Cilostazol as an add-on therapy for patients with Alzheimer’s disease in Taiwan: a case control study

Combination therapy using acetylcholinesterase inhibitors (AChEIs) and cilostazol is of unknown efficacy for patients with Alzheimer’s disease (AD).

Authors: Shu-Yu Tai, Chun-Hung Chen, Chen-Yu Chien and Yuan-Han Yang

Monetary costs of Alzheimer’s disease in China: protocol for a cluster-randomised observational study

Alzheimer’s disease (AD) is the most common type of dementia. International multilateral cost-of-illness (COI) studies have revealed that the cost of treating this disease is huge, which places a significant b...

Authors: Fangyu Li, Shuoqi Chen, Cuibai Wei and Jianping Jia

Serum albumin to globulin ratio is related to cognitive decline via reflection of homeostasis: a nested case-control study

Recent research suggests that several pathogenetic factors, including aging, genetics, inflammation, dyslipidemia, diabetes, and infectious diseases, influence cognitive decline (CD) risk. However, no definiti...

Authors: Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Fumitaro Miyatani, Masaki Kondo, Aiko Tamura, Takashi Kasai, Yoichi Ohshima, Tomokatsu Yoshida, Takahiko Tokuda, Ikuko Mizuta, Shigeto Mizuno, Kei Yamada, Kazuo Takeda…

A profile of The Clinical Course of Cognition and Comorbidity in Mild Cognitive Impairment and Dementia Study (The 4C study): two complementary longitudinal, clinical cohorts in the Netherlands

Heterogeneous disease trajectories of mild cognitive impairment (MCI) and dementia are frequently encountered in clinical practice, but there is still insufficient knowledge to understand the reasons and mecha...

Authors: Weiqi Liao, Renske E. G. Hamel, Marcel G. M. Olde Rikkert, Saskia M. Oosterveld, Pauline Aalten, Frans R. J. Verhey, Philip Scheltens, Nicole Sistermans, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Inez H. G. B. Ramakers and René J. F. Melis

Ratio of apoB/LDL: a potential clinical index for vascular cognitive impairment

Vascular cognitive impairment (VCI), compared to vascular dementia (VD), has a broader definition and highlights the effect of vascular disease in dementia, and stroke seems play an important role in the devel...

Authors: Cheng Qian and Fei Tan

Inverse relationship between Alzheimer’s disease and cancer, and other factors contributing to Alzheimer’s disease: a systematic review

The AD etiology is yet not properly known. Interactions among environmental factors, multiple susceptibility genes and aging, contribute to AD. This study investigates the factors that play role in causing AD ...

Authors: Ovais Shafi

Sporadic Creutzfeldt-Jakob disease with unusual initial presentation as posterior reversible encephalopathy syndrome: a case report

Creutzfeldt - Jakob disease (CJD) is a rapidly progressive and fatal neurodegenerative prion disease. MRI findings are included in diagnostic criteria for probable CJD, giving a sensitivity and specificity mor...

Authors: Edgaras Dirzius, Renata Balnyte, Vesta Steibliene, Rymante Gleizniene, Inga Gudinaviciene, Andrius Radziunas and Kestutis Petrikonis

Association between olfactory identification and cognitive function in community-dwelling elderly: the Shanghai aging study

The smell sense reduction was considered to represent the potentially warning of early stage of neurodegenerative disorders. The Shanghai Aging Study provided us a unique opportunity to explore the association...

Authors: Xiaoniu Liang, Ding Ding, Qianhua Zhao, Qihao Guo, Jianfeng Luo and Zhen Hong

Anxiety and depression symptoms among caregivers of care-recipients with subjective cognitive decline and cognitive impairment

Caregivers of care-recipients with mild cognitive impairment (MCI) or dementia experience high caregiver burden; however, the psychiatric burden of caregivers of care-recipients with subjective cognitive decli...

Authors: Xiaoniu Liang, Qihao Guo, Jianfeng Luo, Fang Li, Ding Ding, Qianhua Zhao and Zhen Hong

Risk factors for recurrent injurious falls that require hospitalization for older adults with dementia: a population based study

Older adults with dementia are at an increased risk of falls, however, little is known about risk factors for recurrent injurious falls (a subsequent fall after the first fall has occurred) among this group. T...

Authors: Lynn B. Meuleners, Michelle L. Fraser, Max K. Bulsara, Kyle Chow and Jonathon Q. Ng

Decreased IL-8 levels in CSF and serum of AD patients and negative correlation of MMSE and IL-1β

It is widely accepted that neuroinflammatory processes play an important role in the pathogenesis of Alzheimer’s disease (AD) and high levels of cytokines and chemokines are detected around Aβ plaques.

Authors: Raphael Hesse, Anke Wahler, Pauline Gummert, Stefanie Kirschmer, Markus Otto, Hayrettin Tumani, Jan Lewerenz, Cathrin Schnack and Christine A. F. von Arnim

Alpha-synuclein measured in cerebrospinal fluid from patients with Alzheimer’s disease, mild cognitive impairment, or healthy controls: a two year follow-up study

α-Synuclein has been proposed as a potential biomarker for Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI). However, results from α-synuclein measurements in cerebrospinal fluid (CSF) ha...

Authors: Guro Berge, Sigrid B. Sando, Grethe Albrektsen, Camilla Lauridsen, Ina Møller, Gøril R. Grøntvedt, Geir Bråthen and Linda R. White

Bilateral strio-pallido-dentate calcinosis (Fahr’s disease): report of seven cases and revision of literature

Fahr’s disease is rare a neurodegenerative idiopathic condition characterized by symmetric and bilateral calcifications of basal ganglia, usually associated with progressive neuropsychiatric dysfunctions and m...

Authors: Elisabetta Savino, Cecilia Soavi, Eleonora Capatti, Massimo Borrelli, Giovanni B. Vigna, Angelina Passaro and Giovanni Zuliani

Erratum to: PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury

Authors: Flora M. Hammond, David N. Alexander, Andrew J. Cutler, Stephen D’Amico, Rachelle S. Doody, William Sauve, Richard D. Zorowitz, Charles S. Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E. Formella and Joao Siffert

Cholinesterase inhibitors do not alter the length of stay in nursing homes among patients with Alzheimer’s disease: a prospective, observational study of factors affecting survival time from admission to death

The survival time in nursing homes (NHs) in Alzheimer’s disease (AD) might be affected by sociodemographic/clinical characteristics, rate of disease progression, and use of specific medications and community-b...

Authors: Carina Wattmo, Elisabet Londos and Lennart Minthon

Applied multimodal diagnostics in a case of presenile dementia

Alzheimer’s disease (AD) is the most common cause of dementia in the elderly. The possibility of disease-modifying strategies has evoked a need for early and accurate diagnosis. To improve the accuracy of the ...

Authors: Sonja Schönecker, Matthias Brendel, Marion Huber, Christian Vollmar, Hans-Juergen Huppertz, Stefan Teipel, Nobuyuki Okamura, Johannes Levin, Axel Rominger and Adrian Danek

Case report of Lewy body disease mimicking Creutzfeldt-Jakob disease in a 44-year-old man

Few patients are reported with dementia with Lewy bodies before fifty years-old, which may partly reflect the difficulty of accurate diagnosis in young population. We report the case of a 44-year-old male with...

Authors: Laure Saint-Aubert, Jérémie Pariente, Herve Dumas, Pierre Payoux, Jean-Philippe Brandel, Michèle Puel, Anne Vital, Eric Guedj, Suzanne Lesage, Katell Peoc’h, Christine Brefel Courbon and Fabienne Ory Magne

Predicting dementia in primary care patients with a cardiovascular health metric: a prospective population-based study

Improving cardiovascular health possibly decreases the risk of dementia. Primary care practices offer a suitable setting for monitoring and controlling cardiovascular risk factors in the older population. The ...

Authors: Johannes Baltasar Hessler, Karl-Heinz Ander, Monika Brönner, Thorleif Etgen, Hans Förstl, Holger Poppert, Dirk Sander and Horst Bickel

A review of clinical trial designs used to detect a disease-modifying effect of drug therapy in Alzheimer’s disease and Parkinson’s disease

Disease-modification clinical trials in neurodegenerative disorders have struggled to separate symptomatic effects of putative agents from disease-modification. In response, a variety of clinical trial designs...

Authors: David J. M. McGhee, Craig W. Ritchie, John P. Zajicek and Carl E. Counsell

PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury

Phase 3 trials supporting dextromethorphan/quinidine (DM/Q) use as a treatment for pseudobulbar affect (PBA) were conducted in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS). The ...

Authors: Flora M. Hammond, David N. Alexander, Andrew J. Cutler, Stephen D’Amico, Rachelle S. Doody, William Sauve, Richard D. Zorowitz, Charles S. Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E. Formella and Joao Siffert