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BMC Neurology

Neurocritical care

Section edited by Andreas Meisel

This section covers life-threatening diseases of the central or peripheral nervous systems. Topics include, but are not limited to, coma, status epilepticus, intracranial hemorrhages, neurotrauma, delirium, metabolic encephalopathies, severe stroke, anoxic-ischemic encephalopathy, central nervous system infections and inflammations, Guillain-Barre syndrome, myasthenia gravis crises, intoxications and withdrawal states.

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  1. Content type: Research article

    Assessing primary rehabilitation needs in patients with acquired brain injury is a challenge due to case complexity and the heterogeneity of symptoms after brain injury. The Rehabilitation Complexity Scale-Ext...

    Authors: Thomas Maribo, Asger R. Pedersen, Jim Jensen and Jørgen F. Nielsen

    Citation: BMC Neurology 2016 16:205

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  2. Content type: Research article

    Clobazam (CLB) is a well characterized antiepileptic drug (AED) that differs from other benzodiazepines by its basic chemical structure and pharmacodynamic properties. Only one previous study examined the effi...

    Authors: Dominik Madžar, Anna Geyer, Ruben U. Knappe, Stephanie Gollwitzer, Joji B. Kuramatsu, Stefan T. Gerner, Hajo M. Hamer and Hagen B. Huttner

    Citation: BMC Neurology 2016 16:202

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  3. Content type: Case report

    Sleep-wake disturbances are frequently reported following traumatic brain injury (TBI), but they remain poorly documented in the acute stage of injury. Little is known about their origin and evolution.

    Authors: Catherine Duclos, Marie Dumont, Marie-Julie Potvin, Alex Desautels, Danielle Gilbert, David K Menon, Francis Bernard and Nadia Gosselin

    Citation: BMC Neurology 2016 16:186

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  4. Content type: Research article

    Patients who experience severe brain injuries are at risk of secondary brain damage, because of delayed vasospasm and edema. Traditionally, many of these patients are kept on prolonged bed rest in order to mai...

    Authors: A. Rocca, J.-M. Pignat, L. Berney, J. Jöhr, D. Van de Ville, R. T. Daniel, M. Levivier, L. Hirt, A. R. Luft, E. Grouzmann and K. Diserens

    Citation: BMC Neurology 2016 16:169

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  5. Content type: Research article

    Bacterial meningitis is associated with significant morbidity and mortality despite advances in medical care. The main objective of this study was to assess the association of adjunctive dexamethasone treatmen...

    Authors: Esayas Kebede Gudina, Markos Tesfaye, Aynishet Adane, Kinfe Lemma, Tamiru Shibiru, Andreas Wieser, Hans-Walter Pfister and Matthias Klein

    Citation: BMC Neurology 2016 16:153

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  6. Content type: Research article

    Methadone maintenance treatment (MMT) is recognized as one of the most effective treatments for heroin addiction but its effect is dimmed by the high incidence of heroin relapse. However, underlying neurobiolo...

    Authors: Haifeng Chang, Wei Li, Qiang Li, Jiajie Chen, Jia Zhu, Jianjun Ye, Jierong Liu, Zhe Li, Yongbin Li, Ming Shi, Yarong Wang and Wei Wang

    Citation: BMC Neurology 2016 16:145

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  7. Content type: Case report

    Anti-NMDA-receptor encephalitis is an immune-mediated inflammatory disorder of the central nervous system. Brain MRI is unremarkable in at least 50 % of patients and highly variable in the remaining patients w...

    Authors: Harald Hegen, Christian Uprimny, Astrid Grams, Irene Virgolini, Melanie Ramberger, Ronny Beer, Raimund Helbok, Bettina Pfausler and Erich Schmutzhard

    Citation: BMC Neurology 2016 16:130

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  8. Content type: Research article

    In vivo proton magnetic resonance spectroscopy (1H-MRS) studies on brain in HIV infected patients have shown significant alteration in neuro-biochemicals.

    Authors: Devender Bairwa, Virendra Kumar, Surabhi Vyas, Bimal Kumar Das, Achal Kumar Srivastava, Ravinder M. Pandey, Surendra K. Sharma, Naranamangalam R. Jagannathan and Sanjeev Sinha

    Citation: BMC Neurology 2016 16:99

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  9. Content type: Research article

    The conjunctival microcirculation has potential as a window to cerebral perfusion due to related blood supply, close anatomical proximity and easy accessibility for microcirculatory imaging technique, such as ...

    Authors: Tomas Tamosuitis, Andrius Pranskunas, Neringa Balciuniene, Vidas Pilvinis and E. Christiaan Boerma

    Citation: BMC Neurology 2016 16:95

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  10. Content type: Research article

    An understanding of the kinetics of a biomarker is essential to its interpretation. Despite this, little kinetic modelling of blood biomarkers can be found in the literature. S100b is an astrocyte related mark...

    Authors: A. Ercole, E. P. Thelin, A. Holst, B. M. Bellander and D. W. Nelson

    Citation: BMC Neurology 2016 16:93

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  11. Content type: Research article

    Patients with a history of mild TBI (post-mTBI-patients) have an unexplained increase in long-term mortality which might be related to central autonomic dysregulation (CAD). We investigated whether standardize...

    Authors: Max J. Hilz, Mao Liu, Julia Koehn, Ruihao Wang, Fabian Ammon, Steven R. Flanagan and Katharina M. Hösl

    Citation: BMC Neurology 2016 16:61

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  12. Content type: Research article

    The noble gas xenon is considered as a neuroprotective agent, but availability of the gas is limited. Studies on neuroprotection with the abundant noble gases helium and argon demonstrated mixed results, and d...

    Authors: Patrick Zuercher, Dirk Springe, Denis Grandgirard, Stephen L. Leib, Marius Grossholz, Stephan Jakob, Jukka Takala and Matthias Haenggi

    Citation: BMC Neurology 2016 16:43

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  13. Content type: Study protocol

    For cases of severe traumatic brain injury, during primary operation, neurosurgeons usually face a dilemma of whether or not to remove the bone flap after mass lesion evacuation. Decompressive craniectomy, whi...

    Authors: He-xiang Zhao, Yi Liao, Ding Xu, Qiang-ping Wang, Qi Gan, Chao You and Chao-hua Yang

    Citation: BMC Neurology 2016 16:1

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  14. Content type: Research article

    Up to half of all people with HIV infection have some degree of cognitive impairment. This impairment is typically mild, but nonetheless often disabling. Although early detection of cognitive impairment offers...

    Authors: Marie-Josée Brouillette, Lesley K. Fellows, Lisa Palladini, Lois Finch, Réjean Thomas and Nancy E. Mayo

    Citation: BMC Neurology 2015 15:224

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  15. Content type: Research article

    Different apoptosis pathways activate caspase-3. In a study involving 27 patients with traumatic brain injury (TBI), higher caspase-3 levels were found in contusion brain tissue resected from non-survivors tha...

    Authors: Leonardo Lorente, María M. Martín, Mónica Argueso, Luis Ramos, Jordi Solé-Violán, Marta Riaño-Ruiz, Alejandro Jiménez and Juan M. Borreguero-León

    Citation: BMC Neurology 2015 15:228

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  16. Content type: Research article

    Natriuresis with polyuria is common after aneurysmal subarachnoid hemorrhage (aSAH). Previous studies have shown an increased risk of symptomatic cerebral vasospasm or delayed cerebral ischemia (DCI) in patien...

    Authors: Robert J. Brown, Brian P. Epling, Ilene Staff, Gilbert Fortunato, James J. Grady and Louise D. McCullough

    Citation: BMC Neurology 2015 15:201

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