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Movement disorders

This section covers all types and aspects of movement disorders. Topics of include, but are not limited to, Parkinson's Disease, transcranial magnetic stimulation, spasticity, dyskinesia, movement disorders, rehabilitation and spinal cord injury.

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  1. Spinal cord injury (SCI) is a severe neurological disorder associated not only with ongoing medical complications but also with a significant loss of mobility and participation. The introduction of robotic tec...

    Authors: Patrizio Sale, Emanuele Francesco Russo, Michele Russo, Stefano Masiero, Francesco Piccione, Rocco Salvatore Calabrò and Serena Filoni

    Citation: BMC Neurology 2016 16:12

    Content type: Research article

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  2. The trend of decreasing length of stay in rehabilitation facilities has led to individuals with spinal cord injury (SCI) entering the community with unmet needs and fewer self-care skills to prevent secondary ...

    Authors: Sarah E. P. Munce, Fiona Webster, Michael G. Fehlings, Sharon E. Straus, Eunice Jang and Susan B. Jaglal

    Citation: BMC Neurology 2016 16:11

    Content type: Research article

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  3. Impaired mobility and falls are clinically important complications of Parkinson’s disease (PD) and a major detractor from quality of life for which there are limited therapies. Pathological, neuroimaging and c...

    Authors: Martina Mancini, Brett W. Fling, Anne Gendreau, Jodi Lapidus, Fay B. Horak, Kathy Chung and John G. Nutt

    Citation: BMC Neurology 2015 15:264

    Content type: Study protocol

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  4. Dentatorubropallidoluysian atrophy (DRPLA) is a rare autosomal dominant neurodegenerative disease that is associated with numerous movement disorders. Ocular problems also occur with DRPLA with reports of corn...

    Authors: Michael R. Silver, Kapil D. Sethi, Shyamal H. Mehta, Fenwick T. Nichols and John C. Morgan

    Citation: BMC Neurology 2015 15:260

    Content type: Case report

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  5. Parkinson’s disease, the second most common neurodegenerative disease, is diagnostically defined by motor impairments, but also includes often under-recognized impairments in cognition, mood, sleep, and the au...

    Authors: Karen Connor, Eric Cheng, Hilary C. Siebens, Martin L. Lee, Brian S. Mittman, David A. Ganz and Barbara Vickrey

    Citation: BMC Neurology 2015 15:258

    Content type: Study protocol

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  6. Niemann-Pick disease type C (NP-C) is a rare neurovisceral lipid storage disorder characterised by progressive, disabling neurological symptoms and premature death in most patients. During the last decade, nat...

    Authors: Jackie Imrie, Lesley Heptinstall, Stephen Knight and Kate Strong

    Citation: BMC Neurology 2015 15:257

    Content type: Research article

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  7. People with disabilities have reported worse health status than people without disabilities and receiving fewer preventive health services such as counseling around exercise habits. This is noteworthy consider...

    Authors: Lena Zetterberg, Charlotte Urell and Elisabeth Anens

    Citation: BMC Neurology 2015 15:247

    Content type: Research article

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  8. The aim of this study is to investigate if early treatment with levodopa has a beneficial disease modifying effect on Parkinson’s disease (PD) symptoms and functional health, improves the ability to (maintain)...

    Authors: Constant V. M. Verschuur, S. R. Suwijn, B. Post, M. Dijkgraaf, B. R. Bloem, J. J. van Hilten, T. van Laar, G. Tissingh, G. Deuschl, A. E. Lang, R. J. de Haan and R. M. A. de Bie

    Citation: BMC Neurology 2015 15:236

    Content type: Study protocol

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  9. Falls frequency increases with age and particularly in neurogeriatric cohorts. The interplay between eye movements and locomotion may contribute substantially to the occurrence of falls, but is hardly investig...

    Authors: Karin Srulijes, David J. Mack, Jochen Klenk, Lars Schwickert, Espen A. F. Ihlen, Michael Schwenk, Ulrich Lindemann, Miriam Meyer, Srijana K.C., Markus A. Hobert, Kathrin Brockmann, Isabel Wurster, Jörn K. Pomper, Matthis Synofzik, Erich Schneider, Uwe Ilg…

    Citation: BMC Neurology 2015 15:192

    Content type: Study protocol

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  10. Different studies have found diminished cardiac metaiodobenzylguanidine (MIBG) uptake in Lewy body (LB) related conditions (Parkinson’s disease (PD) and Lewy body dementia (LBD)). However, delayed heart/medias...

    Authors: Guillaume Lamotte, Rémy Morello, Adrien Lebasnier, Denis Agostini and Gilles L. Defer

    Citation: BMC Neurology 2015 15:83

    Content type: Research article

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  11. Falls amongst people with Parkinson’s (PwP) result in significant disability and reduced quality of life. There is emerging evidence that exercise-based and physiotherapeutic interventions are of benefit for i...

    Authors: Victoria A Goodwin, Ruth Pickering, Claire Ballinger, Helen Roberts, Emma McIntosh, Sarah Lamb, Alice Nieuwboer, Lynn Rochester and Ann Ashburn

    Citation: BMC Neurology 2015 15:81

    Content type: Study protocol

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  12. Growing body of evidence suggests that Parkinson’s disease (PD) is associated with oxidative damage via iron accumulation in the substantia nigra (SN). Low ceruloplasmin (CP)-ferroxidase activity has been iden...

    Authors: Guillaume Grolez, Caroline Moreau, Bernard Sablonnière, Guillaume Garçon, Jean-Christophe Devedjian, Sayah Meguig, Patrick Gelé, Christine Delmaire, Regis Bordet, Luc Defebvre, Ioav Z Cabantchik and David Devos

    Citation: BMC Neurology 2015 15:74

    Content type: Research article

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  13. Motor and non-motor impairments affect quality of life in individuals with Parkinson’s disease. Our preliminary research indicates that forced exercise cycling, a mode of exercise in which a participant’s volu...

    Authors: Anson B Rosenfeldt, Matthew Rasanow, Amanda L Penko, Erik B Beall and Jay L Alberts

    Citation: BMC Neurology 2015 15:63

    Content type: Study protocol

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  14. Parkinson’s disease (PD) is a neurodegenerative disorder with a wide range of motor and non-motor symptoms. Despite optimal medical management, PD still results in a high disability rate and secondary complica...

    Authors: Nicolien M van der Kolk, Sebastiaan Overeem, Nienke M de Vries, Roy PC Kessels, Rogier Donders, Marc Brouwer, Daniela Berg, Bart Post and Bas R Bloem

    Citation: BMC Neurology 2015 15:56

    Content type: Study protocol

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  15. We peformed a ventral intermediate nucleus (Vim) thalamotomy in a patient with Holmes’ tremor and palatal tremor. The frequencies of these movement disorders were 4 Hz and 3 Hz, respectively. Vim thalamotomy s...

    Authors: Futaba Maki, Sumito Sato, Katsushige Watanabe, Toshiyuki Yanagisawa, Yuta Hagiwara, Takahiro Shimizu and Yasuhiro Hasegawa

    Citation: BMC Neurology 2015 15:26

    Content type: Case report

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  16. Achieving optimal symptom control with minimal side effects is a major goal in clinical practice. Dual-agent dopamine receptor agonist (DA) therapy in Parkinson’s disease (PD) may represent a promising approac...

    Authors: Jong-Min Kim, Sun Ju Chung, Jae Woo Kim, Beom Seok Jeon, Pritibha Singh, Stephan Thierfelder, Junji Ikeda and Lars Bauer

    Citation: BMC Neurology 2015 15:17

    Content type: Research article

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  17. Uric acid has antioxidant effects on neurons. Abnormally high levels of uric acid are, however, associated with gout. Previous studies have suggested that high levels of uric acid (and the presence of gout) ma...

    Authors: Julia Pakpoor, Olena O Seminog, Sreeram V Ramagopalan and Michael J Goldacre

    Citation: BMC Neurology 2015 15:16

    Content type: Research article

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  18. Effective treatment of locomotor dysfunction in Parkinson disease (PD) is essential, as gait difficulty is an early and major contributor to disability. Exercise is recommended as an adjunct to traditional tre...

    Authors: Gammon M Earhart, Ryan P Duncan, John L Huang, Joel S Perlmutter and Kristen A Pickett

    Citation: BMC Neurology 2015 15:9

    Content type: Study protocol

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  19. Recent research has argued that removal of relevant sensory information during the planning and control of simple, self-paced walking can result in increased demand on central processing resources in Parkinson...

    Authors: Frederico Pieruccini-Faria, Kaylena A Ehgoetz Martens, Carolina RA Silveira, Jeffery A Jones and Quincy J Almeida

    Citation: BMC Neurology 2014 14:250

    Content type: Research article

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  20. The Mini-BESTest is a clinical balance test that has shown a high sensitivity in detecting balance impairments in elderly with Parkinson's disease (PD). However, its reproducibility between different raters an...

    Authors: Niklas Löfgren, Emma Lenholm, David Conradsson, Agneta Ståhle and Erika Franzén

    Citation: BMC Neurology 2014 14:235

    Content type: Research article

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  21. Quality of life is poorer in Parkinson’s disease than in other conditions and in the general population without Parkinson’s disease. Malnutrition also results in poorer quality of life. This study aimed at det...

    Authors: Jamie M Sheard, Susan Ash, George D Mellick, Peter A Silburn and Graham K Kerr

    Citation: BMC Neurology 2014 14:212

    Content type: Research article

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  22. Given the increasing emphasis on the community management of spinal cord injury (SCI), strategies that could be developed and implemented in order to empower and engage individuals with SCI in promoting their ...

    Authors: Sarah EP Munce, Michael G Fehlings, Sharon E Straus, Natalia Nugaeva, Eunice Jang, Fiona Webster and Susan B Jaglal

    Citation: BMC Neurology 2014 14:209

    Content type: Research article

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  23. Personality traits are deemed important in many fields of Medicine. The present study aimed at evaluating i) the presence of Sense-of-Coherence (SOC) in patients suffering from Parkinson’s Disease (PD) in comp...

    Authors: Annalisa Gison, Federica Rizza, Stefano Bonassi, Valentina Dall’Armi, Stefania Lisi and Salvatore Giaquinto

    Citation: BMC Neurology 2014 14:193

    Content type: Research article

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  24. Pisa Syndrome or Pleurothotonus is a relatively rare truncal dystonia, characterized by tonic flexion of the trunk and head to one side with slight rotation of the body. Since frequently associated to specific...

    Authors: Pasquale Marchione, Aldo Spallone, Marcella Valente, Cristiano Giannone, Floriana De Angelis and Giuseppe Meco

    Citation: BMC Neurology 2014 14:149

    Content type: Case report

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  25. Ventral intermediate thalamic nucleus (VIM) deep brain stimulation (DBS) is an effective treatment for tremor, but there is limited data on long-term efficacy and mortality after VIM-DBS. Here we report the an...

    Authors: Mari Naumann Børretzen, Silje Bjerknes, Terje Sæhle, Mona Skjelland, Inger Marie Skogseid, Mathias Toft and Espen Dietrichs

    Citation: BMC Neurology 2014 14:120

    Content type: Research article

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  26. Cognitive impairment strikingly reduces the quality of life of Parkinson’s disease (PD) patients. Studies find that pathological proteins, neuroinflammatory factors and free radicals may involve in the pathoge...

    Authors: Shu-yang Yu, Li-jun Zuo, Fang Wang, Ze-jie Chen, Yang Hu, Ya-jie Wang, Xiao-min Wang and Wei Zhang

    Citation: BMC Neurology 2014 14:113

    Content type: Research article

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  27. Parkinson’s disease affects facial, vocal and trunk muscles. As symptoms progress, facial expression becomes masked, limiting the person’s ability to communicate emotions and intentions to others. As people wi...

    Authors: Linda Tickle-Degnen, Marie Saint-Hilaire, Cathi A Thomas, Barbara Habermann, Linda S Sprague Martinez, Norma Terrin, Farzad Noubary and Elena N Naumova

    Citation: BMC Neurology 2014 14:95

    Content type: Study protocol

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  28. Botulinum toxins are considered first-line therapy for treatment of cervical dystonia (CD) and must be injected on a repeat basis. Understanding the duration of clinical benefit of botulinum toxins and its imp...

    Authors: Wallace A Marsh, Deirdre M Monroe, Mitchell F Brin and Conor J Gallagher

    Citation: BMC Neurology 2014 14:91

    Content type: Research article

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  29. Deep brain stimulation (DBS) is an established treatment for patients with advanced parkinson’s disease (PD). Research shows that women are under-represented among patients undergoing DBS surgery. This may be ...

    Authors: Katarina Hamberg and Gun-Marie Hariz

    Citation: BMC Neurology 2014 14:89

    Content type: Research article

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  30. Rapid eye movement (REM) sleep behavior disorder (RBD) is a common parasomnia in Parkinson’s disease (PD) patients. The current International Classification of Sleep Disorders (ICSD-II) requires a clinical int...

    Authors: Maartje Louter, Johan BAM Arends, Bastiaan R Bloem and Sebastiaan Overeem

    Citation: BMC Neurology 2014 14:76

    Content type: Research article

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  31. Multiple tasking is an integral part of daily mobility. Patients with Parkinson’s disease have dual tasking difficulties due to their combined motor and cognitive deficits. Two contrasting physiotherapy interv...

    Authors: Carolien Strouwen, Esther ALM Molenaar, Samyra HJ Keus, Liesbeth Münks, Marten Munneke, Wim Vandenberghe, Bastiaan R Bloem and Alice Nieuwboer

    Citation: BMC Neurology 2014 14:61

    Content type: Study protocol

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  32. Essential tremor (ET) and Parkinson’s disease (PD) are considered distinct disorders. The aim of the study was to look for a link or any distinguishing features by transcranial sonography (TCS), together with ...

    Authors: Kristina Laučkaitė, Daiva Rastenytė, Danguolė Šurkienė, Birutė Vaidelytė, Gabrielė Dambrauskaitė, Andrius Sakalauskas, Antanas Vaitkus and Rymantė Gleiznienė

    Citation: BMC Neurology 2014 14:54

    Content type: Research article

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  33. Current evidence has suggested the need for increased self-management support efforts in spinal cord injury (SCI) to reduce secondary complications. However, current self-management programs may not be suitabl...

    Authors: Sarah EP Munce, Fiona Webster, Michael G Fehlings, Sharon E Straus, Eunice Jang and Susan B Jaglal

    Citation: BMC Neurology 2014 14:48

    Content type: Research article

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  34. Pain is a troublesome non-motor symptom of Parkinson’s disease (PD). The RECOVER (Randomized Evaluation of the 24-hour Coverage: Efficacy of Rotigotine; Clintrials.gov: NCT00474058) study demonstrated signific...

    Authors: Jan Kassubek, Kallol Ray Chaudhuri, Theresa Zesiewicz, Erwin Surmann, Babak Boroojerdi, Kimberly Moran, Liesbet Ghys and Claudia Trenkwalder

    Citation: BMC Neurology 2014 14:42

    Content type: Research article

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  35. Current clinical assessments of motor function in Huntington’s Disease (HD) rely on subjective ratings such as the Unified Huntington’s Disease Rating scale (UHDRS). The ability to track disease progression us...

    Authors: Lucy M Collins, Stanley E Lazic and Roger A Barker

    Citation: BMC Neurology 2014 14:35

    Content type: Research article

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  36. Machado-Joseph disease (MJD), also named spinocerebellar ataxia type 3 (SCA3) is the most common autosomal dominant ataxia worldwide. Although nystagmus is one of the most frequently reported ocular alteration...

    Authors: Mafalda Raposo, João Vasconcelos, Conceição Bettencourt, Teresa Kay, Paula Coutinho and Manuela Lima

    Citation: BMC Neurology 2014 14:17

    Content type: Research article

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  37. Long duration spaceflight (i.e., 22 days or longer) has been associated with changes in sensorimotor systems, resulting in difficulties that astronauts experience with posture control, locomotion, and manual c...

    Authors: Vincent Koppelmans, Burak Erdeniz, Yiri E De Dios, Scott J Wood, Patricia A Reuter-Lorenz, Igor Kofman, Jacob J Bloomberg, Ajitkumar P Mulavara and Rachael D Seidler

    Citation: BMC Neurology 2013 13:205

    Content type: Study protocol

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  38. Recent studies suggest that epigenetic factors may play an important role in the pathogenesis of Parkinson’s disease (PD). In our previous work, we sequenced the exomes of sixteen patients from eight Chinese P...

    Authors: Xin-xin Liao, Zi-xiong Zhan, Ying-ying Luo, Kai Li, Jun-ling Wang, Ji-feng Guo, Xin-xiang Yan, Kun Xia, Bei-sha Tang and Lu Shen

    Citation: BMC Neurology 2013 13:196

    Content type: Research article

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  39. The administration of anesthetics determines depression of the central nervous system and general anesthesia by inhalation may cause an environmental pollution of the operating rooms. It may therefore conceive...

    Authors: Giuseppe Mastrangelo, Vera Comiati, Massimiliano dell’Aquila and Emanuele Zamprogno

    Citation: BMC Neurology 2013 13:194

    Content type: Case report

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  40. Alcohol has been suggested to be either protective of, or not associated with Parkinson’s disease (PD). However, experimental animal studies indicate that chronic heavy alcohol consumption may have dopamine ne...

    Authors: Anna-Karin Eriksson, Sofia Löfving, Russell C Callaghan and Peter Allebeck

    Citation: BMC Neurology 2013 13:190

    Content type: Research article

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  41. Gait impairment is common in people with Parkinson’s disease. There is a lack of effective interventions to target this debilitating complication and therefore a need to identify new therapeutic options. An un...

    Authors: Emily J Henderson, Stephen R Lord, Jacqueline CT Close, Andrew D Lawrence, Alan Whone and Yoav Ben-Shlomo

    Citation: BMC Neurology 2013 13:188

    Content type: Study protocol

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  42. Anti-dementia drugs may improve gait performance. No comparison between acetylcholinesterase inhibitors (CEIs) and memantine-related changes in gait variability has been reported. The objectives of this study ...

    Authors: Olivier Beauchet, Cyrille P Launay, Gazan Allali, Gilles Watfa, Karim Gallouj, François R Herrmann and Cédric Annweiler

    Citation: BMC Neurology 2013 13:184

    Content type: Research article

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  43. Paraneoplastic cerebellar degeneration (PCD) is a classical tumor-associated, immune-mediated disease typically associated with gynecological malignancies, small-cell lung-cancer or lymphoma.

    Authors: Christian Henke, Johannes Rieger, Sylvia Hartmann, Marcus Middendorp, Helmuth Steinmetz and Ulf Ziemann

    Citation: BMC Neurology 2013 13:147

    Content type: Case report

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