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Demyelinating diseases

Section edited by Francesco Patti and Tjalf Ziemssen

This section covers all types of demyelinating diseases. Topics of interest include, but are not limited to, multiple sclerosis, neuroimmunology, systemic lupus, vasculitis, lymphoma, and myelitis.

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  1. Content type: Research article

    Neuromyelitis optica (NMO) shows various brain magnetic resonance imaging (MRI) abnormalities with recurrent central nervous system (CNS) attacks, although predominantly affecting the spinal cord and optic ner...

    Authors: Chen Cheng, Ying Jiang, Xiaohong Chen, Yongqiang Dai, Zhuang Kang, Zhengqi Lu, Fuhua Peng and Xueqiang Hu

    Citation: BMC Neurology 2013 13:72

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  2. Content type: Study protocol

    Despite the commonly known benefits of exercise and physical activity evidence shows that persons Multiple Sclerosis (MS) are relatively inactive yet physical activity may be even more important in a populatio...

    Authors: Nancy E Mayo, Mark Bayley, Pierre Duquette, Yves Lapierre, Ross Anderson and Susan Bartlett

    Citation: BMC Neurology 2013 13:69

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  3. Content type: Research article

    Flu-like symptoms (FLS) are common side effects of interferon beta (IFN-β) treatment in patients with Multiple Sclerosis (PwMS) and are associated with post-injection cytokine surge. We hypothesized that vitam...

    Authors: Daniel Golan, Basheer Halhal, Lea Glass-Marmor, Elsebeth Staun-Ram, Orit Rozenberg, Idit Lavi, Sara Dishon, Mira Barak, Sophia Ish-Shalom and Ariel Miller

    Citation: BMC Neurology 2013 13:60

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  4. Content type: Research article

    A debate surrounding multiple sclerosis epidemiology has centred on time-related incidence increases and the need of monitoring. The purpose of this study is to reassess multiple sclerosis incidence in the Eur...

    Authors: Enrique Alcalde-Cabero, Javier Almazán-Isla, Antonio García-Merino, Joao de Sá and Jesús de Pedro-Cuesta

    Citation: BMC Neurology 2013 13:58

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  5. Content type: Research article

    The study of muscle metabolism by near-infrared spectroscopy (NIRS) has been poorly implemented in multiple sclerosis (MS). Aims of the study were to compare resting muscle oxygen consumption (rmVO2) at gastrocne...

    Authors: Anna Maria Malagoni, Michele Felisatti, Nicola Lamberti, Nino Basaglia, Roberto Manfredini, Fabrizio Salvi, Paolo Zamboni and Fabio Manfredini

    Citation: BMC Neurology 2013 13:52

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  6. Content type: Research article

    The aetiology of multiple sclerosis (MS) remains unknown. This hampers molecular diagnosis and the discovery of bio-molecular markers. Consequently, MS diagnostic procedures are complex and criteria for assess...

    Authors: Roberto De Masi, Sergio Pasca, Rocco Scarpello, Adele Idolo and Antonella De Donno

    Citation: BMC Neurology 2013 13:45

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  7. Content type: Research article

    The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, des...

    Authors: Yvonne C Learmonth, Robert W Motl, Brian M Sandroff, John H Pula and Diego Cadavid

    Citation: BMC Neurology 2013 13:37

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  8. Content type: Research article

    Some recent experimental data suggest a possible role of LINGO-1 in the pathogenesis of multiple sclerosis (MS). In an attempt to identify genetic biomarkers related to MS susceptibility, we genotyped two comm...

    Authors: Elena García-Martín, Oswaldo Lorenzo-Betancor, Carmen Martínez, Pau Pastor, Julián Benito-León, Jorge Millán-Pascual, Patricia Calleja, María Díaz-Sánchez, Diana Pisa, Laura Turpín-Fenoll, Hortensia Alonso-Navarro, Lucía Ayuso-Peralta, Dolores Torrecillas, Elena Lorenzo, José Francisco Plaza-Nieto, José A G Agúndez…

    Citation: BMC Neurology 2013 13:34

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  9. Content type: Research article

    Neuromyelitis optica (NMO) includes transverse myelitis, optic neuritis and brain lesions. Recent studies have indicated that the brainstem is an important site of attack in NMO. Longitudinally extensive trans...

    Authors: Nasrin Asgari, Hanne Pernille Bro Skejoe, Soeren Thue Lillevang, Troels Steenstrup, Egon Stenager and Kirsten Ohm Kyvik

    Citation: BMC Neurology 2013 13:33

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  10. Content type: Research article

    This study aimed to investigate the prevalence and clinical relevance of chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis (MS) patients and healthy controls using extra- and intracrania...

    Authors: Roberta Lanzillo, Marcello Mancini, Raffaele Liuzzi, Orlando Di Donato, Elena Salvatore, Valentina Maglio, Giovanni Vacca, Luca Amato, Gennaro D’Anna, Arturo Brunetti and Vincenzo Brescia Morra

    Citation: BMC Neurology 2013 13:20

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  11. Content type: Research article

    To improve quality of life (QOL) in patients with multiple sclerosis (MS), it is important to decrease disability and prevent relapse. The aim of this study was to examine the causal and mutual relationships c...

    Authors: Hiromi Kikuchi, Nobuhiro Mifune, Masaaki Niino, Jun-ichi Kira, Tatsuo Kohriyama, Kohei Ota, Masami Tanaka, Hirofumi Ochi, Shunya Nakane and Seiji Kikuchi

    Citation: BMC Neurology 2013 13:10

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  12. Content type: Research article

    Few studies have systematically addressed the role of epidural analgesia and caesarean delivery in predicting the post-partum disease activity in women with Multiple Sclerosis (MS).

    Authors: Luisa Pastò, Emilio Portaccio, Angelo Ghezzi, Bahia Hakiki, Marta Giannini, Lorenzo Razzolini, Elisa Piscolla, Laura De Giglio, Carlo Pozzilli, Damiano Paolicelli, Maria Trojano, Maria Giovanna Marrosu, Francesco Patti, Loredana La Mantia, Gian Luigi Mancardi, Claudio Solaro…

    Citation: BMC Neurology 2012 12:165

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  13. Content type: Research article

    Physical disability in multiple sclerosis (MS) is frequently characterized by impaired ambulation. Although walking tests have been successfully employed to assess walking ability in MS patients, data analytic...

    Authors: Janina M Burschka, Philipp M Keune, Uwe Menge, Ulrich Hofstadt-van Oy, Patrick Oschmann and Olaf Hoos

    Citation: BMC Neurology 2012 12:161

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  14. Content type: Study protocol

    Nerve damage in leprosy often causes disabilities and deformities. Prednisolone is used to treat nerve function impairment (NFI). However, optimal dose and duration of prednisolone treatment has not been estab...

    Authors: Inge Wagenaar, Wim Brandsma, Erik Post, Wim van Brakel, Diana Lockwood, Peter Nicholls, Paul Saunderson, Cairns Smith, Einar Wilder-Smith and Jan Hendrik Richardus

    Citation: BMC Neurology 2012 12:159

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  15. Content type: Research article

    In patients with relapsing–remitting multiple sclerosis (RRMS), subcutaneous (sc) interferon (IFN)β-1a and IFNβ-1b have been shown to reduce relapse rates. A formulation of IFNβ-1a has been produced without fe...

    Authors: Barry Singer, Daniel Bandari, Mark Cascione, Christopher LaGanke, John Huddlestone, Randy Bennett and Fernando Dangond

    Citation: BMC Neurology 2012 12:154

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  16. Content type: Research article

    Only few studies have assessed safety of in utero exposure to glatiramer acetate (GA). Following a previous study assessing the safety of interferon beta (IFNB) pregnancy exposure in multiple sclerosis (MS), w...

    Authors: Marta Giannini, Emilio Portaccio, Angelo Ghezzi, Bahia Hakiki, Luisa Pastò, Lorenzo Razzolini, Elisa Piscolla, Laura De Giglio, Carlo Pozzilli, Damiano Paolicelli, Maria Trojano, Maria Giovanna Marrosu, Francesco Patti, Loredana La Mantia, Gianluigi Mancardi, Claudio Solaro…

    Citation: BMC Neurology 2012 12:124

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  17. Content type: Research article

    Progressive multifocal leukoencephalopathy (PML), a rare but fatal demyelinating disease caused by JC virus (JCV), occurs mainly in immunocompromised patients. As PML develops in individuals with various under...

    Authors: Kazuo Nakamichi, Hidehiro Mizusawa, Masahito Yamada, Shuji Kishida, Yoshiharu Miura, Toshio Shimokawa, Tomohiko Takasaki, Chang-Kweng Lim, Ichiro Kurane and Masayuki Saijo

    Citation: BMC Neurology 2012 12:121

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  18. Content type: Research article

    In previous studies we found that MHC2TA +1614 genotype frequency was very different when MS patients with and without human herpesvirus 6 (HHV-6) in serum samples were compared; a different clinical behavior ...

    Authors: Maria Inmaculada Dominguez-Mozo, Marta Garcia-Montojo, Virginia De Las Heras, Angel Garcia-Martinez, Ana Maria Arias-Leal, Ignacio Casanova, Rafael Arroyo and Roberto Alvarez-Lafuente

    Citation: BMC Neurology 2012 12:107

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  19. Content type: Research article

    We noticed that a hypothesis based on the effect of geomagnetic disturbances (GMD) has the ability to explain special features of multiple sclerosis (MS). Areas around geomagnetic 60 degree latitude (GM60L) ex...

    Authors: Seyed Aidin Sajedi and Fahimeh Abdollahi

    Citation: BMC Neurology 2012 12:100

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  20. Content type: Research article

    The balance between T helper cells Th2- and Th1-related cytokines plays a key role in multiple sclerosis (MS). A shift from a Th1 towards a Th2 cytokine profile could have a beneficial effect on the clinical c...

    Authors: Celia Oreja-Guevara, Jaime Ramos-Cejudo, Luiz Stark Aroeira, Beatriz Chamorro and Exuperio Diez-Tejedor

    Citation: BMC Neurology 2012 12:95

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  21. Content type: Research article

    Compensation of brain injury in multiple sclerosis (MS) may in part work through mechanisms involving neuronal plasticity on local and interregional scales. Mechanisms limiting excessive neuronal activity may ...

    Authors: Daniel Zeller, Su-Yin Dang, David Weise, Peter Rieckmann, Klaus V Toyka and Joseph Classen

    Citation: BMC Neurology 2012 12:92

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  22. Content type: Research article

    The prognostic value of evoked potentials (EPs) in multiple sclerosis (MS) has not been fully established. The correlations between the Expanded Disability Status Scale (EDSS) at First Neurological Evaluation ...

    Authors: Nicolò Margaritella, Laura Mendozzi, Massimo Garegnani, Raffaello Nemni, Elena Colicino, Elisabetta Gilardi and Luigi Pugnetti

    Citation: BMC Neurology 2012 12:80

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  23. Content type: Review

    Traditionally, multiple sclerosis has been viewed as a disease predominantly affecting white matter. However, this view has lately been subject to numerous changes, as new evidence of anatomical and histologic...

    Authors: Dana Horakova, Tomas Kalincik, Jana Blahova Dusankova and Ondrej Dolezal

    Citation: BMC Neurology 2012 12:10

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  24. Content type: Research article

    There are a lack of biomarkers which can be used to predict clinical outcomes for multiple sclerosis (MS) patients receiving interferon beta (IFN-β). Thus the objective of this study was to characterize change...

    Authors: Jennifer M Kress-Bennett, Garth D Ehrlich, Ashley Bruno, J Christopher Post, Fen Z Hu and Thomas F Scott

    Citation: BMC Neurology 2011 11:155

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  25. Content type: Research article

    Interferon beta (IFNβ) and glatiramer acetate (GA) are administered by subcutaneous (SC) or intramuscular (IM) injection. Patients with multiple sclerosis (MS) often report injection-site reactions (ISRs) as a...

    Authors: Karsten Beer, Martin Müller, Anna Marie Hew-Winzeler, Adriano Bont, Philippe Maire, Xiaojun You, Pamela Foulds, Jessica Mårlind and Daniela Curtius

    Citation: BMC Neurology 2011 11:144

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  26. Content type: Research article

    Chronic cerebrospinal venous insufficiency (CCSVI) has recently been reported to be associated with multiple sclerosis (MS). However, its actual prevalence, possible association with specific MS phenotypes, an...

    Authors: Stefano Bastianello, Alfredo Romani, Gisela Viselner, Enrico Colli Tibaldi, Elisabetta Giugni, Marta Altieri, Pietro Cecconi, Laura Mendozzi, Massimiliano Farina, Donatella Mariani, Antonio Galassi, Claudio Quattrini, Marcello Mancini, Vincenzo Bresciamorra, Angela Lagace, Sandy McDonald…

    Citation: BMC Neurology 2011 11:132

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  27. Content type: Research article

    The Multiple Sclerosis International Quality Of Life (MusiQoL) questionnaire, a 31-item, multidimensional, self-administrated questionnaire that is available in 14 languages including Spanish, has been validat...

    Authors: Oscar Fernández, Victoria Fernández, Karine Baumstarck-Barrau, Luis Muñoz, Maria del Mar Gonzalez Alvarez, José Carlos Arrabal, Antonio León, Ana Alonso, Jose Carlos López-Madrona, Rafael Bustamante, Gloria Luque, Miguel Guerrero, Elisabetta Verdun di Cantogno and Pascal Auquier

    Citation: BMC Neurology 2011 11:127

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  28. Content type: Research article

    The ability to self-inject in patients with multiple sclerosis (MS) has been associated with a reduced risk of missed injections and drug discontinuation, and a beneficial effect on patients' independence. How...

    Authors: J Theodore Phillips, Edward Fox, William Grainger, Dianne Tuccillo, Shifang Liu and Aaron Deykin

    Citation: BMC Neurology 2011 11:126

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  29. Content type: Research article

    Conventional magnetic resonance imaging (MRI) has improved the diagnosis and monitoring of multiple sclerosis (MS). In clinical trials, MRI has been found to detect treatment effects with greater sensitivity t...

    Authors: Stefano Bastianello, Elisabetta Giugni, Maria Pia Amato, Maria-Rosalia Tola, Maria Trojano, Stefano Galletti, Giacomo Luccichenti, Mario Quarantelli, Orietta Picconi and Francesco Patti

    Citation: BMC Neurology 2011 11:125

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  30. Content type: Research article

    The goal of this research was to compare the demographics, clinical characteristics and treatment patterns for newly diagnosed multiple sclerosis (MS) patients in a commercial managed care population who recei...

    Authors: Jay M Margolis, Robert Fowler, Barbara H Johnson, Cheryl A Kassed and Kristijan Kahler

    Citation: BMC Neurology 2011 11:122

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  31. Content type: Research article

    Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) with increasing incidence mainly in high-income countries. One explanation of this phenomenon may be ...

    Authors: Silja Conradi, Uwe Malzahn, Franziska Schröter, Friedemann Paul, Sabine Quill, Eike Spruth, Lutz Harms, Florian Then Bergh, Anna Ditzenbach, Thomas Georgi, Peter Heuschmann and Berit Rosche

    Citation: BMC Neurology 2011 11:123

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  32. Content type: Research article

    Patients with multiple sclerosis (MS) have a decreased frequency of CD8+ T cells reactive to their own Epstein-Barr virus (EBV) infected B cells. We have proposed that this might predispose to the development of ...

    Authors: Michael P Pender, Peter A Csurhes, Casey MM Pfluger and Scott R Burrows

    Citation: BMC Neurology 2011 11:95

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  33. Content type: Research article

    There is need for a cognitive test battery that can be easily used in clinical practice to detect or monitor cognitive performance in patients with multiple sclerosis (MS). In order to conduct, in this patient...

    Authors: Chris Edgar, Peter J Jongen, Evert Sanders, Christian Sindic, Sophie Goffette, Michel Dupuis, Philippe Jacquerye, Daniel Guillaume, Regine Reznik and Keith Wesnes

    Citation: BMC Neurology 2011 11:68

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  34. Content type: Research article

    The aim of this study was to assess the diagnostic accuracy (sensitivity and specificity) of clinical, imaging and motor evoked potentials (MEP) for predicting the short-term prognosis of multiple sclerosis (MS).

    Authors: Bartolome Bejarano, Mariangela Bianco, Dolores Gonzalez-Moron, Jorge Sepulcre, Joaquin Goñi, Juan Arcocha, Oscar Soto, Ubaldo Del Carro, Giancarlo Comi, Letizia Leocani and Pablo Villoslada

    Citation: BMC Neurology 2011 11:67

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  35. Content type: Research article

    Event-related potentials (ERPs) may be used as a highly sensitive way of detecting subtle degrees of cognitive dysfunction. On the other hand, impairment of cognitive skills is increasingly recognised as a hal...

    Authors: Javier J Gonzalez-Rosa, Manuel Vazquez-Marrufo, Encarnacion Vaquero, Pablo Duque, Monica Borges, Carlos M Gomez-Gonzalez and Guillermo Izquierdo

    Citation: BMC Neurology 2011 11:64

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  36. Content type: Research article

    Celiac disease (CD) is a common systemic disease related to a permanent intolerance to gluten and is often associated with different autoimmune and neurological diseases. Its mean prevalence in the general pop...

    Authors: Luis Rodrigo, Carlos Hernández-Lahoz, Dolores Fuentes, Noemí Alvarez, Antonio López-Vázquez and Segundo González

    Citation: BMC Neurology 2011 11:31

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  37. Content type: Research article

    Many individuals diagnosed with Multiple Sclerosis (MS) are sensitive to increased body temperature, which has been recognized as correlating with the symptom of fatigue. The need to explore this association h...

    Authors: Gullvi Flensner, Anna-Christina Ek, Olle Söderhamn and Anne-Marie Landtblom

    Citation: BMC Neurology 2011 11:27

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  38. Content type: Research article

    In daily clinical setting, some patients affected by relapsing-remitting Multiple Sclerosis (RRMS) are switched from the low-dose to the high-dose Interferon beta (IFNB) in order to achieve a better control of...

    Authors: Luca Prosperini, Giovanna Borriello, Laura De Giglio, Laura Leonardi, Valeria Barletta and Carlo Pozzilli

    Citation: BMC Neurology 2011 11:26

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  39. Content type: Research article

    Nearly half of all patients diagnosed with multiple sclerosis (MS) will develop cognitive dysfunction. Studies highlighted from no/weak impact to a strong impact of cognitive impairment on quality of life (QoL...

    Authors: Karine Baumstarck-Barrau, Marie-Claude Simeoni, Françoise Reuter, Irina Klemina, Valérie Aghababian, Jean Pelletier and Pascal Auquier

    Citation: BMC Neurology 2011 11:17

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  40. Content type: Research article

    There is a strong maternal parent-of-origin effect in determining susceptibility to multiple sclerosis (MS). One hypothesis is that an abnormal intrauterine milieu leading to impaired fetal development could p...

    Authors: Sreeram V Ramagopalan, Colleen Guimond, Maria Criscuoli, David A Dyment, Sarah-Michelle Orton, Irene M Yee, George C Ebers and Dessa Sadovnick

    Citation: BMC Neurology 2010 10:115

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  41. Content type: Research article

    The role of different chemokine receptors in the pathogenesis of multiple sclerosis (MS) has been extensively investigated; however, little is known about the difference in the role of chemokine receptors betw...

    Authors: Akiyuki Uzawa, Masahiro Mori, Sei Hayakawa, Saeko Masuda, Fumio Nomura and Satoshi Kuwabara

    Citation: BMC Neurology 2010 10:113

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