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Section edited by Marwan Sabbagh

This section focuses on neurodegeneration. Topics of interest include, but are not limited to, Alzheimer’s disease, Parkinson’s Disease, frontotemporal dementias, Lewy body dementia, vascular dementia, mild cognitive impairment and basic aspects of neurodegenerative diseases and prion diseases.

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  1. Content type: Research article

    The American Stroke Association/American Heart Association recommended the criteria for diagnosis of vascular cognitive impairment and memory impairment (MI) is a feature in the classification of vascular mild...

    Authors: Soo-Jin Cho, Kyung-Ho Yu, Mi Sun Oh, San Jung, Ju-Hun Lee, Im-Seok Koh, Hee-Joon Bae, Yeonwook Kang and Byung-Chul Lee

    Citation: BMC Neurology 2014 14:244

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  2. Content type: Research article

    Cholinesterase inhibitors can delay the progression of Alzheimer’s disease (AD). Several clinical trials of the drug in moderate to severe AD have consistently reported clinically positive effects. A combining ef...

    Authors: Kenichi Meguro, Yoshitaka Ouchi, Kyoko Akanuma, Mitsue Meguro and Mari Kasai

    Citation: BMC Neurology 2014 14:243

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  3. Content type: Case report

    Frontotemporal dementia (FTD) may present with psychiatric symptoms, usually together with neurological ones and in cases with a family history of dementia. We describe the case of an FTD behavioural variant w...

    Authors: Carla Gramaglia, Roberto Cantello, Emanuela Terazzi, Miryam Carecchio, Sandra D’Alfonso, Nunzia Chieppa, Francesca Ressico, Maria Cristina Rizza and Patrizia Zeppegno

    Citation: BMC Neurology 2014 14:228

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  4. Content type: Case report

    Differential diagnosis of severe progressive dementia includes a wide spectrum of inflammatory and neurodegenerative diseases. Particularly challenging is the differentiation of potentially treatable autoimmun...

    Authors: Frédéric Zuhorn, Almut Hübenthal, Andreas Rogalewski, Müjgan Dogan Onugoren, Markus Glatzel, Christian G Bien and Wolf-Rüdiger Schäbitz

    Citation: BMC Neurology 2014 14:227

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  5. Content type: Debate

    Recent studies have revealed an inverse epidemiological correlation between Alzheimer’s disease (AD) and cancer − patients with AD show a reduced risk of cancer, while cancer survivors are less likely to devel...

    Authors: Jian-Ming Li, Chao Liu, Xia Hu, Yan Cai, Chao Ma, Xue-Gang Luo and Xiao-Xin Yan

    Citation: BMC Neurology 2014 14:211

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  6. Content type: Study protocol

    As greater numbers of us are living longer, it is increasingly important to understand how we can age healthily. Although old age is often stereotyped as a time of declining mental abilities and inflexibility,...

    Authors: Meredith A Shafto, Lorraine K Tyler, Marie Dixon, Jason R Taylor, James B Rowe, Rhodri Cusack, Andrew J Calder, William D Marslen-Wilson, John Duncan, Tim Dalgleish, Richard N Henson, Carol Brayne and Fiona E Matthews

    Citation: BMC Neurology 2014 14:204

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  7. Content type: Research article

    In the absence of a gold standard, a panel of experts can be invited to assign a reference diagnosis for use in research. Available literature offers limited guidance on assembling and working with an expert p...

    Authors: Ron L H Handels, Claire A G Wolfs, Pauline Aalten, Patrick M M Bossuyt, Manuela A Joore, Albert F G Leentjens, Johan L Severens and Frans R J Verhey

    Citation: BMC Neurology 2014 14:190

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  8. Content type: Research article

    Dementia includes a group of neurodegenerative disorders characterized by progressive loss of cognitive function and a decrease in the ability to perform activities of daily living. Systematic reviews of diagn...

    Authors: Ingrid Arevalo-Rodriguez, Omar Segura, Ivan Solà, Xavier Bonfill, Erick Sanchez and Pablo Alonso-Coello

    Citation: BMC Neurology 2014 14:183

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  9. Content type: Research article

    Dementia has been associated with an increased risk of hip fracture. However, little research has been conducted on the impact of dementia on wrist or vertebral fracture development. The aim of this study was ...

    Authors: Hao-Kuang Wang, Chao-Ming Hung, Sheng-Hsiang Lin, Yi-Cheng Tai, Kang Lu, Po-Chou Liliang, Chi-Wei Lin, Yi-Che Lee, Pei-Hsuan Fang, Li-Ching Chang and Ying-Chun Li

    Citation: BMC Neurology 2014 14:175

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  10. Content type: Case report

    Creutzfeldt-Jakob disease and Hashimoto's encephalopathy often show similar clinical presentation. Among Creutzfeldt-Jakob disease mimics, Hashimoto's encephalopathy is particularly important as it is treatabl...

    Authors: Jae-Won Jang, So Young Park, Young Ho Park, Jung E Kim and SangYun Kim

    Citation: BMC Neurology 2014 14:179

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  11. Content type: Research article

    The objectives of this study were to explore the relationship between olfactory impairment, cognitive measures, and brain structure volumes in healthy elderly individuals, compared to patients with amnestic mi...

    Authors: Grete Kjelvik, Ingvild Saltvedt, Linda R White, Pål Stenumgård, Olav Sletvold, Knut Engedal, Kristina Skåtun, Ann Kristin Lyngvær, Hill Aina Steffenach and Asta K Håberg

    Citation: BMC Neurology 2014 14:168

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  12. Content type: Research article

    The Kii peninsula of Japan is one of the foci of amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS/PDC) in the world. The purpose of this study is to clarify the neuropsychological features ...

    Authors: Akihiro Shindo, Yukito Ueda, Shigeki Kuzuhara and Yasumasa Kokubo

    Citation: BMC Neurology 2014 14:151

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  13. Content type: Case report

    The diagnosis of dementia with Lewy bodies (DLB) is often challenging in elderly individuals, not only for its various clinical features, sometimes, but also for its rare changes of periodic synchronous discha...

    Authors: Li Sun, Jie Cao, Feng na Chu, Zan Wang and Yudan Lv

    Citation: BMC Neurology 2014 14:112

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  14. Content type: Research article

    Intervention and treatment in Alzheimer’s disease dementia (AD-dementia) can be cost effective but the majority of patients are not diagnosed in a timely manner. Technology is now available that can enable the...

    Authors: Jennifer H Barnett, Lily Lewis, Andrew D Blackwell and Matthew Taylor

    Citation: BMC Neurology 2014 14:101

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  15. Content type: Research article

    Cholinesterase inhibitors (ChEIs) such as donepezil have the effect of delaying progression of Alzheimer’s disease (AD), but their effect on life expectancy is unclear. We analyzed the influence of donepezil o...

    Authors: Kenichi Meguro, Mari Kasai, Kyoko Akanuma, Mitsue Meguro, Hiroshi Ishii and Satoshi Yamaguchi

    Citation: BMC Neurology 2014 14:83

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  16. Content type: Research article

    Biomarkers based on the underlying pathology of Alzheimer’s disease (AD) and Dementia with Lewy Bodies (DLB) have the potential to improve diagnosis and understanding of the substrate for cognitive impairment ...

    Authors: Andrew Siderowf, Michael J Pontecorvo, Holly A Shill, Mark A Mintun, Anupa Arora, Abhinay D Joshi, Ming Lu, Charles H Adler, Douglas Galasko, Carolyn Liebsack, Daniel M Skovronsky and Marwan N Sabbagh

    Citation: BMC Neurology 2014 14:79

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