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BMC Neurology


Section edited by Marwan Sabbagh

This section focuses on neurodegeneration. Topics of interest include, but are not limited to, Alzheimer’s disease, Parkinson’s Disease, frontotemporal dementias, Lewy body dementia, vascular dementia, mild cognitive impairment and basic aspects of neurodegenerative diseases and prion diseases.

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  1. Content type: Database

    Heterogeneous disease trajectories of mild cognitive impairment (MCI) and dementia are frequently encountered in clinical practice, but there is still insufficient knowledge to understand the reasons and mecha...

    Authors: Weiqi Liao, Renske E. G. Hamel, Marcel G. M. Olde Rikkert, Saskia M. Oosterveld, Pauline Aalten, Frans R. J. Verhey, Philip Scheltens, Nicole Sistermans, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Inez H. G. B. Ramakers and René J. F. Melis

    Citation: BMC Neurology 2016 16:242

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  2. Content type: Case report

    Creutzfeldt - Jakob disease (CJD) is a rapidly progressive and fatal neurodegenerative prion disease. MRI findings are included in diagnostic criteria for probable CJD, giving a sensitivity and specificity mor...

    Authors: Edgaras Dirzius, Renata Balnyte, Vesta Steibliene, Rymante Gleizniene, Inga Gudinaviciene, Andrius Radziunas and Kestutis Petrikonis

    Citation: BMC Neurology 2016 16:234

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  3. Content type: Research article

    The smell sense reduction was considered to represent the potentially warning of early stage of neurodegenerative disorders. The Shanghai Aging Study provided us a unique opportunity to explore the association...

    Authors: Xiaoniu Liang, Ding Ding, Qianhua Zhao, Qihao Guo, Jianfeng Luo and Zhen Hong

    Citation: BMC Neurology 2016 16:199

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  4. Content type: Research article

    Caregivers of care-recipients with mild cognitive impairment (MCI) or dementia experience high caregiver burden; however, the psychiatric burden of caregivers of care-recipients with subjective cognitive decli...

    Authors: Xiaoniu Liang, Qihao Guo, Jianfeng Luo, Fang Li, Ding Ding, Qianhua Zhao and Zhen Hong

    Citation: BMC Neurology 2016 16:191

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  5. Content type: Research article

    Older adults with dementia are at an increased risk of falls, however, little is known about risk factors for recurrent injurious falls (a subsequent fall after the first fall has occurred) among this group. T...

    Authors: Lynn B. Meuleners, Michelle L. Fraser, Max K. Bulsara, Kyle Chow and Jonathon Q. Ng

    Citation: BMC Neurology 2016 16:188

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  6. Content type: Research article

    It is widely accepted that neuroinflammatory processes play an important role in the pathogenesis of Alzheimer’s disease (AD) and high levels of cytokines and chemokines are detected around Aβ plaques.

    Authors: Raphael Hesse, Anke Wahler, Pauline Gummert, Stefanie Kirschmer, Markus Otto, Hayrettin Tumani, Jan Lewerenz, Cathrin Schnack and Christine A. F. von Arnim

    Citation: BMC Neurology 2016 16:185

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  7. Content type: Research article

    α-Synuclein has been proposed as a potential biomarker for Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI). However, results from α-synuclein measurements in cerebrospinal fluid (CSF) ha...

    Authors: Guro Berge, Sigrid B. Sando, Grethe Albrektsen, Camilla Lauridsen, Ina Møller, Gøril R. Grøntvedt, Geir Bråthen and Linda R. White

    Citation: BMC Neurology 2016 16:180

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  8. Content type: Case report

    Fahr’s disease is rare a neurodegenerative idiopathic condition characterized by symmetric and bilateral calcifications of basal ganglia, usually associated with progressive neuropsychiatric dysfunctions and m...

    Authors: Elisabetta Savino, Cecilia Soavi, Eleonora Capatti, Massimo Borrelli, Giovanni B. Vigna, Angelina Passaro and Giovanni Zuliani

    Citation: BMC Neurology 2016 16:165

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  9. Content type: Erratum

    Authors: Flora M. Hammond, David N. Alexander, Andrew J. Cutler, Stephen D’Amico, Rachelle S. Doody, William Sauve, Richard D. Zorowitz, Charles S. Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E. Formella and Joao Siffert

    Citation: BMC Neurology 2016 16:160

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    The original article was published in BMC Neurology 2016 16:89

  10. Content type: Research article

    The survival time in nursing homes (NHs) in Alzheimer’s disease (AD) might be affected by sociodemographic/clinical characteristics, rate of disease progression, and use of specific medications and community-b...

    Authors: Carina Wattmo, Elisabet Londos and Lennart Minthon

    Citation: BMC Neurology 2016 16:156

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  11. Content type: Case report

    Alzheimer’s disease (AD) is the most common cause of dementia in the elderly. The possibility of disease-modifying strategies has evoked a need for early and accurate diagnosis. To improve the accuracy of the ...

    Authors: Sonja Schönecker, Matthias Brendel, Marion Huber, Christian Vollmar, Hans-Juergen Huppertz, Stefan Teipel, Nobuyuki Okamura, Johannes Levin, Axel Rominger and Adrian Danek

    Citation: BMC Neurology 2016 16:131

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  12. Content type: Case report

    Few patients are reported with dementia with Lewy bodies before fifty years-old, which may partly reflect the difficulty of accurate diagnosis in young population. We report the case of a 44-year-old male with...

    Authors: Laure Saint-Aubert, Jérémie Pariente, Herve Dumas, Pierre Payoux, Jean-Philippe Brandel, Michèle Puel, Anne Vital, Eric Guedj, Suzanne Lesage, Katell Peoc’h, Christine Brefel Courbon and Fabienne Ory Magne

    Citation: BMC Neurology 2016 16:122

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  13. Content type: Research article

    Improving cardiovascular health possibly decreases the risk of dementia. Primary care practices offer a suitable setting for monitoring and controlling cardiovascular risk factors in the older population. The ...

    Authors: Johannes Baltasar Hessler, Karl-Heinz Ander, Monika Brönner, Thorleif Etgen, Hans Förstl, Holger Poppert, Dirk Sander and Horst Bickel

    Citation: BMC Neurology 2016 16:116

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  14. Content type: Research article

    Disease-modification clinical trials in neurodegenerative disorders have struggled to separate symptomatic effects of putative agents from disease-modification. In response, a variety of clinical trial designs...

    Authors: David J. M. McGhee, Craig W. Ritchie, John P. Zajicek and Carl E. Counsell

    Citation: BMC Neurology 2016 16:92

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  15. Content type: Research article

    Phase 3 trials supporting dextromethorphan/quinidine (DM/Q) use as a treatment for pseudobulbar affect (PBA) were conducted in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS). The ...

    Authors: Flora M. Hammond, David N. Alexander, Andrew J. Cutler, Stephen D’Amico, Rachelle S. Doody, William Sauve, Richard D. Zorowitz, Charles S. Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E. Formella and Joao Siffert

    Citation: BMC Neurology 2016 16:89

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    The Erratum to this article has been published in BMC Neurology 2016 16:160

  16. Content type: Research article

    Executive functions (EF) in Alzheimer’s disease (AD), classically related to the prefrontal cortex, have been forgotten in mild stages, given more importance to temporal lobe associated disorders, such as memo...

    Authors: E. Blanco Martín, I. Ugarriza Serrano, X. Elcoroaristizabal Martín, L. Galdos Alcelay, A. Molano Salazar, R. Bereincua Gandarias, S. Inglés Borda, J. M. Uterga Valiente, M. B. Indakoetxea Juanbeltz, J. Moraza Lopez, M. Barandiarán Amillano and M. Fernández-Martínez

    Citation: BMC Neurology 2016 16:88

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  17. Content type: Case report

    Three main genes are described as causative genes for early-onset Alzheimer dementia (EOAD): APP, PSEN1 and PSEN2. We describe a woman with EOAD had a novel PSEN1 mutation.

    Authors: Seong Soo A. An, Eva Bagyinszky, Hye Ryoun Kim, Ju-Won Seok, Hae-Won Shin, SeunOh Bae, SangYun Kim and Young Chul Youn

    Citation: BMC Neurology 2016 16:71

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  18. Content type: Study protocol

    The ε4 allele of the Apolipoprotein E gene (APOE-ε4) is a potent genetic risk factor for sporadic Alzheimer’s disease (AD). Amnestic mild cognitive impairment (aMCI) is an intermediate state between normal cog...

    Authors: Guan-Qun Chen, Can Sheng, Yu-Xia Li, Yang Yu, Xiao-Ni Wang, Yu Sun, Hong-Yan Li, Xuan-Yu Li, Yun-Yan Xie and Ying Han

    Citation: BMC Neurology 2016 16:64

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  19. Content type: Study protocol

    Considerable variability exists in international prevalence and incidence estimates of dementia. The accuracy of estimates of dementia in the oldest-old and the controversial question of whether dementia incid...

    Authors: Henry Brodaty, Claudia Woolf, Stacy Andersen, Nir Barzilai, Carol Brayne, Karen Siu-Lan Cheung, Maria M. Corrada, John D. Crawford, Catriona Daly, Yasuyuki Gondo, Bo Hagberg, Nobuyoshi Hirose, Henne Holstege, Claudia Kawas, Jeffrey Kaye, Nicole A. Kochan…

    Citation: BMC Neurology 2016 16:52

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