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Dementias

Section edited by Marwan Sabbagh

This section focuses on neurodegeneration. Topics of interest include, but are not limited to, Alzheimer’s disease, Parkinson’s Disease, frontotemporal dementias, Lewy body dementia, vascular dementia, mild cognitive impairment and basic aspects of neurodegenerative diseases and prion diseases.

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  2. The objectives of this study were to explore the relationship between olfactory impairment, cognitive measures, and brain structure volumes in healthy elderly individuals, compared to patients with amnestic mi...

    Authors: Grete Kjelvik, Ingvild Saltvedt, Linda R White, Pål Stenumgård, Olav Sletvold, Knut Engedal, Kristina Skåtun, Ann Kristin Lyngvær, Hill Aina Steffenach and Asta K Håberg

    Citation: BMC Neurology 2014 14:168

    Content type: Research article

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  3. The Kii peninsula of Japan is one of the foci of amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS/PDC) in the world. The purpose of this study is to clarify the neuropsychological features ...

    Authors: Akihiro Shindo, Yukito Ueda, Shigeki Kuzuhara and Yasumasa Kokubo

    Citation: BMC Neurology 2014 14:151

    Content type: Research article

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  5. The diagnosis of dementia with Lewy bodies (DLB) is often challenging in elderly individuals, not only for its various clinical features, sometimes, but also for its rare changes of periodic synchronous discha...

    Authors: Li Sun, Jie Cao, Feng na Chu, Zan Wang and Yudan Lv

    Citation: BMC Neurology 2014 14:112

    Content type: Case report

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  7. Intervention and treatment in Alzheimer’s disease dementia (AD-dementia) can be cost effective but the majority of patients are not diagnosed in a timely manner. Technology is now available that can enable the...

    Authors: Jennifer H Barnett, Lily Lewis, Andrew D Blackwell and Matthew Taylor

    Citation: BMC Neurology 2014 14:101

    Content type: Research article

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  8. Cholinesterase inhibitors (ChEIs) such as donepezil have the effect of delaying progression of Alzheimer’s disease (AD), but their effect on life expectancy is unclear. We analyzed the influence of donepezil o...

    Authors: Kenichi Meguro, Mari Kasai, Kyoko Akanuma, Mitsue Meguro, Hiroshi Ishii and Satoshi Yamaguchi

    Citation: BMC Neurology 2014 14:83

    Content type: Research article

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  9. Biomarkers based on the underlying pathology of Alzheimer’s disease (AD) and Dementia with Lewy Bodies (DLB) have the potential to improve diagnosis and understanding of the substrate for cognitive impairment ...

    Authors: Andrew Siderowf, Michael J Pontecorvo, Holly A Shill, Mark A Mintun, Anupa Arora, Abhinay D Joshi, Ming Lu, Charles H Adler, Douglas Galasko, Carolyn Liebsack, Daniel M Skovronsky and Marwan N Sabbagh

    Citation: BMC Neurology 2014 14:79

    Content type: Research article

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  10. Gait ability and cognitive function are interrelated during both normal walking (NW) and dual-task walking (DTW), and gait ability is thus adversely affected by cognitive impairment in both situations. However...

    Authors: Takehiko Doi, Hiroyuki Shimada, Hyuma Makizako, Kota Tsutsumimoto, Kazuki Uemura, Yuya Anan and Takao Suzuki

    Citation: BMC Neurology 2014 14:67

    Content type: Research article

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  11. We investigated levels of the β-amyloid 1–42 (Aβ42), total tau protein (T-tau) and tau phosphorylated at position threonine 181 (P-tau) in cerebrospinal fluid (CSF) of idiopathic normal pressure hydrocephalus ...

    Authors: Tae Sung Lim, Jun Young Choi, Sun Ah Park, Young Chul Youn, Hyun Young Lee, Byung Gon Kim, In Soo Joo, Kyoon Huh and So Young Moon

    Citation: BMC Neurology 2014 14:66

    Content type: Research article

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  12. The Insulin-like Growth Factor (IGF)-related system is implicated in neuroregeneration and cell repair, as well as regulating lifespan. IGF-II, one component of this system, has also been found to affect memor...

    Authors: Joakim Hertze, Katarina Nägga, Lennart Minthon and Oskar Hansson

    Citation: BMC Neurology 2014 14:64

    Content type: Research article

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  13. The aging of the population has led to the increase of chronic diseases, especially dementia and cardiovascular diseases, and it has become necessary for their relatives to dedicate more time in caregiving.

    Authors: Emiliano Rodriguez-Sánchez, José María Criado-Gutiérrez, Sara Mora-Simón, M Paz Muriel-Diaz, Manuel A Gómez-Marcos, José I Recio-Rodríguez, M Carmen Patino-Alonso, Luis F Valero-Juan, José A Maderuelo-Fernandez and Luis García-Ortiz

    Citation: BMC Neurology 2014 14:63

    Content type: Study protocol

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  14. England has one of the highest rates of hospital death in dementia in Europe. How this has changed over time is unknown. This study aimed to analyse temporal trends in place of death in dementia over a recent ...

    Authors: Katherine E Sleeman, Yuen K Ho, Julia Verne, Wei Gao and Irene J Higginson

    Citation: BMC Neurology 2014 14:59

    Content type: Research article

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  15. TTP488, an antagonist at the Receptor for Advanced Glycation End products, was evaluated as a potential treatment for patients with mild-to-moderate Alzheimer’s disease (AD). A previous report describes decrea...

    Authors: Aaron H Burstein, Imogene Grimes, Douglas R Galasko, Paul S Aisen, Marwan Sabbagh and Adnan MM Mjalli

    Citation: BMC Neurology 2014 14:12

    Content type: Research article

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  16. A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and cond...

    Authors: Perminder S Sachdev, Darren M Lipnicki, Nicole A Kochan, John D Crawford, Kenneth Rockwood, Shifu Xiao, Juan Li, Xia Li, Carol Brayne, Fiona E Matthews, Blossom CM Stephan, Richard B Lipton, Mindy J Katz, Karen Ritchie, Isabelle Carrière, Marie-Laure Ancelin…

    Citation: BMC Neurology 2013 13:165

    Content type: Study protocol

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  17. Due to the nature of neurodegenerative disorders, patients with primary progressive aphasia develop cognitive impairment other than aphasia as the disorder progresses. The progression of logopenic variant prim...

    Authors: Michitaka Funayama, Yoshitaka Nakagawa, Yoko Yamaya, Fumihiro Yoshino, Masaru Mimura and Motoichiro Kato

    Citation: BMC Neurology 2013 13:158

    Content type: Case report

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  18. To determine whether or not jugular venous reflux (JVR) is associated with structural brain parenchyma changes in individuals with mild cognitive impairment (MCI) and Alzheimer’s disease (AD).

    Authors: Clive Beggs, Chih-Ping Chung, Niels Bergsland, Pei-Ning Wang, Simon Shepherd, Chun-Yu Cheng, Michael G Dwyer, Han-Hwa Hu and Robert Zivadinov

    Citation: BMC Neurology 2013 13:157

    Content type: Research article

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  19. Advances in the diagnosis and multi-modality treatment of cancer have increased survival rates for many cancer types leading to an increasing load of long-term sequelae of therapy, including that of cognitive ...

    Authors: Justin Davis, Fiona M Ahlberg, Michael Berk, David M Ashley and Mustafa Khasraw

    Citation: BMC Neurology 2013 13:153

    Content type: Review

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  20. Dysphagia, which can result in aspiration pneumonia and death, is a well-known problem in patients with dementia and Parkinson’s disease. There are few studies on dysphagia in patients with dementia with Lewy ...

    Authors: Elisabet Londos, Oskar Hanxsson, Ingrid Alm Hirsch, Anna Janneskog, Margareta Bülow and Sebastian Palmqvist

    Citation: BMC Neurology 2013 13:140

    Content type: Research article

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  21. The accumulation of the misfolded forms of cellular prion protein, i.e. prions (PrPSc), in the brain is one of the crucial characteristics of fatal neurodegenerative disorders, called transmissible spongiform enc...

    Authors: Eva Dvorakova, Tanja Vranac, Olga Janouskova, Maja Černilec, Simon Koren, Anja Lukan, Jana Nováková, Radoslav Matej, Karel Holada and Vladka Čurin Šerbec

    Citation: BMC Neurology 2013 13:126

    Content type: Research article

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  22. We examined the clinical value of two serum markers of low-grade inflammation, C-reactive protein (CRP) and receptor of advanced glycation products (RAGE), as prognostic indices for cognitive decline.

    Authors: Xia Ge, Xiao-yun Xu, Chun-hua Feng, Yue Wang, Yuan-ling Li and Bo Feng

    Citation: BMC Neurology 2013 13:110

    Content type: Research article

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  23. The risk of falling is associated with cognitive dysfunction. Older adults with mild cognitive impairment (MCI) exhibit an accelerated reduction of brain volume, and face an increased risk of falling. The curr...

    Authors: Hyuma Makizako, Hiroyuki Shimada, Takehiko Doi, Hyuntae Park, Daisuke Yoshida, Kazuki Uemura, Kota Tsutsumimoto, Teresa Liu-Ambrose and Takao Suzuki

    Citation: BMC Neurology 2013 13:102

    Content type: Research article

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  24. In this study we assess the prevalence, characteristics as well as socio-demographic and clinical correlates of a positive screen for HIV-associated dementia in a group of patients on antiretroviral therapy (A...

    Authors: Julius Atashili, Bradley N Gaynes, Brian W Pence, Gladys Tayong, Dmitry Kats, Julie K O’donnell, Peter M Ndumbe and Alfred K Njamnshi

    Citation: BMC Neurology 2013 13:86

    Content type: Research article

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  25. Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme in the synthesis of γ-aminobutyric acid (GABA). Anti-GAD antibodies (GADA) are associated with the progression of stiff person syndrome and other n...

    Authors: Masahito Takagi, Yasushi Ishigaki, Kenji Uno, Shojiro Sawada, Junta Imai, Keizo Kaneko, Yutaka Hasegawa, Tetsuya Yamada, Ai Tokita, Kazumi Iseki, Shigenori Kanno, Yoshiyuki Nishio, Hideki Katagiri and Etsuro Mori

    Citation: BMC Neurology 2013 13:76

    Content type: Research article

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  26. Frontotemporal dementia (FTD) is recognised as a clinically and morphologically heterogeneous group of interrelated neurodegenerative conditions. One of the subtypes within this disease spectrum is the behavio...

    Authors: Maria Landqvist Waldö, Alexander Frizell Santillo, Ulla Passant, Henrik Zetterberg, Lars Rosengren, Christer Nilsson and Elisabet Englund

    Citation: BMC Neurology 2013 13:54

    Content type: Research article

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  27. Carriers of the ApoE ϵ4 allele are at a greater risk for developing Alzheimer’s disease (AD) and those who do develop AD tend to have a much greater neuropathological disease burden. Although several studies h...

    Authors: Marwan N Sabbagh, Michael Malek-Ahmadi, Brittany N Dugger, Katarina Lee, Lucia I Sue, Geidy Serrano, Douglas G Walker, Kathryn Davis, Sandra A Jacobson and Thomas G Beach

    Citation: BMC Neurology 2013 13:44

    Content type: Research article

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  28. Worldwide, millions of people are suffering from dementia and this number is rising. An index of quality of life (QoL) can describe the impact a disease or treatment has on a person’s wellbeing. QoL comprises ...

    Authors: Roxane Anthea Francesca Weijenberg, Frank Lobbezoo, Dirk Lucas Knol, Jori Tomassen and Erik Johan Anton Scherder

    Citation: BMC Neurology 2013 13:26

    Content type: Study protocol

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  29. A strong inverse relationship of functional limitation and socioeconomic status has been established in western ageing society. Functional limitation can be related to chronic diseases, disuse, cognitive decli...

    Authors: Vorapun Senanarong, Kamolthip Harnphadungkit, Niphon Poungvarin, Sathit Vannasaeng, Samut Chongwisal, Tipa Chakorn, Piyanuch Jamjumrus, Atthapon Raksthaput, Sinisa Chaichanettee, Nattapol Aoonkaew, Suthipol Udompunthurak, Rachelle S Doody and Jeffrey L Cummings

    Citation: BMC Neurology 2013 13:3

    Content type: Research article

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  30. Establishing a confident clinical diagnosis before an advanced stage of illness can be difficult in Creutzfeldt-Jakob disease (CJD) but unlike common causes of dementia, prion diseases can often be diagnosed b...

    Authors: Christopher Carswell, Andrew Thompson, Ana Lukic, John Stevens, Peter Rudge, Simon Mead, John Collinge and Harpreet Hyare

    Citation: BMC Neurology 2012 12:153

    Content type: Research article

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  31. Little is known about the long-term success of non-drug therapies for treating dementia, especially whether the effects are sustained after therapy ends. Here, we examined the effects of a one-year multimodal ...

    Authors: Katharina Luttenberger, Benjamin Hofner and Elmar Graessel

    Citation: BMC Neurology 2012 12:151

    Content type: Research article

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  32. To investigate to what extent Alzheimer's Disease (AD) affects Resting State activity, the possible impairment of independent electrophysiological parameters was determined in Eye-open and Eye-closed Condition...

    Authors: Antonio Tartaglione, Luciano Spadavecchia, Marco Maculotti and Fabio Bandini

    Citation: BMC Neurology 2012 12:145

    Content type: Research article

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  33. We report a female patient with familial Creutzfeldt-Jakob disease with V180I mutation (fCJD with V180I), who was serially followed up with magnetic resonance imaging (MRI) and electroencephalogram (EEG) for u...

    Authors: Kentaro Deguchi, Motonori Takamiya, Shoko Deguchi, Nobutoshi Morimoto, Tomoko Kurata, Yoshio Ikeda and Koji Abe

    Citation: BMC Neurology 2012 12:144

    Content type: Case report

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  34. It remains unclear how executive function (EF) is affected in the stage of amnestic mild cognitive impairment (aMCI). Previous studies using different methods to assess EF in patients with aMCI have reached in...

    Authors: Dongming Zheng, Xiaoyu Dong, Hongzan Sun, Yongchuan Xu, Ying Ma and Xiaoming Wang

    Citation: BMC Neurology 2012 12:138

    Content type: Research article

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  35. The Hopkins Verbal Learning Test (HVLT) has been validated for detecting dementia in English-speaking populations. However, no studies have examined the Chinese version of the HVLT scale, and appropriate cut-o...

    Authors: Jing Shi, Jinzhou Tian, Mingqing Wei, Yingchun Miao and Yongyan Wang

    Citation: BMC Neurology 2012 12:136

    Content type: Research article

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  37. To examine the effects of a multicomponent exercise program on the cognitive function of older adults with amnestic mild cognitive impairment (aMCI).

    Authors: Takao Suzuki, Hiroyuki Shimada, Hyuma Makizako, Takehiko Doi, Daisuke Yoshida, Kota Tsutsumimoto, Yuya Anan, Kazuki Uemura, Sangyoon Lee and Hyuntae Park

    Citation: BMC Neurology 2012 12:128

    Content type: Research article

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  38. Maintaining cognitive function is essential for healthy aging and to function autonomously within society. White matter lesions (WMLs) are associated with reduced cognitive function in older adults. However, w...

    Authors: Niousha Bolandzadeh, Jennifer C Davis, Roger Tam, Todd C Handy and Teresa Liu-Ambrose

    Citation: BMC Neurology 2012 12:126

    Content type: Research article

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  39. Mild cognitive impairment (MCI), defined as a transitional zone between normal cognition and dementia, requires a battery of formal neuropsychological tests administered by a trained rater for its diagnosis. T...

    Authors: Qi-hao Guo, Bin Zhou, Qian-hua Zhao, Bei Wang and Zhen Hong

    Citation: BMC Neurology 2012 12:119

    Content type: Research article

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  40. This article reports a rare case of active neurosyphilis in a man with mild to moderate dementia and marked hippocampal atrophy, mimicking early onset Alzheimer’s disease. Few cases have so far described bilat...

    Authors: Shima Mehrabian, Margarita Raycheva, Martina Traykova, Tonya Stankova, Latchezar Penev, Olga Grigorova and Latchezar Traykov

    Citation: BMC Neurology 2012 12:96

    Content type: Case report

    Published on:

  41. To test the hypothesis that white matter lesions (WML) are primarily associated with regional frontal cortical volumes, and to determine the mediating effects of these regional frontal cortices on the associat...

    Authors: Jun-Young Lee, Philip Insel, R Scott Mackin, Norbert Schuff, Helena Chui, Charles DeCarli, Kee Hyung Park, Susanne G Mueller and Michael W Weiner

    Citation: BMC Neurology 2012 12:83

    Content type: Research article

    Published on:

  42. Progressive neurodegeneration in Alzheimer’s disease (AD) induces cognitive deterioration, and there is controversy regarding the optimal treatment strategy in early AD. Stimulation therapy, including physical...

    Authors: Fred Andersen, Matti Viitanen, Dag S Halvorsen, Bjørn Straume, Tom Wilsgaard and Torgeir A Engstad

    Citation: BMC Neurology 2012 12:59

    Content type: Research article

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  43. Previous cost-effectiveness studies of cholinesterase inhibitors have modeled Alzheimer's disease (AD) progression and treatment effects through single or global severity measures, or progression to "Full Time...

    Authors: Susanne Hartz, Denis Getsios, Sunning Tao, Steve Blume and Grant Maclaine

    Citation: BMC Neurology 2012 12:2

    Content type: Research article

    Published on:

  44. Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme for producing γ-aminobutyric acid, and it has been suggested that antibodies against GAD play a role in neurological conditions and type 1 diabetes...

    Authors: Masahito Takagi, Hiroshi Yamasaki, Keiko Endo, Tetsuya Yamada, Keizo Kaneko, Yoshitomo Oka and Etsuro Mori

    Citation: BMC Neurology 2011 11:156

    Content type: Case report

    Published on:

  45. Few data are available on the prevalence of cognitive impairment (CI) in Spain, and the existing information shows important variations depending on the geographical setting and the methodology employed. The a...

    Authors: Emiliano Rodríguez-Sánchez, Sara Mora-Simón, María C Patino-Alonso, Ricardo García-García, Alfonso Escribano-Hernández, Luis García-Ortiz, Ma Victoria Perea- Bartolomé and Manuel A Gómez-Marcos

    Citation: BMC Neurology 2011 11:147

    Content type: Research article

    Published on:

  46. In central nervous system cholesterol cannot be degraded but is secreted into circulation predominantly in the form of its polar metabolite 24(S)-hydroxycholesterol (24S-OH-Chol). Some studies suggested an associ...

    Authors: Giovanni Zuliani, Michela Perrone Donnorso, Cristina Bosi, Angelina Passaro, Edoardo Dalla Nora, Amedeo Zurlo, Francesco Bonetti, Alessia F Mozzi and Claudio Cortese

    Citation: BMC Neurology 2011 11:121

    Content type: Research article

    Published on:

  47. The gamma-isoform of the 14-3-3 protein (14-3-3 gamma) is expressed in neurons, and could be a specific marker for neuronal damage. This protein has been reported as a detectable biomarker, especially in the c...

    Authors: Yuki Matsui, Katsuya Satoh, Toshiaki Miyazaki, Susumu Shirabe, Ryuichiro Atarashi, Kazuo Mutsukura, Akira Satoh, Yasufumi Kataoka and Noriyuki Nishida

    Citation: BMC Neurology 2011 11:120

    Content type: Research article

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  48. Substituted judgment asks the proxy to decide what the patient would have decided, had he or she been competent. It is unclear whether substituted judgment of the patient's quality of life can serve as a surro...

    Authors: Claudia Schiffczyk, Christina Jonas, Constanze Lahmeyer, Friedemann Müller and Matthias W Riepe

    Citation: BMC Neurology 2011 11:118

    Content type: Research article

    Published on:

  49. Dementia is a major and increasing health problem worldwide. This study aims to investigate dementia treatment strategies among physicians specialised in complementary and alternative medicine (CAM) by analysi...

    Authors: Elke Jeschke, Thomas Ostermann, Horst C Vollmar, Manuela Tabali, Friedemann Schad and Harald Matthes

    Citation: BMC Neurology 2011 11:99

    Content type: Research article

    Published on:

  50. To assess and compare the effectiveness and costs of Phototest, Mini Mental State Examination (MMSE), and Memory Impairment Screen (MIS) to screen for dementia (DEM) and cognitive impairment (CI).

    Authors: Cristobal Carnero-Pardo, Beatriz Espejo-Martinez, Samuel Lopez-Alcalde, Maria Espinosa-Garcia, Carmen Saez-Zea, Rosa Vilchez-Carrillo, Elisa Hernandez-Torres and Jose L Navarro-Espigares

    Citation: BMC Neurology 2011 11:92

    Content type: Research article

    Published on:

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