Pain

The thalamus in trigeminal neuralgia: structural and metabolic abnormalities, and influence on surgical response

Medically-refractory trigeminal neuralgia (TN) can be treated successfully with operative intervention, but a significant proportion of patients are non-responders despite undergoing technically successful sur...

Authors: Hayden Danyluk, Jennifer Andrews, Rohit Kesarwani, Peter Seres, Robert Broad, B. Matt Wheatley and Tejas Sankar

Case series of idiopathic intracranial hypertension in three patients with immune-complex glomerulonephritis

Idiopathic intracranial hypertension (IIH) is defined by an increased cerebrospinal fluid pressure in the absence of inflammation, structural obstructions, or mass lesions. Although the underlying pathogenesis...

Authors: Felix Fischbach, Anne Deborah Scholz-Hehn, Christian Gerloff and Monika Pötter-Nerger

Extreme ecchymoses in a migraine patient using concomitant treatment with calcitonin gene-related peptide receptor antibodies and fish oil supplements: a case report

Erenumab, a monoclonal antibody against the calcitonin gene-related peptide (CGRP) receptor, is registered for migraine prevention. Compared to other conventional migraine prevention medicines (i.e. topiramate...

Authors: C. K. Cullum, M. K. Olsen, H. B. Kocadag, M. Ashina and F. M. Amin

Effects of combining manual therapy, neck muscle exercises, and therapeutic pain neuroscience education in patients with migraine: a study protocol for a randomized clinical trial

Non-pharmacological approaches for the management of migraine exhibit low to moderate effectiveness due to a lack of high-quality randomized clinical trials. In fact, previous studies applied isolated techniqu...

Authors: Gabriella de Almeida Tolentino, Lidiane Lima Florencio, Carina Ferreira Pinheiro, Fabíola Dach, César Fernández-de-las-Peñas and Débora Bevilaqua-Grossi

Assessing migraine patients with multifocal pupillographic objective perimetry

To establish the effects of stimulating intrinsically-photosensitive retinal ganglion cells (ipRGCs) on migraine severity, and to determine if migraine produces objectively-measured visual field defects.

Authors: Eman N. Ali, Corinne F. Carle, Christian J. Lueck, Maria Kolic and Ted Maddess

Headache from clinically confirmed hemicrania continua arising from the sternocleidomastoid muscle: a case report

A patient with a history of cluster headaches, now in remission, presented with confirmed hemicrania continua that resolved with a local anaesthetic injection into the Sternocleidomastoid (SCM) muscle. To the ...

Authors: Osnat Wende and Shira Markowitz

An age-dependent outcome analysis of microvascular decompression and percutaneous thermocoagulation in trigeminal neuralgia

Trigeminal neuralgia (TN) is a severe pain condition and the most common facial neuralgia. While microvascular decompression (MVD) presents an excellent treatment in neurovascular compression cases, percutaneo...

Authors: Naureen Keric, Darius Kalasauskas, Sophia L. Kreth, Martin B. Glaser, Harald Krenzlin, Sven R. Kantelhardt and Florian Ringel

Morphine overinfusion of intrathecal drug administration system under magnetic resonance evaluation for the diagnosis of stroke: a case report

Until recently, it is generally considered safe to perform magnetic resonance imaging (MRI) in patients with an intrathecal drug administration system (ITDAS) device. In this study, we presented a case of morp...

Authors: Seoyeon Kim and Min Kyoung Kang

Validity and reliability of the Portuguese version of the modified Migraine Disability Assessment

Migraine Disability Assessment Scale (MIDAS) is a useful tool to measure headache-related disability. Modified MIDAS with 4-week recall period reduces recall bias and improves accuracy of the results. This stu...

Authors: Pedro L. Ferreira, Isabel Luzeiro, Margarida Lopes, André Jorge, Bruno Silva and Lara Ferreira

Microarray analysis reveals an inflammatory transcriptomic signature in peripheral blood for sciatica

Although the pathology of sciatica has been studied extensively, the transcriptional changes in the peripheral blood caused by sciatica have not been characterized. This study aimed to characterize the periphe...

Authors: Yi Wang, Guogang Dai, Ling Jiang, Shichuan Liao and Jiao Xia

Thermographic follow-up of postherpetic neuralgia (PHN) subsequent to Ramsay Hunt syndrome with multicranial nerve (V, VII, VIII and IX) involvement: a case report

Ramsay Hunt syndrome (RHS) is caused by a reactivation of varicella-zoster virus (VZV) infection, and it is characterized by the symptoms of facial paralysis, otalgia, auricular rash, and/or an oral lesion. El...

Authors: Yuan-Mei Liao, Hai-Feng Lu, Peng Xie, Ying Zhao, Qiu Han, Qian-Xi Zhang, Xiao-Hua Zuo, Yan-Na Si and Hong-Guang Bao

Current clinical practice in disabling and chronic migraine in the primary care setting: results from the European My-LIFE anamnesis survey

Migraine is a prevalent and disabling headache disorder that affects more than 1.04 billion individuals world-wide. It can result in reduction in quality of life, increased disability, and high socio-economic ...

Authors: Philippe Ryvlin, Kirill Skorobogatykh, Andrea Negro, Rainel Sanchez-De La Rosa, Heike Israel-Willner, Christina Sundal, E. Anne MacGregor and Angel L. Guerrero

Cervical myelopathy due to neurovascular compression syndrome caused by persistent first intersegmental artery: a case report

Persistent first intersegmental artery (PFIA) is a rare anatomical variation of vertebral arteries and is an asymptomatic finding in most cases. Here we report a rare case of cervical myelopathy caused by spin...

Authors: Takuro Endo, Taku Sugawara and Naoki Higashiyama

Aspergillosis infection over 20 years: a case report of probable vascular invasion in central nervous system

Aspergillosis infection of central nervous system (CNS) is rare and fatal. Diagnosis of invasive aspergillosis remains difficult. Aspergillosis of CNS can be an acute, subacute, or chronic onset, and the longe...

Authors: Yong Zhang, Xu Wu and Yang-Pan Hu

Patients with mild traumatic brain injury and acute neck pain at the emergency department are a distinct category within the mTBI spectrum: a prospective multicentre cohort study

Acute neck pain (ANP) has recently been demonstrated to be a predictor of persistent posttraumatic complaints after mild traumatic brain injury (mTBI). The aim of this study was to determine specific character...

Authors: Sophie M. Coffeng, Bram Jacobs, Myrthe E. de Koning, Gerard Hageman, Gerwin Roks and Joukje van der Naalt

Pain trajectories of dorsomedial prefrontal intermittent theta burst stimulation versus sham treatment in depression

Prefrontal repetitive transcranial magnetic stimulation is an established add-on treatment for major depressive disorder and is increasingly feasible with protocols of short duration, such as intermittent thet...

Authors: Erika Malm, Wiebke Struckmann, Jonas Persson and Robert Bodén

Translation, cross-cultural adaptation, and measurement properties of the Nepali version of the central sensitization inventory (CSI)

Central sensitization is thought to be an important contributing factor in many chronic pain disorders. The Central Sensitization Inventory (CSI) is a patient-reported measure frequently used to assess symptom...

Authors: Saurab Sharma, Jyoti Jha, Anupa Pathak and Randy Neblett

Differentiation of arterial and venous neurovascular conflicts estimates the clinical outcome after microvascular decompression in trigeminal neuralgia

Balanced Steady State Free Precession (b-SSFP) sequences and the newly developed Fast-Spin-Echo (FSE)-sequences enable an optimized visualization of neurovascular compression (NVC) in patients with trigeminal ...

Authors: Sebastian Müller, Eya Khadhraoui, Ali Khanafer, Marios Psychogios, Veit Rohde and Levent Tanrikulu

Factors associated with insufficient response to acute treatment of migraine in Japan: analysis of real-world data from the Adelphi Migraine Disease Specific Programme

Real-world data on sufficient/insufficient response, and predictors of insufficient response, to acute treatments for migraine are limited in Japan. This study aimed to identify factors associated with insuffi...

Authors: Koichi Hirata, Kaname Ueda, Wenyu Ye, Yongin Kim, Mika Komori, James Jackson, Sarah Cotton, Narayan Rajan and Tamas Treuer

Assessment of quality of life in individuals with chronic headache. Psychometric properties of the WHOQOL-BREF

The WHOQOL-BREF is a frequently used instrument for the assessment of health-related quality of life. Unlike other generic instruments used for the assessment of this construct, little is known about its prope...

Authors: Patrick Brzoska

Failure of preventive treatments in migraine: an observational retrospective study in a tertiary headache center

Although the criteria for acute migraine treatment and prevention have been well described, there are still unmet needs, general underuse and low benefits of preventive drugs.

Authors: Marianna Delussi, Eleonora Vecchio, Giuseppe Libro, Silvia Quitadamo and Marina de Tommaso

Evaluation of injection-site-related adverse events with galcanezumab: a post hoc analysis of phase 3 studies in participants with migraine

Injection-site reactions have been reported with biologicals. In this post hoc analysis of Phase 3 studies in participants with migraine, we provide a comprehensive overview and detailed summary of injection-s...

Authors: Virginia L. Stauffer, Shufang Wang, Jo Bonner, ByungKun Kim, Rohit Bhandari, Kathleen A. Day and Angelo Camporeale

Intrathecal blood injection: a case report of a rare complication of an epidural blood patch

Intrathecal injection is a rare complication of spinal anesthesia and an underreported complication of epidural blood patches. Although there are other reported cases of intrathecal blood injection, these case...

Authors: Joseph Seemiller, Sankeerth Challagundla, Travis Taylor and Ramin Zand

Paroxysmal extreme pain disorder in family with c.3892G > T (p.Val1298Phe) in the SCN9A gene mutation – case report

To describe the clinical phenotype of paroxysmal extreme pain disorder, an autosomal dominant condition in four members in one family with the mutation NM_002977.3:c.3892G > T (p.Val1298Phe) in the SCN9A gene. Cl...

Authors: Adam Stępień, Daria Sałacińska, Jacek Staszewski, Marta Durka-Kęsy and Jan Dobrogowski

The Filum disease and the Neuro-Cranio-vertebral syndrome: definition, clinical picture and imaging features

We propose two new concepts, the Filum Disease (FD) and the Neuro-cranio-vertebral syndrome (NCVS), that group together conditions thus far considered idiopathic, such as Arnold-Chiari Syndrome Type I (ACSI), ...

Authors: Miguel B. Royo-Salvador, Marco V. Fiallos-Rivera, Horia C. Salca and Gabriel Ollé-Fortuny

Spinal cerebrospinal fluid leak in the context of pars interarticularis fracture

Spinal cerebrospinal fluid (CSF) leak can lead to intracranial hypotension and is an important differential diagnosis to consider in patients with sudden-onset chronic daily headaches. Pars interarticularis (P...

Authors: Tommy Lik Hang Chan, Robert Cowan, Nada Hindiyeh, Syed Hashmi, Bryan Lanzman and Ian Carroll

Abdominal pain due to the spinothalamic tract injury in patients with mild traumatic brain injury: a case report

We report on a patient with a mild traumatic brain injury (TBI) who developed abdominal pain due to spinothalamic tract (STT) injuries revealed by diffusion tensor tractography (DTT).

Authors: Sung Ho Jang, Young Hyeon Kwon and Sung Jun Lee

Validation of the Spanish version of the migraine disability assessment questionnaire (MIDAS) in university students with migraine

The Migraine Disability Assessment (MIDAS) questionnaire is widely used to determine the degree of migraine-related disability of subjects. So far, and to the best of our knowledge, no Spanish version of this ...

Authors: Daniel Rodríguez-Almagro, Alexander Achalandabaso, Alma Rus, Esteban Obrero-Gaitán, Noelia Zagalaz-Anula and Rafael Lomas-Vega

Pain reduction by inducing sensory-motor adaptation in Complex Regional Pain Syndrome (CRPS PRISMA): protocol for a double-blind randomized controlled trial

Complex Regional Pain Syndrome (CRPS) presents as chronic, continuous pain and sensory, autonomic, and motor abnormalities affecting one or more extremities. People with CRPS can also show changes in their per...

Authors: Monika Halicka, Axel D. Vittersø, Michael J. Proulx and Janet H. Bultitude

An unusual presentation of neuropathic pain following cervical spinal cord injury: a case report

We report a patient with unusual occipital neuropathic pain (at-level neuropathic pain) due to a small central cervical spinal cord injury (SCI).

Authors: Min Cheol Chang, Mathieu Boudier-Revéret, Yoo Jin Choo and Ming-Yen Hsiao

Efficacy and safety of calcitonin-gene-related peptide binding monoclonal antibodies for the preventive treatment of episodic migraine – an updated systematic review and meta-analysis

Migraine is one of the most common neurological disorders that leads to disabilities. However, the conventional drug therapy for migraine might be unsatisfactory at times. Therefore, this meta-analysis aimed t...

Authors: Hong Deng, Gai-gai Li, Hao Nie, Yang-yang Feng, Guang-yu Guo, Wen-liang Guo and Zhou-ping Tang

Variables associated with use of symptomatic medication during a headache attack in individuals with tension-type headache: a European study

Pharmacological treatment of patients with tension-type headache (TTH) includes symptomatic (acute) and prophylactic (preventive) medication. No previous study has investigated variables associated to symptoma...

Authors: César Fernández-de-las-Peñas, Maria Palacios-Ceña, Matteo Castaldo, Kelun Wang, Ángel Guerrero-Peral, Antonella Catena and Lars Arendt-Nielsen

Mindfulness for pain, depression, anxiety, and quality of life in people with spinal cord injury: a systematic review

Populations with reduced sensory and motor function, such as spinal cord injury (SCI) are at increased risk of depression, anxiety, pain, and poorer quality of life (QoL). Mindfulness-Based Interventions (MBIs...

Authors: Jasmine Heath Hearn and Ainslea Cross

Safety and tolerability of monthly galcanezumab injections in patients with migraine: integrated results from migraine clinical studies

Galcanezumab, a humanized monoclonal antibody that selectively binds to calcitonin gene-related peptide, has demonstrated a significant reduction in monthly migraine headache days in phase 2 and 3 trials. In t...

Authors: Mark E. Bangs, David Kudrow, Shufang Wang, Tina M. Oakes, Gisela M. Terwindt, Delphine Magis, Laura Yunes-Medina and Virginia L. Stauffer

An investigation of oxidant/antioxidant balance in patients with migraine: a case-control study

In recent years, the role of neuroinflammation and oxidative stress in migraine pathogenesis has achieved considerable interest; however, to date findings are equivocal. Thus, the objective of this study was t...

Authors: Mansoureh Togha, Soodeh Razeghi Jahromi, Zeinab Ghorbani, Amir Ghaemi and Pegah Rafiee

Long-term deep-TMS does not negatively affect cognitive functions in stroke and spinal cord injury patients with central neuropathic pain

Authors: Priscila Mara Lorencini Selingardi, Antonia Lilian de Lima Rodrigues, Valquíria Aparecida da Silva, Diego Toledo Reis Mendes Fernandes, Jefferson Rosí Jr, Marco Antônio Marcolin, Lin T. Yeng, André R. Brunoni, Manoel J. Teixeira, Ricardo Galhardoni and Daniel Ciampi de Andrade

A case report: Numb Chin Syndrome due to thalamic infarction: a rare case

Numb Chin Syndrome (NCS), which is also characterized as sensory neuropathy of the mental nerve, describes a mostly unilateral numbness of the chin and lower lip. Benign and malignant diseases are known to cau...

Authors: Florian Rimmele, Henning Maschke, Annette Großmann and Tim P. Jürgens

Paranasal sinus air suction for immediate pain relief of acute migraine – a randomized, double blind pilot study

Migraine is a primary headache disorder, which cause significant disability in adolescence. This double blind, randomized clinical trial assessed the immediate effects of suction of paranasal sinus air during ...

Authors: S. M. R. Bandara, S. Samita, A. M. Kiridana, D. M. P. U. K. Ralapanawa and H. M. M. T. B. Herath

Exploration of candidate serum biomarkers potentially related to the chronic pain condition in Medication–overuse headache

Medication Overuse Headache (MOH) is a prevalent and disabling disorder resulting from the overuse of analgesic drugs, triptans or other acute headache medications. In previous proteomic studies, several prote...

Authors: Lanfranco Pellesi, Elisa Bellei, Simona Guerzoni, Maria Michela Cainazzo, Carlo Baraldi, Emanuela Monari and Luigi Alberto Pini

Increased activation of the pregenual anterior cingulate cortex to citalopram challenge in migraine: an fMRI study

The anterior cingulate cortex (ACC) is a key structure of the pain processing network. Several structural and functional alterations of this brain area have been found in migraine. In addition, altered seroton...

Authors: Andrea Edit Edes, Shane McKie, Edina Szabo, Gyongyi Kokonyei, Dorottya Pap, Terezia Zsombok, Mate Magyar, Eva Csepany, Gabor Hullam, Adam Gyorgy Szabo, Lajos Rudolf Kozak, Gyorgy Bagdy and Gabriella Juhasz

The impact of C-reactive protein levels on headache frequency in the HUNT study 2006–2008

Increased high sensitivity C- reactive protein (hs-CRP) levels have been found in many earlier studies on migraine, and recently also in persons with migraine and insomnia. The aim of this study was to see whe...

Authors: Knut Hagen, Lars Jacob Stovner, Kristian Bernhard Nilsen, Espen Saxhaug Kristoffersen and Bendik Slagsvold Winsvold

The bucket test differentiates patients with MRI confirmed brainstem/cerebellar lesions from patients having migraine and dizziness alone

Amongst the most challenging diagnostic dilemmas managing patients with vestibular symptoms (i.e. vertigo, nausea, imbalance) is differentiating dangerous central vestibular disorders from benign causes. Migra...

Authors: Tzu-Pu Chang, Ariel A. Winnick, Yung-Chu Hsu, Pi-Yu Sung and Michael C. Schubert

The long-term clinical outcomes of microvascular decompression for treatment of trigeminal neuralgia compressed by the vertebra-basilar artery: a case series review

Microvascular decompression (MVD) is a type of neurosurgery used to treat trigeminal neuralgia (TN) caused by the vertebrobasilar contact/compression. The surgery is not risk-free, however; it may cause recurr...

Authors: Xuhui Wang, Hong Wang, Sha Chen, Hong Liang, Hao Wang, Minhui Xu and Lunshan Xu

Transforaminal epidural injection versus continued conservative care in acute sciatica (TEIAS trial): study protocol for a randomized controlled trial

Sciatica is a condition that is characterised by radicular pain in the leg and primarily caused by a herniated lumbar intervertebral disk. In addition to leg pain, patients can experience back pain, leg numbne...

Authors: Eduard Verheijen, Alexander G. Munts, Oscar van Haagen, Dirk de Vries, Olaf Dekkers, Wilbert van den Hout and Carmen Vleggeert-Lankamp

A systematic review of cytokines in chronic fatigue syndrome/myalgic encephalomyelitis/systemic exertion intolerance disease (CFS/ME/SEID)

Cytokines in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) patients compared with healthy controls have been extensively studied. However, the evidence ...

Authors: Matthew Corbitt, Natalie Eaton-Fitch, Donald Staines, Hélène Cabanas and Sonya Marshall-Gradisnik

Effect of a rescue or recurrence dose of lasmiditan on efficacy and safety in the acute treatment of migraine: findings from the phase 3 trials (SAMURAI and SPARTAN)

We studied the efficacy and safety of a second dose of lasmiditan for acute treatment of migraine.

Authors: Li Shen Loo, Brian M. Plato, Ira M. Turner, Michael G. Case, Joel Raskin, Sherie A. Dowsett and John H. Krege

Auditory brainstem function in women with vestibular migraine: a controlled study

Vestibular migraine (VM) has been recognized as a diagnostic entity over the past three decades. It affects up to 1% of the general population and 7% of patients seen in dizziness clinics. It is still underdia...

Authors: Alice A. Takeuti, Mariana L. Fávero, Erica Helena Zaia and Fernando F. Ganança

Towards seeing the visual impairments in Parkinson’s disease: protocol for a multicentre observational, cross-sectional study

Visual disorders are common in Parkinson’s disease (PD) but their exact frequency and severity are unknown. Good visual functioning is crucial for patients with PD, because of their need to compensate for loss...

Authors: Carlijn D. J. M. Borm, Mario Werkmann, Femke Visser, Marina Peball, Diana Putz, Klaus Seppi, Werner Poewe, Irene C. Notting, Annemarie Vlaar, Thomas Theelen, Carel Hoyng, Bastiaan R. Bloem and Nienke M. de Vries

A ketogenic diet normalizes interictal cortical but not subcortical responsivity in migraineurs

A short ketogenic diet (KD) treatment can prevent migraine attacks and correct excessive cortical response. Here, we aim to prove if the KD-related changes of cortical excitability are primarily due to cerebra...

Authors: Cherubino Di Lorenzo, Gianluca Coppola, Martina Bracaglia, Davide Di Lenola, Giulio Sirianni, Paolo Rossi, Giorgio Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Mackenzie C. Cervenka and Francesco Pierelli

The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm

Several studies have suggested that migraineurs suffer from neurocognitive abnormalities, but this phenomenon and exact mechanisms remain controversial. In this study, we aimed to reevaluate visual spatial att...

Authors: Yunliang Guo, Qiang Tian, Song Xu, Mimi Han, Yue Sun, Yan Hong, Xunyao Hou and Xueping Liu