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Movement disorders

This section covers all types and aspects of movement disorders. Topics of include, but are not limited to, Parkinson's Disease, transcranial magnetic stimulation, spasticity, dyskinesia, movement disorders, rehabilitation and spinal cord injury.

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  1. A central goal of rehabilitation in patients with paralysis syndromes after stroke or spinal cord injury (SCI) is to restore independent mobility as a pedestrian or wheelchair user. However, after acute rehabi...

    Authors: Andreas Hug, Tamara Spingler, Cornelia Hensel, Stefan Fichtner, Tiziana Daniel, Laura Heutehaus, Michel Wensing, Rüdiger Rupp and Norbert Weidner

    Citation: BMC Neurology 2021 21:149

    Content type: Study protocol

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  2. To investigate the relationship between the position of bilateral STN-DBS location of active contacts and the clinical efficacy of STN-DBS on motor symptoms in Parkinson’s disease (PD) patients.

    Authors: Feng Zhang, Feng Wang, Weiguo Li, Ning Wang, Chunlei Han, Shiying Fan, Peng Li, Lifeng Xu, Jianguo Zhang and Fangang Meng

    Citation: BMC Neurology 2021 21:122

    Content type: Research article

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  3. Facial (lip and jaw) tremor (FT) is associated with Parkinson’s disease (PD) but few studies have been conducted to explore its clinical profile. We performed this study to investigate the prevalence and clini...

    Authors: Ruwei Ou, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Junyu Lin, Zheng Jiang, Bi Zhao, Bei Cao and Huifang Shang

    Citation: BMC Neurology 2021 21:86

    Content type: Research article

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  4. Recent advances in therapeutic options may prevent deterioration related to Huntington’s disease (HD), even at the pre-symptomatic stage. Be that as it may, a well-characterized patient population is essential...

    Authors: Katalin Despotov, Dénes Zádori, Gábor Veres, Katalin Jakab, Gabriella Gárdián, Eszter Tóth, Tamás Zsigmond Kincses, László Vécsei, András Ajtay, Dániel Bereczki and Péter Klivényi

    Citation: BMC Neurology 2021 21:79

    Content type: Research article

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  5. Limited research exists to guide clinical decisions about trialling, selecting, implementing and evaluating eye-gaze control technology. This paper reports on the outcomes of a Delphi study that was conducted ...

    Authors: Petra Karlsson, Tom Griffiths, Michael T. Clarke, Elegast Monbaliu, Kate Himmelmann, Saranda Bekteshi, Abigail Allsop, René Pereksles, Claire Galea and Margaret Wallen

    Citation: BMC Neurology 2021 21:63

    Content type: Research article

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  6. Although several brain networks play important roles in cervical dystonia (CD) patients, regional homogeneity (ReHo) changes in CD patients have not been clarified. We investigated to explore ReHo in CD patien...

    Authors: Shubao Wei, Chunhui Lu, Xiuqiong Chen, Lu Yang, Jing Wei, Wenyan Jiang, Yang Liu, Hui Hui Li, Yuhong Qin, Yiwu Lei, Chao Qin, Caiyou Hu and Shuguang Luo

    Citation: BMC Neurology 2021 21:55

    Content type: Research article

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  7. Many patients with Parkinson’s disease (PD) who receive carbidopa/levodopa experience symptom reemergence or worsening, or “OFF” episodes. This study assessed the association of “OFF” episodes with health-rela...

    Authors: Andrew Thach, Eddie Jones, Eric Pappert, James Pike, Jack Wright and Alexander Gillespie

    Citation: BMC Neurology 2021 21:46

    Content type: Research article

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  8. A recent nurse-led proactive care management intervention, Care Coordination for Health Promotion and Activities in Parkinson Disease (CHAPS), improved care quality when compared to usual care in a randomized ...

    Authors: Karen I. Connor, Hilary C. Siebens, Brian S. Mittman, Donna K. McNeese-Smith, David A. Ganz, Frances Barry, Lisa K. Edwards, Michael G. McGowan, Eric M. Cheng and Barbara G. Vickrey

    Citation: BMC Neurology 2020 20:437

    Content type: Research article

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  9. Parkinsonian variant of multiple system atrophy is a neurodegenerative disorder frequently misdiagnosed as Parkinson’s disease. No early imaging biomarkers currently differentiate these disorders.

    Authors: Rita Moiron Simões, Ana Castro Caldas, Joana Grilo, Daisy Correia, Carla Guerreiro, Patrícia Pita Lobo, Anabela Valadas, Marguerita Fabbri, Leonor Correia Guedes, Miguel Coelho, Mario Miguel Rosa, Joaquim J. Ferreira and Sofia Reimão

    Citation: BMC Neurology 2020 20:432

    Content type: Research article

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  10. Parkinson’s disease is the second most common long-term chronic, progressive, neurodegenerative disease, affecting more than 10 million people worldwide. There has been a rising interest in wearable devices fo...

    Authors: Ghayth AlMahadin, Ahmad Lotfi, Eva Zysk, Francesco Luke Siena, Marie Mc Carthy and Philip Breedon

    Citation: BMC Neurology 2020 20:419

    Content type: Research article

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  11. Cerebral Palsy (CP) is a group of disorders that affect the development of movement and posture. CP results from injuries to the immature brain during the prenatal, perinatal, or postnatal stage of development...

    Authors: Diana Tajik-Parvinchi, Andrew Davis, Sophia Roth, Peter Rosenbaum, Sarah N. Hopmans, Aya Dudin, Geoffrey Hall and Jan Willem Gorter

    Citation: BMC Neurology 2020 20:388

    Content type: Research article

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  12. Parkinson’s disease (PD) is a common neurodegenerative condition associated with a wide range of motor and non-motor symptoms. There has been increasing interest in the potential benefit of performing arts as ...

    Authors: Maxwell S. Barnish and Susannah M. Barran

    Citation: BMC Neurology 2020 20:371

    Content type: Research article

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  13. Cognitive impairment may be correlated with cardiovascular dysautonomia, including blood pressure (BP) dysregulation, in Parkinson’s disease (PD), but the association between these factors in dementia with Lew...

    Authors: Hisayoshi Oka, Tadashi Umehara, Atsuo Nakahara and Hiromasa Matsuno

    Citation: BMC Neurology 2020 20:350

    Content type: Research article

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  14. Neurologists play an essential role in facilitating the patient’s process of living with Parkinson’s disease (PD). The Living with Chronic Illness Scale-PD (LW-CI-PD) is a unique available clinical tool that e...

    Authors: Leire Ambrosio, Carmen Rodriguez-Blazquez, Alba Ayala and Maria João Forjaz

    Citation: BMC Neurology 2020 20:346

    Content type: Research article

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  15. Studies report rates of mild cognitive impairment (MCI) in spinal cord injury (SCI) range between 10 and 60%. This broad estimate of MCI in SCI is most likely a result of: (i) inconsistent operationalization o...

    Authors: Danielle Sandalic, Ashley Craig, Mohit Arora, Ilaria Pozzato, Grahame Simpson, Bamini Gopinath, Jasbeer Kaur, Sachin Shetty, Gerard Weber, Ian Cameron, Yvonne Tran and James Middleton

    Citation: BMC Neurology 2020 20:341

    Content type: Study protocol

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  16. Various wearable devices for objectively evaluating motor symptoms of patients with Parkinson’s disease (PD) have been developed. Importantly, previous studies have suggested protective effects of physical act...

    Authors: Hiroto Ito, Daichi Yokoi, Rei Kobayashi, Hisashi Okada, Yasukazu Kajita and Satoshi Okuda

    Citation: BMC Neurology 2020 20:340

    Content type: Research article

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  17. The progressive neurodegenerative disorder Parkinson disease (PD) is well-established as the second most common neurodegenerative disease. Associations between the sequential risk of PD and gout have been addr...

    Authors: Li-Yu Hu, Albert C. Yang, Shyh-Chyang Lee, Zi-Hong You, Shih-Jen Tsai, Chang-Kuo Hu and Cheng-Che Shen

    Citation: BMC Neurology 2020 20:338

    Content type: Research article

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  18. Cognitive decline and dementia are common in Parkinson’s disease (PD). Cognitive deficits have been linked to the depletion of dopamine in the nigrostriatal pathway, but pharmacological treatments for PD have ...

    Authors: Magdalena Eriksson Domellöf, Lois Walton, Carl-Johan Boraxbekk, David Bäckström, Maria Josefsson, Lars Forsgren and Anna Stigsdotter Neely

    Citation: BMC Neurology 2020 20:337

    Content type: Study protocol

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  19. Anterior spinal cord herniation (aSCH) is a rare cause of myelopathy which may present as pure motor syndrome and mimic other degenerative diseases of the spinal cord. In slowly progressive cases, diagnosis ma...

    Authors: Martin Regensburger, Johannes C. M. Schlachetzki, Jörg Klekamp, Arnd Doerfler and Jürgen Winkler

    Citation: BMC Neurology 2020 20:321

    Content type: Case report

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  20. Parkinson’s disease (PD) causes motor and nonmotor disorders in patients. Unlike aerobic training, potential adaptations from the practice of dance are less understood in PD, particularly compared with better ...

    Authors: Marcela dos Santos Delabary, Elren Passos Monteiro, Rebeca Gimenes Donida, Mariana Wolffenbuttel, Leonardo Alexandre Peyré-Tartaruga and Aline Nogueira Haas

    Citation: BMC Neurology 2020 20:305

    Content type: Research article

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  21. With the growing awareness of restless legs syndrome (RLS), sensory disorders similar to RLS but initially confined to the arms, abdomen, and perineum have been reported. One of them is restless abdomen, which...

    Authors: Xi-Xi Wang, Xiao-Ying Zhu, Zan Wang, Jian-Wei Dong, William G. Ondo and Yun-Cheng Wu

    Citation: BMC Neurology 2020 20:298

    Content type: Research article

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  22. PDSAFE is an individually-tailored, physiotherapist-delivered, balance, strength and strategy training programme aimed at preventing falls among people with Parkinson’s. We evaluated the cost-effectiveness of ...

    Authors: Yiqiao Xin, Ann Ashburn, Ruth M. Pickering, Kim Chivers Seymour, Sophia Hulbert, Carolyn Fitton, Dorit Kunkel, Ioana Marian, Helen C. Roberts, Sarah E. Lamb, Victoria A. Goodwin, Lynn Rochester and Emma McIntosh

    Citation: BMC Neurology 2020 20:295

    Content type: Research article

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  23. The diagnosis of Parkinson’s Disease (PD) remains a challenge and is currently based on the assessment of clinical symptoms. PD is also a heterogeneous disease with great variability in symptoms, disease cours...

    Authors: A. F. Wolters, M. Heijmans, S. Michielse, A. F. G. Leentjens, A. A. Postma, J. F. A. Jansen, D. Ivanov, A. A. Duits, Y. Temel and M. L. Kuijf

    Citation: BMC Neurology 2020 20:292

    Content type: Study protocol

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  24. Dopamine transporter (DAT) imaging may enable clinicians to discriminate idiopathic normal pressure hydrocephalus (iNPH) from other parkinsonian disorders. However, a specific pattern of dopaminergic loss in D...

    Authors: Jeong-Yoon Lee, Soo Bin Park, Mina Lee, Hyunjin Ju, Kayeong Im and Kyum-Yil Kwon

    Citation: BMC Neurology 2020 20:277

    Content type: Research article

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  25. There is growing evidence for proprioceptive dysfunction in patients with Parkinson’s disease (PD). The Lee Silvermann Voice Treatment-BIG therapy (LSVT-BIG), a special training program aiming at an increase o...

    Authors: Manuel Peterka, Thorsten Odorfer, Michael Schwab, Jens Volkmann and Daniel Zeller

    Citation: BMC Neurology 2020 20:276

    Content type: Research article

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  26. In this study, we explored whether the proposed short-echo-time magnitude (setMag) image derived from quantitative susceptibility mapping (QSM) could resemble NM-MRI image in substantia nigra (SN), by quantita...

    Authors: Xue Ling Liu, Li Qin Yang, Feng Tao Liu, Pu-Yeh Wu, Yong Zhang, Han Zhuang, Yong Hong Shi, Jian Wang, Dao Ying Geng and Yu Xin Li

    Citation: BMC Neurology 2020 20:262

    Content type: Research article

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  27. Even though recent research has achieved significant advancement in the development of therapeutic approaches for Wilson’s diseases (WD), the current treatment options available for WD are still limited, espec...

    Authors: Jing Zhang, Lulu Xiao and Wenming Yang

    Citation: BMC Neurology 2020 20:255

    Content type: Research article

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  28. Parkinson’s Disease (PD) is a heterogeneous, progressive neurodegenerative disorder which is characterized by a variety of motor and non-motor symptoms. To date, no disease modifying treatment for PD exists. H...

    Authors: Jeffrey M. Boertien, Sygrid van der Zee, Asterios Chrysou, Marleen J. J. Gerritsen, Nomdo M. Jansonius, Jacoba M. Spikman and Teus van Laar

    Citation: BMC Neurology 2020 20:245

    Content type: Study protocol

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  29. Diffusion tensor imaging (DTI) is an effective method to identify subtle changes to normal-appearing white matter (WM). Here we analyzed the DTI data with other examinations, including motor evoked potentials ...

    Authors: Beike Chen, Qiang Tan, Weikang Zhao, Qiming Yang, Hongyan Zhang, Fabao Gao, Xin Liu, Hua Feng and Dianming Jiang

    Citation: BMC Neurology 2020 20:236

    Content type: Research article

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  30. Palato-pharyngo-laryngeal myoclonus, a variant of palatal myoclonus, is characterized by involuntary rhythmic movements of palatal, pharyngeal, and laryngeal muscles. Symptomatic palatal myoclonus is classical...

    Authors: Jamie L. Fleet, Ronelle Calver, Gihan C. Perera and Zhihui Deng

    Citation: BMC Neurology 2020 20:222

    Content type: Case report

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  31. We investigated the gait characteristics of patients with Parkinson’s disease (PD), under free-living conditions, using a wearable device, and assessed their relationships with global cognitive function and mo...

    Authors: Hiroo Terashi, Takeshi Taguchi, Yuki Ueta, Yoshihiko Okubo, Hiroshi Mitoma and Hitoshi Aizawa

    Citation: BMC Neurology 2020 20:161

    Content type: Research article

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  32. The “hot cross bun” (HCB) sign, a cruciform hyperintensity in the pons on magnetic resonance imaging (MRI), has gradually been identified as a typical finding in multiple system atrophy, cerebellar-type (MSA-C...

    Authors: Atsuhiko Sugiyama, Hajime Yokota, Yoshitaka Yamanaka, Hiroki Mukai, Tatsuya Yamamoto, Shigeki Hirano, Kyosuke Koide, Shoichi Ito and Satoshi Kuwabara

    Citation: BMC Neurology 2020 20:157

    Content type: Research article

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  33. Heart rate variability (HRV) decreases in Parkinson’s disease (PD) and it can be considered a marker for cardiovascular dysautonomia. The purpose of this pilot study is to evaluate long-term time-domain analys...

    Authors: V. Arnao, A. Cinturino, S. Mastrilli, C. Buttà, C. Maida, A. Tuttolomondo, P. Aridon and M. D’Amelio

    Citation: BMC Neurology 2020 20:152

    Content type: Research article

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  34. Parkinson disease (PD) is a debilitating and chronic neurodegenerative disease resulting in ambulation difficulties. Natural walking activity often declines early in disease progression despite the relative st...

    Authors: Kerri S. Rawson, James T. Cavanaugh, Cristina Colon-Semenza, Tami DeAngelis, Ryan P. Duncan, Daniel Fulford, Michael P. LaValley, Pietro Mazzoni, Timothy Nordahl, Lisa M. Quintiliani, Marie Saint-Hilaire, Cathi A. Thomas, Gammon M. Earhart and Terry D. Ellis

    Citation: BMC Neurology 2020 20:146

    Content type: Study protocol

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  35. Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late onset, X-linked genetic, neurodegenerative disorder caused by a “premutation (PM)” in the fragile X mental retardation 1 (FMR1) gene. Here we report a...

    Authors: Cuiping Zhao, Yiming Liu, Yihua Wang, Hongyan Li, Bin Zhang, Yaoxian Yue and Jianyuan Zhang

    Citation: BMC Neurology 2020 20:145

    Content type: Case report

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  36. RLS is known as one of the most common movement disorders during pregnancy, which is most aggravated in the third trimester of pregnancy and can affect up to one-third of pregnant women. This study intends to ...

    Authors: Niloofar Darvishi, Alireza Daneshkhah, Behnam Khaledi-Paveh, Aliakbar Vaisi-Raygani, Masoud Mohammadi, Nader Salari, Fateme Darvishi, Alireza Abdi and Rostam Jalali

    Citation: BMC Neurology 2020 20:132

    Content type: Research article

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  37. Progressive supranuclear palsy (PSP) is a rare movement disorder with poor prognosis. This retrospective study aimed to characterize the natural history of PSP and to find predictors of shorter survival and fa...

    Authors: Shi-Shuang Cui, Hua-Wei Ling, Juan-Juan Du, Yi-Qi Lin, Jing Pan, Hai-Yan Zhou, Gang Wang, Ying Wang, Qin Xiao, Jun Liu, Yu-Yan Tan and Sheng-Di Chen

    Citation: BMC Neurology 2020 20:114

    Content type: Research article

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  38. Phospholipase A2 group VI (PLA2G6) mutations associated with neurodegeneration (PLAN) manifest as heterogeneous neurodegenerative disorders with variable ages of onset. The genotype-phenotype correlation is not w...

    Authors: Yung-Tsai Chu, Han-Yi Lin, Pei-Lung Chen and Chin-Hsien Lin

    Citation: BMC Neurology 2020 20:101

    Content type: Case report

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  39. Intracranial neoplasms are an uncommon cause of symptomatic parkinsonism. We here report a patient with an extensive middle and posterior fossa arachnoid cyst presenting with parkinsonism that was treated by n...

    Authors: Bernadette Wimmer, Stephanie Mangesius, Klaus Seppi, Sarah Iglseder, Franziska Di Pauli, Martin Ortler, Elke Gizewski, Werner Poewe and Gregor Karl Wenning

    Citation: BMC Neurology 2020 20:89

    Content type: Case report

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  40. Huntington’s disease (HD), an inherited, often late-onset, neurodegenerative disorder, is considered to be a rare, orphan disease. Research into its genetic correlates and services for those affected are inade...

    Authors: Nikhil Ratna, Nitish L. Kamble, Sowmya D. Venkatesh, Meera Purushottam, Pramod K. Pal and Sanjeev Jain

    Citation: BMC Neurology 2020 20:87

    Content type: Research article

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  41. Parkinson’s disease (PD) is a devastating neurodegenerative disorder. Reduced balance is one of the cardinal symptoms of PD, predisposing people living with PD to experience difficulties with the execution of ...

    Authors: Sofie LaGrone, Conran Joseph, Hanna Johansson, Birgit Enberg and Erika Franzén

    Citation: BMC Neurology 2020 20:50

    Content type: Research article

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  42. Both Deep Brain Stimulation (DBS) and Continuous intrajejunal Levodopa Infusion (CLI) are effective therapies for the treatment of Parkinson’s disease (PD). To our knowledge, no direct head-to-head comparison ...

    Authors: D. van Poppelen, V. Sisodia, R. J. de Haan, M. G. W. Dijkgraaf, P. R. Schuurman, G. J. Geurtsen, A. E. M. Berk, R. M. A. de Bie and J. M. Dijk

    Citation: BMC Neurology 2020 20:40

    Content type: Study protocol

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