Skip to content



Section edited by Marwan Sabbagh

This section focuses on neurodegeneration. Topics of interest include, but are not limited to, Alzheimer’s disease, Parkinson’s Disease, frontotemporal dementias, Lewy body dementia, vascular dementia, mild cognitive impairment and basic aspects of neurodegenerative diseases and prion diseases.

Page 3 of 3

  1. Content type: Research article

    Dysphagia, which can result in aspiration pneumonia and death, is a well-known problem in patients with dementia and Parkinson’s disease. There are few studies on dysphagia in patients with dementia with Lewy ...

    Authors: Elisabet Londos, Oskar Hanxsson, Ingrid Alm Hirsch, Anna Janneskog, Margareta Bülow and Sebastian Palmqvist

    Citation: BMC Neurology 2013 13:140

    Published on:

  2. Content type: Research article

    The accumulation of the misfolded forms of cellular prion protein, i.e. prions (PrPSc), in the brain is one of the crucial characteristics of fatal neurodegenerative disorders, called transmissible spongiform enc...

    Authors: Eva Dvorakova, Tanja Vranac, Olga Janouskova, Maja Černilec, Simon Koren, Anja Lukan, Jana Nováková, Radoslav Matej, Karel Holada and Vladka Čurin Šerbec

    Citation: BMC Neurology 2013 13:126

    Published on:

  3. Content type: Research article

    We examined the clinical value of two serum markers of low-grade inflammation, C-reactive protein (CRP) and receptor of advanced glycation products (RAGE), as prognostic indices for cognitive decline.

    Authors: Xia Ge, Xiao-yun Xu, Chun-hua Feng, Yue Wang, Yuan-ling Li and Bo Feng

    Citation: BMC Neurology 2013 13:110

    Published on:

  4. Content type: Research article

    The risk of falling is associated with cognitive dysfunction. Older adults with mild cognitive impairment (MCI) exhibit an accelerated reduction of brain volume, and face an increased risk of falling. The curr...

    Authors: Hyuma Makizako, Hiroyuki Shimada, Takehiko Doi, Hyuntae Park, Daisuke Yoshida, Kazuki Uemura, Kota Tsutsumimoto, Teresa Liu-Ambrose and Takao Suzuki

    Citation: BMC Neurology 2013 13:102

    Published on:

  5. Content type: Research article

    In this study we assess the prevalence, characteristics as well as socio-demographic and clinical correlates of a positive screen for HIV-associated dementia in a group of patients on antiretroviral therapy (A...

    Authors: Julius Atashili, Bradley N Gaynes, Brian W Pence, Gladys Tayong, Dmitry Kats, Julie K O’donnell, Peter M Ndumbe and Alfred K Njamnshi

    Citation: BMC Neurology 2013 13:86

    Published on:

  6. Content type: Research article

    Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme in the synthesis of γ-aminobutyric acid (GABA). Anti-GAD antibodies (GADA) are associated with the progression of stiff person syndrome and other n...

    Authors: Masahito Takagi, Yasushi Ishigaki, Kenji Uno, Shojiro Sawada, Junta Imai, Keizo Kaneko, Yutaka Hasegawa, Tetsuya Yamada, Ai Tokita, Kazumi Iseki, Shigenori Kanno, Yoshiyuki Nishio, Hideki Katagiri and Etsuro Mori

    Citation: BMC Neurology 2013 13:76

    Published on:

  7. Content type: Research article

    Frontotemporal dementia (FTD) is recognised as a clinically and morphologically heterogeneous group of interrelated neurodegenerative conditions. One of the subtypes within this disease spectrum is the behavio...

    Authors: Maria Landqvist Waldö, Alexander Frizell Santillo, Ulla Passant, Henrik Zetterberg, Lars Rosengren, Christer Nilsson and Elisabet Englund

    Citation: BMC Neurology 2013 13:54

    Published on:

  8. Content type: Research article

    Carriers of the ApoE ϵ4 allele are at a greater risk for developing Alzheimer’s disease (AD) and those who do develop AD tend to have a much greater neuropathological disease burden. Although several studies h...

    Authors: Marwan N Sabbagh, Michael Malek-Ahmadi, Brittany N Dugger, Katarina Lee, Lucia I Sue, Geidy Serrano, Douglas G Walker, Kathryn Davis, Sandra A Jacobson and Thomas G Beach

    Citation: BMC Neurology 2013 13:44

    Published on:

  9. Content type: Study protocol

    Worldwide, millions of people are suffering from dementia and this number is rising. An index of quality of life (QoL) can describe the impact a disease or treatment has on a person’s wellbeing. QoL comprises ...

    Authors: Roxane Anthea Francesca Weijenberg, Frank Lobbezoo, Dirk Lucas Knol, Jori Tomassen and Erik Johan Anton Scherder

    Citation: BMC Neurology 2013 13:26

    Published on:

  10. Content type: Research article

    A strong inverse relationship of functional limitation and socioeconomic status has been established in western ageing society. Functional limitation can be related to chronic diseases, disuse, cognitive decli...

    Authors: Vorapun Senanarong, Kamolthip Harnphadungkit, Niphon Poungvarin, Sathit Vannasaeng, Samut Chongwisal, Tipa Chakorn, Piyanuch Jamjumrus, Atthapon Raksthaput, Sinisa Chaichanettee, Nattapol Aoonkaew, Suthipol Udompunthurak, Rachelle S Doody and Jeffrey L Cummings

    Citation: BMC Neurology 2013 13:3

    Published on:

  11. Content type: Research article

    Establishing a confident clinical diagnosis before an advanced stage of illness can be difficult in Creutzfeldt-Jakob disease (CJD) but unlike common causes of dementia, prion diseases can often be diagnosed b...

    Authors: Christopher Carswell, Andrew Thompson, Ana Lukic, John Stevens, Peter Rudge, Simon Mead, John Collinge and Harpreet Hyare

    Citation: BMC Neurology 2012 12:153

    Published on:

  12. Content type: Research article

    Little is known about the long-term success of non-drug therapies for treating dementia, especially whether the effects are sustained after therapy ends. Here, we examined the effects of a one-year multimodal ...

    Authors: Katharina Luttenberger, Benjamin Hofner and Elmar Graessel

    Citation: BMC Neurology 2012 12:151

    Published on:

  13. Content type: Research article

    To investigate to what extent Alzheimer's Disease (AD) affects Resting State activity, the possible impairment of independent electrophysiological parameters was determined in Eye-open and Eye-closed Condition...

    Authors: Antonio Tartaglione, Luciano Spadavecchia, Marco Maculotti and Fabio Bandini

    Citation: BMC Neurology 2012 12:145

    Published on:

  14. Content type: Case report

    We report a female patient with familial Creutzfeldt-Jakob disease with V180I mutation (fCJD with V180I), who was serially followed up with magnetic resonance imaging (MRI) and electroencephalogram (EEG) for u...

    Authors: Kentaro Deguchi, Motonori Takamiya, Shoko Deguchi, Nobutoshi Morimoto, Tomoko Kurata, Yoshio Ikeda and Koji Abe

    Citation: BMC Neurology 2012 12:144

    Published on:

  15. Content type: Research article

    It remains unclear how executive function (EF) is affected in the stage of amnestic mild cognitive impairment (aMCI). Previous studies using different methods to assess EF in patients with aMCI have reached in...

    Authors: Dongming Zheng, Xiaoyu Dong, Hongzan Sun, Yongchuan Xu, Ying Ma and Xiaoming Wang

    Citation: BMC Neurology 2012 12:138

    Published on:

  16. Content type: Research article

    The Hopkins Verbal Learning Test (HVLT) has been validated for detecting dementia in English-speaking populations. However, no studies have examined the Chinese version of the HVLT scale, and appropriate cut-o...

    Authors: Jing Shi, Jinzhou Tian, Mingqing Wei, Yingchun Miao and Yongyan Wang

    Citation: BMC Neurology 2012 12:136

    Published on:

  17. Content type: Research article

    To examine the effects of a multicomponent exercise program on the cognitive function of older adults with amnestic mild cognitive impairment (aMCI).

    Authors: Takao Suzuki, Hiroyuki Shimada, Hyuma Makizako, Takehiko Doi, Daisuke Yoshida, Kota Tsutsumimoto, Yuya Anan, Kazuki Uemura, Sangyoon Lee and Hyuntae Park

    Citation: BMC Neurology 2012 12:128

    Published on:

  18. Content type: Research article

    Maintaining cognitive function is essential for healthy aging and to function autonomously within society. White matter lesions (WMLs) are associated with reduced cognitive function in older adults. However, w...

    Authors: Niousha Bolandzadeh, Jennifer C Davis, Roger Tam, Todd C Handy and Teresa Liu-Ambrose

    Citation: BMC Neurology 2012 12:126

    Published on:

  19. Content type: Research article

    Mild cognitive impairment (MCI), defined as a transitional zone between normal cognition and dementia, requires a battery of formal neuropsychological tests administered by a trained rater for its diagnosis. T...

    Authors: Qi-hao Guo, Bin Zhou, Qian-hua Zhao, Bei Wang and Zhen Hong

    Citation: BMC Neurology 2012 12:119

    Published on:

  20. Content type: Case report

    This article reports a rare case of active neurosyphilis in a man with mild to moderate dementia and marked hippocampal atrophy, mimicking early onset Alzheimer’s disease. Few cases have so far described bilat...

    Authors: Shima Mehrabian, Margarita Raycheva, Martina Traykova, Tonya Stankova, Latchezar Penev, Olga Grigorova and Latchezar Traykov

    Citation: BMC Neurology 2012 12:96

    Published on:

  21. Content type: Research article

    To test the hypothesis that white matter lesions (WML) are primarily associated with regional frontal cortical volumes, and to determine the mediating effects of these regional frontal cortices on the associat...

    Authors: Jun-Young Lee, Philip Insel, R Scott Mackin, Norbert Schuff, Helena Chui, Charles DeCarli, Kee Hyung Park, Susanne G Mueller and Michael W Weiner

    Citation: BMC Neurology 2012 12:83

    Published on:

  22. Content type: Research article

    Progressive neurodegeneration in Alzheimer’s disease (AD) induces cognitive deterioration, and there is controversy regarding the optimal treatment strategy in early AD. Stimulation therapy, including physical...

    Authors: Fred Andersen, Matti Viitanen, Dag S Halvorsen, Bjørn Straume, Tom Wilsgaard and Torgeir A Engstad

    Citation: BMC Neurology 2012 12:59

    Published on:

  23. Content type: Research article

    Previous cost-effectiveness studies of cholinesterase inhibitors have modeled Alzheimer's disease (AD) progression and treatment effects through single or global severity measures, or progression to "Full Time...

    Authors: Susanne Hartz, Denis Getsios, Sunning Tao, Steve Blume and Grant Maclaine

    Citation: BMC Neurology 2012 12:2

    Published on:

  24. Content type: Case report

    Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme for producing γ-aminobutyric acid, and it has been suggested that antibodies against GAD play a role in neurological conditions and type 1 diabetes...

    Authors: Masahito Takagi, Hiroshi Yamasaki, Keiko Endo, Tetsuya Yamada, Keizo Kaneko, Yoshitomo Oka and Etsuro Mori

    Citation: BMC Neurology 2011 11:156

    Published on:

  25. Content type: Research article

    Few data are available on the prevalence of cognitive impairment (CI) in Spain, and the existing information shows important variations depending on the geographical setting and the methodology employed. The a...

    Authors: Emiliano Rodríguez-Sánchez, Sara Mora-Simón, María C Patino-Alonso, Ricardo García-García, Alfonso Escribano-Hernández, Luis García-Ortiz, Ma Victoria Perea- Bartolomé and Manuel A Gómez-Marcos

    Citation: BMC Neurology 2011 11:147

    Published on:

  26. Content type: Research article

    In central nervous system cholesterol cannot be degraded but is secreted into circulation predominantly in the form of its polar metabolite 24(S)-hydroxycholesterol (24S-OH-Chol). Some studies suggested an associ...

    Authors: Giovanni Zuliani, Michela Perrone Donnorso, Cristina Bosi, Angelina Passaro, Edoardo Dalla Nora, Amedeo Zurlo, Francesco Bonetti, Alessia F Mozzi and Claudio Cortese

    Citation: BMC Neurology 2011 11:121

    Published on:

  27. Content type: Research article

    The gamma-isoform of the 14-3-3 protein (14-3-3 gamma) is expressed in neurons, and could be a specific marker for neuronal damage. This protein has been reported as a detectable biomarker, especially in the c...

    Authors: Yuki Matsui, Katsuya Satoh, Toshiaki Miyazaki, Susumu Shirabe, Ryuichiro Atarashi, Kazuo Mutsukura, Akira Satoh, Yasufumi Kataoka and Noriyuki Nishida

    Citation: BMC Neurology 2011 11:120

    Published on:

  28. Content type: Research article

    Substituted judgment asks the proxy to decide what the patient would have decided, had he or she been competent. It is unclear whether substituted judgment of the patient's quality of life can serve as a surro...

    Authors: Claudia Schiffczyk, Christina Jonas, Constanze Lahmeyer, Friedemann Müller and Matthias W Riepe

    Citation: BMC Neurology 2011 11:118

    Published on:

  29. Content type: Research article

    Dementia is a major and increasing health problem worldwide. This study aims to investigate dementia treatment strategies among physicians specialised in complementary and alternative medicine (CAM) by analysi...

    Authors: Elke Jeschke, Thomas Ostermann, Horst C Vollmar, Manuela Tabali, Friedemann Schad and Harald Matthes

    Citation: BMC Neurology 2011 11:99

    Published on:

  30. Content type: Research article

    To assess and compare the effectiveness and costs of Phototest, Mini Mental State Examination (MMSE), and Memory Impairment Screen (MIS) to screen for dementia (DEM) and cognitive impairment (CI).

    Authors: Cristobal Carnero-Pardo, Beatriz Espejo-Martinez, Samuel Lopez-Alcalde, Maria Espinosa-Garcia, Carmen Saez-Zea, Rosa Vilchez-Carrillo, Elisa Hernandez-Torres and Jose L Navarro-Espigares

    Citation: BMC Neurology 2011 11:92

    Published on:

  31. Content type: Research article

    Mild cognitive impairment (MCI) is a heterogeneous clinical entity that comprises the prodromal phase of Alzheimer's disease (Pr-AD). New biomarkers are useful in detecting Pr-AD, but they are not universally ...

    Authors: Ana Pozueta, Eloy Rodríguez-Rodríguez, José Luis Vazquez-Higuera, Ignacio Mateo, Pascual Sánchez-Juan, Soraya González-Perez, José Berciano and Onofre Combarros

    Citation: BMC Neurology 2011 11:78

    Published on:

  32. Content type: Research article

    Donepezil 23 mg/d, recently approved in the United States for treatment of moderate to severe Alzheimer's disease (AD), was developed to address the need for an additional treatment option for patients with ad...

    Authors: Martin Farlow, Felix Veloso, Margaret Moline, Jane Yardley, Elimor Brand-Schieber, Francesco Bibbiani, Heng Zou, Timothy Hsu and Andrew Satlin

    Citation: BMC Neurology 2011 11:57

    Published on:

  33. Content type: Research article

    Despite being the fastest growing and the most cognitively impaired age group, the oldest olds are under-represented in clinical research. The purpose of this study was to describe the design, methods, and bas...

    Authors: Ugo Lucca, Mariateresa Garrì, Angela Recchia, Giancarlo Logroscino, Pietro Tiraboschi, Massimo Franceschi, Chiara Bertinotti, Anna Biotti, Elena Gargantini, Marilena Maragna, Alessandro Nobili, Luca Pasina, Carlotta Franchi, Emma Riva and Mauro Tettamanti

    Citation: BMC Neurology 2011 11:54

    Published on:

  34. Content type: Research article

    Multiple pathogenic factors may contribute to the pathophysiology of Alzheimer's disease (AD). Peripheral blood markers have been used to assess biochemical changes associated with AD and mild cognitive impair...

    Authors: Sam-Moon Kim, Juhee Song, Seungwoo Kim, Changsu Han, Moon Ho Park, Youngho Koh, Sangmee Ahn Jo and Young-Youl Kim

    Citation: BMC Neurology 2011 11:51

    Published on:

  35. Content type: Research article

    Simple, non-invasive tests for early detection of degenerative dementia by use of biomarkers are urgently required. However, up to the present, no validated extracerebral diagnostic markers for the early diagn...

    Authors: Felix Bermejo-Pareja, Desiree Antequera, Teo Vargas, Jose A Molina and Eva Carro

    Citation: BMC Neurology 2010 10:108

    Published on: