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Neuro-oncology

This section is focused on neurological tumors. Topics of interest include, but are not limited to, clinical diagnosis, pathology and management of neurological tumours as well as basic science and epidemiological studies

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  1. Erdheim–Chester disease (ECD) is a non-Langerhans histiocytosis that results in multi-organ disease involving the skin, bones, lungs and kidneys. Central nervous system (CNS) involvement occurs in about 50 % o...

    Authors: Pedro Gustavo Barros Rodrigues, Isabelle de Sousa Pereira, Valter Barbalho Lima Filho, Daniel Aguiar Dias, Paulo Ribeiro Nóbrega and Pedro Braga-Neto

    Citation: BMC Neurology 2021 21:81

    Content type: Case report

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  2. Chronic lymphocytic infiltration with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a neuro-inflammatory syndrome first described in 2010. It has a relationship with lymphoproliferative...

    Authors: Yew Li Dang, Hong Kuan Kok, Penelope A. McKelvie, Matthew Ligtermoet, Laura Maddy, David A. Burrows and Douglas E. Crompton

    Citation: BMC Neurology 2021 21:80

    Content type: Case report

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  3. Cerebral radiation injury, including subacute radiation reactions and later stage radiation necrosis, is a severe side effect of brain tumor radiotherapy. A protocol of four infusions of the monoclonal antibod...

    Authors: Martin Voss, Katharina J. Wenger, Emmanouil Fokas, Marie-Thérèse Forster, Joachim P. Steinbach and Michael W. Ronellenfitsch

    Citation: BMC Neurology 2021 21:77

    Content type: Research article

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  4. Symplastic hemangioma is a benign superficial abnormal buildup of blood vessels, with morphological features which can mimic a pseudo malignancy. A few cases have been reported in the literature. We report her...

    Authors: Najwa Abdalkabeer A. Bantan, Ahmed H. Abouissa, Muhammad Saeed, Mustafa Hassan Alwalily, Kamal Bakour Balkhoyour, Khalid Mohammad Ashour, Amal Ali Hassan, Afnan Hisham Falemban and Mohiuddin M. Taher

    Citation: BMC Neurology 2021 21:29

    Content type: Case report

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  5. Meningiomas are the most common benign intracranial tumors, and commonly comprise high-vascularizing but slow-growing tumors. On the other hand, meningiomas arising from the ventricular system are of rare occu...

    Authors: Koichiro Sumi, Takeshi Suma, Reona Yoshida, Ryuta Kajimoto, Masato Kobayashi, Takamichi Katsuhara, Koki Hirayama, Xiaoyan Tang, Naoki Otani and Atsuo Yoshino

    Citation: BMC Neurology 2021 21:25

    Content type: Case report

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  8. Germinomas (IG) account for up to 50% of all intracranial germ cell tumours. These tumours are reputed to be more prevalent in Oriental populations in comparison to Western cohorts. Biological characteristics ...

    Authors: Sharon Yin Yee Low, He Cheng, Ruiyang Zou, Lee Ping Ng, Chik Hong Kuick, Nurfarhanah Bte Syed Sulaiman, Kenneth Tou En Chang, David Chyi Yeu Low, Lihan Zhou and Wan Tew Seow

    Citation: BMC Neurology 2020 20:415

    Content type: Research article

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  9. Glioblastoma (GBM) is known for its devastating intracranial infiltration and its unfavorable prognosis, while extracranial involvement is a very rare event, more commonly attributed to IDH wild-type (primary)...

    Authors: Jessica Rossi, Lucia Giaccherini, Francesco Cavallieri, Manuela Napoli, Claudio Moratti, Elisabetta Froio, Silvia Serra, Alessandro Fraternali, Reza Ghadirpour, Salvatore Cozzi, Patrizia Ciammella, Corrado Iaccarino, Rosario Pascarella, Franco Valzania and Anna Pisanello

    Citation: BMC Neurology 2020 20:382

    Content type: Case report

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  10. Paraneoplastic cerebellar degeneration (PCD) is a devastating paraneoplastic syndrome that occasionally occurs in patients with Hodgkin lymphoma (HL). Anti-Ma2 is a well-characterized onconeuronal antibody and...

    Authors: Ryoma Inui, Kenki Saito, Yoshimitsu Shimomura, Daisuke Yamashita, Michi Kawamoto and Takayuki Ishikawa

    Citation: BMC Neurology 2020 20:355

    Content type: Case report

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  11. The Centers for Medicare and Medicaid Services (CMS) created a new reimbursement model “Bundled Payment for Care Improvement (BPCI)” which reimburses providers a predetermined payment in advance to cover all p...

    Authors: Zaid Aljuboori, Beatrice Ugiliweneza, Dengzhi Wang, Norberto Andaluz, Maxwell Boakye and Brian Williams

    Citation: BMC Neurology 2020 20:312

    Content type: Research article

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  12. Age is associated with the prognosis of glioma patients, but there is no uniform standard of age-group classification to evaluate the prognosis of glioma patients. In this study, we aimed to establish an age g...

    Authors: Zhiying Lin, Runwei Yang, Kaishu Li, Guozhong Yi, Zhiyong Li, Jinglin Guo, Zhou Zhang, Peng Junxiang, Yawei Liu, Songtao Qi and Guanglong Huang

    Citation: BMC Neurology 2020 20:310

    Content type: Research article

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  13. Perioperative cerebrospinal fluid (CSF) leakage is a major complication of pituitary adenomas transsphenoidal surgery. Lumbar drainage (LD) is a common method of treating CSF leakage. But whether intraoperativ...

    Authors: Jiahe Tan, Rui Song, Renzheng Huan, Ning Huang and Jin Chen

    Citation: BMC Neurology 2020 20:303

    Content type: Research article

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  15. The ultrasound based non-invasive ICP measurement method has been recently validated. Correlation of symptoms and signs of intracranial hypertension with actual ICP measurements in patients with large intracra...

    Authors: Jenny C. Kienzler, Rolandas Zakelis, Serge Marbacher, Sabrina Bäbler, Lucia Schwyzer, Elke Remonda and Javier Fandino

    Citation: BMC Neurology 2020 20:268

    Content type: Research article

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  17. The aim of this study was to assess the cognitive function of patients over 60 years old with meningioma using a domain-specific neuropsychological test and to investigate the relevant factors affecting pre-op...

    Authors: Min Ju Kang, Jung-Min Pyun, Min Jae Baek, Kihwan Hwang, Jung Ho Han, Young Ho Park, Chae-Yong Kim and SangYun Kim

    Citation: BMC Neurology 2020 20:225

    Content type: Research article

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  19. Glioblastoma multiforme (GBM) is one of the most aggressive malignant brain tumors. Intracranial GBM metastases to the spine are rarely detected clinically. Secondary gliosarcomas after treatment of primary GB...

    Authors: Bing-Hung Hsu, Wei-Hwa Lee, Shun-Tai Yang, Cheng-Ta Han and Yuan-Yun Tseng

    Citation: BMC Neurology 2020 20:178

    Content type: Case report

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  20. Parasellar meningioma is a common benign tumour in brain. Both surgery and radiosurgery are important treatment modalities for this tumour. The study was designed to investigate whether prior surgery would aff...

    Authors: Yan-jia Hu, Yue-bing Xie, Li-feng Zhang, Chang Ding and Jing Chen

    Citation: BMC Neurology 2020 20:153

    Content type: Research article

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  21. Infratentorial craniotomy patients have a high incidence of postoperative nausea and vomiting (PONV). Enhanced Recovery After Surgery (ERAS) protocols have been shown in...

    Authors: Dan Lu, Yuan Wang, Tianzhi Zhao, Bolin Liu, Lin Ye, Lanfu Zhao, Binfang Zhao, Mingjuan Li, Lin Ma, Zhengmin Li, Jiangtao Niu, Wenhai Lv, Yufu Zhang, Tao Zheng, Yafei Xue, Lei Chen…

    Citation: BMC Neurology 2020 20:150

    Content type: Research article

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    The Retraction Note to this article has been published in BMC Neurology 2020 20:448

  22. Cavernous hemangioma of the orbit is a benign tumor mostly located behind the eye globe, but it rarely spread into the brain, which is called cerebral cavernous malformation as well, the lesion in the brain is...

    Authors: Xingping Qin, Farhana Akter, Lingxia Qin, Qiurong Xie, Yanfei Li, Hongkuan Yang, Xin Li, Guo Zhang, Songlin Wu and Renzhong Liu

    Citation: BMC Neurology 2020 20:149

    Content type: Case report

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  24. A new type of epileptogenic tumor, the polymorphous low-grade neuroepithelial tumor of the young (PLNTY) was firstly reported by Jason T. Huse et al. at 2016. After that, only 1 case of PLNTY was reported by a...

    Authors: Yingqian Chen, Tian Tian, Xinwen Guo, Fenfen Zhang, Miao Fan, Huawei Jin and Dawei Liu

    Citation: BMC Neurology 2020 20:123

    Content type: Case report

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  25. Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disorder arising from mutations of the MEN1 tumor suppressor gene on chromosome 11q13; MEN1 is characterized by the development of neuroe...

    Authors: Hongjuan Zheng, Shishi Zhou, Wanfen Tang, Qinghua Wang, Xia Zhang, Xiayun Jin, Ying Yuan and Jianfei Fu

    Citation: BMC Neurology 2020 20:76

    Content type: Case report

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  26. Family caregivers of elderly patients with spinal tumours experience considerable pain and burden during the care process. This study aims to investigate the factors associated with caregiver burden in family ...

    Authors: Jing Luo, Yongchun Zhou, Haiping Liu and Jing Hu

    Citation: BMC Neurology 2020 20:69

    Content type: Research article

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  27. Human leukocyte antigen-E (HLA-E) has been extensively investigated in various human cancers including glioma. However, the clinical significance of HLA-E expression in glioma patients has not been elucidated....

    Authors: Zhifeng Wu, Jingshan Liang, Zheng Wang, Aimin Li, Xing Fan and Tao Jiang

    Citation: BMC Neurology 2020 20:59

    Content type: Research article

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  28. Perineuriomas are rare benign peripheral nerve sheath tumours of perineurial cell origin and can be classified into intraneural and extraneural perineuriomas. They most commonly present a mononeuropathy of gra...

    Authors: Anne-Kathrin Uerschels, Christos Krogias, Andreas Junker, Ulrich Sure, Karsten H. Wrede and Oliver Gembruch

    Citation: BMC Neurology 2020 20:55

    Content type: Research article

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  29. The medical imaging to differentiate World Health Organization (WHO) grade II (ODG2) from III (ODG3) oligodendrogliomas still remains a challenge. We investigated whether combination of machine leaning with ra...

    Authors: Sha-Sha Zhao, Xiu-Long Feng, Yu-Chuan Hu, Yu Han, Qiang Tian, Ying-Zhi Sun, Jie Zhang, Xiang-Wei Ge, Si-Chao Cheng, Xiu-Li Li, Li Mao, Shu-Ning Shen, Lin-Feng Yan, Guang-Bin Cui and Wen Wang

    Citation: BMC Neurology 2020 20:48

    Content type: Research article

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  30. Progressive spinal deformity has become a well-recognized complication of intracanal tumors resection. However, the factors affecting post-operative spinal stability remain to be further research. Here, we des...

    Authors: Pangbo Wang, Kang Ma, Tunan Chen, Xingsen Xue, Dada Ma, Shi Wang, Xin Chen, Hui Meng, Gaoyu Cui, Boyuan Gao, Jiangkai Lin, Hua Feng and Weihua Chu

    Citation: BMC Neurology 2020 20:34

    Content type: Research article

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  31. Pleomorphic xanthoastrocytoma (PXA) is a rare astrocytic glioma, characterized by large pleomorphic and frequently multinucleated cells, spindle and lipidized cells, a dense pericellular reticulin network, and...

    Authors: Noriyuki Watanabe, Eiichi Ishikawa, Hidehiro Kohzuki, Noriaki Sakamoto, Alexander Zaboronok, Masahide Matsuda, Makoto Shibuya and Akira Matsumura

    Citation: BMC Neurology 2020 20:21

    Content type: Case report

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  32. According to the new WHO classification from 2016, molecular profiles have shown to provide reliable information about prognosis and treatment response. The purpose of our study is to evaluate the diagnostic p...

    Authors: Maike Kern, Timo Alexander Auer, Thomas Picht, Martin Misch and Edzard Wiener

    Citation: BMC Neurology 2020 20:8

    Content type: Research article

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  33. Many peripheral blood biomarkers are associated with glioma grade, but eosinophils (Eo) are scarcely reported. This study assessed preoperative peripheral eosinophil levels and other peripheral biomarkers pres...

    Authors: Zhenxing Huang, Liang Wu, Zonggang Hou, Pengfei Zhang, Gen Li and Jian Xie

    Citation: BMC Neurology 2019 19:313

    Content type: Research article

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  34. Primary central nervous system lymphoma (PCNSL) is a rare, malignant, non-Hodgkin’s lymphoma of the brain, leptomeninges, and rarely the spinal cord. PCNSL has characteristic magnetic resonance imaging (MRI) f...

    Authors: Seung-Ho Jeon, Mi-Kyoung Kang, Seung Jae Lee, Byoung-Soo Shin and Hyun Goo Kang

    Citation: BMC Neurology 2019 19:311

    Content type: Case report

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  36. Paraneoplastic limbic encephalitis (PLE) is a rare autoimmune neurological syndrome observed in cancer patients. PLE is difficult to diagnose and presents a variable response to treatment, depending on the cha...

    Authors: Raffaele Longo, Marc Wagner, Benjamin Savenkoff, Mathilde Chastenet de Castaing, Guillaume Desiro, Zead Tubail, Laurent Hennequin, Sinan Ben Mahmoud, Nathalie Marcon, Philippe Quetin, Marco Campitiello and Francesca Plastino

    Citation: BMC Neurology 2019 19:304

    Content type: Case report

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  37. Glioma is the most common primary malignant brain tumor with high mortality and poor prognosis. Our aim was to clarify the correlation between Kinase-anchored protein 6 (AKAP6) gene polymorphisms and glioma susce...

    Authors: Ming Zhang, Yonglin Zhao, Junjie Zhao, Tingqin Huang and Yuan Wu

    Citation: BMC Neurology 2019 19:296

    Content type: Research article

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  39. Secondary central nervous system lymphoma (SCNSL) is defined as secondary central nervous system (CNS) involvement in patients with systemic lymphoma. It is considered a profoundly adverse complication with in...

    Authors: Yuchen Wu, Yaming Wang, Xuefei Sun, Xueyan Bai, Jun Qian, Hong Zhu, Qu Cui, Ruixian Xing, Yuedan Chen, Qing Liu, Jiayuan Guo, Nan Ji, Shengjun Sun and Yuanbo Liu

    Citation: BMC Neurology 2019 19:268

    Content type: Research article

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  40. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory disorder in the central nervous system (CNS) with distinct clinical, radiological, an...

    Authors: Xiao-hang Liu, Fan Jin, Meng Zhang, Mei-xi Liu, Tao Wang, Bo-ju Pan and Lu Zhang

    Citation: BMC Neurology 2019 19:266

    Content type: Case report

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  41. Cardiac myxoma is the most common benign cardiac tumor. Brain metastases or multiple cerebral aneurysms are extremely rare, especially for the case of both complications. Brain metastases are usually found at ...

    Authors: Yan Wan, Hai Du, Lei Zhang, Shuang Guo, Li Xu, Yuanyuan Li, Hui He, Lian Zhou, Yunping Chen, Ling Mao, Huijuan Jin and Bo Hu

    Citation: BMC Neurology 2019 19:249

    Content type: Case report

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  42. Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, which is the most common type of autoimmune encephalitis, is caused by the production of autoantibodies against NMDA receptor. Anti-NMDAR encephali...

    Authors: Jie Lu, Ji-hong Zhang, Ai-liang Miao, Jun-xiong Yin, Dong-lin Zhu, Xing-jian Lin, Dao-wen Chen and Jing-ping Shi

    Citation: BMC Neurology 2019 19:210

    Content type: Case report

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  43. Primary central nervous system (CNS) small lymphocytic lymphoma (SLL), as a type of low-grade lymphoma, is extremely rare. The diagnosis of CNS SLL is challenging due to its variable clinical and radiological ...

    Authors: Rongjing Guo, Xiaolong Zhang, Chunxiao Niu, Yibin Xi, Hong Yin, Hong Lin and Ting Chang

    Citation: BMC Neurology 2019 19:200

    Content type: Case report

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  46. The neurofibromatoses (NF) are a group of genetic disorders that interfere negatively with the quality of life (QoL) and influence physical, emotional and social statuses. Studying the effects of neurofibromat...

    Authors: Akram Sanagoo, Leila Jouybari, Fatemeh Koohi and Fatemeh Sayehmiri

    Citation: BMC Neurology 2019 19:123

    Content type: Research article

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  47. Primary central nervous system lymphoma (PCNSL) is the most prevalent brain, spinal cord, eyes, and leptomeningeal lymphoma. It is often misdiagnosed due to an unspecific presentation or unavailable biopsy and...

    Authors: Hui Zhao, Miao Ma, Limin Zhang, Guanghui Zheng, Hong Lv, Jie Liu, Xiao Li, Bei Song and Guojun Zhang

    Citation: BMC Neurology 2019 19:90

    Content type: Case report

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  48. Neuroendocrine tumors represent an expansive group of neoplasms that share an etiology of epithelial origin with neuroendocrine differentiation. Poorly-differentiated neuroendocrine carcinomas behave similarly...

    Authors: Julie R. Bloom, Arlen Brickman, Fan J. Yang, Ji-Weon Park and Jonathan Cheponis

    Citation: BMC Neurology 2019 19:76

    Content type: Case report

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  49. Scattered extracellular deposits of amyloid within the brain parenchyma can be found in a heterogeneous group of diseases. Its condensed accumulation in the white matter without evidence for systemic amyloidos...

    Authors: Mario Löhr, Almuth F. Kessler, Camelia-Maria Monoranu, Jens Grosche, Thomas Linsenmann, Ralf-Ingo Ernestus and Wolfgang Härtig

    Citation: BMC Neurology 2019 19:59

    Content type: Case report

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