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Movement disorders

This section covers all types and aspects of movement disorders. Topics of include, but are not limited to, Parkinson's Disease, transcranial magnetic stimulation, spasticity, dyskinesia, movement disorders, rehabilitation and spinal cord injury.

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  1. Content type: Research article

    Gait Initiation (GI) is a functional task that challenges the balance control requiring weight shift and a transition from standing to walking. Individuals with Down Syndrome (DS) walk with low velocity, prolo...

    Authors: Carolina Corsi, Veronica Cimolin, Paolo Capodaglio, Claudia Condoluci and Manuela Galli

    Citation: BMC Neurology 2019 19:66

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  2. Content type: Research article

    Dopaminergic neuronal loss begins years before motor symptoms appear in Parkinson disease (PD). Thus, reliable biomarkers for early diagnosis and prognosis of PD are an essential pre-requisite to develop disea...

    Authors: Dilini Rathnayake, Thashi Chang and Preethi Udagama

    Citation: BMC Neurology 2019 19:56

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  3. Content type: Research article

    There are currently no standard diagnostic criteria for characterizing advanced Parkinson’s disease (APD) in clinical practice, a critical component in determining ongoing clinical care and therapeutic strateg...

    Authors: Alfonso Fasano, Victor S. C. Fung, Leonardo Lopiano, Bulent Elibol, Irina G. Smolentseva, Klaus Seppi, Annamária Takáts, Koray Onuk, Juan Carlos Parra, Lars Bergmann, Kavita Sail, Yash Jalundhwala and Zvezdan Pirtosek

    Citation: BMC Neurology 2019 19:50

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  4. Content type: Research article

    The prevalence of Restless legs syndrome (RLS) in End Stage Renal Disease (ESRD) patients is higher than that in the general population. However, the associations of RLS within the ESRD population are inconsis...

    Authors: Xiao-Wei Lin, Jun-Fang Zhang, Meng-Yao Qiu, Ling-Yan Ni, Hong-Lei Yu, Sheng-Han Kuo, William G. Ondo, Qing Yu and Yun-Cheng Wu

    Citation: BMC Neurology 2019 19:47

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  5. Content type: Research article

    We aimed to produce a detailed neuropathological analysis of pyramidal motor system pathology and provide its clinical pathological correlation in cases with definite progressive supranuclear palsy (PSP).

    Authors: Zuzana Stejskalova, Zdenek Rohan, Robert Rusina, Adam Tesar, Jaromir Kukal, Gabor G. Kovacs, Ales Bartos and Radoslav Matej

    Citation: BMC Neurology 2019 19:42

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  6. Content type: Study protocol

    Currently there are no disease-modifying treatments for Parkinson’s disease dementia (PDD), a condition linked to aggregation of the protein α-synuclein in subcortical and cortical brain areas. One of the lead...

    Authors: C. R. A. Silveira, J. MacKinley, K. Coleman, Z. Li, E. Finger, R. Bartha, S. A. Morrow, J. Wells, M. Borrie, R. G. Tirona, C. A. Rupar, G. Zou, R. A. Hegele, D. Mahuran, P. MacDonald, M. E. Jenkins…

    Citation: BMC Neurology 2019 19:20

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  9. Content type: Case report

    Dopamine agonists (DAs) are efficacious for the treatment of motor and nonmotor symptoms in patients with Parkinson’s disease (PD). The treatment of PD with DAs is often complicated by adverse drug reactions (...

    Authors: Piao Zhang, Yan Li, Kun Nie, Lijuan Wang and Yuhu Zhang

    Citation: BMC Neurology 2018 18:221

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  10. Content type: Study protocol

    Parkinson’s disease (PD) is a chronic progressive disorder leading to increasing disability. While the symptoms and needs of patients in the early stages of their disease are well characterized, little informa...

    Authors: Monika Balzer-Geldsetzer, Joaquim Ferreira, Per Odin, Bastiaan R. Bloem, Wassilios G. Meissner, Stefan Lorenzl, Michael Wittenberg, Richard Dodel and Anette Schrag

    Citation: BMC Neurology 2018 18:185

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  11. Content type: Case report

    Progressive encephalomyelitis with rigidity and myoclonus (PERM) syndrome is a rare neurological condition. Its clinical characteristics include axial and limb muscle rigidity, myoclonus, painful spasms and hy...

    Authors: Aurélie Degeneffe, Marie Dagonnier, Alain D’hondt and Jose Antonio Elosegi

    Citation: BMC Neurology 2018 18:173

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  12. Content type: Research article

    Autonomic nervous system dysfunction, common in patients with Parkinson’s disease (PD), causes significant morbidity and it is correlated with poor quality of life. To assess frequency of urinary symptoms in p...

    Authors: Francesca Valentino, Tommaso Vincenzo Bartolotta, Giuseppe Cosentino, Sergio Mastrilli, Valentina Arnao, Paolo Aridon, Salvatore Scurria, Alice Pavone, Carlo Pavone and Marco D’Amelio

    Citation: BMC Neurology 2018 18:148

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  13. Content type: Case report

    Ocular neuromyotonia (ONM) is characterized by episodic diplopia, which is usually triggered by prolonged eccentric gaze of the affected extraocular muscles. The spell is characterized by involuntary, occasion...

    Authors: Tanyatuth Padungkiatsagul, Panitha Jindahra, Anuchit Poonyathalang, Narong Samipak and Kavin Vanikieti

    Citation: BMC Neurology 2018 18:137

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  14. Content type: Research article

    Neurogenic orthostatic hypotension (nOH) results from impaired vasoconstriction due to dysfunction of the autonomic nervous system and is commonly associated with Parkinson disease (PD), multiple system atroph...

    Authors: Daniel O. Claassen, Charles H. Adler, L. Arthur Hewitt and Christopher Gibbons

    Citation: BMC Neurology 2018 18:125

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  15. Content type: Research article

    Chinese guidelines for management of Parkinson’s disease (PD) have been issued and updated regularly since 2006. We undertook a cross-sectional survey to evaluate the impact of the latest edition (2014) on cur...

    Authors: Gang Wang, Hai-Lun Cui, Jun Liu, Qin Xiao, Ying Wang, Jian-Fang Ma, Hai-Yan Zhou, Jing Pan, Yu-Yan Tan and Sheng-Di Chen

    Citation: BMC Neurology 2018 18:122

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  16. Content type: Research article

    Deficits in gait and balance are common among neurological inpatients. Currently, assessment of these patients is mainly subjective. New assessment options using wearables may provide complementary and more ob...

    Authors: Felix P. Bernhard, Jennifer Sartor, Kristina Bettecken, Markus A. Hobert, Carina Arnold, Yvonne G. Weber, Sven Poli, Nils G. Margraf, Christian Schlenstedt, Clint Hansen and Walter Maetzler

    Citation: BMC Neurology 2018 18:114

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  18. Content type: Research article

    Sleep disturbances are common in patients with advanced Parkinson disease (PD). The aim of this study was to evaluate a possible association of cortical thickness, cortical and subcortical volume with sleep di...

    Authors: Andrius Radziunas, Vytenis Pranas Deltuva, Arimantas Tamasauskas, Rymante Gleizniene, Aiste Pranckeviciene, Kestutis Petrikonis and Adomas Bunevicius

    Citation: BMC Neurology 2018 18:88

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  19. Content type: Case report

    Horizontal gaze palsy with progressive scoliosis (HGPPS) is a rare autosomal recessive congenital anomaly characterized by horizontal gaze limitation and progressive scoliosis. We investigated the underlying p...

    Authors: Chi-Wei Lin, Chung-Ping Lo and Min-Chien Tu

    Citation: BMC Neurology 2018 18:75

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  20. Content type: Research article

    The respiratory dysfunction of patients with Parkinson’s disease (PD) has drawn increasing attention. This study evaluated the relationship between gray matter volume (GMV), as determined by voxel-based morpho...

    Authors: Sieh-Yang Lee, Meng-Hsiang Chen, Pi-Ling Chiang, Hsiu-Ling Chen, Kun-Hsien Chou, Yueh-Cheng Chen, Chiun-Chieh Yu, Nai-Wen Tsai, Shau-Hsuan Li, Cheng-Hsien Lu and Wei-Che Lin

    Citation: BMC Neurology 2018 18:73

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  21. Content type: Study protocol

    Differentiation of Parkinson’s disease (PD) from the various types of atypical parkinsonism (AP) such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), dementia with Lewy bodies (DLB), co...

    Authors: Anouke van Rumund, Marjolein B. Aerts, Rianne A. J. Esselink, Frederick J. A. Meijer, Marcel M. Verbeek and Bastiaan R. Bloem

    Citation: BMC Neurology 2018 18:69

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  22. Content type: Case report

    Some metabolic disorders, including abnormal calcium metabolism, can develop and worsen parkinsonism. However, whether hyperparathyroidism can cause parkinsonism remains controversial.

    Authors: Yuichiro Ohya, Masato Osaki, Shota Sakai, Shunsuke Kimura, Chiharu Yasuda, Tetsuro Ago, Takanari Kitazono and Shuji Arakawa

    Citation: BMC Neurology 2018 18:62

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  23. Content type: Case report

    Hepatic encephalopathy may manifest by a wide spectrum of neuropsychiatric symptoms, including cognitive impairment, seizures or extrapyramidal symptoms. The liver transplant can lead to improvement of the sig...

    Authors: Karin Gmitterová, Michal Minár, Miroslav Žigrai, Zuzana Košutzká, Alice Kušnírová and Peter Valkovič

    Citation: BMC Neurology 2018 18:44

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  24. Content type: Research article

    Wilson disease is a rare genetic disorder in which impaired copper excretion results in toxic copper levels and tissue damage. Manifestations are primarily hepatic and/or neuropsychiatric, with a variety of ne...

    Authors: Anna Członkowska, Tomasz Litwin, Karolina Dzieżyc, Michal Karliński, Johan Bring and Carl Bjartmar

    Citation: BMC Neurology 2018 18:34

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  25. Content type: Research article

    Constipation is one of the most frequent non-motor symptoms (NMS) in Parkinson’s disease (PD) and the prevalence of constipation in PD patients varies among different studies. We designed this study to survey ...

    Authors: Jing Gan, Ying Wan, Junjie Shi, Mingzhu Zhou, Zhiyin Lou and Zhenguo Liu

    Citation: BMC Neurology 2018 18:29

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  26. Content type: Research article

    Spiral drawing on papers is a common tremor evaluation tool for diagnosing patients with essential tremor (ET) or Parkinson’s disease (PD). No standard drawing methods and parameters that use graphic tablets a...

    Authors: Po-Chieh Lin, Kai-Hsiang Chen, Bing-Shiang Yang and Yu-Jung Chen

    Citation: BMC Neurology 2018 18:25

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  27. Content type: Research article

    Parkinson’s disease is a heterogeneous disorder where genetic factors may underlie clinical variability. Rapid eye movement sleep behavior disorder (RBD) is a parasomnia strongly linked to synucleinopathies, i...

    Authors: Kari Anne Bjørnarå, Lasse Pihlstrøm, Espen Dietrichs and Mathias Toft

    Citation: BMC Neurology 2018 18:20

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  28. Content type: Research article

    Comparisons between neurological conditions have the potential to inform service providers by identifying particular areas of difficulty experienced by affected individuals. This study aimed to identify predic...

    Authors: David Morley, Sarah Dummett, Laura Kelly, Ray Fitzpatrick and Crispin Jenkinson

    Citation: BMC Neurology 2018 18:19

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  29. Content type: Research article

    Transcranial ultrasound is a useful tool for providing the evidences for the early diagnosis and differential diagnosis of Parkinson disease (PD). However, the relationship between hyper echogenicity in substa...

    Authors: Shu-yang Yu, Chen-jie Cao, Li-jun Zuo, Ze-jie Chen, Teng-hong Lian, Fang Wang, Yang Hu, Ying-shan Piao, Li-xia Li, Peng Guo, Li Liu, Qiu-jin Yu, Rui-dan Wang, Piu Chan, Sheng-di Chen, Xiao-min Wang…

    Citation: BMC Neurology 2018 18:9

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  30. Content type: Research article

    Spinocerebellar ataxia (SCA) subtypes are often caused by expansions in non-coding regions of genes like SCA8, SCA10, SCA12 and SCA36. Other ataxias are known to be associated with repeat expansions such as fragi...

    Authors: Gülsah Aydin, Gabriele Dekomien, Sabine Hoffjan, Wanda Maria Gerding, Jörg T. Epplen and Larissa Arning

    Citation: BMC Neurology 2018 18:3

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  31. Content type: Research article

    Individuals with cerebral palsy have smaller muscle volumes normalised to body mass than their typically developing peers. The aim of this study is to investigate the relationship between lower limb muscle vol...

    Authors: Jonathan J. Noble, Emily Chruscikowski, Nicola R. D. Fry, Andrew P. Lewis, Martin Gough and Adam P. Shortland

    Citation: BMC Neurology 2017 17:223

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  32. Content type: Research article

    Evaluation of speech disorders in PD taking into account sociodemographic conditions is not frequent. This paper aims to establish correlations between articulation disorders in PD patients and factors such as...

    Authors: Wioletta Pawlukowska, Karolina Skonieczna-Żydecka, Iwona Rotter, Krystyna Honczarenko and Przemysław Nowacki

    Citation: BMC Neurology 2017 17:221

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  33. Content type: Research article

    Real world data have an important role to play in the evaluation of epidemiology and burden of disease; and in assisting health-care decision-makers, especially related to coverage and payment decisions. Howev...

    Authors: Audrey Tanguy, Linus Jönsson and Lianna Ishihara

    Citation: BMC Neurology 2017 17:213

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  34. Content type: Research article

    The loss of the swallow-tail sign of the substantia nigra has been proposed for diagnosis of Parkinson’s disease. Aim was to evaluate, if the sign occurs consistently in healthy subjects and if it can be relia...

    Authors: Manuel A. Schmidt, Tobias Engelhorn, Franz Marxreiter, Juergen Winkler, Stefan Lang, Stephan Kloska, Philipp Goelitz and Arnd Doerfler

    Citation: BMC Neurology 2017 17:194

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  35. Content type: Case report

    Vacuolar protein sorting 35 (VPS35) was recently reported to be a genetic cause for late-onset autosomal dominant Parkinson’s disease (PD). However, VPS35 mutations are rarely reported in Asian populations. Herei...

    Authors: Ying-Fa Chen, Yung-Yee Chang, Min-Yu Lan, Pei-Lung Chen and Chin-Hsien Lin

    Citation: BMC Neurology 2017 17:191

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  36. Content type: Case report

    Frontotemporal degeneration (FTD) is a clinically and genetically heterogeneous neurodegenerative disorder characterized by deficits in executive function that frequently overlaps with parkinsonism and motor n...

    Authors: Hui-Chi Lin, Chin-Hsien Lin, Pei-Lung Chen, Shih-Jung Cheng and Pei-Hao Chen

    Citation: BMC Neurology 2017 17:186

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  37. Content type: Case report

    Huntington’s disease (HD) is an autosomal dominant disorder, typically characterized by chorea due to a trinucleotide repeat expansion in the HTT gene, although the clinical manifestations of patients with juv...

    Authors: Shi-Shuang Cui, Ru-Jing Ren, Ying Wang, Gang Wang and Sheng-Di Chen

    Citation: BMC Neurology 2017 17:152

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  38. Content type: Case report

    Spinal cord stimulation (SCS) has recently been reported to be effective for truncal postural abnormalities such as camptocormia and Pisa syndrome in Parkinson’s disease. In this case report, we describe a cas...

    Authors: Hisanao Akiyama, Saki Nukui, Masashi Akamatu, Yasuhiro Hasegawa, Osamu Nishikido and Soichiro Inoue

    Citation: BMC Neurology 2017 17:148

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  39. Content type: Research article

    Individuals with Cerebral Palsy (CP) present with sensorimotor dysfunction which make the control and execution of movements difficult. This study aimed to verify the speed-accuracy trade-off in individuals wi...

    Authors: Deborah Cristina Gonçalves Luiz Fernani, Maria Tereza Artero Prado, Talita Dias da Silva, Thais Massetti, Luiz Carlos de Abreu, Fernando Henrique Magalhães, Helen Dawes and Carlos Bandeira de Mello Monteiro

    Citation: BMC Neurology 2017 17:143

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  40. Content type: Research article

    Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism resulting in multifaceted neurological, hepatic, and psychiatric symptoms. The objective of the study was to comparatively assess t...

    Authors: Hanna M. Volpert, Jan Pfeiffenberger, Jan B. Gröner, Wolfgang Stremmel, Daniel N. Gotthardt, Mark Schäfer, Karl Heinz Weiss and Markus Weiler

    Citation: BMC Neurology 2017 17:140

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  41. Content type: Case report

    Parasomnia overlap disorder (POD) is a distinct parasomnia and characterized by concomitant manifestation of rapid-eye-movement (REM)- and non-REM (NREM)-parasomnias. Although not uncommon among patients with ...

    Authors: Panagiotis Bargiotas, Julia Muellner, W.M. Michael Schuepbach and Claudio L. Bassetti

    Citation: BMC Neurology 2017 17:137

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  43. Content type: Research article

    Parkinson’s disease is complicated by comorbidity and polypharmacy, but the extent and patterns of these are unclear. We describe comorbidity and polypharmacy in patients with and without Parkinson’s disease a...

    Authors: Gary McLean, John V. Hindle, Bruce Guthrie and Stewart W. Mercer

    Citation: BMC Neurology 2017 17:126

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  45. Content type: Case report

    Camptocormia is severe flexion of the thoracolumbar spine, exaggerated during standing and walking but minimized in supine position. Even though camptocormia is a relatively common condition during the course ...

    Authors: Yoon Kim, Ahro Kim, Aryun Kim and Beomseok Jeon

    Citation: BMC Neurology 2017 17:118

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  47. Content type: Research article

    Impulse control and related disorders (ICRDs) are clinically complications in Parkinson’s disease (PD). However, the clinical characteristics of ICRDs in Chinese PD patients were rarely reported. We aimed to e...

    Authors: Yu Zhang, An qi He, Lin Li, Wei Chen and Zhen guo Liu

    Citation: BMC Neurology 2017 17:98

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  50. Content type: Technical advance

    Transcranial magnetic resonance guided focused ultrasound is an emerging technology under evaluation for treatment of essential tremor, a prevalent movement disorder. A qualitative evaluation is performed by a...

    Authors: Fred Tam, Yuexi Huang, Michael L. Schwartz, Tom A. Schweizer, Kullervo Hynynen and Simon J. Graham

    Citation: BMC Neurology 2017 17:74

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