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Demyelinating diseases

Section edited by Francesco Patti and Tjalf Ziemssen

This section covers all types of demyelinating diseases. Topics of interest include, but are not limited to, multiple sclerosis, neuroimmunology, systemic lupus, vasculitis, lymphoma, and myelitis.

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  1. Content type: Research article

    Little is known about whether tolerability and adherence to treatment can be influenced by weather and temperature conditions. The objective of this study was to assess monthly and seasonal adherence to and sa...

    Authors: Spyros N. Deftereos, Evangelos Koutlas, Efrosini Koutsouraki, Athanassios Kyritsis, Panagiotis Papathanassopoulos, Nikolaos Fakas, Vaia Tsimourtou, Nikolaos Vlaikidis, Antonios Tavernarakis, Konstantinos Voumvourakis, Michalis Arvanitis, Dimitrios Sakellariou and Filippo DeLorenzo

    Citation: BMC Neurology 2018 18:186

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  2. Content type: Research article

    Deep venous thrombosis (DVT) is a severe complication in longitudinally extensive transverse myelitis (LETM) patients. It may interfere with LETM treatment and delay the recovery of the spinal dysfunction. How...

    Authors: Tian Song, Xindi Li, Yonghong Liu and Xinghu Zhang

    Citation: BMC Neurology 2018 18:179

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  3. Content type: Case report

    Alemtuzumab has been demonstrated to reduce the risks of relapse and accumulation of sustained disability in Multiple Sclerosis (MS) patients compared to β-interferon. It acts against CD52, leading primarily t...

    Authors: A. G. Vakrakou, D. Tzanetakos, S. Valsami, E. Grigoriou, K. Psarra, J. Tzartos, M. Anagnostouli, E. Andreadou, M. E. Evangelopoulos, G. Koutsis, C. Chrysovitsanou, E. Gialafos, A. Dimitrakopoulos, L. Stefanis and C. Kilidireas

    Citation: BMC Neurology 2018 18:178

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  4. Content type: Research article

    Neuromyelitis optica spectrum disorders (NMOSD) often coexist with connective tissue disorders (CTD). The aim of this study was to investigate and compare the features of NMOSD with and without CTD.

    Authors: Chun-Sheng Yang, Qiu Xia Zhang, Sheng Hui Chang, Lin Jie Zhang, Li Min Li, Yuan Qi, Jing Wang, Zhi Hua Sun, Nannan Zhangning, Li Yang and Fu-Dong Shi

    Citation: BMC Neurology 2018 18:177

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  5. Content type: Research article

    The validation of international cognitive batteries in different multiple sclerosis (MS) populations is essential. Our objective was to obtain normative data for the Portuguese population of the Brief Internat...

    Authors: Cláudia Sousa, Mariana Rigueiro-Neves, Telma Miranda, Paulo Alegria, José Vale, Ana Margarida Passos, Dawn Langdon and Maria José Sá

    Citation: BMC Neurology 2018 18:172

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  6. Content type: Case report

    Besides CSF-flow obstruction, syringomyelia is associated with inflammatory spinal cord lesions. However, syringomyelia-like syndrome concomitant with neuromyelitis optica spectrum disorder (NMOSD) and primary...

    Authors: Xiangling Li, Zhengqi Lu and Yanqiang Wang

    Citation: BMC Neurology 2018 18:168

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  7. Content type: Case report

    Herpes zoster ophthalmicus (HZO) is an inflammation related to reactivation of the latent varicella zoster virus (VZV), involving the ophthalmic branch of the trigeminal nerve. Optic neuritis (ON), a rare ocul...

    Authors: Kavin Vanikieti, Anuchit Poonyathalang, Panitha Jindahra, Piyaphon Cheecharoen, Patchalin Patputtipong and Tanyatuth Padungkiatsagul

    Citation: BMC Neurology 2018 18:165

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  8. Content type: Research article

    We systematically reviewed the comparative effectiveness of injectable beta-interferons (IFN-β) and glatiramer acetate (GA) on annualised relapse rate (ARR), progression and discontinuation due to adverse even...

    Authors: G. J. Melendez-Torres, Xavier Armoiry, Rachel Court, Jacoby Patterson, Alan Kan, Peter Auguste, Jason Madan, Carl Counsell, Olga Ciccarelli and Aileen Clarke

    Citation: BMC Neurology 2018 18:162

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  9. Content type: Research article

    To investigate visual recovery after treatment of acute optic neuritis (ON) with either oral or intravenous high-dose methylprednisolone, in order to establish the best route of administration.

    Authors: Magdalena Naumovska, Rafi Sheikh, Boel Bengtsson, Malin Malmsjö and Björn Hammar

    Citation: BMC Neurology 2018 18:160

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  10. Content type: Research article

    In the PRISMS study, interferon beta-1a subcutaneously (IFN β-1a SC) reduced clinical and radiological disease burden at 2 years in patients with relapsing–remitting multiple sclerosis. The study aimed to char...

    Authors: Anthony Traboulsee, David K. B. Li, Mark Cascione, Juanzhi Fang, Fernando Dangond and Aaron Miller

    Citation: BMC Neurology 2018 18:143

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  11. Content type: Research article

    It is essential to investigate cognitive deficits in multiple sclerosis (MS) to develop evidence-based cognitive rehabilitation strategies. Here we refined cognitive decline assessment using the automated test...

    Authors: Hideraldo Luis Souza Cabeça, Luciano Chaves Rocha, Amanda Ferreira Sabbá, Alessandra Mendonça Tomás, Natali Valim Oliver Bento-Torres, Daniel Clive Anthony and Cristovam Wanderley Picanço Diniz

    Citation: BMC Neurology 2018 18:140

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  12. Content type: Research article

    Sleep disorders and fatigue are common in multiple sclerosis (MS). The underlying causes are not fully understood, and prospective studies are lacking. Therefore, we conducted a prospective, observational coho...

    Authors: Sylvia Kotterba, Thomas Neusser, Christiane Norenberg, Patrick Bussfeld, Thomas Glaser, Martin Dörner and Markus Schürks

    Citation: BMC Neurology 2018 18:123

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  13. Content type: Study protocol

    Multiple sclerosis (MS) is one of the most frequently observed neurological conditions in Switzerland, but data sources for country-wide epidemiological trend monitoring are lacking. Moreover, while clinical a...

    Authors: Nina Steinemann, Jens Kuhle, Pasquale Calabrese, Jürg Kesselring, Giulio Disanto, Doron Merkler, Caroline Pot, Vladeta Ajdacic-Gross, Stephanie Rodgers, Milo Alan Puhan and Viktor von Wyl

    Citation: BMC Neurology 2018 18:111

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  14. Content type: Research article

    Diffusion kurtosis imaging (DKI) has the potential to provide microstructural insights into myelin and axonal pathology with additional kurtosis parameters. To our knowledge, few studies are available in the c...

    Authors: Hai Qing Li, Bo Yin, Chao Quan, Dao Ying Geng, Hai Yu, Yi Fang Bao, Jun Liu and Yu Xin Li

    Citation: BMC Neurology 2018 18:108

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  15. Content type: Research article

    Nocturia is a common urinary symptom of multiple sclerosis (MS) which can affect quality of life (QoL) adversely. Melatonin is a hormone known to regulate circadian rhythm and reduce smooth muscle activity suc...

    Authors: Marcus J. Drake, Luke Canham, Nikki Cotterill, Debbie Delgado, Jenny Homewood, Kirsty Inglis, Lyndsey Johnson, Mary C. Kisanga, Denise Owen, Paul White and David Cottrell

    Citation: BMC Neurology 2018 18:107

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  16. Content type: Research article

    Multiple sclerosis (MS) is the most common non-traumatic condition that leads to disability among young individuals. It is associated with demyelination, inflammation, and neurodegeneration within the central ...

    Authors: Osama Al Wutayd, Ashri Gad Mohamed, Jameelah Saeedi, Hessa Al Otaibi and Mohammed Al Jumah

    Citation: BMC Neurology 2018 18:86

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  17. Content type: Case report

    Guillain-Barré syndrome (GBS), Miller Fisher syndrome (MFS) and Bickerstaff brainstem encephalitis (BBE) are a group of autoimmune neurological disorders (GBS spectrum disorder) that rarely recur. Recently, an...

    Authors: Hiroto Ito, Yuki Hatanaka, Yuki Fukami, Yumiko Harada, Rei Kobayashi, Hisashi Okada, Ayumi Uchibori, Atsuro Chiba and Satoshi Okuda

    Citation: BMC Neurology 2018 18:72

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  18. Content type: Research article

    On-treatment magnetic resonance imaging lesions may predict long-term clinical outcomes in patients receiving interferon β-1a. This study aimed to assess the effect of active T2 and T1 gadolinium-enhancing (Gd...

    Authors: Anthony Traboulsee, David K. B. Li, Mark Cascione, Juanzhi Fang, Fernando Dangond and Aaron Miller

    Citation: BMC Neurology 2018 18:68

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  19. Content type: Research article

    The principal biomarker of neurodegeneration in multiple sclerosis (MS) is believed to be brain volume, which is associated with cognitive functions and retinal nerve fibre layer (RNFL). A cross-sectional and ...

    Authors: Jessica Frau, Giuseppe Fenu, Alessio Signori, Giancarlo Coghe, Lorena Lorefice, Maria Antonietta Barracciu, Vincenzo Sechi, Federico Cabras, Mauro Badas, Maria Giovanna Marrosu and Eleonora Cocco

    Citation: BMC Neurology 2018 18:67

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  20. Content type: Research article

    Neuromyelitis optica (NMO) spectrum disorder (NMOSD) is a devastating autoimmune inflammatory disorder of the central nervous system, which can result in blindness or paralysis. Currently, there is a dire need...

    Authors: Yujuan Jiao, Lei Cui, Weihe Zhang, Chunyu Zhang, Yeqiong Zhang, Xin Zhang and Jinsong Jiao

    Citation: BMC Neurology 2018 18:47

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  21. Content type: Research article

    Congenital sphingosine-1-phosphate (S1P) lyase deficiency due to biallelic mutations in SGPL1 gene has recently been described in association with primary adrenal insufficiency and steroid-resistant nephrotic syn...

    Authors: Gulin Sunter, Ece Oge Enver, Azad Akbarzade, Serap Turan, Pinar Vatansever, Dilek Ince Gunal, Goncagul Haklar, Abdullah Bereket, Kadriye Agan and Tulay Guran

    Citation: BMC Neurology 2018 18:48

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  22. Content type: Case report

    The development of progressive multifocal leukoencephalopathy (PML) is associated with severe cellular immunosuppression. Good’s syndrome (GS) is a rare immunodeficiency syndrome related to thymoma, with the d...

    Authors: Tatsuya Ueno, Nobuyuki Sato, Tomoya Kon, Rie Haga, Jin-ichi Nunomura, Kazuo Nakamichi, Masayuki Saijo and Masahiko Tomiyama

    Citation: BMC Neurology 2018 18:37

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  23. Content type: Research article

    Pediatric-onset multiple sclerosis (POMS) prevalence and incidence rates are increasing globally. No disease-modifying therapy are approved for MS pediatric population. Hence, we aim to review the literature o...

    Authors: Raed Alroughani and Alexey Boyko

    Citation: BMC Neurology 2018 18:27

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  24. Content type: Research article

    Tehran is the capital of Iran with an increasing multiple sclerosis (MS) prevalence. A retrospective population-based study was conducted to evaluate the trends of MS prevalence in Tehran.

    Authors: Sharareh Eskandarieh, Narges Sistany Allahabadi, Malihe Sadeghi and Mohammad Ali Sahraian

    Citation: BMC Neurology 2018 18:15

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  25. Content type: Research article

    Some rheumatologic disorders may initially manifest with central nervous system (CNS) affection, mimicking the clinical, magnetic resonance imaging, and cerebrospinal fluid findings of multiple sclerosis (MS)....

    Authors: Tilman Hottenrott, Rick Dersch, Benjamin Berger, Dominique Endres, Daniela Huzly, Jens Thiel, Sebastian Rauer, Oliver Stich, Ulrich Salzer and Nils Venhoff

    Citation: BMC Neurology 2018 18:14

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  26. Content type: Research article

    Cognitive impairment may be seen in as many as 43–70% of patients with multiple sclerosis (MS) and may be observed in all MS subtypes. The Brief International Cognitive Assessment in Multiple Sclerosis (BICAMS...

    Authors: Serkan Ozakbas, Pinar Yigit, Bilge Piri Cinar, Hatice Limoncu, Turhan Kahraman and Görkem Kösehasanoğulları

    Citation: BMC Neurology 2017 17:208

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  27. Content type: Research article

    The benefits of physical activity in persons with Multiple Sclerosis (MS) are considerable. Knowledge about factors that correlate to physical activity is helpful in order to develop successful strategies to i...

    Authors: Elisabeth Anens, Lena Zetterberg, Charlotte Urell, Margareta Emtner and Karin Hellström

    Citation: BMC Neurology 2017 17:204

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  28. Content type: Study protocol

    Cognitive problems frequently occur in patients with multiple sclerosis (MS) and profoundly affect their quality of life. So far, the best cognitive treatment options for MS patients are a matter of debate. Th...

    Authors: Ilse M. Nauta, Anne E. M. Speckens, Roy P. C. Kessels, Jeroen J. G. Geurts, Vincent de Groot, Bernard M. J. Uitdehaag, Luciano Fasotti and Brigit A. de Jong

    Citation: BMC Neurology 2017 17:201

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  29. Content type: Case report

    The presence of circulating anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) has been described in sera of patients with different inflammatory conditions of the central nervous system. In adults ...

    Authors: Sara Mariotto, Salvatore Monaco, Patrick Peschl, Ilaria Coledan, Romualdo Mazzi, Romana Höftberger, Markus Reindl and Sergio Ferrari

    Citation: BMC Neurology 2017 17:190

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  30. Content type: Research article

    In recent years, shared decision making (SDM) has been promoted as a model to guide interactions between persons with MS and their neurologists to reach mutually satisfying decisions about disease management –...

    Authors: S. Michelle Driedger, Ryan Maier, Ruth Ann Marrie and Melissa Brouwers

    Citation: BMC Neurology 2017 17:176

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  31. Content type: Research article

    Maintaining patient adherence to disease modifying drugs in multiple sclerosis is a challenge, which can be improved by autoinjectors. The BETACONNECT® is a fully electronic autoinjector for the injection of i...

    Authors: Ingo Kleiter, Michael Lang, Judith Jeske, Christiane Norenberg, Barbara Stollfuß and Markus Schürks

    Citation: BMC Neurology 2017 17:174

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  32. Content type: Research article

    The cerebral subcortical deep gray matter nuclei (DGM) are a common, early, and clinically-relevant site of atrophy in multiple sclerosis (MS). Robust and reliable DGM segmentation could prove useful to evalua...

    Authors: Renxin Chu, Shelley Hurwitz, Shahamat Tauhid and Rohit Bakshi

    Citation: BMC Neurology 2017 17:172

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  33. Content type: Research article

    Patient adherence to treatment is key to preventing the worsening of neurological disability in multiple sclerosis (MS). The RebiSmart® autoinjector facilitates self-administration of subcutaneous interferon β...

    Authors: Chiara Zecca, Giulio Disanto, Sarah Mühl and Claudio Gobbi

    Citation: BMC Neurology 2017 17:171

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  34. Content type: Research article

    Multiple sclerosis (MS) is a demyelinating disease with a wide range of symptoms including walking impairment and neuropathic pain mainly represented by mechanical allodynia. Noteworthy, exercise preconditioni...

    Authors: Danielle Bernardes and Alexandre Leite Rodrigues Oliveira

    Citation: BMC Neurology 2017 17:160

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  35. Content type: Research article

    Patients with multiple sclerosis (MS) receiving long-term, subcutaneous interferon β-1b (IFN β-1b; Extavia®) often experience injection-site reactions and injection-site pain, which together with other side-ef...

    Authors: Frank A. Hoffmann, Anastasiya Trenova, Miguel A. Llaneza, Johannes Fischer, Giacomo Lus, Dorothea von Bredow, Núria Lara, Elaine Lam, Marlies Van Hoef and Rajesh Bakshi

    Citation: BMC Neurology 2017 17:156

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  36. Content type: Research article

    The association between multiple sclerosis (MS) and cancer has long been investigated with conflicting results. Several reports suggest an increased cancer risk among MS patients treated with immunosuppressant...

    Authors: Paolo Ragonese, Paolo Aridon, Giulia Vazzoler, Maria Antonietta Mazzola, Vincenzina Lo Re, Marianna Lo Re, Sabrina Realmuto, Simona Alessi, Marco D’Amelio, Giovanni Savettieri and Giuseppe Salemi

    Citation: BMC Neurology 2017 17:155

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  37. Content type: Research article

    Evidence on the use of fingolimod in real-world clinical practice and data on patient-reported health-related quality of life (HRQoL) in countries such as the Middle East are sparse. The Prospective Evaluation...

    Authors: Anat Achiron, Hany Aref, Jihad Inshasi, Mohamad Harb, Raed Alroughani, Mahendra Bijarnia, Kathryn Cooke and Ozgur Yuksel

    Citation: BMC Neurology 2017 17:150

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  38. Content type: Research article

    In multiple sclerosis (MS), neurological disability results from incomplete remission of relapses and from relapse-independent progression. Intravenous high dose methylprednisolone (IVMP) is the established st...

    Authors: Muriel Stoppe, Maria Busch, Luise Krizek and Florian Then Bergh

    Citation: BMC Neurology 2017 17:151

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  39. Content type: Research article

    Clinically isolated syndrome (CIS) represents first neurological symptoms suggestive of demyelinating lesion in the central nervous system (CNS). Currently, there are no sufficient immunological or genetic mar...

    Authors: Helena Posová, Dana Horáková, Václav Čapek, Tomáš Uher, Zdenka Hrušková and Eva Havrdová

    Citation: BMC Neurology 2017 17:145

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  40. Content type: Research article

    Post-traumatic Guillain-Barré syndrome (GBS) is a rarely described potentially life-threatening cause of weakness. We sought to elucidate the clinical features and electrophysiological patterns of post-traumat...

    Authors: Xiaowen Li, Jinting Xiao, Yanan Ding, Jing Xu, Chuanxia Li, Yating He, Hui Zhai, Bingdi Xie and Junwei Hao

    Citation: BMC Neurology 2017 17:142

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  41. Content type: Research article

    The impact of comorbidity on multiple sclerosis (MS) is a new area of interest. Limited data on the risk factors of metabolic syndrome (MetS) is currently available. The aim of this study was to estimate the p...

    Authors: Antoni Sicras-Mainar, Elena Ruíz-Beato, Ruth Navarro-Artieda and Jorge Maurino

    Citation: BMC Neurology 2017 17:134

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  42. Content type: Research article

    Neuromyelitis optica spectrum disorders (NMOSD) are demyelinating autoimmune diseases in the central nervous system (CNS) that are characterized by a high relapse rate and the presence of anti-aquaporin 4 anti...

    Authors: Xindi Li, Shenghui Mei, Xiaoqing Gong, Heng Zhou, Li Yang, Anna Zhou, Yonghong Liu, Xingang Li, Zhigang Zhao and Xinghu Zhang

    Citation: BMC Neurology 2017 17:130

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  43. Content type: Case report

    Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder characterized by multiple affected systems. More than half of SLE patients will suffer from neuropsychiatric lupus erythematosus (NPSLE...

    Authors: Bolin Hu, Pengcheng Wu, Yibiao Zhou, Yan Peng, Xiaoping Tang, Weijiang Ding, Ming Zhang and Xueliang Qi

    Citation: BMC Neurology 2017 17:123

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  44. Content type: Research article

    Recent exercise guidelines for people with multiple sclerosis (MS) recommend a minimum of 30 min moderate intensity aerobic exercise and resistance exercise twice per week. This trial compared the secondary ou...

    Authors: Susan Coote, Marcin Uszynski, Matthew P. Herring, Sara Hayes, Carl Scarrott, John Newell, Stephen Gallagher, Aidan Larkin and Robert W Motl

    Citation: BMC Neurology 2017 17:119

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  45. Content type: Research article

    Administrative healthcare claims data provide a mechanism for assessing and monitoring multiple sclerosis (MS) disease status across large, clinically representative “real-world” populations. The estimation of...

    Authors: Michael Munsell, Molly Frean, Joseph Menzin and Amy L. Phillips

    Citation: BMC Neurology 2017 17:106

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  46. Content type: Case Report

    Mild encephalitis/encephalopathy with reversible splenial lesion (MERS) is a rare clinico-radiological entity characterized by the magnetic resonance imaging (MRI) finding of a reversible lesion in the corpus ...

    Authors: Junliang Yuan, Shuna Yang, Shuangkun Wang, Wei Qin, Lei Yang and Wenli Hu

    Citation: BMC Neurology 2017 17:103

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  47. Content type: Research article

    Multiple sclerosis (MS) is a stressful condition. Mental health comorbidity is common. Stress can increase the risk of depression, reduce quality of life (QOL), and possibly exacerbate disease activity in MS. ...

    Authors: Robert Simpson, Frances S. Mair and Stewart W. Mercer

    Citation: BMC Neurology 2017 17:94

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  48. Content type: Research article

    Chronic inflammatory demyelinating polyneuropathy (CIDP) is presented by a large heterogeneity of clinical phenotypes. Around 50% of patients suffer from typical CIDP and show better therapy response than atyp...

    Authors: M. Staudt, J. M. Diederich, C. Meisel, A. Meisel and J. Klehmet

    Citation: BMC Neurology 2017 17:81

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  49. Content type: Case report

    Anti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are detected in various demyelinating diseases, such as pediatric acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-...

    Authors: Yoshitsugu Nakamura, Hideto Nakajima, Hiroki Tani, Takafumi Hosokawa, Shimon Ishida, Fumiharu Kimura, Kimihiko Kaneko, Toshiyuki Takahashi and Ichiro Nakashima

    Citation: BMC Neurology 2017 17:76

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  50. Content type: Research article

    People with multiple sclerosis have high risk of osteoporosis and fractures. A poor vitamin D status is a risk factor for MS, and vitamin D supplementation has been recommended both to prevent MS progression a...

    Authors: Trygve Holmøy, Jonas Christoffer Lindstrøm, Erik Fink Eriksen, Linn Hofsøy Steffensen and Margitta T. Kampman

    Citation: BMC Neurology 2017 17:67

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