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Dementias

This section focuses on neurodegeneration. Topics of interest include, but are not limited to, Alzheimer's disease, Parkinson's Disease, frontotemporal dementias, Lewy body dementia, vascular dementia, mild cognitive impairment and basic aspects of neurodegenerative diseases and prion diseases.

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  1. Long non-coding RNA (LncRNA) have been reported to be involved in the pathogenesis of neurodegenerative diseases, but whether it can serve as a biomarker for Alzheimer disease (AD) is not yet known.

    Authors: Liang Feng, Yu-Ting Liao, Jin-Cai He, Cheng-Long Xie, Si-Yan Chen, Hui-Hui Fan, Zhi-Peng Su and Zhen Wang

    Citation: BMC Neurology 2018 18:4

    Content type: Research article

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  2. Enlarged perivascular spaces (PVS) are common magnetic resonance imaging (MRI) findings, whereas widespread enlarged PVS are extremely rare. Although most patients with widespread enlarged PVS remain asymptoma...

    Authors: Daisuke Taniguchi, Hideki Shimura, Masao Watanabe, Nobutaka Hattori and Takao Urabe

    Citation: BMC Neurology 2017 17:210

    Content type: Case report

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  3. The clinical features of Alzheimer’s disease (AD) are related to brain network degeneration, and hyperhomocysteinemia is related to greater white matter hyperintensities. We investigated the changes in four di...

    Authors: Chen-Chang Lee, Shih-Wei Hsu, Chi-Wei Huang, Wen-Neng Chang, Sz-Fan Chen, Ming-Kung Wu, Chiung-Chih Chang, Lain-Chyr Hwang and Po-Chou Chen

    Citation: BMC Neurology 2017 17:192

    Content type: Research article

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  4. Progranulin gene (GRN) mutations are major causes of frontotemporal lobar degeneration. To date, 68 pathogenic GRN mutations have been identified. However, very few of these mutations have been reported in Asians...

    Authors: Takashi Hosaka, Kazuhiro Ishii, Takeshi Miura, Naomi Mezaki, Kensaku Kasuga, Takeshi Ikeuchi and Akira Tamaoka

    Citation: BMC Neurology 2017 17:182

    Content type: Case report

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  5. Cerebral amyloid angiopathy (CAA) is characterized by the deposition of ß-amyloid peptides (Aß) in and surrounding the wall of microvasculature in the central nervous system, together with parenchymal amyloid ...

    Authors: Jian-Ming Li, Li-Ling Huang, Fei Liu, Bei-Sha Tang and Xiao-Xin Yan

    Citation: BMC Neurology 2017 17:163

    Content type: Debate

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  6. The causes of behavioral and psychological symptoms of dementia (BPSD) vary according to the dementia subtype and associated neuropathology. The present study aimed to (i) compare BPSD between patients with su...

    Authors: Min-Chien Tu, Wen-Hui Huang, Yen-Hsuan Hsu, Chung-Ping Lo, Jie Fu Deng and Ching-Feng Huang

    Citation: BMC Neurology 2017 17:144

    Content type: Research article

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    The Correction to this article has been published in BMC Neurology 2017 17:189

  7. The mini-mental state examination (MMSE) was adapted by individual countries according to their languages and cultures, though it has not been systematically compared. The objective of this study was to compar...

    Authors: Yong S. Shim, Dong Won Yang, Hee-Jin Kim, Young Ho Park and SangYun Kim

    Citation: BMC Neurology 2017 17:141

    Content type: Research article

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  8. Vascular cognitive impairment (VCI) is a heterogeneous entity with multiple aetiologies, all linked to underlying vascular disease. Among these, VCI related to subcortical small vessel disease (SSVD) is emergi...

    Authors: A. Wallin, E. Kapaki, M. Boban, S. Engelborghs, D. M. Hermann, B. Huisa, M. Jonsson, M. G. Kramberger, L. Lossi, B. Malojcic, S. Mehrabian, A. Merighi, E. B. Mukaetova-Ladinska, G. P. Paraskevas, B. O. Popescu, R. Ravid…

    Citation: BMC Neurology 2017 17:102

    Content type: Research article

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  9. To analyze voxel-wise correlation between cerebral blood flow (CBF) measured using ASL-MRI and cognition in patients with Alzheimer’s disease (AD).

    Authors: Tomohiro Kaneta, Omi Katsuse, Takamasa Hirano, Matsuyoshi Ogawa, Ayako Shihikura-Hino, Keisuke Yoshida, Toshinari Odawara, Yoshio Hirayasu and Tomio Inoue

    Citation: BMC Neurology 2017 17:91

    Content type: Research article

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  10. Dementia with Lewy bodies (DLB) is the second most frequent diagnosis of progressive degenerative dementia in older people. Delusions are common features in DLB and, among them, Capgras syndrome represents the...

    Authors: Paolo Solla, Gioia Mura, Antonino Cannas, Gianluca Floris, Davide Fonti, Gianni Orofino, Mauro Giovanni Carta and Francesco Marrosu

    Citation: BMC Neurology 2017 17:78

    Content type: Case report

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  11. Increasing age is the biggest risk factor for dementia, of which Alzheimer’s disease is the commonest cause. The pathological changes underpinning Alzheimer’s disease are thought to develop at least a decade p...

    Authors: Christopher A. Lane, Thomas D. Parker, Dave M. Cash, Kirsty Macpherson, Elizabeth Donnachie, Heidi Murray-Smith, Anna Barnes, Suzie Barker, Daniel G. Beasley, Jose Bras, David Brown, Ninon Burgos, Michelle Byford, M. Jorge Cardoso, Ana Carvalho, Jessica Collins…

    Citation: BMC Neurology 2017 17:75

    Content type: Study protocol

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  12. Traditional approaches to clinical research have, as yet, failed to provide effective treatments for vascular dementia (VaD). Novel approaches to collation and synthesis of data may allow for time and cost eff...

    Authors: Fergus N. Doubal, Myzoon Ali, G. David Batty, Andreas Charidimou, Maria Eriksdotter, Martin Hofmann-Apitius, Yun-Hee Kim, Deborah A. Levine, Gillian Mead, Hermann A. M. Mucke, Craig W. Ritchie, Charlotte J. Roberts, Tom C. Russ, Robert Stewart, William Whiteley and Terence J. Quinn

    Citation: BMC Neurology 2017 17:72

    Content type: Commentary

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  13. Alzheimer’s disease (AD) is a globally prevalent neurodegenerative condition, clinically characterized by progressive memory loss and gradual impairment of cognitive functions. Bapineuzumab is a fully humanize...

    Authors: Abdelrahman Ibrahim Abushouk, Ahmed Elmaraezy, Amro Aglan, Reham Salama, Samar Fouda, Rana Fouda and Ammar M. AlSafadi

    Citation: BMC Neurology 2017 17:66

    Content type: Research article

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  14. Alzheimer’s disease (AD) is the most common type of dementia. International multilateral cost-of-illness (COI) studies have revealed that the cost of treating this disease is huge, which places a significant b...

    Authors: Fangyu Li, Shuoqi Chen, Cuibai Wei and Jianping Jia

    Citation: BMC Neurology 2017 17:15

    Content type: Research article

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  15. Recent research suggests that several pathogenetic factors, including aging, genetics, inflammation, dyslipidemia, diabetes, and infectious diseases, influence cognitive decline (CD) risk. However, no definiti...

    Authors: Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Fumitaro Miyatani, Masaki Kondo, Aiko Tamura, Takashi Kasai, Yoichi Ohshima, Tomokatsu Yoshida, Takahiko Tokuda, Ikuko Mizuta, Shigeto Mizuno, Kei Yamada, Kazuo Takeda…

    Citation: BMC Neurology 2016 16:253

    Content type: Research article

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  16. Heterogeneous disease trajectories of mild cognitive impairment (MCI) and dementia are frequently encountered in clinical practice, but there is still insufficient knowledge to understand the reasons and mecha...

    Authors: Weiqi Liao, Renske E. G. Hamel, Marcel G. M. Olde Rikkert, Saskia M. Oosterveld, Pauline Aalten, Frans R. J. Verhey, Philip Scheltens, Nicole Sistermans, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Inez H. G. B. Ramakers and René J. F. Melis

    Citation: BMC Neurology 2016 16:242

    Content type: Database

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  17. Creutzfeldt - Jakob disease (CJD) is a rapidly progressive and fatal neurodegenerative prion disease. MRI findings are included in diagnostic criteria for probable CJD, giving a sensitivity and specificity mor...

    Authors: Edgaras Dirzius, Renata Balnyte, Vesta Steibliene, Rymante Gleizniene, Inga Gudinaviciene, Andrius Radziunas and Kestutis Petrikonis

    Citation: BMC Neurology 2016 16:234

    Content type: Case report

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  18. The smell sense reduction was considered to represent the potentially warning of early stage of neurodegenerative disorders. The Shanghai Aging Study provided us a unique opportunity to explore the association...

    Authors: Xiaoniu Liang, Ding Ding, Qianhua Zhao, Qihao Guo, Jianfeng Luo and Zhen Hong

    Citation: BMC Neurology 2016 16:199

    Content type: Research article

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  19. Caregivers of care-recipients with mild cognitive impairment (MCI) or dementia experience high caregiver burden; however, the psychiatric burden of caregivers of care-recipients with subjective cognitive decli...

    Authors: Xiaoniu Liang, Qihao Guo, Jianfeng Luo, Fang Li, Ding Ding, Qianhua Zhao and Zhen Hong

    Citation: BMC Neurology 2016 16:191

    Content type: Research article

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  20. Older adults with dementia are at an increased risk of falls, however, little is known about risk factors for recurrent injurious falls (a subsequent fall after the first fall has occurred) among this group. T...

    Authors: Lynn B. Meuleners, Michelle L. Fraser, Max K. Bulsara, Kyle Chow and Jonathon Q. Ng

    Citation: BMC Neurology 2016 16:188

    Content type: Research article

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  21. It is widely accepted that neuroinflammatory processes play an important role in the pathogenesis of Alzheimer’s disease (AD) and high levels of cytokines and chemokines are detected around Aβ plaques.

    Authors: Raphael Hesse, Anke Wahler, Pauline Gummert, Stefanie Kirschmer, Markus Otto, Hayrettin Tumani, Jan Lewerenz, Cathrin Schnack and Christine A. F. von Arnim

    Citation: BMC Neurology 2016 16:185

    Content type: Research article

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  22. α-Synuclein has been proposed as a potential biomarker for Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI). However, results from α-synuclein measurements in cerebrospinal fluid (CSF) ha...

    Authors: Guro Berge, Sigrid B. Sando, Grethe Albrektsen, Camilla Lauridsen, Ina Møller, Gøril R. Grøntvedt, Geir Bråthen and Linda R. White

    Citation: BMC Neurology 2016 16:180

    Content type: Research article

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  23. Fahr’s disease is rare a neurodegenerative idiopathic condition characterized by symmetric and bilateral calcifications of basal ganglia, usually associated with progressive neuropsychiatric dysfunctions and m...

    Authors: Elisabetta Savino, Cecilia Soavi, Eleonora Capatti, Massimo Borrelli, Giovanni B. Vigna, Angelina Passaro and Giovanni Zuliani

    Citation: BMC Neurology 2016 16:165

    Content type: Case report

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  24. Authors: Flora M. Hammond, David N. Alexander, Andrew J. Cutler, Stephen D’Amico, Rachelle S. Doody, William Sauve, Richard D. Zorowitz, Charles S. Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E. Formella and Joao Siffert

    Citation: BMC Neurology 2016 16:160

    Content type: Erratum

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    The original article was published in BMC Neurology 2016 16:89

  25. The survival time in nursing homes (NHs) in Alzheimer’s disease (AD) might be affected by sociodemographic/clinical characteristics, rate of disease progression, and use of specific medications and community-b...

    Authors: Carina Wattmo, Elisabet Londos and Lennart Minthon

    Citation: BMC Neurology 2016 16:156

    Content type: Research article

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  26. Alzheimer’s disease (AD) is the most common cause of dementia in the elderly. The possibility of disease-modifying strategies has evoked a need for early and accurate diagnosis. To improve the accuracy of the ...

    Authors: Sonja Schönecker, Matthias Brendel, Marion Huber, Christian Vollmar, Hans-Juergen Huppertz, Stefan Teipel, Nobuyuki Okamura, Johannes Levin, Axel Rominger and Adrian Danek

    Citation: BMC Neurology 2016 16:131

    Content type: Case report

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  27. Few patients are reported with dementia with Lewy bodies before fifty years-old, which may partly reflect the difficulty of accurate diagnosis in young population. We report the case of a 44-year-old male with...

    Authors: Laure Saint-Aubert, Jérémie Pariente, Herve Dumas, Pierre Payoux, Jean-Philippe Brandel, Michèle Puel, Anne Vital, Eric Guedj, Suzanne Lesage, Katell Peoc’h, Christine Brefel Courbon and Fabienne Ory Magne

    Citation: BMC Neurology 2016 16:122

    Content type: Case report

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  28. Improving cardiovascular health possibly decreases the risk of dementia. Primary care practices offer a suitable setting for monitoring and controlling cardiovascular risk factors in the older population. The ...

    Authors: Johannes Baltasar Hessler, Karl-Heinz Ander, Monika Brönner, Thorleif Etgen, Hans Förstl, Holger Poppert, Dirk Sander and Horst Bickel

    Citation: BMC Neurology 2016 16:116

    Content type: Research article

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  29. Disease-modification clinical trials in neurodegenerative disorders have struggled to separate symptomatic effects of putative agents from disease-modification. In response, a variety of clinical trial designs...

    Authors: David J. M. McGhee, Craig W. Ritchie, John P. Zajicek and Carl E. Counsell

    Citation: BMC Neurology 2016 16:92

    Content type: Research article

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  30. Phase 3 trials supporting dextromethorphan/quinidine (DM/Q) use as a treatment for pseudobulbar affect (PBA) were conducted in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS). The ...

    Authors: Flora M. Hammond, David N. Alexander, Andrew J. Cutler, Stephen D’Amico, Rachelle S. Doody, William Sauve, Richard D. Zorowitz, Charles S. Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E. Formella and Joao Siffert

    Citation: BMC Neurology 2016 16:89

    Content type: Research article

    Published on:

    The Erratum to this article has been published in BMC Neurology 2016 16:160

  31. Executive functions (EF) in Alzheimer’s disease (AD), classically related to the prefrontal cortex, have been forgotten in mild stages, given more importance to temporal lobe associated disorders, such as memo...

    Authors: E. Blanco Martín, I. Ugarriza Serrano, X. Elcoroaristizabal Martín, L. Galdos Alcelay, A. Molano Salazar, R. Bereincua Gandarias, S. Inglés Borda, J. M. Uterga Valiente, M. B. Indakoetxea Juanbeltz, J. Moraza Lopez, M. Barandiarán Amillano and M. Fernández-Martínez

    Citation: BMC Neurology 2016 16:88

    Content type: Research article

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  32. Three main genes are described as causative genes for early-onset Alzheimer dementia (EOAD): APP, PSEN1 and PSEN2. We describe a woman with EOAD had a novel PSEN1 mutation.

    Authors: Seong Soo A. An, Eva Bagyinszky, Hye Ryoun Kim, Ju-Won Seok, Hae-Won Shin, SeunOh Bae, SangYun Kim and Young Chul Youn

    Citation: BMC Neurology 2016 16:71

    Content type: Case report

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  33. The ε4 allele of the Apolipoprotein E gene (APOE-ε4) is a potent genetic risk factor for sporadic Alzheimer’s disease (AD). Amnestic mild cognitive impairment (aMCI) is an intermediate state between normal cog...

    Authors: Guan-Qun Chen, Can Sheng, Yu-Xia Li, Yang Yu, Xiao-Ni Wang, Yu Sun, Hong-Yan Li, Xuan-Yu Li, Yun-Yan Xie and Ying Han

    Citation: BMC Neurology 2016 16:64

    Content type: Study protocol

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  34. Considerable variability exists in international prevalence and incidence estimates of dementia. The accuracy of estimates of dementia in the oldest-old and the controversial question of whether dementia incid...

    Authors: Henry Brodaty, Claudia Woolf, Stacy Andersen, Nir Barzilai, Carol Brayne, Karen Siu-Lan Cheung, Maria M. Corrada, John D. Crawford, Catriona Daly, Yasuyuki Gondo, Bo Hagberg, Nobuyoshi Hirose, Henne Holstege, Claudia Kawas, Jeffrey Kaye, Nicole A. Kochan…

    Citation: BMC Neurology 2016 16:52

    Content type: Study protocol

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  35. The production of inflammatory cytokines resulting from amyloid β (Aβ) is associated with the initiation of Alzheimer’s disease (AD). Atorvastatin (ATV) has been reported to improve AD, however, it is unclear ...

    Authors: Liandong Zhao, Tingting Chen, Chonghui Wang, Guoxi Li, Wenhui Zhi, Jun Yin, Qi Wan and Ling Chen

    Citation: BMC Neurology 2016 16:18

    Content type: Research article

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  36. Chronic HIV infection commonly affects both cognition and mental health, even with excellent systemic viral control. The causes of compromised brain health are likely to be a multi-factorial combination of HIV...

    Authors: Nancy E. Mayo, Marie-Josée Brouillette and Lesley K. Fellows

    Citation: BMC Neurology 2016 16:8

    Content type: Study protocol

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  37. Deep brain stimulation has recently been considered a potential therapy in improving memory function. It has been shown that a change of neurotransmitters has an effect on memory function. However, much about ...

    Authors: Ji Eun Lee, Da Un Jeong, Jihyeon Lee, Won Seok Chang and Jin Woo Chang

    Citation: BMC Neurology 2016 16:6

    Content type: Research article

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  38. Cobalamin (Cbl) deficiency has been associated with various neuropsychiatric symptoms of different severities. While some studies dedicated in structural neuroimaging credibly address negative impact of low Cb...

    Authors: Min-Chien Tu, Chung-Ping Lo, Ching-Yuan Chen and Ching-Feng Huang

    Citation: BMC Neurology 2015 15:251

    Content type: Research article

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  39. Cerebral amyloid angiopathy (CAA) refers to the deposition of β-amyloid (Aβ) peptides in the wall of brain vasculature, commonly involving capillaries and arterioles. Also being considered a part of CAA is the...

    Authors: Zhi-Qin Xue, Zheng-Wen He, Jian-Jun Yu, Yan Cai, Wen-Ying Qiu, Aihua Pan, Wei-Ping Gai, Huaibin Cai, Xue-Gang Luo, Chao Ma and Xiao-Xin Yan

    Citation: BMC Neurology 2015 15:71

    Content type: Research article

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  40. Cholinesterase inhibitors are used to treat the symptoms of dementia and can theoretically cause bradycardia. Previous studies suggest that patients taking these medications have an increased risk of undergoin...

    Authors: Allen R Huang, Calum J Redpath and Carl van Walraven

    Citation: BMC Neurology 2015 15:66

    Content type: Research article

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  41. One of the usual problems psychologists and clinicians face in clinical practice is differential diagnostics of Alzheimer’s disease and depression. It has been reported that the ACE and ACE-R could discriminat...

    Authors: Augustinas Rotomskis, Ramunė Margevičiūtė, Arūnas Germanavičius, Gintaras Kaubrys, Valmantas Budrys and Albinas Bagdonas

    Citation: BMC Neurology 2015 15:57

    Content type: Research article

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  42. Cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau and p-tau have a characteristic pattern in Alzheimer’s Disease (AD). Their roles in HIV-associated neurocognitive disorder (HAND) remains unclear.

    Authors: Lucette A Cysique, Timothy Hewitt, Juliana Croitoru-Lamoury, Kevin Taddei, Ralph N Martins, Constance SN Chew, Nicholas NWS Davies, Patricia Price and Bruce J Brew

    Citation: BMC Neurology 2015 15:51

    Content type: Research article

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  43. Proteinase-activated receptor 2 (PAR-2) has been shown to promote both neurotoxic and neuroprotective effects. Similarly, other routinely used nonspecific markers of neuronal damage can be found in cerebrospin...

    Authors: Zdenek Rohan, Magdalena Smetakova, Jaromir Kukal, Robert Rusina and Radoslav Matej

    Citation: BMC Neurology 2015 15:50

    Content type: Research article

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  44. Heritability of Alzheimer’s disease (AD) is estimated at 74% and genetic contributors have been widely sought. The ε4 allele of apolipoprotein E (APOE) remains the strongest common risk factor for AD, with numero...

    Authors: Jennifer S Yokoyama, Luke W Bonham, Renee L Sears, Eric Klein, Anna Karydas, Joel H Kramer, Bruce L Miller and Giovanni Coppola

    Citation: BMC Neurology 2015 15:47

    Content type: Research article

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  45. Because our previous study showed disparate voxel based morphometry (VBM) results between SPM and FSL softwares in the brain of amyotrophic lateral sclerosis patients with frontotemporal dementia (ALS-FTD), we...

    Authors: Venkateswaran Rajagopalan and Erik P Pioro

    Citation: BMC Neurology 2015 15:32

    Content type: Research article

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