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Movement disorders

This section covers all types and aspects of movement disorders. Topics of include, but are not limited to, Parkinson's Disease, transcranial magnetic stimulation, spasticity, dyskinesia, movement disorders, rehabilitation and spinal cord injury.

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  1. Spiral drawing on papers is a common tremor evaluation tool for diagnosing patients with essential tremor (ET) or Parkinson’s disease (PD). No standard drawing methods and parameters that use graphic tablets a...

    Authors: Po-Chieh Lin, Kai-Hsiang Chen, Bing-Shiang Yang and Yu-Jung Chen

    Citation: BMC Neurology 2018 18:25

    Content type: Research article

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  2. Parkinson’s disease is a heterogeneous disorder where genetic factors may underlie clinical variability. Rapid eye movement sleep behavior disorder (RBD) is a parasomnia strongly linked to synucleinopathies, i...

    Authors: Kari Anne Bjørnarå, Lasse Pihlstrøm, Espen Dietrichs and Mathias Toft

    Citation: BMC Neurology 2018 18:20

    Content type: Research article

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  3. Comparisons between neurological conditions have the potential to inform service providers by identifying particular areas of difficulty experienced by affected individuals. This study aimed to identify predic...

    Authors: David Morley, Sarah Dummett, Laura Kelly, Ray Fitzpatrick and Crispin Jenkinson

    Citation: BMC Neurology 2018 18:19

    Content type: Research article

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  4. Transcranial ultrasound is a useful tool for providing the evidences for the early diagnosis and differential diagnosis of Parkinson disease (PD). However, the relationship between hyper echogenicity in substa...

    Authors: Shu-yang Yu, Chen-jie Cao, Li-jun Zuo, Ze-jie Chen, Teng-hong Lian, Fang Wang, Yang Hu, Ying-shan Piao, Li-xia Li, Peng Guo, Li Liu, Qiu-jin Yu, Rui-dan Wang, Piu Chan, Sheng-di Chen, Xiao-min Wang…

    Citation: BMC Neurology 2018 18:9

    Content type: Research article

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  5. Spinocerebellar ataxia (SCA) subtypes are often caused by expansions in non-coding regions of genes like SCA8, SCA10, SCA12 and SCA36. Other ataxias are known to be associated with repeat expansions such as fragi...

    Authors: Gülsah Aydin, Gabriele Dekomien, Sabine Hoffjan, Wanda Maria Gerding, Jörg T. Epplen and Larissa Arning

    Citation: BMC Neurology 2018 18:3

    Content type: Research article

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  6. Individuals with cerebral palsy have smaller muscle volumes normalised to body mass than their typically developing peers. The aim of this study is to investigate the relationship between lower limb muscle vol...

    Authors: Jonathan J. Noble, Emily Chruscikowski, Nicola R. D. Fry, Andrew P. Lewis, Martin Gough and Adam P. Shortland

    Citation: BMC Neurology 2017 17:223

    Content type: Research article

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  7. Evaluation of speech disorders in PD taking into account sociodemographic conditions is not frequent. This paper aims to establish correlations between articulation disorders in PD patients and factors such as...

    Authors: Wioletta Pawlukowska, Karolina Skonieczna-Żydecka, Iwona Rotter, Krystyna Honczarenko and Przemysław Nowacki

    Citation: BMC Neurology 2017 17:221

    Content type: Research article

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  8. Real world data have an important role to play in the evaluation of epidemiology and burden of disease; and in assisting health-care decision-makers, especially related to coverage and payment decisions. Howev...

    Authors: Audrey Tanguy, Linus Jönsson and Lianna Ishihara

    Citation: BMC Neurology 2017 17:213

    Content type: Research article

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  9. The loss of the swallow-tail sign of the substantia nigra has been proposed for diagnosis of Parkinson’s disease. Aim was to evaluate, if the sign occurs consistently in healthy subjects and if it can be relia...

    Authors: Manuel A. Schmidt, Tobias Engelhorn, Franz Marxreiter, Juergen Winkler, Stefan Lang, Stephan Kloska, Philipp Goelitz and Arnd Doerfler

    Citation: BMC Neurology 2017 17:194

    Content type: Research article

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  10. Vacuolar protein sorting 35 (VPS35) was recently reported to be a genetic cause for late-onset autosomal dominant Parkinson’s disease (PD). However, VPS35 mutations are rarely reported in Asian populations. Herei...

    Authors: Ying-Fa Chen, Yung-Yee Chang, Min-Yu Lan, Pei-Lung Chen and Chin-Hsien Lin

    Citation: BMC Neurology 2017 17:191

    Content type: Case report

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  11. Frontotemporal degeneration (FTD) is a clinically and genetically heterogeneous neurodegenerative disorder characterized by deficits in executive function that frequently overlaps with parkinsonism and motor n...

    Authors: Hui-Chi Lin, Chin-Hsien Lin, Pei-Lung Chen, Shih-Jung Cheng and Pei-Hao Chen

    Citation: BMC Neurology 2017 17:186

    Content type: Case report

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  12. Huntington’s disease (HD) is an autosomal dominant disorder, typically characterized by chorea due to a trinucleotide repeat expansion in the HTT gene, although the clinical manifestations of patients with juv...

    Authors: Shi-Shuang Cui, Ru-Jing Ren, Ying Wang, Gang Wang and Sheng-Di Chen

    Citation: BMC Neurology 2017 17:152

    Content type: Case report

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  13. Spinal cord stimulation (SCS) has recently been reported to be effective for truncal postural abnormalities such as camptocormia and Pisa syndrome in Parkinson’s disease. In this case report, we describe a cas...

    Authors: Hisanao Akiyama, Saki Nukui, Masashi Akamatu, Yasuhiro Hasegawa, Osamu Nishikido and Soichiro Inoue

    Citation: BMC Neurology 2017 17:148

    Content type: Case report

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  14. Individuals with Cerebral Palsy (CP) present with sensorimotor dysfunction which make the control and execution of movements difficult. This study aimed to verify the speed-accuracy trade-off in individuals wi...

    Authors: Deborah Cristina Gonçalves Luiz Fernani, Maria Tereza Artero Prado, Talita Dias da Silva, Thais Massetti, Luiz Carlos de Abreu, Fernando Henrique Magalhães, Helen Dawes and Carlos Bandeira de Mello Monteiro

    Citation: BMC Neurology 2017 17:143

    Content type: Research article

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  15. Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism resulting in multifaceted neurological, hepatic, and psychiatric symptoms. The objective of the study was to comparatively assess t...

    Authors: Hanna M. Volpert, Jan Pfeiffenberger, Jan B. Gröner, Wolfgang Stremmel, Daniel N. Gotthardt, Mark Schäfer, Karl Heinz Weiss and Markus Weiler

    Citation: BMC Neurology 2017 17:140

    Content type: Research article

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  16. Parasomnia overlap disorder (POD) is a distinct parasomnia and characterized by concomitant manifestation of rapid-eye-movement (REM)- and non-REM (NREM)-parasomnias. Although not uncommon among patients with ...

    Authors: Panagiotis Bargiotas, Julia Muellner, W.M. Michael Schuepbach and Claudio L. Bassetti

    Citation: BMC Neurology 2017 17:137

    Content type: Case report

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  17. Parkinson’s disease is complicated by comorbidity and polypharmacy, but the extent and patterns of these are unclear. We describe comorbidity and polypharmacy in patients with and without Parkinson’s disease a...

    Authors: Gary McLean, John V. Hindle, Bruce Guthrie and Stewart W. Mercer

    Citation: BMC Neurology 2017 17:126

    Content type: Research article

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  18. Camptocormia is severe flexion of the thoracolumbar spine, exaggerated during standing and walking but minimized in supine position. Even though camptocormia is a relatively common condition during the course ...

    Authors: Yoon Kim, Ahro Kim, Aryun Kim and Beomseok Jeon

    Citation: BMC Neurology 2017 17:118

    Content type: Case report

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  19. Impulse control and related disorders (ICRDs) are clinically complications in Parkinson’s disease (PD). However, the clinical characteristics of ICRDs in Chinese PD patients were rarely reported. We aimed to e...

    Authors: Yu Zhang, An qi He, Lin Li, Wei Chen and Zhen guo Liu

    Citation: BMC Neurology 2017 17:98

    Content type: Research article

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  20. Transcranial magnetic resonance guided focused ultrasound is an emerging technology under evaluation for treatment of essential tremor, a prevalent movement disorder. A qualitative evaluation is performed by a...

    Authors: Fred Tam, Yuexi Huang, Michael L. Schwartz, Tom A. Schweizer, Kullervo Hynynen and Simon J. Graham

    Citation: BMC Neurology 2017 17:74

    Content type: Technical advance

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  21. Down syndrome (DS) has unique physical, motor and cognitive characteristics. Despite cognitive and motor difficulties, there is a possibility of intervention based on the knowledge of motor learning. However, ...

    Authors: Carlos Bandeira de Mello Monteiro, Talita Dias da Silva, Luiz Carlos de Abreu, Felipe Fregni, Luciano Vieira de Araujo, Fernando Henrique Inocêncio Borba Ferreira and Claudio Leone

    Citation: BMC Neurology 2017 17:71

    Content type: Research article

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  22. Periodic leg movements (PLM) during sleep (PLMS) are considered strongly related to restless legs syndrome (RLS), and are associated with polymorphisms in RLS risk genes. Various software for automatic analysi...

    Authors: Ambra Stefani, Anna Heidbreder, Heinz Hackner and Birgit Högl

    Citation: BMC Neurology 2017 17:42

    Content type: Research article

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  23. Complaints of imbalance are common non-resolving signs in individuals with post-concussive syndrome. Yet, there is no consensus rehabilitation for non-resolving balance complaints following mild traumatic brai...

    Authors: Peter C. Fino, Robert J. Peterka, Timothy E. Hullar, Chad Murchison, Fay B. Horak, James C. Chesnutt and Laurie A. King

    Citation: BMC Neurology 2017 17:41

    Content type: Study protocol

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  24. The introduction of deep brain stimulation (DBS) about 25 years ago provided one of the major breakthroughs in the treatment of Parkinson’s disease (PD). However, a high percentage of patients are reluctant to...

    Authors: Lars Dinkelbach, Bettina Möller, Karsten Witt, Alfons Schnitzler and Martin Südmeyer

    Citation: BMC Neurology 2017 17:36

    Content type: Research article

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  25. If people with progressive neurological diseases are to avail of evidence-based rehabilitation, programs found effective in randomized controlled trials (RCT’s) must firstly be adapted and tested in clinical e...

    Authors: Breiffni Leavy, Lydia Kwak, Maria Hagströmer and Erika Franzén

    Citation: BMC Neurology 2017 17:27

    Content type: Study protocol

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  26. Despite the benefits of balance exercise in clinical populations, balance training programs tend to be poorly described, which in turn makes it difficult to evaluate important training components and compare b...

    Authors: David Conradsson, Håkan Nero, Niklas Löfgren, Maria Hagströmer and Erika Franzén

    Citation: BMC Neurology 2017 17:19

    Content type: Research article

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  27. Cerebellar ataxia (CA) is a frequent and often disabling condition that impairs motor functioning and impacts on quality of life (QoL). No medication has yet been proven effective for the symptomatic or even c...

    Authors: Katharina Feil, Christine Adrion, Julian Teufel, Sylvia Bösch, Jens Claassen, Ilaria Giordano, Holger Hengel, Heike Jacobi, Thomas Klockgether, Thomas Klopstock, Wolfgang Nachbauer, Ludger Schöls, Claudia Stendel, Ellen Uslar, Bart van de Warrenburg, Ingrid Berger…

    Citation: BMC Neurology 2017 17:7

    Content type: Study protocol

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  28. Parkinson’s Disease is a progressive neurodegenerative disease, characterized by symptoms of motor impairment, resulting from the loss of dopaminergic neurons in the midbrain, however non-neuronal symptoms are...

    Authors: Anu Planken, Lille Kurvits, Ene Reimann, Liis Kadastik-Eerme, Külli Kingo, Sulev Kõks and Pille Taba

    Citation: BMC Neurology 2017 17:6

    Content type: Research article

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  29. Depression and anxiety remain under-diagnosed and under-treated in those with neurologic diseases such as dementia or Parkinson’s Disease (PD). Our objectives were to first, to provide a synthesis of high qual...

    Authors: Zahra Goodarzi, Bria Mele, Selynne Guo, Heather Hanson, Nathalie Jette, Scott Patten, Tamara Pringsheim and Jayna Holroyd-Leduc

    Citation: BMC Neurology 2016 16:244

    Content type: Research article

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  30. Essential tremor (ET) is characterized by a frequent family history. No monogenic form of ET has been identified. We aimed at exploring ET patients to identify distinct subgroups and facilitate the identificat...

    Authors: Mathilde Renaud, Christophe Marcel, Gabrielle Rudolf, Mickaël Schaeffer, Ouhaïd Lagha-Boukbiza, Jean-Baptiste Chanson, Jamel Chelly, Mathieu Anheim and Christine Tranchant

    Citation: BMC Neurology 2016 16:238

    Content type: Research article

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  31. Myoclonus is a clinical sign characterized by sudden, brief jerky, shock-like involuntary movements of a muscle or group of muscles. Dystonia is defined as a syndrome of sustained muscle contractions, frequent...

    Authors: Guangxun Shen, Guangxian Nan, Chae-Won Shin, Hyeyoung Park, Kwee-Yum Lee and Beomseok Jeon

    Citation: BMC Neurology 2016 16:228

    Content type: Case report

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  32. Belly dancer’s dyskinesia is an extremely rare condition. It manifests as semicontinuous, slow, writhing, sinuous abdominal wall movements that are bothersome to the patient. Management of this condition is ex...

    Authors: Asmahan Alshubaili, Hussam Abou-Al-Shaar, Ponnusamy Santhamoorthy, Hosam Attia and Saeed Bohlega

    Citation: BMC Neurology 2016 16:226

    Content type: Technical advance

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  33. Rapid-onset dystonia-parkinsonism (RDP) is a rare autosomal dominant disorder that is caused by mutations in the ATP1A3 gene and is characterized by an acute onset of asymmetric dystonia and parkinsonism. To d...

    Authors: Yanqiu Liu, Yan Lu, Xinqing Zhang, Shuping Xie, Tingting Wang, Tianwen Wu and Chaoyan Wang

    Citation: BMC Neurology 2016 16:218

    Content type: Case report

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  34. In accordance with German neurosurgical and neurological consensus recommendations, lead placements for deep brain stimulation (DBS) in patients with Parkinson’s disease (PD) are usually performed with the pat...

    Authors: Kajetan L. von Eckardstein, Friederike Sixel-Döring, Stephan Kazmaier, Claudia Trenkwalder, Jason M. Hoover and Veit Rohde

    Citation: BMC Neurology 2016 16:216

    Content type: Case report

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  35. In Parkinson’s disease (PD), cognitive impairment is an important non-motor symptom heralding the development of dementia. Effective treatments to slow down the rate of cognitive decline in PD patients with mi...

    Authors: Sjors C. F. van de Weijer, Annelien A. Duits, Bastiaan R. Bloem, Roy P. Kessels, Jacobus F. A. Jansen, Sebastian Köhler, Gerrit Tissingh and Mark L. Kuijf

    Citation: BMC Neurology 2016 16:209

    Content type: Study protocol

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  36. Parkinson’s disease (PD) is the second commonest neurodegenerative disease in developed countries. Current treatment for PD is pharmacologically focused and can have significant side-effects. There is increasi...

    Authors: Jenny Advocat, Joanne Enticott, Brooke Vandenberg, Craig Hassed, Jennifer Hester and Grant Russell

    Citation: BMC Neurology 2016 16:166

    Content type: Research article

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  37. Droxidopa is an orally active prodrug that significantly improved dizziness/lightheadedness measured using the Orthostatic Hypotension Symptom Assessment (OHSA) Item 1 in patients with neurogenic orthostatic h...

    Authors: Clément François, Gerald J. Rowse, L. Arthur Hewitt, Pamela Vo and Robert A. Hauser

    Citation: BMC Neurology 2016 16:143

    Content type: Research article

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  38. Patients with spinal cord injury (SCI) have a higher prevalence of cardiovascular diseases compared to the healthy population. Aerobic exercise training is one of the recommended treatments. However, literatur...

    Authors: Der-Sheng Han, Ming-Yen Hsiao, Tyng-Guey Wang, Ssu-Yuan Chen and Wei-Shiung Yang

    Citation: BMC Neurology 2016 16:142

    Content type: Research article

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  39. Spinal muscular atrophy (SMA) is the most common autosomal recessive disease in children, and the diagnosis is complicated and difficult, especially at early stage. Early diagnosis of SMA is able to improve th...

    Authors: Zhidai Liu, Penghui Zhang, Xiaoyan He, Shan Liu, Shi Tang, Rong Zhang, Xinbin Wang, Junjie Tan, Bin Peng, Li Jiang, Siqi Hong and Lin Zou

    Citation: BMC Neurology 2016 16:141

    Content type: Research article

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  40. Our study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD (pRBD) in a rural community based on RBD1Q-C and investigate the associ...

    Authors: Jian-Fang Ma, Miao-Miao Hou, Hui-Dong Tang, Xiang Gao, Liang Liang, Li-Fang Zhu, Yi Zhou, Sheng-Yu Zha, Shi-Shuang Cui, Juan-Juan Du, Gen Li, Jun Liu and Sheng-Di Chen

    Citation: BMC Neurology 2016 16:123

    Content type: Research article

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  41. Hemifacial spasm (HFS) is a disabling neurological condition. Vascular tortuosity in HFS patients has not been quantified objectively and its relationship with hypertension and posterior fossa volume (PF) is u...

    Authors: Evan Cyril Edmond, Samantha Xue-Li Sim, Hui-Hua Li, Eng-King Tan and Ling-Ling Chan

    Citation: BMC Neurology 2016 16:120

    Content type: Research article

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  42. This multicenter, double-blind, placebo-controlled study assessed the efficacy of rotigotine transdermal patch on apathy and motor symptoms in patients with Parkinson’s disease (PD).

    Authors: Robert A Hauser, Jaroslaw Slawek, Paolo Barone, Elisabeth Dohin, Erwin Surmann, Mahnaz Asgharnejad and Lars Bauer

    Citation: BMC Neurology 2016 16:90

    Content type: Research article

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  43. There is limited knowledge concerning fall-related activity avoidance in people with Parkinson’s disease (PD); such knowledge would be of importance for the development of more efficient PD-care and rehabilita...

    Authors: Manzur Kader, Susanne Iwarsson, Per Odin and Maria H. Nilsson

    Citation: BMC Neurology 2016 16:84

    Content type: Research article

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