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BMC Neurology

Dementias

Section edited by Marwan Sabbagh

This section focuses on neurodegeneration. Topics of interest include, but are not limited to, Alzheimer’s disease, Parkinson’s Disease, frontotemporal dementias, Lewy body dementia, vascular dementia, mild cognitive impairment and basic aspects of neurodegenerative diseases and prion diseases.

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  1. Content type: Research article

    Cobalamin (Cbl) deficiency has been associated with various neuropsychiatric symptoms of different severities. While some studies dedicated in structural neuroimaging credibly address negative impact of low Cb...

    Authors: Min-Chien Tu, Chung-Ping Lo, Ching-Yuan Chen and Ching-Feng Huang

    Citation: BMC Neurology 2015 15:251

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  2. Content type: Research article

    Cerebral amyloid angiopathy (CAA) refers to the deposition of β-amyloid (Aβ) peptides in the wall of brain vasculature, commonly involving capillaries and arterioles. Also being considered a part of CAA is the...

    Authors: Zhi-Qin Xue, Zheng-Wen He, Jian-Jun Yu, Yan Cai, Wen-Ying Qiu, Aihua Pan, Wei-Ping Gai, Huaibin Cai, Xue-Gang Luo, Chao Ma and Xiao-Xin Yan

    Citation: BMC Neurology 2015 15:71

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  3. Content type: Research article

    Cholinesterase inhibitors are used to treat the symptoms of dementia and can theoretically cause bradycardia. Previous studies suggest that patients taking these medications have an increased risk of undergoin...

    Authors: Allen R Huang, Calum J Redpath and Carl van Walraven

    Citation: BMC Neurology 2015 15:66

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  4. Content type: Research article

    One of the usual problems psychologists and clinicians face in clinical practice is differential diagnostics of Alzheimer’s disease and depression. It has been reported that the ACE and ACE-R could discriminat...

    Authors: Augustinas Rotomskis, Ramunė Margevičiūtė, Arūnas Germanavičius, Gintaras Kaubrys, Valmantas Budrys and Albinas Bagdonas

    Citation: BMC Neurology 2015 15:57

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  5. Content type: Research article

    Cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau and p-tau have a characteristic pattern in Alzheimer’s Disease (AD). Their roles in HIV-associated neurocognitive disorder (HAND) remains unclear.

    Authors: Lucette A Cysique, Timothy Hewitt, Juliana Croitoru-Lamoury, Kevin Taddei, Ralph N Martins, Constance SN Chew, Nicholas NWS Davies, Patricia Price and Bruce J Brew

    Citation: BMC Neurology 2015 15:51

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  6. Content type: Research article

    Proteinase-activated receptor 2 (PAR-2) has been shown to promote both neurotoxic and neuroprotective effects. Similarly, other routinely used nonspecific markers of neuronal damage can be found in cerebrospin...

    Authors: Zdenek Rohan, Magdalena Smetakova, Jaromir Kukal, Robert Rusina and Radoslav Matej

    Citation: BMC Neurology 2015 15:50

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  7. Content type: Research article

    Heritability of Alzheimer’s disease (AD) is estimated at 74% and genetic contributors have been widely sought. The ε4 allele of apolipoprotein E (APOE) remains the strongest common risk factor for AD, with numero...

    Authors: Jennifer S Yokoyama, Luke W Bonham, Renee L Sears, Eric Klein, Anna Karydas, Joel H Kramer, Bruce L Miller and Giovanni Coppola

    Citation: BMC Neurology 2015 15:47

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  8. Content type: Research article

    Because our previous study showed disparate voxel based morphometry (VBM) results between SPM and FSL softwares in the brain of amyotrophic lateral sclerosis patients with frontotemporal dementia (ALS-FTD), we...

    Authors: Venkateswaran Rajagopalan and Erik P Pioro

    Citation: BMC Neurology 2015 15:32

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  9. Content type: Research article

    Mitochondrial dysfunction is a hallmark of neurodegenerative diseases including Alzheimer’s disease (AD), with morphological and functional abnormalities limiting the electron transport chain and ATP productio...

    Authors: Aaron N Long, Katrina Owens, Anna E Schlappal, Tibor Kristian, Paul S Fishman and Rosemary A Schuh

    Citation: BMC Neurology 2015 15:19

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  10. Content type: Research article

    Alzheimer’s disease (AD) is the most common form of dementia and patients often have visual disorders. Mild cognitive impairment (MCI) is characterized by a memory deficit when compared with those of a similar...

    Authors: Dachuan Liu, Lina Zhang, Zhen Li, Xuxiang Zhang, Yue Wu, Huiqing Yang, Baoquan Min, Xinqing Zhang, Daqing Ma and Yan Lu

    Citation: BMC Neurology 2015 15:14

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  11. Content type: Study protocol

    The Parelsnoer Institute is a collaboration between 8 Dutch University Medical Centers in which clinical data and biomaterials from patients suffering from chronic diseases (so called “Pearls”) are collected acco...

    Authors: Pauline Aalten, Inez HGB Ramakers, Geert Jan Biessels, Peter Paul de Deyn, Huiberdina L Koek, Marcel GM OldeRikkert, Ania M Oleksik, Edo Richard, Lieke L Smits, John C van Swieten, Laura K Teune, Aad van der Lugt, Frederik Barkhof, Charlotte E Teunissen, Nico Rozendaal, Frans RJ Verhey…

    Citation: BMC Neurology 2014 14:254

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  12. Content type: Research article

    The American Stroke Association/American Heart Association recommended the criteria for diagnosis of vascular cognitive impairment and memory impairment (MI) is a feature in the classification of vascular mild...

    Authors: Soo-Jin Cho, Kyung-Ho Yu, Mi Sun Oh, San Jung, Ju-Hun Lee, Im-Seok Koh, Hee-Joon Bae, Yeonwook Kang and Byung-Chul Lee

    Citation: BMC Neurology 2014 14:244

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  13. Content type: Research article

    Cholinesterase inhibitors can delay the progression of Alzheimer’s disease (AD). Several clinical trials of the drug in moderate to severe AD have consistently reported clinically positive effects. A combining ef...

    Authors: Kenichi Meguro, Yoshitaka Ouchi, Kyoko Akanuma, Mitsue Meguro and Mari Kasai

    Citation: BMC Neurology 2014 14:243

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  14. Content type: Case report

    Frontotemporal dementia (FTD) may present with psychiatric symptoms, usually together with neurological ones and in cases with a family history of dementia. We describe the case of an FTD behavioural variant w...

    Authors: Carla Gramaglia, Roberto Cantello, Emanuela Terazzi, Miryam Carecchio, Sandra D’Alfonso, Nunzia Chieppa, Francesca Ressico, Maria Cristina Rizza and Patrizia Zeppegno

    Citation: BMC Neurology 2014 14:228

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  15. Content type: Case report

    Differential diagnosis of severe progressive dementia includes a wide spectrum of inflammatory and neurodegenerative diseases. Particularly challenging is the differentiation of potentially treatable autoimmun...

    Authors: Frédéric Zuhorn, Almut Hübenthal, Andreas Rogalewski, Müjgan Dogan Onugoren, Markus Glatzel, Christian G Bien and Wolf-Rüdiger Schäbitz

    Citation: BMC Neurology 2014 14:227

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  16. Content type: Debate

    Recent studies have revealed an inverse epidemiological correlation between Alzheimer’s disease (AD) and cancer − patients with AD show a reduced risk of cancer, while cancer survivors are less likely to devel...

    Authors: Jian-Ming Li, Chao Liu, Xia Hu, Yan Cai, Chao Ma, Xue-Gang Luo and Xiao-Xin Yan

    Citation: BMC Neurology 2014 14:211

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  17. Content type: Study protocol

    As greater numbers of us are living longer, it is increasingly important to understand how we can age healthily. Although old age is often stereotyped as a time of declining mental abilities and inflexibility,...

    Authors: Meredith A Shafto, Lorraine K Tyler, Marie Dixon, Jason R Taylor, James B Rowe, Rhodri Cusack, Andrew J Calder, William D Marslen-Wilson, John Duncan, Tim Dalgleish, Richard N Henson, Carol Brayne and Fiona E Matthews

    Citation: BMC Neurology 2014 14:204

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  18. Content type: Research article

    In the absence of a gold standard, a panel of experts can be invited to assign a reference diagnosis for use in research. Available literature offers limited guidance on assembling and working with an expert p...

    Authors: Ron L H Handels, Claire A G Wolfs, Pauline Aalten, Patrick M M Bossuyt, Manuela A Joore, Albert F G Leentjens, Johan L Severens and Frans R J Verhey

    Citation: BMC Neurology 2014 14:190

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  19. Content type: Research article

    Dementia includes a group of neurodegenerative disorders characterized by progressive loss of cognitive function and a decrease in the ability to perform activities of daily living. Systematic reviews of diagn...

    Authors: Ingrid Arevalo-Rodriguez, Omar Segura, Ivan Solà, Xavier Bonfill, Erick Sanchez and Pablo Alonso-Coello

    Citation: BMC Neurology 2014 14:183

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