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Section edited by Ying Mao 

This section is focused on neurological tumors. Topics of interest include, but are not limited to, clinical diagnosis, pathology and management of neurological tumours as well as basic science and epidemiological studies

  1. Content type: Case report

    Cardiac myxoma is the most common benign cardiac tumor. Brain metastases or multiple cerebral aneurysms are extremely rare, especially for the case of both complications. Brain metastases are usually found at ...

    Authors: Yan Wan, Hai Du, Lei Zhang, Shuang Guo, Li Xu, Yuanyuan Li, Hui He, Lian Zhou, Yunping Chen, Ling Mao, Huijuan Jin and Bo Hu

    Citation: BMC Neurology 2019 19:249

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  2. Content type: Case report

    Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, which is the most common type of autoimmune encephalitis, is caused by the production of autoantibodies against NMDA receptor. Anti-NMDAR encephali...

    Authors: Jie Lu, Ji-hong Zhang, Ai-liang Miao, Jun-xiong Yin, Dong-lin Zhu, Xing-jian Lin, Dao-wen Chen and Jing-ping Shi

    Citation: BMC Neurology 2019 19:210

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  3. Content type: Case report

    Primary central nervous system (CNS) small lymphocytic lymphoma (SLL), as a type of low-grade lymphoma, is extremely rare. The diagnosis of CNS SLL is challenging due to its variable clinical and radiological ...

    Authors: Rongjing Guo, Xiaolong Zhang, Chunxiao Niu, Yibin Xi, Hong Yin, Hong Lin and Ting Chang

    Citation: BMC Neurology 2019 19:200

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  4. Content type: Research article

    The neurofibromatoses (NF) are a group of genetic disorders that interfere negatively with the quality of life (QoL) and influence physical, emotional and social statuses. Studying the effects of neurofibromat...

    Authors: Akram Sanagoo, Leila Jouybari, Fatemeh Koohi and Fatemeh Sayehmiri

    Citation: BMC Neurology 2019 19:123

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  5. Content type: Case report

    Primary central nervous system lymphoma (PCNSL) is the most prevalent brain, spinal cord, eyes, and leptomeningeal lymphoma. It is often misdiagnosed due to an unspecific presentation or unavailable biopsy and...

    Authors: Hui Zhao, Miao Ma, Limin Zhang, Guanghui Zheng, Hong Lv, Jie Liu, Xiao Li, Bei Song and Guojun Zhang

    Citation: BMC Neurology 2019 19:90

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  6. Content type: Case report

    Neuroendocrine tumors represent an expansive group of neoplasms that share an etiology of epithelial origin with neuroendocrine differentiation. Poorly-differentiated neuroendocrine carcinomas behave similarly...

    Authors: Julie R. Bloom, Arlen Brickman, Fan J. Yang, Ji-Weon Park and Jonathan Cheponis

    Citation: BMC Neurology 2019 19:76

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  7. Content type: Case report

    Scattered extracellular deposits of amyloid within the brain parenchyma can be found in a heterogeneous group of diseases. Its condensed accumulation in the white matter without evidence for systemic amyloidos...

    Authors: Mario Löhr, Almuth F. Kessler, Camelia-Maria Monoranu, Jens Grosche, Thomas Linsenmann, Ralf-Ingo Ernestus and Wolfgang Härtig

    Citation: BMC Neurology 2019 19:59

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  8. Content type: Research article

    Frequent somatic mutations of BRAF and CTNNB1 were identified in both histological subtypes of craniopharyngioma (adamantinomatous and papillary) which shed light on target therapy to cure this oncogenic disea...

    Authors: Xi Chen, Yusheng Tong, Zhifeng Shi, Hong Chen, Zhong Yang, Yuanyuan Wang, Liang Chen and Jinhua Yu

    Citation: BMC Neurology 2019 19:6

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  9. Content type: Case report

    Paraneoplastic neurological syndromes (PNS) are rare disorders associated with cancer and are believed to be immune mediated. Patients with autonomic PNS suffer from variable combinations of parasympathetic an...

    Authors: Tatsuya Ueno, Yukihiro Hasegawa, Rie Hagiwara, Tomoya Kon, Jin-ichi Nunomura and Masahiko Tomiyama

    Citation: BMC Neurology 2018 18:189

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  10. Content type: Research article

    Glioma metastasis, invasion, epithelial-mesenchymal transition (EMT) and chemoresistance indicate poor prognosis. Accumulating evidence reveals that Notch1 is an important factor in tumour progression. However...

    Authors: Jianlong Li, Qingbin Li, Lin Lin, Rui Wang, Lingchao Chen, Wenzhong Du, Chuanlu Jiang and Ruiyan Li

    Citation: BMC Neurology 2018 18:133

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  11. Content type: Research article

    Central nervous system (CNS) tuberculoma is a rare disease with severe neurological deficits. This retrospective research is to review the data of patients diagnosed as CNS tuberculoma. Surgeries were performe...

    Authors: Fanfan Chen, Lei Chen, Yongfu Cao, Yongjun Yi, Jingwen Zhuang, Wuhua Le, Wei Xie, Lanbo Tu, Peng Li, Yimin Fang, Ling Li, Yuqing Kou, Kaikai Fu, Hua He and Hongbin Ju

    Citation: BMC Neurology 2018 18:10

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  12. Content type: Case report

    Anterior sacral meningoceles are rare, and usually occur with other malformations of the posterior lower spine. While these are more frequently reported in pediatric cohorts, we report a case in an elderly woman.

    Authors: Anne K. Braczynski, Marc A. Brockmann, Torben Scholz, Jan-Philipp Bach, Jörg B. Schulz and Simone C. Tauber

    Citation: BMC Neurology 2017 17:212

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  13. Content type: Research article

    Tumor location served as an important prognostic factor in glioma patients was considered to postulate molecular features according to cell origin theory. However, anatomic distribution of unique molecular sub...

    Authors: Qisheng Tang, Yuxi Lian, Jinhua Yu, Yuanyuan Wang, Zhifeng Shi and Liang Chen

    Citation: BMC Neurology 2017 17:183

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  14. Content type: Research article

    Juglone is a natural pigment, which has cytotoxic effect against various human tumor cells. However, its cytotoxicity to glioma cells, especially to tumor stem-like cells (TSCs) has not been demonstrated.

    Authors: Jinfeng Wu, Haibo Zhang, Yang Xu, Jingwen Zhang, Wei Zhu, Yi Zhang, Liang Chen, Wei Hua and Ying Mao

    Citation: BMC Neurology 2017 17:70

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  15. Content type: Research article

    The dysregulation of long noncoding RNAs (lncRNAs) has been identified in a variety of cancers. An increasing number of studies have found the critical role of lncRNAs in the regulation of cellular processes, ...

    Authors: Shujun Xia, Ri Ji and Weiwei Zhan

    Citation: BMC Neurology 2017 17:30

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  16. Content type: Research article

    Intracranial vestibular schwannoma still remain to be difficulty for its unique microsurgical technique and preservation of neuro-function, as well as reducing common complications that may arise in surgery.

    Authors: Xiang Huang, Jian Xu, Ming Xu, Mingyu Chen, Kaiyuan Ji, Junwei Ren and Ping Zhong

    Citation: BMC Neurology 2017 17:18

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  17. Content type: Research article

    MicroRNAs are significantly involved in tumorigenesis and progression of glioma. However, the critical part they play in glioma have not been fully elaborated. miR-491 and Tripartite motif containing 28 (TRIM2...

    Authors: Zengxin Qi, Shengyong Cai, Jiajun Cai, Lingchao Chen, Yu Yao, Liang Chen and Ying Mao

    Citation: BMC Neurology 2016 16:248

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  18. Content type: Research article

    We aim to study surgical technique and analyze the related factors affecting tumor total removal and postoperative endocrinological remission for endoscopic endonasal pituitary adenomas surgery.

    Authors: Xuefei Shou, Ming Shen, Qilin Zhang, Yichao Zhang, Wenqiang He, Zengyi Ma, Yao Zhao, Shiqi Li and Yongfei Wang

    Citation: BMC Neurology 2016 16:247

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  19. Content type: Research article

    Paclitaxel-based regimens are frequently associated with the development of peripheral neuropathy. The autonomous nervous system (ANS) effects, however, of this chemotherapeutic agent remain unexplored.

    Authors: Emmanouil V. Dermitzakis, Vasilios K. Kimiskidis, George Lazaridis, Zoi Alexopoulou, Eleni Timotheadou, Alexandros Papanikolaou, Ourania Romanidou, George Georgiadis, Konstantine T. Kalogeras, Iakovos Tsiptsios, Basil Tarlatzis and George Fountzilas

    Citation: BMC Neurology 2016 16:190

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  20. Content type: Research article

    Past studies found that cerebral developmental venous anomaly (DVA) is often concurrent with cavernous malformation (CM). But the reason of the concurrency remains unknown. The purpose of this study was to con...

    Authors: Tengfei Yu, Xing Liu, Xiangjiang Lin, Chuanfeng Bai, Jizong Zhao, Junting Zhang, Liwei Zhang, Zhen Wu, Shuo Wang, Yuanli Zhao and Guolu Meng

    Citation: BMC Neurology 2016 16:183

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  21. Content type: Research article

    Glioblastoma is refractory to conventional treatment, which is combined of surgery, chemotherapy and radiotherapy. Recent studies have shown that glioma initiating cells (GICs) contribute to tumorigenesis and ...

    Authors: Hongxing Ye, Mantao Chen, Fei Cao, Hongguang Huang, Renya Zhan and Xiujue Zheng

    Citation: BMC Neurology 2016 16:178

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  22. Content type: Case report

    Timely diagnosis of meningeal carcinomatosis is often difficult even with the assistant of magnetic resonance imaging examination, cerebrospinal fluid analysis, or both. To the best of our knowledge, gadobutro...

    Authors: Xinfa Pan, Yongfu Lu, Liang Wen, Xiujue Zheng and Yuehui Ma

    Citation: BMC Neurology 2016 16:158

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  23. Content type: Research article

    Urgent referral for suspected central nervous system (CNS) cancer is recommended, but little analysis of the referral criteria diagnostic performance has been conducted. New 2015 NICE guidance recommends direc...

    Authors: Hasan Raza Mohammad, Jeremy Boardman, Laura Howell, Roger J. Mills and Hedley C. A. Emsley

    Citation: BMC Neurology 2016 16:152

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  24. Content type: Research article

    Paraneoplastic syndromes are serious immune caused diseases of the peripheral and/or central nervous system associated with malignant neoplasm. Symptoms develop when antibodies against antigens expressed by tu...

    Authors: Philipp Schwenkenbecher, Lisa Priya Chacko, Ulrich Wurster, Kaweh Pars, Refik Pul, Kurt-Wolfram Sühs, Martin Stangel and Thomas Skripuletz

    Citation: BMC Neurology 2016 16:136

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  25. Content type: Case report

    Lymphomatosis cerebri (LC) is a rare subtype of primary central nervous system malignant lymphoma. The typical features of this disease exhibited on magnetic resonance imaging (MRI) without contrast enhancemen...

    Authors: Takenobu Murakami, Kenji Yoshida, Mari Segawa, Akioh Yoshihara, Akihiko Hoshi, Koichiro Nakamura, Masahiro Ichikawa, Osamu Suzuki, Yuichi Yokoyama, Yasuko Toyoshima, Yoshihiro Sugiura, Hiroshi Ito, Kiyoshi Saito, Yuko Hashimoto, Akiyoshi Kakita, Hitoshi Takahashi…

    Citation: BMC Neurology 2016 16:128

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  26. Content type: Case report

    Circulating Tumor Cells (CTCs) are promising biomarkers for monitoring solid cancer and were used to monitor brain tumors. Here we report two cases in which, for the first time, CTCs were used in cytological d...

    Authors: N. Malara, G. Guzzi, C. Mignogna, V. Trunzo, C. Camastra, A. Della Torre, A. Di Vito, A. M. Lavecchia, M. Gliozzi, C. Ceccotti, G. Volpentesta, A. Lavano, G. Donato and V Mollace

    Citation: BMC Neurology 2016 16:127

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  27. Content type: Research article

    Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been shown to be effective and safe in the treatment of subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex (...

    Authors: Andras Fogarasi, Liesbeth De Waele, Gabriella Bartalini, Sergiusz Jozwiak, Nicola Laforgia, Helene Verhelst, Borivoj Petrak, Jean-Michel Pedespan, Olaf Witt, Ramon Castellana, Stefania Crippa, Gabriella Gislimberti and Zsuzsanna Gyorsok

    Citation: BMC Neurology 2016 16:126

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  28. Content type: Case report

    Medulloblastoma is the most common malignant brain tumor in children. To date only few cases of medulloblastoma with hemorrhages have been reported in the literature. Although some studies speculate on the pat...

    Authors: Angela Di Giannatale, Andrea Carai, Antonella Cacchione, Antonio Marrazzo, Vito Andrea Dell’Anna, Giovanna Stefania Colafati, Francesca Diomedi-Camassei, Evelina Miele, Agnese Po, Elisabetta Ferretti, Franco Locatelli and Angela Mastronuzzi

    Citation: BMC Neurology 2016 16:103

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  29. Content type: Case report

    It is extremely rare to see cerebrospinal fluid dissemination of intraventricular meningioma, particularly with the development of acute, progressive brainstem/cerebellar dysfunction with an absence of mass fo...

    Authors: Motoki Fujimaki, Masashi Takanashi, Manami Kobayashi, Kei-ichiro Wada, Yutaka Machida, Akihide Kondo, Nobutaka Hattori and Hideto Miwa

    Citation: BMC Neurology 2016 16:82

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  30. Content type: Case report

    Primary central nervous system lymphoma (PCNSL) may rarely be preceded by “sentinel demyelination,” a pathologic entity characterized by histologically confirmed demyelinating inflammatory brain lesions that m...

    Authors: Mark D. Kvarta, Deva Sharma, Rudolph J. Castellani, Robert E. Morales, Stephen G. Reich, Amy S. Kimball and Robert K. Shin

    Citation: BMC Neurology 2016 16:72

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  31. Content type: Research article

    Patients with intravascular lymphoma (IVL) frequently have neurological signs and symptoms. Prompt diagnosis and treatment is therefore crucial for their survival. However, the spectrum of neurological present...

    Authors: Ekokobe Fonkem, Samantha Dayawansa, Edana Stroberg, Edwin Lok, Paul C. Bricker, Batool Kirmani, Eric T. Wong and Jason H. Huang

    Citation: BMC Neurology 2016 16:9

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  32. Content type: Study protocol

    Radiotherapy is one of the most important treatments of primary and metastatic brain tumors. Unfortunately, it can involve moderate to severe complications among which leukoencephalopathy is very frequent and ...

    Authors: Thomas Durand, Sophie Jacob, Laura Lebouil, Hassen Douzane, Philippe Lestaevel, Amithys Rahimian, Dimitri Psimaras, Loïc Feuvret, Delphine Leclercq, Bruno Brochet, Radia Tamarat, Fabien Milliat, Marc Benderitter, Nicolas Vayatis, Georges Noël, Khê Hoang-Xuan…

    Citation: BMC Neurology 2015 15:261

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  33. Content type: Case report

    Primary diffuse leptomeningeal gliomatosis (PDLG) is a lethal neoplasm that is characterized by glioma cells exclusively infiltrating into cerebral and spinal meninges. Intraventricular hemorrhage as an initia...

    Authors: Min Zhu, JunJun Zheng, Yuanzhao Zhu, Hui Wan, Yuchen Wu and Daojun Hong

    Citation: BMC Neurology 2015 15:77

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  34. Content type: Case report

    Extraventricular neurocytomas (EVNs) are rare parenchymal brain tumors, distinct from central neurocytomas that are typically located within the supratentorial ventricular system. Seizures and headache represe...

    Authors: Raffaella Messina, Maria Giuseppina Cefalo, Domitilla Elena Secco, Simona Cappelletti, Erika Rebessi, Andrea Carai, Giovanna Stefania Colafati, Francesca Diomedi Camassei, Antonella Cacchione, Carlo Efisio Marras and Angela Mastronuzzi

    Citation: BMC Neurology 2014 14:242

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  35. Content type: Research article

    SOX4 is a transcription factor required for tissue development and differentiation in vertebrates. Overexpression of SOX4 has been reported in many cancers including glioblastoma multiforme (GBM), however, the...

    Authors: Jing Zhang, Huawei Jiang, Jiaofang Shao, Ruifang Mao, Jie Liu, Yingying Ma, Xuefeng Fang, Na Zhao, Shu Zheng and Biaoyang Lin

    Citation: BMC Neurology 2014 14:207

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  36. Content type: Case report

    Intracranial hemorrhage in central nervous system lymphoma is extremely rare. T2*-weighted gradient-echo magnetic resonance imaging is of particularly use in detecting silent hemorrhage as hypointense signals ...

    Authors: Xun-zhe Yang, Jun Ni and Li-ying Cui

    Citation: BMC Neurology 2014 14:184

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  37. Content type: Study protocol

    Epilepsy is common in patients with a glioma. Antiepileptic drugs (AEDs) are the mainstay of epilepsy treatment, but may cause side effects and may negatively impact neurocognitive functioning and quality of l...

    Authors: Johan A F Koekkoek, Melissa Kerkhof, Linda Dirven, Jan J Heimans, Tjeerd J Postma, Maaike J Vos, Jacoline E C Bromberg, Martin J van den Bent, Jaap C Reijneveld and Martin J B Taphoorn

    Citation: BMC Neurology 2014 14:157

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  38. Content type: Study protocol

    Among glioma patients, depression is estimated to be more prevalent than in both the general population and the cancer patient population. This can have negative consequences for both patients and their primar...

    Authors: Florien W Boele, Irma M Verdonck-de Leeuw, Pim Cuijpers, Jaap C Reijneveld, Jan J Heimans and Martin Klein

    Citation: BMC Neurology 2014 14:81

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  39. Content type: Case report

    The Mulvihill-Smith Syndrome was first recognized in 1975. After the recognition of the Mulvihill-Smith Syndrome, ten cases have been described.

    Authors: Paulo Breinis, Flavio Geraldes Alves, Camila AE Alves, Rafael G Cintra, Débora Almeida, Priscila C Passarelli, Camila Domingues, Talita Gerbim, Régia Gasparetto, Luiz Carlos de Abreu, Vitor E Valenti, Adriana Gonçalves de Oliveira, Carlos Bandeira de Mello Monteiro and Rubens Wajnzstejn

    Citation: BMC Neurology 2014 14:4

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  40. Content type: Study protocol

    Many brain-injured patients referred for outpatient rehabilitation have executive deficits, notably difficulties with planning, problem-solving and goal directed behaviour. Goal Management Training (GMT) has p...

    Authors: Dirk Bertens, Luciano Fasotti, Danielle HE Boelen and Roy PC Kessels

    Citation: BMC Neurology 2013 13:64

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