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Dementias

This section focuses on neurodegeneration. Topics of interest include, but are not limited to, Alzheimer's disease, Parkinson's Disease, frontotemporal dementias, Lewy body dementia, vascular dementia, mild cognitive impairment and basic aspects of neurodegenerative diseases and prion diseases.

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  1. To examine the effects of a multicomponent exercise program on the cognitive function of older adults with amnestic mild cognitive impairment (aMCI).

    Authors: Takao Suzuki, Hiroyuki Shimada, Hyuma Makizako, Takehiko Doi, Daisuke Yoshida, Kota Tsutsumimoto, Yuya Anan, Kazuki Uemura, Sangyoon Lee and Hyuntae Park

    Citation: BMC Neurology 2012 12:128

    Content type: Research article

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  2. Maintaining cognitive function is essential for healthy aging and to function autonomously within society. White matter lesions (WMLs) are associated with reduced cognitive function in older adults. However, w...

    Authors: Niousha Bolandzadeh, Jennifer C Davis, Roger Tam, Todd C Handy and Teresa Liu-Ambrose

    Citation: BMC Neurology 2012 12:126

    Content type: Research article

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  3. Mild cognitive impairment (MCI), defined as a transitional zone between normal cognition and dementia, requires a battery of formal neuropsychological tests administered by a trained rater for its diagnosis. T...

    Authors: Qi-hao Guo, Bin Zhou, Qian-hua Zhao, Bei Wang and Zhen Hong

    Citation: BMC Neurology 2012 12:119

    Content type: Research article

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  4. This article reports a rare case of active neurosyphilis in a man with mild to moderate dementia and marked hippocampal atrophy, mimicking early onset Alzheimer’s disease. Few cases have so far described bilat...

    Authors: Shima Mehrabian, Margarita Raycheva, Martina Traykova, Tonya Stankova, Latchezar Penev, Olga Grigorova and Latchezar Traykov

    Citation: BMC Neurology 2012 12:96

    Content type: Case report

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  5. To test the hypothesis that white matter lesions (WML) are primarily associated with regional frontal cortical volumes, and to determine the mediating effects of these regional frontal cortices on the associat...

    Authors: Jun-Young Lee, Philip Insel, R Scott Mackin, Norbert Schuff, Helena Chui, Charles DeCarli, Kee Hyung Park, Susanne G Mueller and Michael W Weiner

    Citation: BMC Neurology 2012 12:83

    Content type: Research article

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  6. Progressive neurodegeneration in Alzheimer’s disease (AD) induces cognitive deterioration, and there is controversy regarding the optimal treatment strategy in early AD. Stimulation therapy, including physical...

    Authors: Fred Andersen, Matti Viitanen, Dag S Halvorsen, Bjørn Straume, Tom Wilsgaard and Torgeir A Engstad

    Citation: BMC Neurology 2012 12:59

    Content type: Research article

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  7. Previous cost-effectiveness studies of cholinesterase inhibitors have modeled Alzheimer's disease (AD) progression and treatment effects through single or global severity measures, or progression to "Full Time...

    Authors: Susanne Hartz, Denis Getsios, Sunning Tao, Steve Blume and Grant Maclaine

    Citation: BMC Neurology 2012 12:2

    Content type: Research article

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  8. Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme for producing γ-aminobutyric acid, and it has been suggested that antibodies against GAD play a role in neurological conditions and type 1 diabetes...

    Authors: Masahito Takagi, Hiroshi Yamasaki, Keiko Endo, Tetsuya Yamada, Keizo Kaneko, Yoshitomo Oka and Etsuro Mori

    Citation: BMC Neurology 2011 11:156

    Content type: Case report

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  9. Few data are available on the prevalence of cognitive impairment (CI) in Spain, and the existing information shows important variations depending on the geographical setting and the methodology employed. The a...

    Authors: Emiliano Rodríguez-Sánchez, Sara Mora-Simón, María C Patino-Alonso, Ricardo García-García, Alfonso Escribano-Hernández, Luis García-Ortiz, Ma Victoria Perea- Bartolomé and Manuel A Gómez-Marcos

    Citation: BMC Neurology 2011 11:147

    Content type: Research article

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  10. In central nervous system cholesterol cannot be degraded but is secreted into circulation predominantly in the form of its polar metabolite 24(S)-hydroxycholesterol (24S-OH-Chol). Some studies suggested an associ...

    Authors: Giovanni Zuliani, Michela Perrone Donnorso, Cristina Bosi, Angelina Passaro, Edoardo Dalla Nora, Amedeo Zurlo, Francesco Bonetti, Alessia F Mozzi and Claudio Cortese

    Citation: BMC Neurology 2011 11:121

    Content type: Research article

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  11. The gamma-isoform of the 14-3-3 protein (14-3-3 gamma) is expressed in neurons, and could be a specific marker for neuronal damage. This protein has been reported as a detectable biomarker, especially in the c...

    Authors: Yuki Matsui, Katsuya Satoh, Toshiaki Miyazaki, Susumu Shirabe, Ryuichiro Atarashi, Kazuo Mutsukura, Akira Satoh, Yasufumi Kataoka and Noriyuki Nishida

    Citation: BMC Neurology 2011 11:120

    Content type: Research article

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  12. Substituted judgment asks the proxy to decide what the patient would have decided, had he or she been competent. It is unclear whether substituted judgment of the patient's quality of life can serve as a surro...

    Authors: Claudia Schiffczyk, Christina Jonas, Constanze Lahmeyer, Friedemann Müller and Matthias W Riepe

    Citation: BMC Neurology 2011 11:118

    Content type: Research article

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  13. Dementia is a major and increasing health problem worldwide. This study aims to investigate dementia treatment strategies among physicians specialised in complementary and alternative medicine (CAM) by analysi...

    Authors: Elke Jeschke, Thomas Ostermann, Horst C Vollmar, Manuela Tabali, Friedemann Schad and Harald Matthes

    Citation: BMC Neurology 2011 11:99

    Content type: Research article

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  14. To assess and compare the effectiveness and costs of Phototest, Mini Mental State Examination (MMSE), and Memory Impairment Screen (MIS) to screen for dementia (DEM) and cognitive impairment (CI).

    Authors: Cristobal Carnero-Pardo, Beatriz Espejo-Martinez, Samuel Lopez-Alcalde, Maria Espinosa-Garcia, Carmen Saez-Zea, Rosa Vilchez-Carrillo, Elisa Hernandez-Torres and Jose L Navarro-Espigares

    Citation: BMC Neurology 2011 11:92

    Content type: Research article

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  15. Mild cognitive impairment (MCI) is a heterogeneous clinical entity that comprises the prodromal phase of Alzheimer's disease (Pr-AD). New biomarkers are useful in detecting Pr-AD, but they are not universally ...

    Authors: Ana Pozueta, Eloy Rodríguez-Rodríguez, José Luis Vazquez-Higuera, Ignacio Mateo, Pascual Sánchez-Juan, Soraya González-Perez, José Berciano and Onofre Combarros

    Citation: BMC Neurology 2011 11:78

    Content type: Research article

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  16. Donepezil 23 mg/d, recently approved in the United States for treatment of moderate to severe Alzheimer's disease (AD), was developed to address the need for an additional treatment option for patients with ad...

    Authors: Martin Farlow, Felix Veloso, Margaret Moline, Jane Yardley, Elimor Brand-Schieber, Francesco Bibbiani, Heng Zou, Timothy Hsu and Andrew Satlin

    Citation: BMC Neurology 2011 11:57

    Content type: Research article

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  17. Despite being the fastest growing and the most cognitively impaired age group, the oldest olds are under-represented in clinical research. The purpose of this study was to describe the design, methods, and bas...

    Authors: Ugo Lucca, Mariateresa Garrì, Angela Recchia, Giancarlo Logroscino, Pietro Tiraboschi, Massimo Franceschi, Chiara Bertinotti, Anna Biotti, Elena Gargantini, Marilena Maragna, Alessandro Nobili, Luca Pasina, Carlotta Franchi, Emma Riva and Mauro Tettamanti

    Citation: BMC Neurology 2011 11:54

    Content type: Research article

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  18. Multiple pathogenic factors may contribute to the pathophysiology of Alzheimer's disease (AD). Peripheral blood markers have been used to assess biochemical changes associated with AD and mild cognitive impair...

    Authors: Sam-Moon Kim, Juhee Song, Seungwoo Kim, Changsu Han, Moon Ho Park, Youngho Koh, Sangmee Ahn Jo and Young-Youl Kim

    Citation: BMC Neurology 2011 11:51

    Content type: Research article

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  19. Simple, non-invasive tests for early detection of degenerative dementia by use of biomarkers are urgently required. However, up to the present, no validated extracerebral diagnostic markers for the early diagn...

    Authors: Felix Bermejo-Pareja, Desiree Antequera, Teo Vargas, Jose A Molina and Eva Carro

    Citation: BMC Neurology 2010 10:108

    Content type: Research article

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