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Demyelinating diseases

Section edited by Francesco Patti and Tjalf Ziemssen

This section covers all types of demyelinating diseases. Topics of interest include, but are not limited to, multiple sclerosis, neuroimmunology, systemic lupus, vasculitis, lymphoma, and myelitis.

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  1. Content type: Research article

    On-treatment magnetic resonance imaging lesions may predict long-term clinical outcomes in patients receiving interferon β-1a. This study aimed to assess the effect of active T2 and T1 gadolinium-enhancing (Gd...

    Authors: Anthony Traboulsee, David K. B. Li, Mark Cascione, Juanzhi Fang, Fernando Dangond and Aaron Miller

    Citation: BMC Neurology 2018 18:68

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  2. Content type: Research article

    The principal biomarker of neurodegeneration in multiple sclerosis (MS) is believed to be brain volume, which is associated with cognitive functions and retinal nerve fibre layer (RNFL). A cross-sectional and ...

    Authors: Jessica Frau, Giuseppe Fenu, Alessio Signori, Giancarlo Coghe, Lorena Lorefice, Maria Antonietta Barracciu, Vincenzo Sechi, Federico Cabras, Mauro Badas, Maria Giovanna Marrosu and Eleonora Cocco

    Citation: BMC Neurology 2018 18:67

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  3. Content type: Research article

    Neuromyelitis optica (NMO) spectrum disorder (NMOSD) is a devastating autoimmune inflammatory disorder of the central nervous system, which can result in blindness or paralysis. Currently, there is a dire need...

    Authors: Yujuan Jiao, Lei Cui, Weihe Zhang, Chunyu Zhang, Yeqiong Zhang, Xin Zhang and Jinsong Jiao

    Citation: BMC Neurology 2018 18:47

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  4. Content type: Research article

    Congenital sphingosine-1-phosphate (S1P) lyase deficiency due to biallelic mutations in SGPL1 gene has recently been described in association with primary adrenal insufficiency and steroid-resistant nephrotic syn...

    Authors: Gulin Sunter, Ece Oge Enver, Azad Akbarzade, Serap Turan, Pinar Vatansever, Dilek Ince Gunal, Goncagul Haklar, Abdullah Bereket, Kadriye Agan and Tulay Guran

    Citation: BMC Neurology 2018 18:48

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  5. Content type: Case report

    The development of progressive multifocal leukoencephalopathy (PML) is associated with severe cellular immunosuppression. Good’s syndrome (GS) is a rare immunodeficiency syndrome related to thymoma, with the d...

    Authors: Tatsuya Ueno, Nobuyuki Sato, Tomoya Kon, Rie Haga, Jin-ichi Nunomura, Kazuo Nakamichi, Masayuki Saijo and Masahiko Tomiyama

    Citation: BMC Neurology 2018 18:37

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  6. Content type: Research article

    Pediatric-onset multiple sclerosis (POMS) prevalence and incidence rates are increasing globally. No disease-modifying therapy are approved for MS pediatric population. Hence, we aim to review the literature o...

    Authors: Raed Alroughani and Alexey Boyko

    Citation: BMC Neurology 2018 18:27

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  7. Content type: Research article

    Tehran is the capital of Iran with an increasing multiple sclerosis (MS) prevalence. A retrospective population-based study was conducted to evaluate the trends of MS prevalence in Tehran.

    Authors: Sharareh Eskandarieh, Narges Sistany Allahabadi, Malihe Sadeghi and Mohammad Ali Sahraian

    Citation: BMC Neurology 2018 18:15

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  8. Content type: Research article

    Some rheumatologic disorders may initially manifest with central nervous system (CNS) affection, mimicking the clinical, magnetic resonance imaging, and cerebrospinal fluid findings of multiple sclerosis (MS)....

    Authors: Tilman Hottenrott, Rick Dersch, Benjamin Berger, Dominique Endres, Daniela Huzly, Jens Thiel, Sebastian Rauer, Oliver Stich, Ulrich Salzer and Nils Venhoff

    Citation: BMC Neurology 2018 18:14

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  9. Content type: Research article

    Cognitive impairment may be seen in as many as 43–70% of patients with multiple sclerosis (MS) and may be observed in all MS subtypes. The Brief International Cognitive Assessment in Multiple Sclerosis (BICAMS...

    Authors: Serkan Ozakbas, Pinar Yigit, Bilge Piri Cinar, Hatice Limoncu, Turhan Kahraman and Görkem Kösehasanoğulları

    Citation: BMC Neurology 2017 17:208

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  10. Content type: Research article

    The benefits of physical activity in persons with Multiple Sclerosis (MS) are considerable. Knowledge about factors that correlate to physical activity is helpful in order to develop successful strategies to i...

    Authors: Elisabeth Anens, Lena Zetterberg, Charlotte Urell, Margareta Emtner and Karin Hellström

    Citation: BMC Neurology 2017 17:204

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  11. Content type: Study protocol

    Cognitive problems frequently occur in patients with multiple sclerosis (MS) and profoundly affect their quality of life. So far, the best cognitive treatment options for MS patients are a matter of debate. Th...

    Authors: Ilse M. Nauta, Anne E. M. Speckens, Roy P. C. Kessels, Jeroen J. G. Geurts, Vincent de Groot, Bernard M. J. Uitdehaag, Luciano Fasotti and Brigit A. de Jong

    Citation: BMC Neurology 2017 17:201

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  12. Content type: Case report

    The presence of circulating anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) has been described in sera of patients with different inflammatory conditions of the central nervous system. In adults ...

    Authors: Sara Mariotto, Salvatore Monaco, Patrick Peschl, Ilaria Coledan, Romualdo Mazzi, Romana Höftberger, Markus Reindl and Sergio Ferrari

    Citation: BMC Neurology 2017 17:190

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  13. Content type: Research article

    In recent years, shared decision making (SDM) has been promoted as a model to guide interactions between persons with MS and their neurologists to reach mutually satisfying decisions about disease management –...

    Authors: S. Michelle Driedger, Ryan Maier, Ruth Ann Marrie and Melissa Brouwers

    Citation: BMC Neurology 2017 17:176

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  14. Content type: Research article

    Maintaining patient adherence to disease modifying drugs in multiple sclerosis is a challenge, which can be improved by autoinjectors. The BETACONNECT® is a fully electronic autoinjector for the injection of i...

    Authors: Ingo Kleiter, Michael Lang, Judith Jeske, Christiane Norenberg, Barbara Stollfuß and Markus Schürks

    Citation: BMC Neurology 2017 17:174

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  15. Content type: Research article

    The cerebral subcortical deep gray matter nuclei (DGM) are a common, early, and clinically-relevant site of atrophy in multiple sclerosis (MS). Robust and reliable DGM segmentation could prove useful to evalua...

    Authors: Renxin Chu, Shelley Hurwitz, Shahamat Tauhid and Rohit Bakshi

    Citation: BMC Neurology 2017 17:172

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  16. Content type: Research article

    Patient adherence to treatment is key to preventing the worsening of neurological disability in multiple sclerosis (MS). The RebiSmart® autoinjector facilitates self-administration of subcutaneous interferon β...

    Authors: Chiara Zecca, Giulio Disanto, Sarah Mühl and Claudio Gobbi

    Citation: BMC Neurology 2017 17:171

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  17. Content type: Research article

    Multiple sclerosis (MS) is a demyelinating disease with a wide range of symptoms including walking impairment and neuropathic pain mainly represented by mechanical allodynia. Noteworthy, exercise preconditioni...

    Authors: Danielle Bernardes and Alexandre Leite Rodrigues Oliveira

    Citation: BMC Neurology 2017 17:160

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  18. Content type: Research article

    Patients with multiple sclerosis (MS) receiving long-term, subcutaneous interferon β-1b (IFN β-1b; Extavia®) often experience injection-site reactions and injection-site pain, which together with other side-ef...

    Authors: Frank A. Hoffmann, Anastasiya Trenova, Miguel A. Llaneza, Johannes Fischer, Giacomo Lus, Dorothea von Bredow, Núria Lara, Elaine Lam, Marlies Van Hoef and Rajesh Bakshi

    Citation: BMC Neurology 2017 17:156

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  19. Content type: Research article

    The association between multiple sclerosis (MS) and cancer has long been investigated with conflicting results. Several reports suggest an increased cancer risk among MS patients treated with immunosuppressant...

    Authors: Paolo Ragonese, Paolo Aridon, Giulia Vazzoler, Maria Antonietta Mazzola, Vincenzina Lo Re, Marianna Lo Re, Sabrina Realmuto, Simona Alessi, Marco D’Amelio, Giovanni Savettieri and Giuseppe Salemi

    Citation: BMC Neurology 2017 17:155

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  20. Content type: Research article

    In multiple sclerosis (MS), neurological disability results from incomplete remission of relapses and from relapse-independent progression. Intravenous high dose methylprednisolone (IVMP) is the established st...

    Authors: Muriel Stoppe, Maria Busch, Luise Krizek and Florian Then Bergh

    Citation: BMC Neurology 2017 17:151

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