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Section edited by Ravindra kumar Garg

This section is dedicated to epilepsy and seizures. Topics of interest include any condition where the main manifestations are seizures (epileptic or not), whether the issues studied pertain to diagnosis or management.

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  1. Content type: Research article

    Nowadays, few surgery analysis has been reported in cases of epilepsy after viral encephalitis(VE). Herein, this study was to evaluate the efficacy of surgery and capability of stereoelectroencephalography (SE...

    Authors: Yi-Ou Liu, Wen-Jing Zhou, Bo Hong, Tong Zhao and Yue-feng Wang

    Citation: BMC Neurology 2019 19:165

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  2. Content type: Research article

    Epilepsy is a common neurological disease with substantial impact on the subject and their caretakers. This exploratory study identified barriers to care for persons living with epilepsy (PLWE) to develop a cu...

    Authors: Mark Kaddumukasa, Haddy Nalubwama, Martin N. Kaddumukasa, Samden Lhatoo, Nelson Sewankambo, Elly Katabira, Martha Sajatovic and Carol Blixen

    Citation: BMC Neurology 2019 19:161

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  3. Content type: Research article

    Epigenetics underlying refractory epilepsy is poorly understood. DNA methylation may affect gene expression in epilepsy patients without affecting DNA sequences. Herein, we investigated the association between...

    Authors: Yudan Lv, Xiangyu Zheng, Mingchao Shi, Zan Wang and Li Cui

    Citation: BMC Neurology 2019 19:114

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  4. Content type: Case report

    Gall bladder cancer (GBC) is associated with abdominal pain, lump, nausea, vomiting, and jaundice due to either gall bladder mass or the involved adjacent peritoneal structures. Gall bladder cancer presenting ...

    Authors: Shweta Pandey, Ravindra Kumar Garg, Hardeep Singh Malhotra, Ravi Uniyal and Neeraj Kumar

    Citation: BMC Neurology 2019 19:95

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  5. Content type: Research article

    Albeit the few resting-state fMRI neuroimaging studies in frontal lobe epilepsy (FLE) patients, these studies focused on functional connectivity. The aim of this current study was to examine the effective conn...

    Authors: Benjamin Klugah-Brown, Cheng Luo, Rui Peng, Hui He, Jianfu Li, Li Dong and Dezhong Yao

    Citation: BMC Neurology 2019 19:70

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  6. Content type: Research article

    Individuals with epilepsy who cannot be adequately controlled with anti-epileptic drugs, refractory epilepsy, may be suitable for surgical treatment following detailed assessment. This is a complex process and...

    Authors: Virginia Mumford, Frances Rapport, Patti Shih, Rebecca Mitchell, Andrew Bleasel, Armin Nikpour, Geoffrey Herkes, Amy MacRae, Melissa Bartley, Sanjyot Vagholkar and Jeffrey Braithwaite

    Citation: BMC Neurology 2019 19:29

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  7. Content type: Research article

    Epilepsy is one of the most common chronic disabling neurologic diseases. The purpose of our study was to investigate whether there is an association between t-PA (tissue plasminogen activator, rs2020918 and rs46...

    Authors: Wenxiu Han, Pei Jiang, Yujin Guo, Pengfei Xu, Ruili Dang, Gongying Li, Xin He, Dehua Liao and Genquan Yan

    Citation: BMC Neurology 2019 19:13

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  8. Content type: Research article

    Living with a chronic condition such as epilepsy can have a debilitating effect on the individual and their carers. Managing epilepsy among people with learning disabilities may present a challenge because of ...

    Authors: Jerry Paul K. Ninnoni

    Citation: BMC Neurology 2019 19:12

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  9. Content type: Research article

    Recurrent seizure risks in HIV-positive people with new-onset seizure are largely unknown, making it challenging to offer optimal recommendations regarding antiepileptic drug (AED) initiation. Existing outcome...

    Authors: Melissa A. Elafros, Brent A. Johnson, Omar K. Siddiqi, Jason F. Okulicz, Izukanji Sikazwe, Christopher M. Bositis, Michael J. Potchen, Igor J. Koralnik, William H. Theodore, Lisa Kalungwana and Gretchen L. Birbeck

    Citation: BMC Neurology 2018 18:201

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  10. Content type: Case report

    Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic condition which comprises various neurological symptoms. This syndrome could be complicated by intracranial hemorrhage including subarachnoid...

    Authors: Dan Hu, Jing Xiong, Yunfei Zha and Zhaohui Zhang

    Citation: BMC Neurology 2018 18:182

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  11. Content type: Case report

    Posterior reversible encephalopathy syndrome (PRES) is a reversible clinical and neurological entity. There are varieties of comorbid conditions which are associated with PRES. Chronic obstructive pulmonary di...

    Authors: Sushil Khanal and Subhash Prasad Acharya

    Citation: BMC Neurology 2018 18:180

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  12. Content type: Case report

    Crohn’s disease (CD) is associated with a variety of extra-intestinal manifestations. Most commonly these involve the eye, skin, joints, coagulation system and liver. Cerebral manifestations of CD have been re...

    Authors: Konrad Whittaker, Konstanze Guggenberger, Nils Venhoff, Soroush Doostkam, Hans-Eckart Schaefer and Brita Fritsch

    Citation: BMC Neurology 2018 18:161

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  13. Content type: Research article

    Little is known of how accurately a first-time seizure witness can provide reliable details of a semiology. Our goal was to determine how accurately first-time seizure witnesses could identify key elements of ...

    Authors: Taim A. Muayqil, Mohammed H. Alanazy, Hassan M. Almalak, Hussain Khaled Alsalman, Faroq Walid Abdulfattah, Abdullah Ibrahim Aldraihem, Fawaz Al-hussain and Bandar N. Aljafen

    Citation: BMC Neurology 2018 18:135

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  14. Content type: Research article

    Seizures arising from the precuneus are rare, and few studies have aimed at characterizing the clinical presentation of such seizures within the anatomic context of the frontoparietal circuits. We aimed to cha...

    Authors: Yanfeng Yang, Haixiang Wang, Wenjing Zhou, Tianyi Qian, Wei Sun and Guoguang Zhao

    Citation: BMC Neurology 2018 18:110

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  15. Content type: Case report

    Epileptic seizures can lead to cardiac arrhythmias. The arrhythmias may be in the form of tachycardia, bradycardia or asystole. Ictal bradycardia and asystole can lead to sudden unexpected death.

    Authors: Nirmeen Kishk, Amani Nawito, Ahmed El-Damaty and Amany Ragab

    Citation: BMC Neurology 2018 18:100

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  16. Content type: Research article

    Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium-glucose linked transporters (SGLTs),...

    Authors: Mumin Alper Erdogan, Dimas Yusuf, Joanna Christy, Volkan Solmaz, Arife Erdogan, Emin Taskiran and Oytun Erbas

    Citation: BMC Neurology 2018 18:81

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  17. Content type: Research article

    The general principles in the administration of anesthetic drugs entail not only the suppression of seizure activity but also the achievement of electroencephalography burst suppression (BS). However, previous...

    Authors: Kanitpong Phabphal, Suparat Chisurajinda, Thapanee Somboon, Kanjana Unwongse and Alan Geater

    Citation: BMC Neurology 2018 18:46

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  18. Content type: Research article

    The aim of this study was to evaluate whether the glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null alleles may contribute to carbamazepine-induced hepatotoxicity.

    Authors: Chahra Chbili, Anis Hassine, Neila Fathallah, Manel Nouira, Salma Naija, Sofiene Ben Ammou and Saad Saguem

    Citation: BMC Neurology 2018 18:24

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  19. Content type: Research article

    Generalized tonic-clonic seizures (GTCS) frequently lead to emergency inpatient referrals. Laboratory blood values are routinely performed on admission to detect underlying causes and metabolic or cardiac comp...

    Authors: Robert D. Nass, Sina Meiling, René P. Andrié, Christian E. Elger and Rainer Surges

    Citation: BMC Neurology 2017 17:187

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  20. Content type: Research article

    The insular cortex is not routinely removed in modified functional hemispherectomy due to the risk of injury to the main arteries and to deep structures. Our study evaluates the safety and usefulness of applyi...

    Authors: Gun-Ha Kim, Joo Hee Seo, James E. Baumgartner, Fatima Ajmal and Ki Hyeong Lee

    Citation: BMC Neurology 2017 17:162

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  21. Content type: Research article

    Epilepsy is a serious and costly long-term condition that negatively affects quality of life, especially if seizures persist on medication. Studies show that people with epilepsy (PWE) want to learn more about...

    Authors: Amelia Smith, Alison McKinlay, Gabriella Wojewodka and Leone Ridsdale

    Citation: BMC Neurology 2017 17:114

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  22. Content type: Case report

    Vagal nerve stimulation (VNS) for refractory epilepsy is well established. Trigeminal neuralgia itself is a common disease in adults, and thus, late-onset pain in the trigeminal region under VNS, which is extr...

    Authors: Gabriela Timarova and Andrej Šteňo

    Citation: BMC Neurology 2017 17:113

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  23. Content type: Research article

    Some antiepileptic drugs (AEDs) induce expression of hepatic enzymes. This can contribute to comorbidities via interference with metabolic pathways and concomitant drug metabolization, thereby increasing the l...

    Authors: Simon Borghs, Solène Thieffry, Matthias Noack-Rink, Peter Dedeken, Lai San Hong, Laura Byram, John Logan, Jane Chan and Victor Kiri

    Citation: BMC Neurology 2017 17:59

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  24. Content type: Research article

    Mindfulness based interventions (MBIs) are increasingly used to help patients cope with physical and mental long-term conditions (LTCs). Epilepsy is associated with a range of mental and physical comorbidities...

    Authors: Karen Wood, Maggie Lawrence, Bhautesh Jani, Robert Simpson and Stewart W. Mercer

    Citation: BMC Neurology 2017 17:52

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  25. Content type: Research article

    Differential diagnosis between syncope and epilepsy in patients with transient loss of consciousness of uncertain etiology is still unclear. Thus, the aim of the present work is to evaluate the prevalence of s...

    Authors: Andrea Ungar, Alice Ceccofiglio, Francesca Pescini, Chiara Mussi, Gianni Tava, Martina Rafanelli, Assunta Langellotto, Niccolò Marchionni, J. Gert van Dijk, Gianlugi Galizia, Domenico Bonaduce and Pasquale Abete

    Citation: BMC Neurology 2017 17:45

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  26. Content type: Case report

    Versive seizure characterized by conjugate eye movement during epileptic seizure has been considered commonly as one of the most valuable semiological signs for epilepsy localization, especially for frontal lo...

    Authors: Wei Zhang, Xingzhou Liu, Lijun Zuo, Qiang Guo, Qi chen and Yongjun Wang

    Citation: BMC Neurology 2017 17:38

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    The Erratum to this article has been published in BMC Neurology 2017 17:83

  27. Content type: Research article

    Antiepileptic drugs (AEDs) are effective medications available for epilepsy. However, many patients do not respond to this treatment and become resistant. Genetic polymorphisms may be involved in the variation...

    Authors: Malek Chouchi, Wajih Kaabachi, Hedia Klaa, Kalthoum Tizaoui, Ilhem Ben-Youssef Turki and Lamia Hila

    Citation: BMC Neurology 2017 17:32

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  28. Content type: Case report

    Dancing is a very rare seizure semiology, and has only few case reports so far. Moreover, no case regarded as dancing with both description and video was presented.

    Authors: Keun Tae Kim, Kon Chu and Sang Kun Lee

    Citation: BMC Neurology 2017 17:16

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  29. Content type: Research article

    Autism spectrum disorder (ASD) is a heterogeneous disorder characterized not only by deficits in communication and social interactions but also a high rate of co-occurring disorders, including metabolic abnorm...

    Authors: Lena M. McCue, Louise H. Flick, Kimberly A. Twyman, Hong Xian and Thomas E. Conturo

    Citation: BMC Neurology 2016 16:245

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  30. Content type: Research article

    To explore the cortical network sustaining action myoclonus and to found markers of the resulting functional impairment, we evaluated the distribution of the cortico-muscular coherence (CMC) and the frequency ...

    Authors: Silvana Franceschetti, Laura Canafoglia, Fabio Rotondi, Elisa Visani, Alice Granvillano and Ferruccio Panzica

    Citation: BMC Neurology 2016 16:214

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  31. Content type: Research article

    The number of patients suffering post-stroke seizure after ischemic stroke (PSSi) is quite considerable, especially because ischemic stroke is more prevalent than hemorrhage in the general population. This stu...

    Authors: Hyeon Jin Kim, Kee Duk Park, Kyoung-Gyu Choi and Hyang Woon Lee

    Citation: BMC Neurology 2016 16:212

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    The Erratum to this article has been published in BMC Neurology 2017 17:84

  32. Content type: Research article

    In Ethiopia where the burden of epilepsy is highest among school age children and teenagers, and where people with epilepsy (PWE) and their relatives suffers from high level of perceived stigma, there had not ...

    Authors: Meron Awraris Gebrewold, Fikre Enquselassie, Redda Teklehaimanot and Seid Ali Gugssa

    Citation: BMC Neurology 2016 16:167

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  33. Content type: Research article

    Few clinical trials have evaluated the efficacy and tolerability of antiepileptic drugs (AEDs) as initial monotherapy for elderly patients.

    Authors: Bernd Pohlmann-Eden, Anthony G. Marson, Matthias Noack-Rink, Francisco Ramirez, Azita Tofighy, Konrad J. Werhahn, Imane Wild and Eugen Trinka

    Citation: BMC Neurology 2016 16:149

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  34. Content type: Research article

    In this review we aimed to determine the economic impact of epilepsy and factors associated with costs to individuals and health systems.

    Authors: Katharina Allers, Beverley M. Essue, Maree L. Hackett, Janani Muhunthan, Craig S. Anderson, Kristen Pickles, Franziska Scheibe and Stephen Jan

    Citation: BMC Neurology 2015 15:245

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  35. Content type: Research article

    Acute seizures are a common cause of paediatric admissions to hospitals in Africa, and malaria is an important cause of seizures in endemic areas. Malaria has declined in the past decade whilst neonatal admiss...

    Authors: George K. Serem, Charles RJC Newton and Symon M. Kariuki

    Citation: BMC Neurology 2015 15:180

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  36. Content type: Research article

    Early identification of cardiac asystole as a reason for syncope is of uttermost significance, as insertion of a cardiac pacemaker can save the patient’s life and prevent severe injury. The aim of this work wa...

    Authors: Asaf Honig, Shmuel Chen, Felix Benninger, Rima Bar-Yossef, Roni Eichel, Svetlana Kipervasser, Ilan Blatt, Miri Y. Neufeld and Dana Ekstein

    Citation: BMC Neurology 2015 15:80

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  37. Content type: Research article

    Eslicarbazepine acetate (ESL, Aptiom®) is a once-daily (QD) anticonvulsant, approved as adjunctive treatment of partial-onset seizures (POS). It is extensively converted after oral administration to eslicarbaz...

    Authors: Mercedes P Jacobson, Ladislav Pazdera, Perminder Bhatia, Todd Grinnell, Hailong Cheng and David Blum

    Citation: BMC Neurology 2015 15:46

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  38. Content type: Study protocol

    In patients with epilepsy, poor adherence to anti-epileptic drugs has been shown to be the most important cause of poorly controlled epilepsy. Furthermore, it has been noted that the quality of life among pati...

    Authors: Loes AM Leenen, Ben FM Wijnen, Reina JA de Kinderen, Marian HJM Majoie, Caroline M van Heugten and Silvia MAA Evers

    Citation: BMC Neurology 2014 14:255

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  39. Content type: Research article

    Some recent studies suggest that some imaging-negative temporal lobe epilepsy (TLE) had significant amygdala enlargement (AE). Contradictory data were also reported in previous studies regarding the associatio...

    Authors: Rui-Juan Lv, Zhen-Rong Sun, Tao Cui, Hong-Zhi Guan, Hai-Tao Ren and Xiao-Qiu Shao

    Citation: BMC Neurology 2014 14:194

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  40. Content type: Research article

    Status epilepticus (SE) is a medical emergency with high mortality rates. Of all SE’s, 7% are caused by a brain tumor. Clinical guidelines on the management of SE do not make a distinction between tumor-relate...

    Authors: Yunus Arik, Frans SS Leijten, Tatjana Seute, Pierre A Robe and Tom J Snijders

    Citation: BMC Neurology 2014 14:152

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  41. Content type: Case report

    Status epilepticus (SE) may occur in the setting of several internal or neurologic diseases. Anti-neutrophilic cytoplasmic antibodies (ANCA) are a group of Ig that may be observed in patients with different au...

    Authors: Edoardo Ferlazzo, Antonio Gambardella, Marina Bellavia, Sara Gasparini, Laura Mumoli, Angelo Labate, Vittoria Cianci, Concetta Russo and Umberto Aguglia

    Citation: BMC Neurology 2014 14:148

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  42. Content type: Research article

    We analyzed the frequency of heart rate (HR) changes related to seizures, and we sought to identify the influencing factors of these changes during partial seizures, to summarize the regularity of the HR chang...

    Authors: Wei Chen, Chang-Li Guo, Pei-Song Zhang, Chong Liu, Hui Qiao, Jian-Guo Zhang and Fan-Gang Meng

    Citation: BMC Neurology 2014 14:135

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  43. Content type: Research article

    Temporal lobe epilepsy (TLE) and idiopathic generalized epilepsy (IGE) patients have each been associated with extensive brain atrophy findings, yet to date there are no reports of head to head comparison of b...

    Authors: Hila Goldberg, Arie Weinstock, Niels Bergsland, Michael G Dwyer, Osman Farooq, Mona Sazgar, Guy Poloni, Cierra Treu, Bianca Weinstock-Guttman, Murali Ramanathan and Robert Zivadinov

    Citation: BMC Neurology 2014 14:131

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  44. Content type: Research article

    Although many studies have found abnormalities in subcortical grey matter (GM) in patients with temporal lobe epilepsy or generalised epilepsies, few studies have examined subcortical GM in focal neocortical s...

    Authors: Syu-Jyun Peng, Tomor Harnod, Jang-Zern Tsai, Ming-Dou Ker, Jun-Chern Chiou, Herming Chiueh, Chung-Yu Wu and Yue-Loong Hsin

    Citation: BMC Neurology 2014 14:104

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  45. Content type: Research article

    Mesial temporal lobe epilepsy (MTLE) is the most common type of focal epilepsy in adults and can be successfully cured by surgery. One of the main complications of this surgery however is a decline in language...

    Authors: Júlia Miró, Pablo Ripollés, Diana López-Barroso, Adrià Vilà-Balló, Montse Juncadella, Ruth de Diego-Balaguer, Josep Marco-Pallares, Antoni Rodríguez-Fornells and Mercè Falip

    Citation: BMC Neurology 2014 14:98

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  46. Content type: Study protocol

    Teaching people with epilepsy to identify and manage seizure triggers, implement strategies to remember to take antiepileptic drugs, implement precautions to minimize risks during seizures, tell others what to...

    Authors: Ines Kralj-Hans, Laura H Goldstein, Adam J Noble, Sabine Landau, Nicholas Magill, Paul McCrone, Gus Baker, Myfanwy Morgan, Mark Richardson, Stephanie Taylor and Leone Ridsdale

    Citation: BMC Neurology 2014 14:69

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  47. Content type: Research article

    Idiopathic epilepsies and epileptic syndromes predominate childhood and adolescence epilepsy. The aim of the present study was to investigate the clinical course and outcome of idiopathic childhood epilepsy an...

    Authors: Pinelopi Dragoumi, Olga Tzetzi, Efthimia Vargiami, Evangelos Pavlou, Konstantinos Krikonis, Eleftherios Kontopoulos and Dimitrios I Zafeiriou

    Citation: BMC Neurology 2013 13:206

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