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Demyelinating diseases

Section edited by Francesco Patti and Tjalf Ziemssen

This section covers all types of demyelinating diseases. Topics of interest include, but are not limited to, multiple sclerosis, neuroimmunology, systemic lupus, vasculitis, lymphoma, and myelitis.

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  1. Only few studies have assessed safety of in utero exposure to glatiramer acetate (GA). Following a previous study assessing the safety of interferon beta (IFNB) pregnancy exposure in multiple sclerosis (MS), w...

    Authors: Marta Giannini, Emilio Portaccio, Angelo Ghezzi, Bahia Hakiki, Luisa Pastò, Lorenzo Razzolini, Elisa Piscolla, Laura De Giglio, Carlo Pozzilli, Damiano Paolicelli, Maria Trojano, Maria Giovanna Marrosu, Francesco Patti, Loredana La Mantia, Gianluigi Mancardi, Claudio Solaro…

    Citation: BMC Neurology 2012 12:124

    Content type: Research article

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  2. Progressive multifocal leukoencephalopathy (PML), a rare but fatal demyelinating disease caused by JC virus (JCV), occurs mainly in immunocompromised patients. As PML develops in individuals with various under...

    Authors: Kazuo Nakamichi, Hidehiro Mizusawa, Masahito Yamada, Shuji Kishida, Yoshiharu Miura, Toshio Shimokawa, Tomohiko Takasaki, Chang-Kweng Lim, Ichiro Kurane and Masayuki Saijo

    Citation: BMC Neurology 2012 12:121

    Content type: Research article

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  3. In previous studies we found that MHC2TA +1614 genotype frequency was very different when MS patients with and without human herpesvirus 6 (HHV-6) in serum samples were compared; a different clinical behavior ...

    Authors: Maria Inmaculada Dominguez-Mozo, Marta Garcia-Montojo, Virginia De Las Heras, Angel Garcia-Martinez, Ana Maria Arias-Leal, Ignacio Casanova, Rafael Arroyo and Roberto Alvarez-Lafuente

    Citation: BMC Neurology 2012 12:107

    Content type: Research article

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  4. We noticed that a hypothesis based on the effect of geomagnetic disturbances (GMD) has the ability to explain special features of multiple sclerosis (MS). Areas around geomagnetic 60 degree latitude (GM60L) ex...

    Authors: Seyed Aidin Sajedi and Fahimeh Abdollahi

    Citation: BMC Neurology 2012 12:100

    Content type: Research article

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  5. The balance between T helper cells Th2- and Th1-related cytokines plays a key role in multiple sclerosis (MS). A shift from a Th1 towards a Th2 cytokine profile could have a beneficial effect on the clinical c...

    Authors: Celia Oreja-Guevara, Jaime Ramos-Cejudo, Luiz Stark Aroeira, Beatriz Chamorro and Exuperio Diez-Tejedor

    Citation: BMC Neurology 2012 12:95

    Content type: Research article

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  6. Compensation of brain injury in multiple sclerosis (MS) may in part work through mechanisms involving neuronal plasticity on local and interregional scales. Mechanisms limiting excessive neuronal activity may ...

    Authors: Daniel Zeller, Su-Yin Dang, David Weise, Peter Rieckmann, Klaus V Toyka and Joseph Classen

    Citation: BMC Neurology 2012 12:92

    Content type: Research article

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  7. The prognostic value of evoked potentials (EPs) in multiple sclerosis (MS) has not been fully established. The correlations between the Expanded Disability Status Scale (EDSS) at First Neurological Evaluation ...

    Authors: Nicolò Margaritella, Laura Mendozzi, Massimo Garegnani, Raffaello Nemni, Elena Colicino, Elisabetta Gilardi and Luigi Pugnetti

    Citation: BMC Neurology 2012 12:80

    Content type: Research article

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  8. Traditionally, multiple sclerosis has been viewed as a disease predominantly affecting white matter. However, this view has lately been subject to numerous changes, as new evidence of anatomical and histologic...

    Authors: Dana Horakova, Tomas Kalincik, Jana Blahova Dusankova and Ondrej Dolezal

    Citation: BMC Neurology 2012 12:10

    Content type: Review

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  9. There are a lack of biomarkers which can be used to predict clinical outcomes for multiple sclerosis (MS) patients receiving interferon beta (IFN-β). Thus the objective of this study was to characterize change...

    Authors: Jennifer M Kress-Bennett, Garth D Ehrlich, Ashley Bruno, J Christopher Post, Fen Z Hu and Thomas F Scott

    Citation: BMC Neurology 2011 11:155

    Content type: Research article

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  10. Interferon beta (IFNβ) and glatiramer acetate (GA) are administered by subcutaneous (SC) or intramuscular (IM) injection. Patients with multiple sclerosis (MS) often report injection-site reactions (ISRs) as a...

    Authors: Karsten Beer, Martin Müller, Anna Marie Hew-Winzeler, Adriano Bont, Philippe Maire, Xiaojun You, Pamela Foulds, Jessica Mårlind and Daniela Curtius

    Citation: BMC Neurology 2011 11:144

    Content type: Research article

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  11. Chronic cerebrospinal venous insufficiency (CCSVI) has recently been reported to be associated with multiple sclerosis (MS). However, its actual prevalence, possible association with specific MS phenotypes, an...

    Authors: Stefano Bastianello, Alfredo Romani, Gisela Viselner, Enrico Colli Tibaldi, Elisabetta Giugni, Marta Altieri, Pietro Cecconi, Laura Mendozzi, Massimiliano Farina, Donatella Mariani, Antonio Galassi, Claudio Quattrini, Marcello Mancini, Vincenzo Bresciamorra, Angela Lagace, Sandy McDonald…

    Citation: BMC Neurology 2011 11:132

    Content type: Research article

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  12. The Multiple Sclerosis International Quality Of Life (MusiQoL) questionnaire, a 31-item, multidimensional, self-administrated questionnaire that is available in 14 languages including Spanish, has been validat...

    Authors: Oscar Fernández, Victoria Fernández, Karine Baumstarck-Barrau, Luis Muñoz, Maria del Mar Gonzalez Alvarez, José Carlos Arrabal, Antonio León, Ana Alonso, Jose Carlos López-Madrona, Rafael Bustamante, Gloria Luque, Miguel Guerrero, Elisabetta Verdun di Cantogno and Pascal Auquier

    Citation: BMC Neurology 2011 11:127

    Content type: Research article

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  13. The ability to self-inject in patients with multiple sclerosis (MS) has been associated with a reduced risk of missed injections and drug discontinuation, and a beneficial effect on patients' independence. How...

    Authors: J Theodore Phillips, Edward Fox, William Grainger, Dianne Tuccillo, Shifang Liu and Aaron Deykin

    Citation: BMC Neurology 2011 11:126

    Content type: Research article

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  14. Conventional magnetic resonance imaging (MRI) has improved the diagnosis and monitoring of multiple sclerosis (MS). In clinical trials, MRI has been found to detect treatment effects with greater sensitivity t...

    Authors: Stefano Bastianello, Elisabetta Giugni, Maria Pia Amato, Maria-Rosalia Tola, Maria Trojano, Stefano Galletti, Giacomo Luccichenti, Mario Quarantelli, Orietta Picconi and Francesco Patti

    Citation: BMC Neurology 2011 11:125

    Content type: Research article

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  15. Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) with increasing incidence mainly in high-income countries. One explanation of this phenomenon may be ...

    Authors: Silja Conradi, Uwe Malzahn, Franziska Schröter, Friedemann Paul, Sabine Quill, Eike Spruth, Lutz Harms, Florian Then Bergh, Anna Ditzenbach, Thomas Georgi, Peter Heuschmann and Berit Rosche

    Citation: BMC Neurology 2011 11:123

    Content type: Research article

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  16. The goal of this research was to compare the demographics, clinical characteristics and treatment patterns for newly diagnosed multiple sclerosis (MS) patients in a commercial managed care population who recei...

    Authors: Jay M Margolis, Robert Fowler, Barbara H Johnson, Cheryl A Kassed and Kristijan Kahler

    Citation: BMC Neurology 2011 11:122

    Content type: Research article

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  17. Patients with multiple sclerosis (MS) have a decreased frequency of CD8+ T cells reactive to their own Epstein-Barr virus (EBV) infected B cells. We have proposed that this might predispose to the development of ...

    Authors: Michael P Pender, Peter A Csurhes, Casey MM Pfluger and Scott R Burrows

    Citation: BMC Neurology 2011 11:95

    Content type: Research article

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  18. There is need for a cognitive test battery that can be easily used in clinical practice to detect or monitor cognitive performance in patients with multiple sclerosis (MS). In order to conduct, in this patient...

    Authors: Chris Edgar, Peter J Jongen, Evert Sanders, Christian Sindic, Sophie Goffette, Michel Dupuis, Philippe Jacquerye, Daniel Guillaume, Regine Reznik and Keith Wesnes

    Citation: BMC Neurology 2011 11:68

    Content type: Research article

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  19. The aim of this study was to assess the diagnostic accuracy (sensitivity and specificity) of clinical, imaging and motor evoked potentials (MEP) for predicting the short-term prognosis of multiple sclerosis (MS).

    Authors: Bartolome Bejarano, Mariangela Bianco, Dolores Gonzalez-Moron, Jorge Sepulcre, Joaquin Goñi, Juan Arcocha, Oscar Soto, Ubaldo Del Carro, Giancarlo Comi, Letizia Leocani and Pablo Villoslada

    Citation: BMC Neurology 2011 11:67

    Content type: Research article

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  20. Event-related potentials (ERPs) may be used as a highly sensitive way of detecting subtle degrees of cognitive dysfunction. On the other hand, impairment of cognitive skills is increasingly recognised as a hal...

    Authors: Javier J Gonzalez-Rosa, Manuel Vazquez-Marrufo, Encarnacion Vaquero, Pablo Duque, Monica Borges, Carlos M Gomez-Gonzalez and Guillermo Izquierdo

    Citation: BMC Neurology 2011 11:64

    Content type: Research article

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  21. Celiac disease (CD) is a common systemic disease related to a permanent intolerance to gluten and is often associated with different autoimmune and neurological diseases. Its mean prevalence in the general pop...

    Authors: Luis Rodrigo, Carlos Hernández-Lahoz, Dolores Fuentes, Noemí Alvarez, Antonio López-Vázquez and Segundo González

    Citation: BMC Neurology 2011 11:31

    Content type: Research article

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  22. Many individuals diagnosed with Multiple Sclerosis (MS) are sensitive to increased body temperature, which has been recognized as correlating with the symptom of fatigue. The need to explore this association h...

    Authors: Gullvi Flensner, Anna-Christina Ek, Olle Söderhamn and Anne-Marie Landtblom

    Citation: BMC Neurology 2011 11:27

    Content type: Research article

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  23. In daily clinical setting, some patients affected by relapsing-remitting Multiple Sclerosis (RRMS) are switched from the low-dose to the high-dose Interferon beta (IFNB) in order to achieve a better control of...

    Authors: Luca Prosperini, Giovanna Borriello, Laura De Giglio, Laura Leonardi, Valeria Barletta and Carlo Pozzilli

    Citation: BMC Neurology 2011 11:26

    Content type: Research article

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  24. Nearly half of all patients diagnosed with multiple sclerosis (MS) will develop cognitive dysfunction. Studies highlighted from no/weak impact to a strong impact of cognitive impairment on quality of life (QoL...

    Authors: Karine Baumstarck-Barrau, Marie-Claude Simeoni, Françoise Reuter, Irina Klemina, Valérie Aghababian, Jean Pelletier and Pascal Auquier

    Citation: BMC Neurology 2011 11:17

    Content type: Research article

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  25. There is a strong maternal parent-of-origin effect in determining susceptibility to multiple sclerosis (MS). One hypothesis is that an abnormal intrauterine milieu leading to impaired fetal development could p...

    Authors: Sreeram V Ramagopalan, Colleen Guimond, Maria Criscuoli, David A Dyment, Sarah-Michelle Orton, Irene M Yee, George C Ebers and Dessa Sadovnick

    Citation: BMC Neurology 2010 10:115

    Content type: Research article

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  26. The role of different chemokine receptors in the pathogenesis of multiple sclerosis (MS) has been extensively investigated; however, little is known about the difference in the role of chemokine receptors betw...

    Authors: Akiyuki Uzawa, Masahiro Mori, Sei Hayakawa, Saeko Masuda, Fumio Nomura and Satoshi Kuwabara

    Citation: BMC Neurology 2010 10:113

    Content type: Research article

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