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Neurocritical care

Section edited by Andreas Meisel

This section covers life-threatening diseases of the central or peripheral nervous systems. Topics include, but are not limited to, coma, status epilepticus, intracranial hemorrhages, neurotrauma, delirium, metabolic encephalopathies, severe stroke, anoxic-ischemic encephalopathy, central nervous system infections and inflammations, Guillain-Barre syndrome, myasthenia gravis crises, intoxications and withdrawal states.

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  1. Persistent post-concussive symptoms (PPCS) affect up to 30% of individuals following mild traumatic brain injury. PPCS frequently includes exercise intolerance. Sub-symptom threshold aerobic exercise has been ...

    Authors: Leah J. Mercier, Tak S. Fung, Ashley D. Harris, Sean P. Dukelow and Chantel T. Debert

    Citation: BMC Neurology 2020 20:46

    Content type: Study protocol

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  2. While the burden of neurologic illness in developing countries is increasing, less is known about mortality among patients admitted to sub-Saharan African hospitals with neurologic disease. We sought to charac...

    Authors: Monica M. Diaz, Xin Hu, Brenda T. Fenton, Ivan Kimuli, Allison Lee, Hayley Lindsey, Jeffrey K. Bigelow, Samuel Maiser, Hamada H. Altalib and Jason J. Sico

    Citation: BMC Neurology 2020 20:42

    Content type: Research article

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  3. While both hypercapnia and hypocapnia are harmful in patients with subarachnoid hemorrhage (SAH), it is unknown whether high-normal PaCO2 values are better than low-normal values. We hypothesized that high-normal...

    Authors: Tilman Reiff, Oliver Barthel, Silvia Schönenberger and Sibu Mundiyanapurath

    Citation: BMC Neurology 2020 20:31

    Content type: Research article

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  4. Transverse myelitis (TM) is due to inflammatory spinal cord injury with bilateral neurologic involvement, which is sensory, motor, or autonomic in nature. It may be associated with autoimmune disease, vaccinat...

    Authors: Fangfang Qu, Zhenzhen Qu, Yingqian Lv, Bo Song and Bailin Wu

    Citation: BMC Neurology 2020 20:13

    Content type: Case report

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  5. Hypertrophic pachymeningitis (HP) is a rare disorder that involves localized or diffuse thickening of the dura mater. HP is associated with various inflammatory, infectious, and malignant diseases, such as rhe...

    Authors: Eiichiro Amano, Keisuke Uchida, Tasuku Ishihara, Shinichi Otsu, Akira Machida and Yoshinobu Eishi

    Citation: BMC Neurology 2020 20:11

    Content type: Case report

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  6. The traditional approaches for diagnosing catheter-related bloodstream infection(CRBSI) is time consuming, which could not meet the clinical requirement. Our aim was to investigate the value of serum procalcit...

    Authors: Yicheng Xu, Ruiwei Chen, Wei Qin, Peifu Wang, Peiyao Li, Wenli Hu and Jichen Du

    Citation: BMC Neurology 2020 20:6

    Content type: Research article

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  7. Large hemispheric infarction (LHI) is a severe form of stroke with high mortality and disability rates. The purpose of this study was to explore predictive indicators of the in-hospital mortality of LHI patien...

    Authors: Wenzhe Sun, Guo Li, Ziqiang Liu, Jinfeng Miao, Zhaoxia Yang, Qiao Zhou, Run Liu, Suiqiang Zhu and Zhou Zhu

    Citation: BMC Neurology 2019 19:347

    Content type: Research article

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  8. The incidence of autoimmune encephalitis has risen globally. There are two general categories of disease-associated antibodies that can be tested for: neuronal surface and intracellular. However, testing both ...

    Authors: Abhinbhen W. Saraya, Kanthita Worachotsueptrakun, Kritchai Vutipongsatorn, Chanikarn Sonpee and Thiravat Hemachudha

    Citation: BMC Neurology 2019 19:273

    Content type: Research article

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  10. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe and most common autoimmune encephalitis in patients under 40 years old. Anti-NMDAR encephalitis has various clinical and neuroimaging finding...

    Authors: Yun Jiang, Jianpeng Ma, Tao Gong, Hongjun Hao and Haibo Chen

    Citation: BMC Neurology 2019 19:230

    Content type: Case report

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  12. Neurological disorders are the most common cause of morbidity and mortality in developing countries. Available evidence on urban–rural differences on neurological diseases is scare in such countries. Our study...

    Authors: Safia Awan, Alam Ibrahim Siddiqi, Ahmed Asif, Naveeduddin Ahmed, Hazim Brohi, Sajad Jalbani and Mohammad Wasay

    Citation: BMC Neurology 2019 19:192

    Content type: Research article

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  14. Higher circulating levels of tissue inhibitor of matrix metalloproteinases (TIMP)-1 early after ischemic stroke have been associated with lower survival. The objectives of this study were to determine serum TI...

    Authors: Leonardo Lorente, María M. Martín, Luis Ramos, Mónica Argueso, Juan J. Cáceres, Jordi Solé-Violán, Alejandro Jiménez, Juan M. Borreguero-León, Agustín F. González-Rivero, Josune Orbe, José A. Rodríguez and José A. Páramo

    Citation: BMC Neurology 2019 19:167

    Content type: Research article

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  15. Paroxysmal Sympathetic Hyperactivity (PSH) is a frequently observed condition among critically ill patients on intensive care units. According to different studies, PSH is associated with worse recovery and in...

    Authors: Alan Totikov, Melanie Boltzmann, Simone B. Schmidt and Jens D. Rollnik

    Citation: BMC Neurology 2019 19:162

    Content type: Research article

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  16. Body weight supported treadmill training (BWSTT) is a frequently used approach for restoring the ability to walk after spinal cord injury (SCI). However, the duration of BWSTT is usually limited by fatigue of ...

    Authors: Eddy Yu Yeung Cheung, Kevin Ka Ki Yu, Rachel Lai Chu Kwan, Carmen Ka Man Ng, Rosanna Mei Wa Chau and Gladys Lai Ying Cheing

    Citation: BMC Neurology 2019 19:140

    Content type: Research article

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  17. Following spinal cord injury (SCI), family members are often called upon to undertake the caregiving role. This change in the nature of the relationship between the individuals with SCI and their families can ...

    Authors: Gaya Jeyathevan, Jill I. Cameron, B. Catharine Craven, Sarah E. P. Munce and Susan B. Jaglal

    Citation: BMC Neurology 2019 19:117

    Content type: Research article

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  19. Patients with severe brain injury is usual at high risk of extubation failure, despite of those with no/minor primary respiratory problem, majority of them still needs long term respiratory support and has sev...

    Authors: Meiling Dong, Yongfang Zhou, Jing Yang, Jie Yang, Xuelian Liao and Yan Kang

    Citation: BMC Neurology 2019 19:79

    Content type: Research article

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  20. To evaluate the utility of the revised coma remission scale (CRS-r), together with other clinical variables, in predicting emergence from disorders of consciousness (DoC) during intensive rehabilitation care.

    Authors: Lucia Francesca Lucca, Danilo Lofaro, Loris Pignolo, Elio Leto, Maria Ursino, Maria Daniela Cortese, Domenico Conforti, Paolo Tonin and Antonio Cerasa

    Citation: BMC Neurology 2019 19:68

    Content type: Research article

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  21. Traumatic Brain Injury (TBI) is the most common cause of injury-related death and disability globally, and a common sequelae is cognitive impairment. Addressing post-TBI cognitive deficits is crucial because t...

    Authors: Joao Ricardo Nickenig Vissoci, Leonardo Pestillo de Oliveira, Temitope Gafaar, Michael M. Haglund, Mark Mvungi, Blandina Theophil Mmbaga and Catherine A. Staton

    Citation: BMC Neurology 2019 19:57

    Content type: Research article

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  22. Parenchymal neurocysticercosis is a frequent cause of seizures in areas endemic for Taenia solium. At present there is scarce data on the evolution of the levels of circulating metacestodal antigen before, during...

    Authors: Richar Rodríguez-Hidalgo, Arturo Carpio, Erwin Van den Enden and Washington Benítez-Ortiz

    Citation: BMC Neurology 2019 19:52

    Content type: Case report

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  24. Contrast-induced encephalopathy (CIE) is a well-known complication of iodinated contrast agents during angiography and vascular interventions. It can manifest as hemiparesis, cortical blindness, speech changes...

    Authors: Wei Zhao, Jinping Zhang, Yun Song, Lili Sun, Meimei Zheng, Hao Yin, Jun Zhang, Wei Wang and Ju Han

    Citation: BMC Neurology 2019 19:46

    Content type: Case report

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  25. Periodic alternating ping-pong gaze (PPG) is a rare disease with few reports. To our knowledge, there was no report on anti GQ1b antibody syndrome accompanied by PPG. This paper reported a case of anti GQ1b an...

    Authors: Jingzhe Han, Yanan Xie, Haiyan Yan, Yuecheng Cao, HongmeiWang and Duanhua Cao

    Citation: BMC Neurology 2019 19:28

    Content type: Case report

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  26. Traumatic brain injuries in Uganda are on the increase, however little is known about the neuropsychological outcomes in survivors. This study characterized patients with traumatic brain injury (TBI) and the a...

    Authors: Paul Bangirana, Bruno Giordani, Olive Kobusingye, Letisia Murungyi, Charles Mock, Chandy C. John and Richard Idro

    Citation: BMC Neurology 2019 19:18

    Content type: Research article

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  27. A few reliable national data concerning the etiology of non-traumatic spinal cord injury (SCI) in sub-Sahara Africa exists, mainly because of the limitations of diagnostic imaging. These are both expensive and...

    Authors: Abdu K. Musubire, David B. Meya, Elly T. Katabira, Ana Claire L. Meyer, Paul R. Bohjanen, David R. Boulware and Frank Minja

    Citation: BMC Neurology 2019 19:10

    Content type: Research article

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  28. Intracranial hemorrhage is a rare but potentially severe complication of spinal surgery. Most reported post-operative ICH cases consist of cerebellar hemorrhage. There are fewer reported cases of supratentoria...

    Authors: Brent Berry, Malik Ghannam, Caitlin Bell, Sami Ghazaleh, Sherief Boss, Christopher Streib and Mustapha Ezzeddine

    Citation: BMC Neurology 2018 18:204

    Content type: Case report

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  29. In cases showing cerebrospinal fluid (CSF) redistribution as a compensatory mechanism in acute intracranial hypertension, the optic nerve sheath diameter (ONSD) can be used to estimate intracranial pressure (I...

    Authors: Yuzhi Gao, Qiang Li, Chunshuang Wu, Shaoyun Liu and Mao Zhang

    Citation: BMC Neurology 2018 18:199

    Content type: Research article

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  30. Posterior reversible encephalopathy syndrome (PRES) is described as a clinical-radiological disease entity with good prognosis. In brain MRI, PRES generally presents with vasogenic edema. Although PRES is indu...

    Authors: Yoshitsugu Nakamura, Masakazu Sugino, Akihiro Tsukahara, Hiroko Nakazawa, Naomune Yamamoto and Shigeki Arawaka

    Citation: BMC Neurology 2018 18:190

    Content type: Case report

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  31. Respiratory mechanics affects the effect of positive end-expiratory pressure (PEEP) on intracranial pressure (ICP). Respiratory mechanics of the lung and the chest wall was not differentiated in previous studi...

    Authors: Han Chen, Jing Zhou, Yi-Qin Lin, Jian-Xin Zhou and Rong-Guo Yu

    Citation: BMC Neurology 2018 18:183

    Content type: Research article

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  32. Herpes simplex encephalitis is the most common type of sporadic encephalitis worldwide. Frank intracerebral hemorrhage complicating the disease course in herpes simplex encephalitis patients is rare, especiall...

    Authors: Yoon Hwan Byun, Eun Jin Ha, Sang-Bae Ko and Kyung Hyun Kim

    Citation: BMC Neurology 2018 18:176

    Content type: Case report

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  33. Currently, it is challenging to detect the awareness of patients who suffer disorders of consciousness (DOC). Brain-computer interfaces (BCIs), which do not depend on the behavioral response of patients, may s...

    Authors: Qiuyou Xie, Jiahui Pan, Yan Chen, Yanbin He, Xiaoxiao Ni, Jiechun Zhang, Fei Wang, Yuanqing Li and Ronghao Yu

    Citation: BMC Neurology 2018 18:144

    Content type: Research article

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  34. Catheter-related blood stream infection (CRBSI) is one of the most common intractable healthcare-associated infections because catheters can be easily contaminated by resistant bacteria, and is associated with...

    Authors: Nobuhiko Arai, Yutaka Mine, Hiroshi Kagami and Makoto Inaba

    Citation: BMC Neurology 2018 18:158

    Content type: Case report

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  35. Critical care covers multiple disciplines. However, the causes of critical illness in the ICU, particularly the most common causes, remain unclear. We aimed to investigate the incidence and the most common cau...

    Authors: Ye-Ting Zhou, Dao-Ming Tong, Shao-Dan Wang, Song Ye, Ben-Wen Xu and Chen-Xi Yang

    Citation: BMC Neurology 2018 18:127

    Content type: Research article

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  36. Respiratory system elastance (ERS) is an important determinant of the responsiveness of intracranial pressure (ICP) to positive end-expiratory pressure (PEEP). However, lung elastance (EL) and chest wall elastanc...

    Authors: Han Chen, Kai Chen, Jing-Qing Xu, Ying-Rui Zhang, Rong-Guo Yu and Jian-Xin Zhou

    Citation: BMC Neurology 2018 18:124

    Content type: Research article

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  37. Immunoglobulin associated meningitis is a rare disease that mimics infectious meningitis. This is, to our knowledge, the first case of Immunoglobulin-associated meningitis described in a patient with Systemic ...

    Authors: Luísa Graça, Joana Alves, João Nuak and António Sarmento

    Citation: BMC Neurology 2018 18:97

    Content type: Case report

    Published on:

  38. Brain autoimmunity has been reported in patients with preceding infection of the central nervous system by herpesviridae. It has been hypothesized that neuronal damage releasing antigens might trigger secondary i...

    Authors: Harald Hegen, Raimund Helbok, Mario Kofler, Bettina Pfausler, Alois Schiefecker, Erich Schmutzhard and Ronny Beer

    Citation: BMC Neurology 2018 18:89

    Content type: Research article

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  40. HIV is a neurotropic virus, and it can bring about neurodegeneration and may even result in cognitive impairments. The precise mechanism of HIV-associated white matter (WM) injury is unknown. The effects of mu...

    Authors: Rui-li Li, Jun Sun, Zhen-chao Tang, Jing-ji Zhang and Hong-jun Li

    Citation: BMC Neurology 2018 18:66

    Content type: Research article

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  41. Granulomatosis with polyangiitis (GPA, formerly Wegener’s granulomatosis) is a multisystem vasculitis of small- to medium-sized blood vessels. Cranial involvement can result in cranial nerve palsies and, rarel...

    Authors: James E. Peters, Vivek Gupta, Ibtisam T. Saeed, Curtis Offiah and Ali S. M. Jawad

    Citation: BMC Neurology 2018 18:59

    Content type: Case report

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  42. Persistent and uncontrollable intracranial hypertension (ICH) and difficulty in reducing Cryptococcus count are severe problems in cryptococcal meningitis (CM) patients. The therapeutic effects of ventriculope...

    Authors: Jia Liu, Zhuo-lin Chen, Min Li, Chuan Chen, Huan Yi, Li Xu, Feng Tan and Fu-hua Peng

    Citation: BMC Neurology 2018 18:58

    Content type: Research article

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  44. Behavioral assessment has been acted as the gold standard for the diagnosis of disorders of consciousness (DOC) patients. The item “Functional Object Use” in the motor function sub-scale in the Coma Recovery S...

    Authors: Yuxiao Sun, Jianan Wang, Lizette Heine, Wangshan Huang, Jing Wang, Nantu Hu, Xiaohua Hu, Xiaohui Fang, Supeng Huang, Steven Laureys and Haibo Di

    Citation: BMC Neurology 2018 18:38

    Content type: Research article

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  45. Nosocomial infection (NI) control is an important issue in neurocritical care due to secondary brain damage and the increased morbidity and mortality of primary acute neurocritical care patients. The primary a...

    Authors: Vera Spatenkova, Ondrej Bradac, Daniela Fackova, Zdenka Bohunova and Petr Suchomel

    Citation: BMC Neurology 2018 18:23

    Content type: Research article

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  46. The objective of this study was to evaluate and identify the risk factors for developing a new or enlarged intracranial hemorrhage (ICH) after the placement of an external ventricular drain.

    Authors: A. Shaun Rowe, Derrick R. Rinehart, Stephanie Lezatte and J. Russell Langdon

    Citation: BMC Neurology 2018 18:22

    Content type: Research article

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  47. Nitrous oxide (N2O), a long-standing anesthetic, is also neurotoxic by interfering with the bioavailability of vitamin B12 if abused. A few case studies have reported the neurological and psychiatric complicat...

    Authors: Jun Liang Yuan, Shuang Kun Wang, Tao Jiang and Wen Li Hu

    Citation: BMC Neurology 2017 17:222

    Content type: Case report

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  48. The effectiveness of pharmacological strategies exclusively targeting secondary brain damage (SBD) following ischemic stroke, aneurysmal subarachnoid hemorrhage, aSAH, intracerebral hemorrhage (ICH), traumatic...

    Authors: Thomas Beez, Hans-Jakob Steiger and Nima Etminan

    Citation: BMC Neurology 2017 17:209

    Content type: Research article

    Published on:

  49. Moderate hypothermia after decompressive surgery might not be beneficial for stroke patients. However, normothermia may prove to be an effective method of enhancing neurological outcomes. The study aims were t...

    Authors: Jan Rahmig, Matthias Kuhn, Hermann Neugebauer, Eric Jüttler, Heinz Reichmann and Hauke Schneider

    Citation: BMC Neurology 2017 17:205

    Content type: Research article

    Published on:

  50. Rapidly determining the causes of a depressed level of consciousness (DLOC) including coma is a common clinical challenge. Quantitative analysis of the electroencephalogram (EEG) has the potential to improve D...

    Authors: MohammadMehdi Kafashan, Shoko Ryu, Mitchell J. Hargis, Osvaldo Laurido-Soto, Debra E. Roberts, Akshay Thontakudi, Lawrence Eisenman, Terrance T. Kummer and ShiNung Ching

    Citation: BMC Neurology 2017 17:197

    Content type: Technical advance

    Published on:

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