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Movement disorders

Section edited by Yih-Ru Wu

This section covers all types and aspects of movement disorders. Topics of include, but are not limited to, Parkinson's Disease, transcranial magnetic stimulation, spasticity, dyskinesia, movement disorders, rehabilitation and spinal cord injury.

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  1. Content type: Research article

    Despite the benefits of balance exercise in clinical populations, balance training programs tend to be poorly described, which in turn makes it difficult to evaluate important training components and compare b...

    Authors: David Conradsson, Håkan Nero, Niklas Löfgren, Maria Hagströmer and Erika Franzén

    Citation: BMC Neurology 2017 17:19

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  2. Content type: Study protocol

    Cerebellar ataxia (CA) is a frequent and often disabling condition that impairs motor functioning and impacts on quality of life (QoL). No medication has yet been proven effective for the symptomatic or even c...

    Authors: Katharina Feil, Christine Adrion, Julian Teufel, Sylvia Bösch, Jens Claassen, Ilaria Giordano, Holger Hengel, Heike Jacobi, Thomas Klockgether, Thomas Klopstock, Wolfgang Nachbauer, Ludger Schöls, Claudia Stendel, Ellen Uslar, Bart van de Warrenburg, Ingrid Berger…

    Citation: BMC Neurology 2017 17:7

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  3. Content type: Research article

    Parkinson’s Disease is a progressive neurodegenerative disease, characterized by symptoms of motor impairment, resulting from the loss of dopaminergic neurons in the midbrain, however non-neuronal symptoms are...

    Authors: Anu Planken, Lille Kurvits, Ene Reimann, Liis Kadastik-Eerme, Külli Kingo, Sulev Kõks and Pille Taba

    Citation: BMC Neurology 2017 17:6

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  4. Content type: Research article

    Depression and anxiety remain under-diagnosed and under-treated in those with neurologic diseases such as dementia or Parkinson’s Disease (PD). Our objectives were to first, to provide a synthesis of high qual...

    Authors: Zahra Goodarzi, Bria Mele, Selynne Guo, Heather Hanson, Nathalie Jette, Scott Patten, Tamara Pringsheim and Jayna Holroyd-Leduc

    Citation: BMC Neurology 2016 16:244

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  5. Content type: Research article

    Essential tremor (ET) is characterized by a frequent family history. No monogenic form of ET has been identified. We aimed at exploring ET patients to identify distinct subgroups and facilitate the identificat...

    Authors: Mathilde Renaud, Christophe Marcel, Gabrielle Rudolf, Mickaël Schaeffer, Ouhaïd Lagha-Boukbiza, Jean-Baptiste Chanson, Jamel Chelly, Mathieu Anheim and Christine Tranchant

    Citation: BMC Neurology 2016 16:238

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  6. Content type: Case report

    Myoclonus is a clinical sign characterized by sudden, brief jerky, shock-like involuntary movements of a muscle or group of muscles. Dystonia is defined as a syndrome of sustained muscle contractions, frequent...

    Authors: Guangxun Shen, Guangxian Nan, Chae-Won Shin, Hyeyoung Park, Kwee-Yum Lee and Beomseok Jeon

    Citation: BMC Neurology 2016 16:228

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  7. Content type: Technical advance

    Belly dancer’s dyskinesia is an extremely rare condition. It manifests as semicontinuous, slow, writhing, sinuous abdominal wall movements that are bothersome to the patient. Management of this condition is ex...

    Authors: Asmahan Alshubaili, Hussam Abou-Al-Shaar, Ponnusamy Santhamoorthy, Hosam Attia and Saeed Bohlega

    Citation: BMC Neurology 2016 16:226

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  8. Content type: Case report

    Rapid-onset dystonia-parkinsonism (RDP) is a rare autosomal dominant disorder that is caused by mutations in the ATP1A3 gene and is characterized by an acute onset of asymmetric dystonia and parkinsonism. To d...

    Authors: Yanqiu Liu, Yan Lu, Xinqing Zhang, Shuping Xie, Tingting Wang, Tianwen Wu and Chaoyan Wang

    Citation: BMC Neurology 2016 16:218

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  9. Content type: Case report

    In accordance with German neurosurgical and neurological consensus recommendations, lead placements for deep brain stimulation (DBS) in patients with Parkinson’s disease (PD) are usually performed with the pat...

    Authors: Kajetan L. von Eckardstein, Friederike Sixel-Döring, Stephan Kazmaier, Claudia Trenkwalder, Jason M. Hoover and Veit Rohde

    Citation: BMC Neurology 2016 16:216

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  10. Content type: Study protocol

    In Parkinson’s disease (PD), cognitive impairment is an important non-motor symptom heralding the development of dementia. Effective treatments to slow down the rate of cognitive decline in PD patients with mi...

    Authors: Sjors C. F. van de Weijer, Annelien A. Duits, Bastiaan R. Bloem, Roy P. Kessels, Jacobus F. A. Jansen, Sebastian Köhler, Gerrit Tissingh and Mark L. Kuijf

    Citation: BMC Neurology 2016 16:209

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  11. Content type: Research article

    Parkinson’s disease (PD) is the second commonest neurodegenerative disease in developed countries. Current treatment for PD is pharmacologically focused and can have significant side-effects. There is increasi...

    Authors: Jenny Advocat, Joanne Enticott, Brooke Vandenberg, Craig Hassed, Jennifer Hester and Grant Russell

    Citation: BMC Neurology 2016 16:166

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  12. Content type: Research article

    Droxidopa is an orally active prodrug that significantly improved dizziness/lightheadedness measured using the Orthostatic Hypotension Symptom Assessment (OHSA) Item 1 in patients with neurogenic orthostatic h...

    Authors: Clément François, Gerald J. Rowse, L. Arthur Hewitt, Pamela Vo and Robert A. Hauser

    Citation: BMC Neurology 2016 16:143

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  13. Content type: Research article

    Patients with spinal cord injury (SCI) have a higher prevalence of cardiovascular diseases compared to the healthy population. Aerobic exercise training is one of the recommended treatments. However, literatur...

    Authors: Der-Sheng Han, Ming-Yen Hsiao, Tyng-Guey Wang, Ssu-Yuan Chen and Wei-Shiung Yang

    Citation: BMC Neurology 2016 16:142

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  14. Content type: Research article

    Spinal muscular atrophy (SMA) is the most common autosomal recessive disease in children, and the diagnosis is complicated and difficult, especially at early stage. Early diagnosis of SMA is able to improve th...

    Authors: Zhidai Liu, Penghui Zhang, Xiaoyan He, Shan Liu, Shi Tang, Rong Zhang, Xinbin Wang, Junjie Tan, Bin Peng, Li Jiang, Siqi Hong and Lin Zou

    Citation: BMC Neurology 2016 16:141

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  15. Content type: Research article

    Our study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD (pRBD) in a rural community based on RBD1Q-C and investigate the associ...

    Authors: Jian-Fang Ma, Miao-Miao Hou, Hui-Dong Tang, Xiang Gao, Liang Liang, Li-Fang Zhu, Yi Zhou, Sheng-Yu Zha, Shi-Shuang Cui, Juan-Juan Du, Gen Li, Jun Liu and Sheng-Di Chen

    Citation: BMC Neurology 2016 16:123

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  16. Content type: Research article

    Hemifacial spasm (HFS) is a disabling neurological condition. Vascular tortuosity in HFS patients has not been quantified objectively and its relationship with hypertension and posterior fossa volume (PF) is u...

    Authors: Evan Cyril Edmond, Samantha Xue-Li Sim, Hui-Hua Li, Eng-King Tan and Ling-Ling Chan

    Citation: BMC Neurology 2016 16:120

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  17. Content type: Research article

    This multicenter, double-blind, placebo-controlled study assessed the efficacy of rotigotine transdermal patch on apathy and motor symptoms in patients with Parkinson’s disease (PD).

    Authors: Robert A Hauser, Jaroslaw Slawek, Paolo Barone, Elisabeth Dohin, Erwin Surmann, Mahnaz Asgharnejad and Lars Bauer

    Citation: BMC Neurology 2016 16:90

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  18. Content type: Research article

    There is limited knowledge concerning fall-related activity avoidance in people with Parkinson’s disease (PD); such knowledge would be of importance for the development of more efficient PD-care and rehabilita...

    Authors: Manzur Kader, Susanne Iwarsson, Per Odin and Maria H. Nilsson

    Citation: BMC Neurology 2016 16:84

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  19. Content type: Research article

    The aim of this study was to develop an assessment tool for activities of daily living (ADL) from the perspective of patients with Parkinson’s disease (PD) and examine the validity and reliability of the asses...

    Authors: Su-Yun Lee, Sung Kwan Kim, Sang-Myung Cheon, Jung-Wook Seo, Min Ah Kim and Jae Woo Kim

    Citation: BMC Neurology 2016 16:73

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  20. Content type: Study protocol

    Our previous randomized double-blind study showed that drinking hydrogen (H2) water for 48 weeks significantly improved the total Unified Parkinson’s Disease Rating Scale (UPDRS) score of Parkinson’s disease (PD)...

    Authors: Asako Yoritaka, Takashi Abe, Chigumi Ohtsuka, Tetsuya Maeda, Masaaki Hirayama, Hirohisa Watanabe, Hidemoto Saiki, Genko Oyama, Jiro Fukae, Yasushi Shimo, Taku Hatano, Sumihiro Kawajiri, Yasuyuki Okuma, Yutaka Machida, Hideto Miwa, Chikako Suzuki…

    Citation: BMC Neurology 2016 16:66

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  21. Content type: Research article

    Patients affected by progressive long-term neurological conditions might benefit from specialist palliative care involvement. However, little is known on how neurology and specialist palliative care services i...

    Authors: Liesbeth M. van Vliet, Wei Gao, Daniel DiFrancesco, Vincent Crosby, Andrew Wilcock, Anthony Byrne, Ammar Al-Chalabi, K. Ray Chaudhuri, Catherine Evans, Eli Silber, Carolyn Young, Farida Malik, Rachel Quibell and Irene J. Higginson

    Citation: BMC Neurology 2016 16:63

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  22. Content type: Erratum

    Authors: Diego Santos-García, Pablo Mir, Esther Cubo, Lydia Vela, Mari Cruz Rodríguez-Oroz, Maria José Martí, José Matías Arbelo, Jon Infante, Jaime Kulisevsky and Pablo Martínez-Martín

    Citation: BMC Neurology 2016 16:44

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    The original article was published in BMC Neurology 2016 16:26

  23. Content type: Research article

    Primary dystonia is a chronic neurological movement disorder that causes abnormal muscle movements. Pain and emotional distress may accompany these physical symptoms. Behavioural interventions are used to help...

    Authors: C. J. Bernstein, D. R. Ellard, G. Davies, E. Hertenstein, N. K. Y. Tang, M. Underwood and H. Sandhu

    Citation: BMC Neurology 2016 16:40

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  24. Content type: Study protocol

    Parkinson’s disease (PD) is a progressive neurodegenerative disorder causing motor and non-motor symptoms that can affect independence, social adjustment and the quality of life (QoL) of both patients and care...

    Authors: Diego Santos-García, Pablo Mir, Esther Cubo, Lydia Vela, Mari Cruz Rodríguez-Oroz, Maria José Martí, José Matías Arbelo, Jon Infante, Jaime Kulisevsky and Pablo Martínez-Martín

    Citation: BMC Neurology 2016 16:26

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    The Erratum to this article has been published in BMC Neurology 2016 16:44

  25. Content type: Research article

    The 10-Meter Walk Tests (10MWT) and the 6-Minute Walk Test (6MinWT) are applied to assess gait capacity in paediatric patients. To better objectify changes in qualitative aspects of gait, temporo-spatial param...

    Authors: Judith V. Graser, Claudia Letsch and Hubertus J. A. van Hedel

    Citation: BMC Neurology 2016 16:15

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  26. Content type: Research article

    Spinal cord injury (SCI) is a severe neurological disorder associated not only with ongoing medical complications but also with a significant loss of mobility and participation. The introduction of robotic tec...

    Authors: Patrizio Sale, Emanuele Francesco Russo, Michele Russo, Stefano Masiero, Francesco Piccione, Rocco Salvatore Calabrò and Serena Filoni

    Citation: BMC Neurology 2016 16:12

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  27. Content type: Research article

    The trend of decreasing length of stay in rehabilitation facilities has led to individuals with spinal cord injury (SCI) entering the community with unmet needs and fewer self-care skills to prevent secondary ...

    Authors: Sarah E. P. Munce, Fiona Webster, Michael G. Fehlings, Sharon E. Straus, Eunice Jang and Susan B. Jaglal

    Citation: BMC Neurology 2016 16:11

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  28. Content type: Study protocol

    Impaired mobility and falls are clinically important complications of Parkinson’s disease (PD) and a major detractor from quality of life for which there are limited therapies. Pathological, neuroimaging and c...

    Authors: Martina Mancini, Brett W. Fling, Anne Gendreau, Jodi Lapidus, Fay B. Horak, Kathy Chung and John G. Nutt

    Citation: BMC Neurology 2015 15:264

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  29. Content type: Case report

    Dentatorubropallidoluysian atrophy (DRPLA) is a rare autosomal dominant neurodegenerative disease that is associated with numerous movement disorders. Ocular problems also occur with DRPLA with reports of corn...

    Authors: Michael R. Silver, Kapil D. Sethi, Shyamal H. Mehta, Fenwick T. Nichols and John C. Morgan

    Citation: BMC Neurology 2015 15:260

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  30. Content type: Study protocol

    Parkinson’s disease, the second most common neurodegenerative disease, is diagnostically defined by motor impairments, but also includes often under-recognized impairments in cognition, mood, sleep, and the au...

    Authors: Karen Connor, Eric Cheng, Hilary C. Siebens, Martin L. Lee, Brian S. Mittman, David A. Ganz and Barbara Vickrey

    Citation: BMC Neurology 2015 15:258

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  31. Content type: Research article

    Niemann-Pick disease type C (NP-C) is a rare neurovisceral lipid storage disorder characterised by progressive, disabling neurological symptoms and premature death in most patients. During the last decade, nat...

    Authors: Jackie Imrie, Lesley Heptinstall, Stephen Knight and Kate Strong

    Citation: BMC Neurology 2015 15:257

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  32. Content type: Research article

    People with disabilities have reported worse health status than people without disabilities and receiving fewer preventive health services such as counseling around exercise habits. This is noteworthy consider...

    Authors: Lena Zetterberg, Charlotte Urell and Elisabeth Anens

    Citation: BMC Neurology 2015 15:247

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  33. Content type: Study protocol

    The aim of this study is to investigate if early treatment with levodopa has a beneficial disease modifying effect on Parkinson’s disease (PD) symptoms and functional health, improves the ability to (maintain)...

    Authors: Constant V. M. Verschuur, S. R. Suwijn, B. Post, M. Dijkgraaf, B. R. Bloem, J. J. van Hilten, T. van Laar, G. Tissingh, G. Deuschl, A. E. Lang, R. J. de Haan and R. M. A. de Bie

    Citation: BMC Neurology 2015 15:236

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  34. Content type: Study protocol

    Falls frequency increases with age and particularly in neurogeriatric cohorts. The interplay between eye movements and locomotion may contribute substantially to the occurrence of falls, but is hardly investig...

    Authors: Karin Srulijes, David J. Mack, Jochen Klenk, Lars Schwickert, Espen A. F. Ihlen, Michael Schwenk, Ulrich Lindemann, Miriam Meyer, Srijana K.C., Markus A. Hobert, Kathrin Brockmann, Isabel Wurster, Jörn K. Pomper, Matthis Synofzik, Erich Schneider, Uwe Ilg…

    Citation: BMC Neurology 2015 15:192

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  35. Content type: Research article

    Different studies have found diminished cardiac metaiodobenzylguanidine (MIBG) uptake in Lewy body (LB) related conditions (Parkinson’s disease (PD) and Lewy body dementia (LBD)). However, delayed heart/medias...

    Authors: Guillaume Lamotte, Rémy Morello, Adrien Lebasnier, Denis Agostini and Gilles L. Defer

    Citation: BMC Neurology 2015 15:83

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  36. Content type: Study protocol

    Falls amongst people with Parkinson’s (PwP) result in significant disability and reduced quality of life. There is emerging evidence that exercise-based and physiotherapeutic interventions are of benefit for i...

    Authors: Victoria A Goodwin, Ruth Pickering, Claire Ballinger, Helen Roberts, Emma McIntosh, Sarah Lamb, Alice Nieuwboer, Lynn Rochester and Ann Ashburn

    Citation: BMC Neurology 2015 15:81

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  37. Content type: Research article

    Growing body of evidence suggests that Parkinson’s disease (PD) is associated with oxidative damage via iron accumulation in the substantia nigra (SN). Low ceruloplasmin (CP)-ferroxidase activity has been iden...

    Authors: Guillaume Grolez, Caroline Moreau, Bernard Sablonnière, Guillaume Garçon, Jean-Christophe Devedjian, Sayah Meguig, Patrick Gelé, Christine Delmaire, Regis Bordet, Luc Defebvre, Ioav Z Cabantchik and David Devos

    Citation: BMC Neurology 2015 15:74

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  38. Content type: Study protocol

    Motor and non-motor impairments affect quality of life in individuals with Parkinson’s disease. Our preliminary research indicates that forced exercise cycling, a mode of exercise in which a participant’s volu...

    Authors: Anson B Rosenfeldt, Matthew Rasanow, Amanda L Penko, Erik B Beall and Jay L Alberts

    Citation: BMC Neurology 2015 15:63

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  39. Content type: Study protocol

    Parkinson’s disease (PD) is a neurodegenerative disorder with a wide range of motor and non-motor symptoms. Despite optimal medical management, PD still results in a high disability rate and secondary complica...

    Authors: Nicolien M van der Kolk, Sebastiaan Overeem, Nienke M de Vries, Roy PC Kessels, Rogier Donders, Marc Brouwer, Daniela Berg, Bart Post and Bas R Bloem

    Citation: BMC Neurology 2015 15:56

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  40. Content type: Case report

    We peformed a ventral intermediate nucleus (Vim) thalamotomy in a patient with Holmes’ tremor and palatal tremor. The frequencies of these movement disorders were 4 Hz and 3 Hz, respectively. Vim thalamotomy s...

    Authors: Futaba Maki, Sumito Sato, Katsushige Watanabe, Toshiyuki Yanagisawa, Yuta Hagiwara, Takahiro Shimizu and Yasuhiro Hasegawa

    Citation: BMC Neurology 2015 15:26

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  41. Content type: Research article

    Achieving optimal symptom control with minimal side effects is a major goal in clinical practice. Dual-agent dopamine receptor agonist (DA) therapy in Parkinson’s disease (PD) may represent a promising approac...

    Authors: Jong-Min Kim, Sun Ju Chung, Jae Woo Kim, Beom Seok Jeon, Pritibha Singh, Stephan Thierfelder, Junji Ikeda and Lars Bauer

    Citation: BMC Neurology 2015 15:17

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  42. Content type: Research article

    Uric acid has antioxidant effects on neurons. Abnormally high levels of uric acid are, however, associated with gout. Previous studies have suggested that high levels of uric acid (and the presence of gout) ma...

    Authors: Julia Pakpoor, Olena O Seminog, Sreeram V Ramagopalan and Michael J Goldacre

    Citation: BMC Neurology 2015 15:16

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  43. Content type: Study protocol

    Effective treatment of locomotor dysfunction in Parkinson disease (PD) is essential, as gait difficulty is an early and major contributor to disability. Exercise is recommended as an adjunct to traditional tre...

    Authors: Gammon M Earhart, Ryan P Duncan, John L Huang, Joel S Perlmutter and Kristen A Pickett

    Citation: BMC Neurology 2015 15:9

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  44. Content type: Research article

    Recent research has argued that removal of relevant sensory information during the planning and control of simple, self-paced walking can result in increased demand on central processing resources in Parkinson...

    Authors: Frederico Pieruccini-Faria, Kaylena A Ehgoetz Martens, Carolina RA Silveira, Jeffery A Jones and Quincy J Almeida

    Citation: BMC Neurology 2014 14:250

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