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Dementias

Section edited by Marwan Sabbagh

This section focuses on neurodegeneration. Topics of interest include, but are not limited to, Alzheimer’s disease, Parkinson’s Disease, frontotemporal dementias, Lewy body dementia, vascular dementia, mild cognitive impairment and basic aspects of neurodegenerative diseases and prion diseases.

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  1. Content type: Research article

    Executive functions (EF) in Alzheimer’s disease (AD), classically related to the prefrontal cortex, have been forgotten in mild stages, given more importance to temporal lobe associated disorders, such as memo...

    Authors: E. Blanco Martín, I. Ugarriza Serrano, X. Elcoroaristizabal Martín, L. Galdos Alcelay, A. Molano Salazar, R. Bereincua Gandarias, S. Inglés Borda, J. M. Uterga Valiente, M. B. Indakoetxea Juanbeltz, J. Moraza Lopez, M. Barandiarán Amillano and M. Fernández-Martínez

    Citation: BMC Neurology 2016 16:88

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  2. Content type: Case report

    Three main genes are described as causative genes for early-onset Alzheimer dementia (EOAD): APP, PSEN1 and PSEN2. We describe a woman with EOAD had a novel PSEN1 mutation.

    Authors: Seong Soo A. An, Eva Bagyinszky, Hye Ryoun Kim, Ju-Won Seok, Hae-Won Shin, SeunOh Bae, SangYun Kim and Young Chul Youn

    Citation: BMC Neurology 2016 16:71

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  3. Content type: Study protocol

    The ε4 allele of the Apolipoprotein E gene (APOE-ε4) is a potent genetic risk factor for sporadic Alzheimer’s disease (AD). Amnestic mild cognitive impairment (aMCI) is an intermediate state between normal cog...

    Authors: Guan-Qun Chen, Can Sheng, Yu-Xia Li, Yang Yu, Xiao-Ni Wang, Yu Sun, Hong-Yan Li, Xuan-Yu Li, Yun-Yan Xie and Ying Han

    Citation: BMC Neurology 2016 16:64

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  4. Content type: Study protocol

    Considerable variability exists in international prevalence and incidence estimates of dementia. The accuracy of estimates of dementia in the oldest-old and the controversial question of whether dementia incid...

    Authors: Henry Brodaty, Claudia Woolf, Stacy Andersen, Nir Barzilai, Carol Brayne, Karen Siu-Lan Cheung, Maria M. Corrada, John D. Crawford, Catriona Daly, Yasuyuki Gondo, Bo Hagberg, Nobuyoshi Hirose, Henne Holstege, Claudia Kawas, Jeffrey Kaye, Nicole A. Kochan…

    Citation: BMC Neurology 2016 16:52

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  5. Content type: Research article

    The production of inflammatory cytokines resulting from amyloid β (Aβ) is associated with the initiation of Alzheimer’s disease (AD). Atorvastatin (ATV) has been reported to improve AD, however, it is unclear ...

    Authors: Liandong Zhao, Tingting Chen, Chonghui Wang, Guoxi Li, Wenhui Zhi, Jun Yin, Qi Wan and Ling Chen

    Citation: BMC Neurology 2016 16:18

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  6. Content type: Study protocol

    Chronic HIV infection commonly affects both cognition and mental health, even with excellent systemic viral control. The causes of compromised brain health are likely to be a multi-factorial combination of HIV...

    Authors: Nancy E. Mayo, Marie-Josée Brouillette and Lesley K. Fellows

    Citation: BMC Neurology 2016 16:8

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  7. Content type: Research article

    Deep brain stimulation has recently been considered a potential therapy in improving memory function. It has been shown that a change of neurotransmitters has an effect on memory function. However, much about ...

    Authors: Ji Eun Lee, Da Un Jeong, Jihyeon Lee, Won Seok Chang and Jin Woo Chang

    Citation: BMC Neurology 2016 16:6

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  8. Content type: Research article

    Cobalamin (Cbl) deficiency has been associated with various neuropsychiatric symptoms of different severities. While some studies dedicated in structural neuroimaging credibly address negative impact of low Cb...

    Authors: Min-Chien Tu, Chung-Ping Lo, Ching-Yuan Chen and Ching-Feng Huang

    Citation: BMC Neurology 2015 15:251

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  9. Content type: Research article

    Cerebral amyloid angiopathy (CAA) refers to the deposition of β-amyloid (Aβ) peptides in the wall of brain vasculature, commonly involving capillaries and arterioles. Also being considered a part of CAA is the...

    Authors: Zhi-Qin Xue, Zheng-Wen He, Jian-Jun Yu, Yan Cai, Wen-Ying Qiu, Aihua Pan, Wei-Ping Gai, Huaibin Cai, Xue-Gang Luo, Chao Ma and Xiao-Xin Yan

    Citation: BMC Neurology 2015 15:71

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  10. Content type: Research article

    Cholinesterase inhibitors are used to treat the symptoms of dementia and can theoretically cause bradycardia. Previous studies suggest that patients taking these medications have an increased risk of undergoin...

    Authors: Allen R Huang, Calum J Redpath and Carl van Walraven

    Citation: BMC Neurology 2015 15:66

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  11. Content type: Research article

    One of the usual problems psychologists and clinicians face in clinical practice is differential diagnostics of Alzheimer’s disease and depression. It has been reported that the ACE and ACE-R could discriminat...

    Authors: Augustinas Rotomskis, Ramunė Margevičiūtė, Arūnas Germanavičius, Gintaras Kaubrys, Valmantas Budrys and Albinas Bagdonas

    Citation: BMC Neurology 2015 15:57

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  12. Content type: Research article

    Cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau and p-tau have a characteristic pattern in Alzheimer’s Disease (AD). Their roles in HIV-associated neurocognitive disorder (HAND) remains unclear.

    Authors: Lucette A Cysique, Timothy Hewitt, Juliana Croitoru-Lamoury, Kevin Taddei, Ralph N Martins, Constance SN Chew, Nicholas NWS Davies, Patricia Price and Bruce J Brew

    Citation: BMC Neurology 2015 15:51

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  13. Content type: Research article

    Proteinase-activated receptor 2 (PAR-2) has been shown to promote both neurotoxic and neuroprotective effects. Similarly, other routinely used nonspecific markers of neuronal damage can be found in cerebrospin...

    Authors: Zdenek Rohan, Magdalena Smetakova, Jaromir Kukal, Robert Rusina and Radoslav Matej

    Citation: BMC Neurology 2015 15:50

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  14. Content type: Research article

    Heritability of Alzheimer’s disease (AD) is estimated at 74% and genetic contributors have been widely sought. The ε4 allele of apolipoprotein E (APOE) remains the strongest common risk factor for AD, with numero...

    Authors: Jennifer S Yokoyama, Luke W Bonham, Renee L Sears, Eric Klein, Anna Karydas, Joel H Kramer, Bruce L Miller and Giovanni Coppola

    Citation: BMC Neurology 2015 15:47

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  15. Content type: Research article

    Because our previous study showed disparate voxel based morphometry (VBM) results between SPM and FSL softwares in the brain of amyotrophic lateral sclerosis patients with frontotemporal dementia (ALS-FTD), we...

    Authors: Venkateswaran Rajagopalan and Erik P Pioro

    Citation: BMC Neurology 2015 15:32

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  16. Content type: Research article

    Mitochondrial dysfunction is a hallmark of neurodegenerative diseases including Alzheimer’s disease (AD), with morphological and functional abnormalities limiting the electron transport chain and ATP productio...

    Authors: Aaron N Long, Katrina Owens, Anna E Schlappal, Tibor Kristian, Paul S Fishman and Rosemary A Schuh

    Citation: BMC Neurology 2015 15:19

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  17. Content type: Research article

    Alzheimer’s disease (AD) is the most common form of dementia and patients often have visual disorders. Mild cognitive impairment (MCI) is characterized by a memory deficit when compared with those of a similar...

    Authors: Dachuan Liu, Lina Zhang, Zhen Li, Xuxiang Zhang, Yue Wu, Huiqing Yang, Baoquan Min, Xinqing Zhang, Daqing Ma and Yan Lu

    Citation: BMC Neurology 2015 15:14

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  18. Content type: Study protocol

    The Parelsnoer Institute is a collaboration between 8 Dutch University Medical Centers in which clinical data and biomaterials from patients suffering from chronic diseases (so called “Pearls”) are collected acco...

    Authors: Pauline Aalten, Inez HGB Ramakers, Geert Jan Biessels, Peter Paul de Deyn, Huiberdina L Koek, Marcel GM OldeRikkert, Ania M Oleksik, Edo Richard, Lieke L Smits, John C van Swieten, Laura K Teune, Aad van der Lugt, Frederik Barkhof, Charlotte E Teunissen, Nico Rozendaal, Frans RJ Verhey…

    Citation: BMC Neurology 2014 14:254

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