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Neuro-oncology

Section edited by Ying Mao 

This section is focused on neurological tumors. Topics of interest include, but are not limited to, clinical diagnosis, pathology and management of neurological tumours as well as basic science and epidemiological studies

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  1. Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disorder arising from mutations of the MEN1 tumor suppressor gene on chromosome 11q13; MEN1 is characterized by the development of neuroe...

    Authors: Hongjuan Zheng, Shishi Zhou, Wanfen Tang, Qinghua Wang, Xia Zhang, Xiayun Jin, Ying Yuan and Jianfei Fu

    Citation: BMC Neurology 2020 20:76

    Content type: Case report

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  2. Family caregivers of elderly patients with spinal tumours experience considerable pain and burden during the care process. This study aims to investigate the factors associated with caregiver burden in family ...

    Authors: Jing Luo, Yongchun Zhou, Haiping Liu and Jing Hu

    Citation: BMC Neurology 2020 20:69

    Content type: Research article

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  3. Human leukocyte antigen-E (HLA-E) has been extensively investigated in various human cancers including glioma. However, the clinical significance of HLA-E expression in glioma patients has not been elucidated....

    Authors: Zhifeng Wu, Jingshan Liang, Zheng Wang, Aimin Li, Xing Fan and Tao Jiang

    Citation: BMC Neurology 2020 20:59

    Content type: Research article

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  4. Perineuriomas are rare benign peripheral nerve sheath tumours of perineurial cell origin and can be classified into intraneural and extraneural perineuriomas. They most commonly present a mononeuropathy of gra...

    Authors: Anne-Kathrin Uerschels, Christos Krogias, Andreas Junker, Ulrich Sure, Karsten H. Wrede and Oliver Gembruch

    Citation: BMC Neurology 2020 20:55

    Content type: Research article

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  5. The medical imaging to differentiate World Health Organization (WHO) grade II (ODG2) from III (ODG3) oligodendrogliomas still remains a challenge. We investigated whether combination of machine leaning with ra...

    Authors: Sha-Sha Zhao, Xiu-Long Feng, Yu-Chuan Hu, Yu Han, Qiang Tian, Ying-Zhi Sun, Jie Zhang, Xiang-Wei Ge, Si-Chao Cheng, Xiu-Li Li, Li Mao, Shu-Ning Shen, Lin-Feng Yan, Guang-Bin Cui and Wen Wang

    Citation: BMC Neurology 2020 20:48

    Content type: Research article

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  6. Progressive spinal deformity has become a well-recognized complication of intracanal tumors resection. However, the factors affecting post-operative spinal stability remain to be further research. Here, we des...

    Authors: Pangbo Wang, Kang Ma, Tunan Chen, Xingsen Xue, Dada Ma, Shi Wang, Xin Chen, Hui Meng, Gaoyu Cui, Boyuan Gao, Jiangkai Lin, Hua Feng and Weihua Chu

    Citation: BMC Neurology 2020 20:34

    Content type: Research article

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  7. Pleomorphic xanthoastrocytoma (PXA) is a rare astrocytic glioma, characterized by large pleomorphic and frequently multinucleated cells, spindle and lipidized cells, a dense pericellular reticulin network, and...

    Authors: Noriyuki Watanabe, Eiichi Ishikawa, Hidehiro Kohzuki, Noriaki Sakamoto, Alexander Zaboronok, Masahide Matsuda, Makoto Shibuya and Akira Matsumura

    Citation: BMC Neurology 2020 20:21

    Content type: Case report

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  8. According to the new WHO classification from 2016, molecular profiles have shown to provide reliable information about prognosis and treatment response. The purpose of our study is to evaluate the diagnostic p...

    Authors: Maike Kern, Timo Alexander Auer, Thomas Picht, Martin Misch and Edzard Wiener

    Citation: BMC Neurology 2020 20:8

    Content type: Research article

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  9. Many peripheral blood biomarkers are associated with glioma grade, but eosinophils (Eo) are scarcely reported. This study assessed preoperative peripheral eosinophil levels and other peripheral biomarkers pres...

    Authors: Zhenxing Huang, Liang Wu, Zonggang Hou, Pengfei Zhang, Gen Li and Jian Xie

    Citation: BMC Neurology 2019 19:313

    Content type: Research article

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  10. Primary central nervous system lymphoma (PCNSL) is a rare, malignant, non-Hodgkin’s lymphoma of the brain, leptomeninges, and rarely the spinal cord. PCNSL has characteristic magnetic resonance imaging (MRI) f...

    Authors: Seung-Ho Jeon, Mi-Kyoung Kang, Seung Jae Lee, Byoung-Soo Shin and Hyun Goo Kang

    Citation: BMC Neurology 2019 19:311

    Content type: Case report

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  11. Paraneoplastic limbic encephalitis (PLE) is a rare autoimmune neurological syndrome observed in cancer patients. PLE is difficult to diagnose and presents a variable response to treatment, depending on the cha...

    Authors: Raffaele Longo, Marc Wagner, Benjamin Savenkoff, Mathilde Chastenet de Castaing, Guillaume Desiro, Zead Tubail, Laurent Hennequin, Sinan Ben Mahmoud, Nathalie Marcon, Philippe Quetin, Marco Campitiello and Francesca Plastino

    Citation: BMC Neurology 2019 19:304

    Content type: Case report

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  12. Glioma is the most common primary malignant brain tumor with high mortality and poor prognosis. Our aim was to clarify the correlation between Kinase-anchored protein 6 (AKAP6) gene polymorphisms and glioma susce...

    Authors: Ming Zhang, Yonglin Zhao, Junjie Zhao, Tingqin Huang and Yuan Wu

    Citation: BMC Neurology 2019 19:296

    Content type: Research article

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  13. Secondary central nervous system lymphoma (SCNSL) is defined as secondary central nervous system (CNS) involvement in patients with systemic lymphoma. It is considered a profoundly adverse complication with in...

    Authors: Yuchen Wu, Yaming Wang, Xuefei Sun, Xueyan Bai, Jun Qian, Hong Zhu, Qu Cui, Ruixian Xing, Yuedan Chen, Qing Liu, Jiayuan Guo, Nan Ji, Shengjun Sun and Yuanbo Liu

    Citation: BMC Neurology 2019 19:268

    Content type: Research article

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  14. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory disorder in the central nervous system (CNS) with distinct clinical, radiological, an...

    Authors: Xiao-hang Liu, Fan Jin, Meng Zhang, Mei-xi Liu, Tao Wang, Bo-ju Pan and Lu Zhang

    Citation: BMC Neurology 2019 19:266

    Content type: Case report

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  15. Cardiac myxoma is the most common benign cardiac tumor. Brain metastases or multiple cerebral aneurysms are extremely rare, especially for the case of both complications. Brain metastases are usually found at ...

    Authors: Yan Wan, Hai Du, Lei Zhang, Shuang Guo, Li Xu, Yuanyuan Li, Hui He, Lian Zhou, Yunping Chen, Ling Mao, Huijuan Jin and Bo Hu

    Citation: BMC Neurology 2019 19:249

    Content type: Case report

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  16. Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, which is the most common type of autoimmune encephalitis, is caused by the production of autoantibodies against NMDA receptor. Anti-NMDAR encephali...

    Authors: Jie Lu, Ji-hong Zhang, Ai-liang Miao, Jun-xiong Yin, Dong-lin Zhu, Xing-jian Lin, Dao-wen Chen and Jing-ping Shi

    Citation: BMC Neurology 2019 19:210

    Content type: Case report

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  17. Primary central nervous system (CNS) small lymphocytic lymphoma (SLL), as a type of low-grade lymphoma, is extremely rare. The diagnosis of CNS SLL is challenging due to its variable clinical and radiological ...

    Authors: Rongjing Guo, Xiaolong Zhang, Chunxiao Niu, Yibin Xi, Hong Yin, Hong Lin and Ting Chang

    Citation: BMC Neurology 2019 19:200

    Content type: Case report

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  18. The neurofibromatoses (NF) are a group of genetic disorders that interfere negatively with the quality of life (QoL) and influence physical, emotional and social statuses. Studying the effects of neurofibromat...

    Authors: Akram Sanagoo, Leila Jouybari, Fatemeh Koohi and Fatemeh Sayehmiri

    Citation: BMC Neurology 2019 19:123

    Content type: Research article

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  19. Primary central nervous system lymphoma (PCNSL) is the most prevalent brain, spinal cord, eyes, and leptomeningeal lymphoma. It is often misdiagnosed due to an unspecific presentation or unavailable biopsy and...

    Authors: Hui Zhao, Miao Ma, Limin Zhang, Guanghui Zheng, Hong Lv, Jie Liu, Xiao Li, Bei Song and Guojun Zhang

    Citation: BMC Neurology 2019 19:90

    Content type: Case report

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  20. Neuroendocrine tumors represent an expansive group of neoplasms that share an etiology of epithelial origin with neuroendocrine differentiation. Poorly-differentiated neuroendocrine carcinomas behave similarly...

    Authors: Julie R. Bloom, Arlen Brickman, Fan J. Yang, Ji-Weon Park and Jonathan Cheponis

    Citation: BMC Neurology 2019 19:76

    Content type: Case report

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  21. Scattered extracellular deposits of amyloid within the brain parenchyma can be found in a heterogeneous group of diseases. Its condensed accumulation in the white matter without evidence for systemic amyloidos...

    Authors: Mario Löhr, Almuth F. Kessler, Camelia-Maria Monoranu, Jens Grosche, Thomas Linsenmann, Ralf-Ingo Ernestus and Wolfgang Härtig

    Citation: BMC Neurology 2019 19:59

    Content type: Case report

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  22. Frequent somatic mutations of BRAF and CTNNB1 were identified in both histological subtypes of craniopharyngioma (adamantinomatous and papillary) which shed light on target therapy to cure this oncogenic disea...

    Authors: Xi Chen, Yusheng Tong, Zhifeng Shi, Hong Chen, Zhong Yang, Yuanyuan Wang, Liang Chen and Jinhua Yu

    Citation: BMC Neurology 2019 19:6

    Content type: Research article

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  23. Paraneoplastic neurological syndromes (PNS) are rare disorders associated with cancer and are believed to be immune mediated. Patients with autonomic PNS suffer from variable combinations of parasympathetic an...

    Authors: Tatsuya Ueno, Yukihiro Hasegawa, Rie Hagiwara, Tomoya Kon, Jin-ichi Nunomura and Masahiko Tomiyama

    Citation: BMC Neurology 2018 18:189

    Content type: Case report

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  24. Glioma metastasis, invasion, epithelial-mesenchymal transition (EMT) and chemoresistance indicate poor prognosis. Accumulating evidence reveals that Notch1 is an important factor in tumour progression. However...

    Authors: Jianlong Li, Qingbin Li, Lin Lin, Rui Wang, Lingchao Chen, Wenzhong Du, Chuanlu Jiang and Ruiyan Li

    Citation: BMC Neurology 2018 18:133

    Content type: Research article

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  25. Central nervous system (CNS) tuberculoma is a rare disease with severe neurological deficits. This retrospective research is to review the data of patients diagnosed as CNS tuberculoma. Surgeries were performe...

    Authors: Fanfan Chen, Lei Chen, Yongfu Cao, Yongjun Yi, Jingwen Zhuang, Wuhua Le, Wei Xie, Lanbo Tu, Peng Li, Yimin Fang, Ling Li, Yuqing Kou, Kaikai Fu, Hua He and Hongbin Ju

    Citation: BMC Neurology 2018 18:10

    Content type: Research article

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  26. Anterior sacral meningoceles are rare, and usually occur with other malformations of the posterior lower spine. While these are more frequently reported in pediatric cohorts, we report a case in an elderly woman.

    Authors: Anne K. Braczynski, Marc A. Brockmann, Torben Scholz, Jan-Philipp Bach, Jörg B. Schulz and Simone C. Tauber

    Citation: BMC Neurology 2017 17:212

    Content type: Case report

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  27. Tumor location served as an important prognostic factor in glioma patients was considered to postulate molecular features according to cell origin theory. However, anatomic distribution of unique molecular sub...

    Authors: Qisheng Tang, Yuxi Lian, Jinhua Yu, Yuanyuan Wang, Zhifeng Shi and Liang Chen

    Citation: BMC Neurology 2017 17:183

    Content type: Research article

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  28. Juglone is a natural pigment, which has cytotoxic effect against various human tumor cells. However, its cytotoxicity to glioma cells, especially to tumor stem-like cells (TSCs) has not been demonstrated.

    Authors: Jinfeng Wu, Haibo Zhang, Yang Xu, Jingwen Zhang, Wei Zhu, Yi Zhang, Liang Chen, Wei Hua and Ying Mao

    Citation: BMC Neurology 2017 17:70

    Content type: Research article

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  29. The dysregulation of long noncoding RNAs (lncRNAs) has been identified in a variety of cancers. An increasing number of studies have found the critical role of lncRNAs in the regulation of cellular processes, ...

    Authors: Shujun Xia, Ri Ji and Weiwei Zhan

    Citation: BMC Neurology 2017 17:30

    Content type: Research article

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  30. Intracranial vestibular schwannoma still remain to be difficulty for its unique microsurgical technique and preservation of neuro-function, as well as reducing common complications that may arise in surgery.

    Authors: Xiang Huang, Jian Xu, Ming Xu, Mingyu Chen, Kaiyuan Ji, Junwei Ren and Ping Zhong

    Citation: BMC Neurology 2017 17:18

    Content type: Research article

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  31. MicroRNAs are significantly involved in tumorigenesis and progression of glioma. However, the critical part they play in glioma have not been fully elaborated. miR-491 and Tripartite motif containing 28 (TRIM2...

    Authors: Zengxin Qi, Shengyong Cai, Jiajun Cai, Lingchao Chen, Yu Yao, Liang Chen and Ying Mao

    Citation: BMC Neurology 2016 16:248

    Content type: Research article

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  32. We aim to study surgical technique and analyze the related factors affecting tumor total removal and postoperative endocrinological remission for endoscopic endonasal pituitary adenomas surgery.

    Authors: Xuefei Shou, Ming Shen, Qilin Zhang, Yichao Zhang, Wenqiang He, Zengyi Ma, Yao Zhao, Shiqi Li and Yongfei Wang

    Citation: BMC Neurology 2016 16:247

    Content type: Research article

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  33. Paclitaxel-based regimens are frequently associated with the development of peripheral neuropathy. The autonomous nervous system (ANS) effects, however, of this chemotherapeutic agent remain unexplored.

    Authors: Emmanouil V. Dermitzakis, Vasilios K. Kimiskidis, George Lazaridis, Zoi Alexopoulou, Eleni Timotheadou, Alexandros Papanikolaou, Ourania Romanidou, George Georgiadis, Konstantine T. Kalogeras, Iakovos Tsiptsios, Basil Tarlatzis and George Fountzilas

    Citation: BMC Neurology 2016 16:190

    Content type: Research article

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  34. Past studies found that cerebral developmental venous anomaly (DVA) is often concurrent with cavernous malformation (CM). But the reason of the concurrency remains unknown. The purpose of this study was to con...

    Authors: Tengfei Yu, Xing Liu, Xiangjiang Lin, Chuanfeng Bai, Jizong Zhao, Junting Zhang, Liwei Zhang, Zhen Wu, Shuo Wang, Yuanli Zhao and Guolu Meng

    Citation: BMC Neurology 2016 16:183

    Content type: Research article

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  35. Glioblastoma is refractory to conventional treatment, which is combined of surgery, chemotherapy and radiotherapy. Recent studies have shown that glioma initiating cells (GICs) contribute to tumorigenesis and ...

    Authors: Hongxing Ye, Mantao Chen, Fei Cao, Hongguang Huang, Renya Zhan and Xiujue Zheng

    Citation: BMC Neurology 2016 16:178

    Content type: Research article

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  36. Timely diagnosis of meningeal carcinomatosis is often difficult even with the assistant of magnetic resonance imaging examination, cerebrospinal fluid analysis, or both. To the best of our knowledge, gadobutro...

    Authors: Xinfa Pan, Yongfu Lu, Liang Wen, Xiujue Zheng and Yuehui Ma

    Citation: BMC Neurology 2016 16:158

    Content type: Case report

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  37. Urgent referral for suspected central nervous system (CNS) cancer is recommended, but little analysis of the referral criteria diagnostic performance has been conducted. New 2015 NICE guidance recommends direc...

    Authors: Hasan Raza Mohammad, Jeremy Boardman, Laura Howell, Roger J. Mills and Hedley C. A. Emsley

    Citation: BMC Neurology 2016 16:152

    Content type: Research article

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  38. Paraneoplastic syndromes are serious immune caused diseases of the peripheral and/or central nervous system associated with malignant neoplasm. Symptoms develop when antibodies against antigens expressed by tu...

    Authors: Philipp Schwenkenbecher, Lisa Priya Chacko, Ulrich Wurster, Kaweh Pars, Refik Pul, Kurt-Wolfram Sühs, Martin Stangel and Thomas Skripuletz

    Citation: BMC Neurology 2016 16:136

    Content type: Research article

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  39. Lymphomatosis cerebri (LC) is a rare subtype of primary central nervous system malignant lymphoma. The typical features of this disease exhibited on magnetic resonance imaging (MRI) without contrast enhancemen...

    Authors: Takenobu Murakami, Kenji Yoshida, Mari Segawa, Akioh Yoshihara, Akihiko Hoshi, Koichiro Nakamura, Masahiro Ichikawa, Osamu Suzuki, Yuichi Yokoyama, Yasuko Toyoshima, Yoshihiro Sugiura, Hiroshi Ito, Kiyoshi Saito, Yuko Hashimoto, Akiyoshi Kakita, Hitoshi Takahashi…

    Citation: BMC Neurology 2016 16:128

    Content type: Case report

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  40. Circulating Tumor Cells (CTCs) are promising biomarkers for monitoring solid cancer and were used to monitor brain tumors. Here we report two cases in which, for the first time, CTCs were used in cytological d...

    Authors: N. Malara, G. Guzzi, C. Mignogna, V. Trunzo, C. Camastra, A. Della Torre, A. Di Vito, A. M. Lavecchia, M. Gliozzi, C. Ceccotti, G. Volpentesta, A. Lavano, G. Donato and V Mollace

    Citation: BMC Neurology 2016 16:127

    Content type: Case report

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