompanied by cognitive impairments, is associated with systemic oxidative stress and abnormal structural changes on brain images. We aimed to identify the correlation bet...

    Authors: Ta-Chih Chang, Yi-Cun Chen, Yu-Chi Huang, Wei-Che Lin and Cheng-Hsien Lu

    Citation: BMC Neurology 2021 21:16

    Content type: Research article

    Published on:

  13. Vascular Parkinsonism(VaP) is defined as parkinsonism resulting from cerebral vascular disease(CVD), with presence of variable motor and non-motor signs that are corroborated by clinical, anatomic or imaging f...

    Authors: Shouzi Zhang, Yuanyuan Wang, Lixin Liu, Li Zhang, Li Ma, Haiyan Wu, Xuelin He, Mingwei Zhu, Luning Wang and Fan Mei

    Citation: BMC Neurology 2021 21:15

    Content type: Case report

    Published on:

  15. Apathy is one of the most common symptoms of Alzheimer’s disease (AD), however, correlations of apathy with demographic variables, cognitive functions, neuropsychiatric symptoms, activity of daily living and o...

    Authors: Shu-yang Yu, Teng-hong Lian, Peng Guo, Li-xia Li, Du-yu Ding, Dan-ning Li, Li Liu, Hui Zhao, Yang Hu, Li-jun Zuo, Jun-hua Gao, Qiu-jin Yu, Zhao Jin, Rui-dan Wang, Rong-yan Zhu, Xiao-min Wang…

    Citation: BMC Neurology 2020 20:416

    Content type: Research article

    Published on:

  19. The ventricular system plays a vital role in blood-cerebrospinal fluid (CSF) exchange and interstitial fluid-CSF drainage pathways. CSF is formed in the specialized secretory tissue called the choroid plexus, ...

    Authors: Andrew Pearson, Rosa Ajoy, Gogce Crynen, Jon M. Reed, Moustafa Algamal, Michael Mullan, Dushyant Purohit, Fiona Crawford and Joseph O. Ojo

    Citation: BMC Neurology 2020 20:317

    Content type: Research article

    Published on:

  20. The blood-brain barrier has been a hindrance to developing blood-based diagnostic tests for dementias, as it limits the appearance of brain biomarkers in the blood. Our aim was to see if the natural opening of...

    Authors: Dennis W. Choi, Tae Song Kim, Young Soo Kim and Dong Jin Kim

    Citation: BMC Neurology 2020 20:293

    Content type: Research article

    Published on:

  22. The level of function of instrumental activities of daily living (IADL) is crucial for a person’s autonomy. A clear understanding of the nature of IADL and its limitations in people with mild cognitive impairm...

    Authors: Marina Bruderer-Hofstetter, Sietske A. M. Sikkes, Thomas Münzer and Karin Niedermann

    Citation: BMC Neurology 2020 20:264

    Content type: Research article

    Published on:

  23. Lowering vascular risk is associated with a decrease in the prevalence of cardiovascular disease and dementia. However, it is still unknown whether lowering of vascular risk with pharmacological treatment pres...

    Authors: Marlise E. A. van Eersel, Sipke T. Visser, Hanneke Joosten, Ron T. Gansevoort, Joris P. J. Slaets and Gerbrand J. Izaks

    Citation: BMC Neurology 2020 20:242

    Content type: Research article

    Published on:

  24. By 2050, the prevalence of Alzheimer’s disease (AD) in the United States is predicted to reach 13.8 million. Despite worldwide research efforts, a cure for AD has not been identified. Thus, it is critical to i...

    Authors: Kyoung Shin Park, Alexis B. Ganesh, Nathaniel T. Berry, Yashonda P. Mobley, William B. Karper, Jeffrey D. Labban, Christopher N. Wahlheim, Tomika M. Williams, Laurie Wideman and Jennifer L. Etnier

    Citation: BMC Neurology 2020 20:231

    Content type: Study protocol

    Published on:

  25. The association between cytomegalovirus (CMV) and dementia remains controversial. Previous studies have suggested that CMV serostatus, as assessed by serum immunoglobulin G, plays a role in neurodegeneration w...

    Authors: Kyoung Hwa Lee, Da Eun Kwon, Kyung Do Han, Yeonju La and Sang Hoon Han

    Citation: BMC Neurology 2020 20:216

    Content type: Research article

    Published on:

  26. Pisa syndrome (PS) is characterized by an abnormally sustained posture, with flexion of the body and head to one side and slight rotation of the trunk. Although PS most commonly arises as an adverse effect of ...

    Authors: Yu Mimura, Shin Kurose, Taketo Takata, Hajime Tabuchi, Masaru Mimura and Michitaka Funayama

    Citation: BMC Neurology 2020 20:183

    Content type: Case report

    Published on:

  27. Mild cognitive impairment (MCI) is an intermediate stage between normal aging and dementia. Studies on MCI progression are important for Alzheimer’s disease (AD) prevention. 18F fluoro-deoxy-glucose positron e...

    Authors: Lirong Teng, Yongchao Li, Yu Zhao, Tao Hu, Zhe Zhang, Zhijun Yao and Bin Hu

    Citation: BMC Neurology 2020 20:148

    Content type: Research article

    Published on:

  28. Presently, for patients presenting with suspected Normal Pressure Hydrocephalus (NPH) who undergo temporary drainage of cerebrospinal fluid (CSF) there is no defined model to differentiate chance improvement f...

    Authors: Alexander Davis, Sevil Yasar, Iris Emerman, Seema Gulyani, Kristina Khingelova, Aruna Rao, Lacie Manthripragada, Mark Luciano and Abhay Moghekar

    Citation: BMC Neurology 2020 20:140

    Content type: Research article

    Published on:

  30. Patients with Alzheimer’s disease dementia (ADD) are thought to exhibit taste disorders; however, this has not been extensively studied. We investigated gustatory functions and factors affecting taste in patie...

    Authors: Minoru Kouzuki, Junya Ichikawa, Daiki Shirasagi, Fumiya Katsube, Yuuki Kobashi, Hideki Matsumoto, Huichia Chao, Shintaro Yoshida and Katsuya Urakami

    Citation: BMC Neurology 2020 20:110

    Content type: Research article

    Published on:

  31. Dementia and cognitive decline are serious social and economic burdens. An increase in the population of older people, as well as longer lifespans mean that numbers of dementia cases are exponentially rising. ...

    Authors: Katrin Müller, Stephanie Fröhlich, Andresa M. C. Germano, Jyothsna Kondragunta, Maria Fernanda del Carmen Agoitia Hurtado, Julian Rudisch, Daniel Schmidt, Gangolf Hirtz, Peter Stollmann and Claudia Voelcker-Rehage

    Citation: BMC Neurology 2020 20:84

    Content type: Study protocol

    Published on:

  32. Subtle cognitive decline (SCD) may represent a very early stage of objective cognitive impairment before mild cognitive impairment (MCI), with less neuronal damage and more functional reservation. Detecting in...

    Authors: Feng-Feng Pan, Lin Huang, Ke-liang Chen, Qian-hua Zhao and Qi-hao Guo

    Citation: BMC Neurology 2020 20:78

    Content type: Research article

    Published on:

  33. We investigated the potential associations between cerebro-spinal fluid (CSF) levels of phosphorylated tau (P-tau) and total tau (T-tau) with short-term response to cholinesterase inhibitor (ChEI) treatment, l...

    Authors: Carina Wattmo, Kaj Blennow and Oskar Hansson

    Citation: BMC Neurology 2020 20:10

    Content type: Research article

    Published on:

  34. Frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are associated with divergent differences in grey matter volume, white matter diffusion, and functional connectivity. However, it is unknown at what d...

    Authors: Rogier A. Feis, Mark J. R. J. Bouts, Elise G. P. Dopper, Nicola Filippini, Verena Heise, Aaron J. Trachtenberg, John C. van Swieten, Mark A. van Buchem, Jeroen van der Grond, Clare E. Mackay and Serge A. R. B. Rombouts

    Citation: BMC Neurology 2019 19:343

    Content type: Research article

    Published on:

  35. Early consultation is important to delay the onset of dementia. The present study aimed to explore the reasons for delaying a consultation of dementia while focusing on the differences in the perception of cog...

    Authors: Nobue Nakahori, Michikazu Sekine, Masaaki Yamada, Takashi Tatsuse, Hideki Kido and Michio Suzuki

    Citation: BMC Neurology 2019 19:338

    Content type: Research article

    Published on:

  36. Mild Cognitive Impairment (MCI) carries a high risk of progression to Alzheimer’s disease (AD) dementia. Previous clinical trials testing whether cholinesterase inhibitors can slow the rate of progression from...

    Authors: Joy L. Taylor, Benjamin C. Hambro, Nicole D. Strossman, Priyanka Bhatt, Beatriz Hernandez, J. Wesson Ashford, Jauhtai Joseph Cheng, Michael Iv, Maheen M. Adamson, Laura C. Lazzeroni and Margaret Windy McNerney

    Citation: BMC Neurology 2019 19:326

    Content type: Study protocol

    Published on:

  37. Neologisms are commonly encountered in patients with acute cerebrovascular diseases, particularly in those with Wernicke’s aphasia. However, few studies have investigated primary progressive aphasia with neolo...

    Authors: Hiroyuki Watanabe, Manabu Ikeda and Etsuro Mori

    Citation: BMC Neurology 2019 19:299

    Content type: Case report

    Published on:

  39. To determine whether items of the Chinese version of the Montreal Cognitive Assessment Basic (MoCA-BC) could discriminate among cognitively normal controls (NC), and those with mild cognitive impairment (MCI),...

    Authors: Yan-Rong Zhang, Yun-Long Ding, Ke-liang Chen, Yan Liu, Can Wei, Ting-ting Zhai, Wen-Juan Wang and Wan-Li Dong

    Citation: BMC Neurology 2019 19:269

    Content type: Research article

    Published on:

  40. As investigations of disease modifying drugs aim to slow down progression of Alzheimer’ disease (AD) biomarkers to reliably track disease progression gain more importance. This is especially important as clini...

    Authors: Marion Ortner, René Drost, Dennis Heddderich, Oliver Goldhardt, Felix Müller-Sarnowski, Janine Diehl-Schmid, Hans Förstl, Igor Yakushev and Timo Grimmer

    Citation: BMC Neurology 2019 19:264

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Neurology 2020 20:80

  41. Activated Vitamin D has anti-inflammatory properties and adequate 25-hydroxyvitamin D [25(OH)D] concentrations may be important for neurocognitive function and protection against neurologic injury. We examined...

    Authors: Oluwaseun E. Fashanu, Di Zhao, Andrea L. C. Schneider, Andreea M. Rawlings, A. Richey Sharrett, Pamela L. Lutsey, Rebecca F. Gottesman, Alden L. Gross, Eliseo Guallar, Alvaro Alonso, Thomas H. Mosley and Erin D. Michos

    Citation: BMC Neurology 2019 19:244

    Content type: Research article

    Published on:

  42. Neurodegeneration with brain iron accumulation (NBIA) is characterized by pathological iron accumulation in the subcortical nuclei and the cortex. As age-related iron accumulation studies in these structures a...

    Authors: Marlous C. M. van der Weijden, Peter Jan van Laar, Roald A. Lambrechts, Dineke S. Verbeek and Marina A. J. Tijssen

    Citation: BMC Neurology 2019 19:233

    Content type: Research article

    Published on:

  43. Hip fracture represents a substantial acute inflammatory trauma, which may constitute a significant insult to the degenerating brain. Research suggests that an injury of this kind can affect memory and thinkin...

    Authors: Nick Leavey, Simon P. Hammond, Lee Shepstone, Jane Cross, Henrik Zetterberg, Colm Cunningham, Alasdair MacLullich, Leiv Otto Watne, Anne Marie Minihane, Clive Ballard, Anne-Brita Knapskog, Roanna Hall, Gregory Howard, Matt Hammond and Chris Fox

    Citation: BMC Neurology 2019 19:223

    Content type: Study protocol

    Published on:

  44. THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine o...

    Authors: Hee Jin Kim, Hanna Cho, Seongbeom Park, Hyemin Jang, Young Hoon Ryu, Jae Yong Choi, Seung Hwan Moon, Seung Jun Oh, Minyoung Oh, Duk L. Na, Chul Hyoung Lyoo, Eun-Joo Kim, William W. Seeley, Jae Seung Kim, Kyung Chan Choi and Sang Won Seo

    Citation: BMC Neurology 2019 19:211

    Content type: Case report

    Published on:

  45. Subcortical ischemic vascular dementia (SIVD) is very common among the older people, but has no approved treatment. Preclinical trials show that remote ischemic conditioning (RIC) reduces recurrence of ischemi...

    Authors: Zhangyuan Liao, Yali Bu, Meijie Li, Ranran Han, Nan Zhang, Junwei Hao and Wei Jiang

    Citation: BMC Neurology 2019 19:206

    Content type: Research article

    Published on:

  46. Previous studies have shown that obstructive sleep apnea (OSA) is associated with a higher risk of cognitive impairment or dementia in the elderly, leading to deleterious health effects and decreasing quality ...

    Authors: Talha Mubashir, Lusine Abrahamyan, Ayan Niazi, Deween Piyasena, Abdul A. Arif, Jean Wong, Ricardo S. Osorio, Clodagh M. Ryan and Frances Chung

    Citation: BMC Neurology 2019 19:195

    Content type: Research article

    Published on:

  47. Cognitive dysfunction is highly prevalent in Parkinson’s disease (PD) and a large proportion of patients eventually develops PD-related dementia. Currently, no effective treatment is available. Cognitive train...

    Authors: Tim D. van Balkom, Henk W. Berendse, Ysbrand D. van der Werf, Jos W. R. Twisk, Iris Zijlstra, Rob H. Hagen, Tanja Berk, Chris Vriend and Odile A. van den Heuvel

    Citation: BMC Neurology 2019 19:179

    Content type: Study protocol

    Published on:

  49. Cholinesterase inhibitors remain the first line therapy for people with mild to moderate Alzheimer’s disease (AD). Response is modest and difficult to predict from pre-treatment characteristics. We hypothesise...

    Authors: Peter J. Connelly, Fiona Adams, Ziad I. Tayar and Faisel Khan

    Citation: BMC Neurology 2019 19:88

    Content type: Research article

    Published on:

  50. Aging is often associated with behavioral impairments, but some people age more gracefully than others. Why? One factor that may play a role is individual differences in the distinctiveness of neural represent...

    Authors: Holly Gagnon, Molly Simmonite, Kaitlin Cassady, Jordan Chamberlain, Erin Freiburger, Poortata Lalwani, Shannon Kelley, Bradley Foerster, Denise C. Park, Myria Petrou, Rachael D. Seidler, Stephan F. Taylor, Daniel H. Weissman and Thad A. Polk

    Citation: BMC Neurology 2019 19:61

    Content type: Study protocol

    Published on:

Submit manuscript

Follow

Annual Journal Metrics

BMC Neurology

ISSN: 1471-2377

Contact us