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Dementias

Section edited by Marwan Sabbagh

This section focuses on neurodegeneration. Topics of interest include, but are not limited to, Alzheimer’s disease, Parkinson’s Disease, frontotemporal dementias, Lewy body dementia, vascular dementia, mild cognitive impairment and basic aspects of neurodegenerative diseases and prion diseases.

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  1. Content type: Research article

    Cholinesterase inhibitors (ChEIs) such as donepezil have the effect of delaying progression of Alzheimer’s disease (AD), but their effect on life expectancy is unclear. We analyzed the influence of donepezil o...

    Authors: Kenichi Meguro, Mari Kasai, Kyoko Akanuma, Mitsue Meguro, Hiroshi Ishii and Satoshi Yamaguchi

    Citation: BMC Neurology 2014 14:83

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  2. Content type: Research article

    Biomarkers based on the underlying pathology of Alzheimer’s disease (AD) and Dementia with Lewy Bodies (DLB) have the potential to improve diagnosis and understanding of the substrate for cognitive impairment ...

    Authors: Andrew Siderowf, Michael J Pontecorvo, Holly A Shill, Mark A Mintun, Anupa Arora, Abhinay D Joshi, Ming Lu, Charles H Adler, Douglas Galasko, Carolyn Liebsack, Daniel M Skovronsky and Marwan N Sabbagh

    Citation: BMC Neurology 2014 14:79

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  3. Content type: Study protocol

    The aging of the population has led to the increase of chronic diseases, especially dementia and cardiovascular diseases, and it has become necessary for their relatives to dedicate more time in caregiving.

    Authors: Emiliano Rodriguez-Sánchez, José María Criado-Gutiérrez, Sara Mora-Simón, M Paz Muriel-Diaz, Manuel A Gómez-Marcos, José I Recio-Rodríguez, M Carmen Patino-Alonso, Luis F Valero-Juan, José A Maderuelo-Fernandez and Luis García-Ortiz

    Citation: BMC Neurology 2014 14:63

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  4. Content type: Research article

    We investigated levels of the β-amyloid 1–42 (Aβ42), total tau protein (T-tau) and tau phosphorylated at position threonine 181 (P-tau) in cerebrospinal fluid (CSF) of idiopathic normal pressure hydrocephalus ...

    Authors: Tae Sung Lim, Jun Young Choi, Sun Ah Park, Young Chul Youn, Hyun Young Lee, Byung Gon Kim, In Soo Joo, Kyoon Huh and So Young Moon

    Citation: BMC Neurology 2014 14:66

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  5. Content type: Research article

    The Insulin-like Growth Factor (IGF)-related system is implicated in neuroregeneration and cell repair, as well as regulating lifespan. IGF-II, one component of this system, has also been found to affect memor...

    Authors: Joakim Hertze, Katarina Nägga, Lennart Minthon and Oskar Hansson

    Citation: BMC Neurology 2014 14:64

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  6. Content type: Research article

    Gait ability and cognitive function are interrelated during both normal walking (NW) and dual-task walking (DTW), and gait ability is thus adversely affected by cognitive impairment in both situations. However...

    Authors: Takehiko Doi, Hiroyuki Shimada, Hyuma Makizako, Kota Tsutsumimoto, Kazuki Uemura, Yuya Anan and Takao Suzuki

    Citation: BMC Neurology 2014 14:67

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  7. Content type: Research article

    England has one of the highest rates of hospital death in dementia in Europe. How this has changed over time is unknown. This study aimed to analyse temporal trends in place of death in dementia over a recent ...

    Authors: Katherine E Sleeman, Yuen K Ho, Julia Verne, Wei Gao and Irene J Higginson

    Citation: BMC Neurology 2014 14:59

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  8. Content type: Research article

    TTP488, an antagonist at the Receptor for Advanced Glycation End products, was evaluated as a potential treatment for patients with mild-to-moderate Alzheimer’s disease (AD). A previous report describes decrea...

    Authors: Aaron H Burstein, Imogene Grimes, Douglas R Galasko, Paul S Aisen, Marwan Sabbagh and Adnan MM Mjalli

    Citation: BMC Neurology 2014 14:12

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  9. Content type: Study protocol

    A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and cond...

    Authors: Perminder S Sachdev, Darren M Lipnicki, Nicole A Kochan, John D Crawford, Kenneth Rockwood, Shifu Xiao, Juan Li, Xia Li, Carol Brayne, Fiona E Matthews, Blossom CM Stephan, Richard B Lipton, Mindy J Katz, Karen Ritchie, Isabelle Carrière, Marie-Laure Ancelin…

    Citation: BMC Neurology 2013 13:165

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  10. Content type: Case report

    Due to the nature of neurodegenerative disorders, patients with primary progressive aphasia develop cognitive impairment other than aphasia as the disorder progresses. The progression of logopenic variant prim...

    Authors: Michitaka Funayama, Yoshitaka Nakagawa, Yoko Yamaya, Fumihiro Yoshino, Masaru Mimura and Motoichiro Kato

    Citation: BMC Neurology 2013 13:158

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  11. Content type: Research article

    To determine whether or not jugular venous reflux (JVR) is associated with structural brain parenchyma changes in individuals with mild cognitive impairment (MCI) and Alzheimer’s disease (AD).

    Authors: Clive Beggs, Chih-Ping Chung, Niels Bergsland, Pei-Ning Wang, Simon Shepherd, Chun-Yu Cheng, Michael G Dwyer, Han-Hwa Hu and Robert Zivadinov

    Citation: BMC Neurology 2013 13:157

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  12. Content type: Review

    Advances in the diagnosis and multi-modality treatment of cancer have increased survival rates for many cancer types leading to an increasing load of long-term sequelae of therapy, including that of cognitive ...

    Authors: Justin Davis, Fiona M Ahlberg, Michael Berk, David M Ashley and Mustafa Khasraw

    Citation: BMC Neurology 2013 13:153

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  13. Content type: Research article

    Dysphagia, which can result in aspiration pneumonia and death, is a well-known problem in patients with dementia and Parkinson’s disease. There are few studies on dysphagia in patients with dementia with Lewy ...

    Authors: Elisabet Londos, Oskar Hanxsson, Ingrid Alm Hirsch, Anna Janneskog, Margareta Bülow and Sebastian Palmqvist

    Citation: BMC Neurology 2013 13:140

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  14. Content type: Research article

    The accumulation of the misfolded forms of cellular prion protein, i.e. prions (PrPSc), in the brain is one of the crucial characteristics of fatal neurodegenerative disorders, called transmissible spongiform enc...

    Authors: Eva Dvorakova, Tanja Vranac, Olga Janouskova, Maja Černilec, Simon Koren, Anja Lukan, Jana Nováková, Radoslav Matej, Karel Holada and Vladka Čurin Šerbec

    Citation: BMC Neurology 2013 13:126

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  15. Content type: Research article

    We examined the clinical value of two serum markers of low-grade inflammation, C-reactive protein (CRP) and receptor of advanced glycation products (RAGE), as prognostic indices for cognitive decline.

    Authors: Xia Ge, Xiao-yun Xu, Chun-hua Feng, Yue Wang, Yuan-ling Li and Bo Feng

    Citation: BMC Neurology 2013 13:110

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  16. Content type: Research article

    The risk of falling is associated with cognitive dysfunction. Older adults with mild cognitive impairment (MCI) exhibit an accelerated reduction of brain volume, and face an increased risk of falling. The curr...

    Authors: Hyuma Makizako, Hiroyuki Shimada, Takehiko Doi, Hyuntae Park, Daisuke Yoshida, Kazuki Uemura, Kota Tsutsumimoto, Teresa Liu-Ambrose and Takao Suzuki

    Citation: BMC Neurology 2013 13:102

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  17. Content type: Research article

    In this study we assess the prevalence, characteristics as well as socio-demographic and clinical correlates of a positive screen for HIV-associated dementia in a group of patients on antiretroviral therapy (A...

    Authors: Julius Atashili, Bradley N Gaynes, Brian W Pence, Gladys Tayong, Dmitry Kats, Julie K O’donnell, Peter M Ndumbe and Alfred K Njamnshi

    Citation: BMC Neurology 2013 13:86

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  18. Content type: Research article

    Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme in the synthesis of γ-aminobutyric acid (GABA). Anti-GAD antibodies (GADA) are associated with the progression of stiff person syndrome and other n...

    Authors: Masahito Takagi, Yasushi Ishigaki, Kenji Uno, Shojiro Sawada, Junta Imai, Keizo Kaneko, Yutaka Hasegawa, Tetsuya Yamada, Ai Tokita, Kazumi Iseki, Shigenori Kanno, Yoshiyuki Nishio, Hideki Katagiri and Etsuro Mori

    Citation: BMC Neurology 2013 13:76

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  19. Content type: Research article

    Frontotemporal dementia (FTD) is recognised as a clinically and morphologically heterogeneous group of interrelated neurodegenerative conditions. One of the subtypes within this disease spectrum is the behavio...

    Authors: Maria Landqvist Waldö, Alexander Frizell Santillo, Ulla Passant, Henrik Zetterberg, Lars Rosengren, Christer Nilsson and Elisabet Englund

    Citation: BMC Neurology 2013 13:54

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  20. Content type: Research article

    Carriers of the ApoE ϵ4 allele are at a greater risk for developing Alzheimer’s disease (AD) and those who do develop AD tend to have a much greater neuropathological disease burden. Although several studies h...

    Authors: Marwan N Sabbagh, Michael Malek-Ahmadi, Brittany N Dugger, Katarina Lee, Lucia I Sue, Geidy Serrano, Douglas G Walker, Kathryn Davis, Sandra A Jacobson and Thomas G Beach

    Citation: BMC Neurology 2013 13:44

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