Pain

Evaluation of injection-site-related adverse events with galcanezumab: a post hoc analysis of phase 3 studies in participants with migraine

Injection-site reactions have been reported with biologicals. In this post hoc analysis of Phase 3 studies in participants with migraine, we provide a comprehensive overview and detailed summary of injection-s...

Authors: Virginia L. Stauffer, Shufang Wang, Jo Bonner, ByungKun Kim, Rohit Bhandari, Kathleen A. Day and Angelo Camporeale

Intrathecal blood injection: a case report of a rare complication of an epidural blood patch

Intrathecal injection is a rare complication of spinal anesthesia and an underreported complication of epidural blood patches. Although there are other reported cases of intrathecal blood injection, these case...

Authors: Joseph Seemiller, Sankeerth Challagundla, Travis Taylor and Ramin Zand

Paroxysmal extreme pain disorder in family with c.3892G > T (p.Val1298Phe) in the SCN9A gene mutation – case report

To describe the clinical phenotype of paroxysmal extreme pain disorder, an autosomal dominant condition in four members in one family with the mutation NM_002977.3:c.3892G > T (p.Val1298Phe) in the SCN9A gene. Cl...

Authors: Adam Stępień, Daria Sałacińska, Jacek Staszewski, Marta Durka-Kęsy and Jan Dobrogowski

The Filum disease and the Neuro-Cranio-vertebral syndrome: definition, clinical picture and imaging features

We propose two new concepts, the Filum Disease (FD) and the Neuro-cranio-vertebral syndrome (NCVS), that group together conditions thus far considered idiopathic, such as Arnold-Chiari Syndrome Type I (ACSI), ...

Authors: Miguel B. Royo-Salvador, Marco V. Fiallos-Rivera, Horia C. Salca and Gabriel Ollé-Fortuny

Spinal cerebrospinal fluid leak in the context of pars interarticularis fracture

Spinal cerebrospinal fluid (CSF) leak can lead to intracranial hypotension and is an important differential diagnosis to consider in patients with sudden-onset chronic daily headaches. Pars interarticularis (P...

Authors: Tommy Lik Hang Chan, Robert Cowan, Nada Hindiyeh, Syed Hashmi, Bryan Lanzman and Ian Carroll

Abdominal pain due to the spinothalamic tract injury in patients with mild traumatic brain injury: a case report

We report on a patient with a mild traumatic brain injury (TBI) who developed abdominal pain due to spinothalamic tract (STT) injuries revealed by diffusion tensor tractography (DTT).

Authors: Sung Ho Jang, Young Hyeon Kwon and Sung Jun Lee

Validation of the Spanish version of the migraine disability assessment questionnaire (MIDAS) in university students with migraine

The Migraine Disability Assessment (MIDAS) questionnaire is widely used to determine the degree of migraine-related disability of subjects. So far, and to the best of our knowledge, no Spanish version of this ...

Authors: Daniel Rodríguez-Almagro, Alexander Achalandabaso, Alma Rus, Esteban Obrero-Gaitán, Noelia Zagalaz-Anula and Rafael Lomas-Vega

Pain reduction by inducing sensory-motor adaptation in Complex Regional Pain Syndrome (CRPS PRISMA): protocol for a double-blind randomized controlled trial

Complex Regional Pain Syndrome (CRPS) presents as chronic, continuous pain and sensory, autonomic, and motor abnormalities affecting one or more extremities. People with CRPS can also show changes in their per...

Authors: Monika Halicka, Axel D. Vittersø, Michael J. Proulx and Janet H. Bultitude

An unusual presentation of neuropathic pain following cervical spinal cord injury: a case report

We report a patient with unusual occipital neuropathic pain (at-level neuropathic pain) due to a small central cervical spinal cord injury (SCI).

Authors: Min Cheol Chang, Mathieu Boudier-Revéret, Yoo Jin Choo and Ming-Yen Hsiao

Efficacy and safety of calcitonin-gene-related peptide binding monoclonal antibodies for the preventive treatment of episodic migraine – an updated systematic review and meta-analysis

Migraine is one of the most common neurological disorders that leads to disabilities. However, the conventional drug therapy for migraine might be unsatisfactory at times. Therefore, this meta-analysis aimed t...

Authors: Hong Deng, Gai-gai Li, Hao Nie, Yang-yang Feng, Guang-yu Guo, Wen-liang Guo and Zhou-ping Tang

Variables associated with use of symptomatic medication during a headache attack in individuals with tension-type headache: a European study

Pharmacological treatment of patients with tension-type headache (TTH) includes symptomatic (acute) and prophylactic (preventive) medication. No previous study has investigated variables associated to symptoma...

Authors: César Fernández-de-las-Peñas, Maria Palacios-Ceña, Matteo Castaldo, Kelun Wang, Ángel Guerrero-Peral, Antonella Catena and Lars Arendt-Nielsen

Mindfulness for pain, depression, anxiety, and quality of life in people with spinal cord injury: a systematic review

Populations with reduced sensory and motor function, such as spinal cord injury (SCI) are at increased risk of depression, anxiety, pain, and poorer quality of life (QoL). Mindfulness-Based Interventions (MBIs...

Authors: Jasmine Heath Hearn and Ainslea Cross

Safety and tolerability of monthly galcanezumab injections in patients with migraine: integrated results from migraine clinical studies

Galcanezumab, a humanized monoclonal antibody that selectively binds to calcitonin gene-related peptide, has demonstrated a significant reduction in monthly migraine headache days in phase 2 and 3 trials. In t...

Authors: Mark E. Bangs, David Kudrow, Shufang Wang, Tina M. Oakes, Gisela M. Terwindt, Delphine Magis, Laura Yunes-Medina and Virginia L. Stauffer

An investigation of oxidant/antioxidant balance in patients with migraine: a case-control study

In recent years, the role of neuroinflammation and oxidative stress in migraine pathogenesis has achieved considerable interest; however, to date findings are equivocal. Thus, the objective of this study was t...

Authors: Mansoureh Togha, Soodeh Razeghi Jahromi, Zeinab Ghorbani, Amir Ghaemi and Pegah Rafiee

Long-term deep-TMS does not negatively affect cognitive functions in stroke and spinal cord injury patients with central neuropathic pain

Authors: Priscila Mara Lorencini Selingardi, Antonia Lilian de Lima Rodrigues, Valquíria Aparecida da Silva, Diego Toledo Reis Mendes Fernandes, Jefferson Rosí Jr, Marco Antônio Marcolin, Lin T. Yeng, André R. Brunoni, Manoel J. Teixeira, Ricardo Galhardoni and Daniel Ciampi de Andrade

A case report: Numb Chin Syndrome due to thalamic infarction: a rare case

Numb Chin Syndrome (NCS), which is also characterized as sensory neuropathy of the mental nerve, describes a mostly unilateral numbness of the chin and lower lip. Benign and malignant diseases are known to cau...

Authors: Florian Rimmele, Henning Maschke, Annette Großmann and Tim P. Jürgens

Paranasal sinus air suction for immediate pain relief of acute migraine – a randomized, double blind pilot study

Migraine is a primary headache disorder, which cause significant disability in adolescence. This double blind, randomized clinical trial assessed the immediate effects of suction of paranasal sinus air during ...

Authors: S. M. R. Bandara, S. Samita, A. M. Kiridana, D. M. P. U. K. Ralapanawa and H. M. M. T. B. Herath

Exploration of candidate serum biomarkers potentially related to the chronic pain condition in Medication–overuse headache

Medication Overuse Headache (MOH) is a prevalent and disabling disorder resulting from the overuse of analgesic drugs, triptans or other acute headache medications. In previous proteomic studies, several prote...

Authors: Lanfranco Pellesi, Elisa Bellei, Simona Guerzoni, Maria Michela Cainazzo, Carlo Baraldi, Emanuela Monari and Luigi Alberto Pini

Increased activation of the pregenual anterior cingulate cortex to citalopram challenge in migraine: an fMRI study

The anterior cingulate cortex (ACC) is a key structure of the pain processing network. Several structural and functional alterations of this brain area have been found in migraine. In addition, altered seroton...

Authors: Andrea Edit Edes, Shane McKie, Edina Szabo, Gyongyi Kokonyei, Dorottya Pap, Terezia Zsombok, Mate Magyar, Eva Csepany, Gabor Hullam, Adam Gyorgy Szabo, Lajos Rudolf Kozak, Gyorgy Bagdy and Gabriella Juhasz

The impact of C-reactive protein levels on headache frequency in the HUNT study 2006–2008

Increased high sensitivity C- reactive protein (hs-CRP) levels have been found in many earlier studies on migraine, and recently also in persons with migraine and insomnia. The aim of this study was to see whe...

Authors: Knut Hagen, Lars Jacob Stovner, Kristian Bernhard Nilsen, Espen Saxhaug Kristoffersen and Bendik Slagsvold Winsvold

The bucket test differentiates patients with MRI confirmed brainstem/cerebellar lesions from patients having migraine and dizziness alone

Amongst the most challenging diagnostic dilemmas managing patients with vestibular symptoms (i.e. vertigo, nausea, imbalance) is differentiating dangerous central vestibular disorders from benign causes. Migra...

Authors: Tzu-Pu Chang, Ariel A. Winnick, Yung-Chu Hsu, Pi-Yu Sung and Michael C. Schubert

The long-term clinical outcomes of microvascular decompression for treatment of trigeminal neuralgia compressed by the vertebra-basilar artery: a case series review

Microvascular decompression (MVD) is a type of neurosurgery used to treat trigeminal neuralgia (TN) caused by the vertebrobasilar contact/compression. The surgery is not risk-free, however; it may cause recurr...

Authors: Xuhui Wang, Hong Wang, Sha Chen, Hong Liang, Hao Wang, Minhui Xu and Lunshan Xu

Transforaminal epidural injection versus continued conservative care in acute sciatica (TEIAS trial): study protocol for a randomized controlled trial

Sciatica is a condition that is characterised by radicular pain in the leg and primarily caused by a herniated lumbar intervertebral disk. In addition to leg pain, patients can experience back pain, leg numbne...

Authors: Eduard Verheijen, Alexander G. Munts, Oscar van Haagen, Dirk de Vries, Olaf Dekkers, Wilbert van den Hout and Carmen Vleggeert-Lankamp

A systematic review of cytokines in chronic fatigue syndrome/myalgic encephalomyelitis/systemic exertion intolerance disease (CFS/ME/SEID)

Cytokines in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) patients compared with healthy controls have been extensively studied. However, the evidence ...

Authors: Matthew Corbitt, Natalie Eaton-Fitch, Donald Staines, Hélène Cabanas and Sonya Marshall-Gradisnik

Effect of a rescue or recurrence dose of lasmiditan on efficacy and safety in the acute treatment of migraine: findings from the phase 3 trials (SAMURAI and SPARTAN)

We studied the efficacy and safety of a second dose of lasmiditan for acute treatment of migraine.

Authors: Li Shen Loo, Brian M. Plato, Ira M. Turner, Michael G. Case, Joel Raskin, Sherie A. Dowsett and John H. Krege

Auditory brainstem function in women with vestibular migraine: a controlled study

Vestibular migraine (VM) has been recognized as a diagnostic entity over the past three decades. It affects up to 1% of the general population and 7% of patients seen in dizziness clinics. It is still underdia...

Authors: Alice A. Takeuti, Mariana L. Fávero, Erica Helena Zaia and Fernando F. Ganança

Towards seeing the visual impairments in Parkinson’s disease: protocol for a multicentre observational, cross-sectional study

Visual disorders are common in Parkinson’s disease (PD) but their exact frequency and severity are unknown. Good visual functioning is crucial for patients with PD, because of their need to compensate for loss...

Authors: Carlijn D. J. M. Borm, Mario Werkmann, Femke Visser, Marina Peball, Diana Putz, Klaus Seppi, Werner Poewe, Irene C. Notting, Annemarie Vlaar, Thomas Theelen, Carel Hoyng, Bastiaan R. Bloem and Nienke M. de Vries

A ketogenic diet normalizes interictal cortical but not subcortical responsivity in migraineurs

A short ketogenic diet (KD) treatment can prevent migraine attacks and correct excessive cortical response. Here, we aim to prove if the KD-related changes of cortical excitability are primarily due to cerebra...

Authors: Cherubino Di Lorenzo, Gianluca Coppola, Martina Bracaglia, Davide Di Lenola, Giulio Sirianni, Paolo Rossi, Giorgio Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Mackenzie C. Cervenka and Francesco Pierelli

The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm

Several studies have suggested that migraineurs suffer from neurocognitive abnormalities, but this phenomenon and exact mechanisms remain controversial. In this study, we aimed to reevaluate visual spatial att...

Authors: Yunliang Guo, Qiang Tian, Song Xu, Mimi Han, Yue Sun, Yan Hong, Xunyao Hou and Xueping Liu

Diffusion tensor imaging for assessment of microstructural changes associate with treatment outcome at one-year after radiofrequency Rhizotomy in trigeminal neuralgia

Trigeminal neuralgia (TN) is characterized by facial pain that may be sudden, intense, and recurrent. Neurosurgical interventions, such as radiofrequency rhizotomy, can relieve TN pain, but their mechanisms an...

Authors: Shu-Tian Chen, Jen-Tsung Yang, Hsu-Huei Weng, Hsueh-Lin Wang, Mei-Yu Yeh and Yuan-Hsiung Tsai

Global assessment of migraine severity measure: preliminary evidence of construct validity

In persons with migraine, severity of migraine is an important determinant of several health outcomes (e.g., patient quality of life and health care resource utilization). This study investigated how migraine ...

Authors: Tolulope T. Sajobi, Farnaz Amoozegar, Meng Wang, Natalie Wiebe, Kirsten M. Fiest, Scott B. Patten and Nathalie Jette

Motor cortex stimulation: a systematic literature-based analysis of effectiveness and case series experience

Aim to quantitatively analyze the clinical effectiveness for motor cortex stimulation (MCS) to refractory pain.

Authors: Jia-Jie Mo, Wen-Han Hu, Chao Zhang, Xiu Wang, Chang Liu, Bao-Tian Zhao, Jun-Jian Zhou and Kai Zhang

First three cases of scalp temperature change in symptomatic areas affected by nummular headache: a case report

Nummular headache is a distinct headache disorder characterized by a rounded or elliptical symptomatic area that is typically 2 to 6 cm in diameter and does not change in shape or size with time. Although the ...

Authors: Yonghui Liu and Tianlu Wei

The effect of occipital nerve field stimulation on the descending pain pathway in patients with fibromyalgia: a water PET and EEG imaging study

Fibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory, and mood problems. Recently, occipital nerve field stimulation (ONS) has been proposed...

Authors: Shaheen Ahmed, Mark Plazier, Jan Ost, Gaetane Stassijns, Steven Deleye, Sarah Ceyssens, Patrick Dupont, Sigrid Stroobants, Steven Staelens, Dirk De Ridder and Sven Vanneste

A phase 3, long-term, open-label safety study of Galcanezumab in patients with migraine

Galcanezumab, a humanized monoclonal antibody that selectively binds to the calcitonin gene-related peptide, has demonstrated in previous Phase 2 and Phase 3 clinical studies (≤6-month of treatment) a reductio...

Authors: Angelo Camporeale, David Kudrow, Ryan Sides, Shufang Wang, Annelies Van Dycke, Katherine J. Selzler and Virginia L. Stauffer

The management of common recurrent headaches by chiropractors: a descriptive analysis of a nationally representative survey

Headache management is common within chiropractic clinical settings; however, little is yet known about how this provider group manage headache sufferers. The aim of this study is to report on the prevalence o...

Authors: Craig Moore, Andrew Leaver, David Sibbritt and Jon Adams

Comorbidity of migraine with ADHD in adults

Migraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy ...

Authors: Thomas Folkmann Hansen, Louise K. Hoeffding, Lisette Kogelman, Thilde Marie Haspang, Henrik Ullum, Erik Sørensen, Christian Erikstrup, Ole Birger Pedersen, Kaspar René Nielsen, Henrik Hjalgrim, Helene M. Paarup, Thomas Werge and Kristoffer Burgdorf

Do fragments and glycosylated isoforms of alpha-1-antitrypsin in CSF mirror spinal pathophysiological mechanisms in chronic peripheral neuropathic pain? An exploratory, discovery phase study

Post-translational modifications (PTMs) generate a tremendous protein diversity from the ~ 20,000 protein-coding genes of the human genome. In chronic pain conditions, exposure to pathological processes in the...

Authors: Emmanuel Bäckryd, Sofia Edström, Björn Gerdle and Bijar Ghafouri

Migraine-related disability and co-morbid depression among migraineurs in Ethiopia: a cross-sectional study

Migraine headache is a neurologic disorder which mainly affects younger and productive segment of population. Migraine not only causes pain; but also affects quality of life in terms of low productivity and ec...

Authors: Biniyam Alemayehu Ayele and Yared Mamushet Yifru

Circadian rhythms of migraine attacks in episodic and chronic patients: a cross sectional study in a headache center population

Migraine is considered a disease with diurnal and 24 h pattern, though the existence of a prevalent circadian rhythm associated to migraine frequency and severity is still not clear. This observational cross-s...

Authors: Marina de Tommaso and Marianna Delussi

Association of white matter hyperintensities with migraine features and prognosis

White matter hyperintensities (WMHs) are frequently detected in migraine patients. However, their significance and correlation to migraine disease burden remain unclear. This study aims to examine the correlat...

Authors: Hui Xie, Qiang Zhang, Kang Huo, Rui Liu, Zhi-Jie Jian, Yi-Tong Bian, Guo-Liang Li, Dan Zhu, Li-Hui Zhang, Jian Yang and Guo-Gang Luo

Avoiding Catch-22: validating the PainDETECT in a population of patients with chronic pain

Neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory nervous system and is a major therapeutic challenge. Several screening tools have been developed to help physicians detect...

Authors: Hans Timmerman, André P. Wolff, Ewald M. Bronkhorst, Oliver H. G. Wilder-Smith, Marcel J. Schenkels, Nick T. van Dasselaar, Frank J. P. M. Huygen, Monique A. H. Steegers and Kris C. P. Vissers

Comparison of electroencephalographic changes in response to acute electrical and thermal stimuli with the tail flick and hot plate test in rats administered with opiorphin

The objective of this study was to compare the changes in the electroencephalogram (EEG) in response to noxious stimuli with tail flick and hot plate responses of rats administered opiorphin.

Authors: Preet Singh, Kavitha Kongara, David Harding, Neil Ward, Venkata Sayoji Rao Dukkipati, Craig Johnson and Paul Chambers

The cold pressor test in interictal migraine patients – different parasympathetic pupillary response indicates dysbalance of the cranial autonomic nervous system

Data on autonomic nervous system (ANS) activations in migraine patients are quite controversial, with previous studies reporting over- and underactivation of the sympathetic as well as parasympathetic nervous ...

Authors: Ozan E. Eren, Ruth Ruscheweyh, Christoph Schankin, Florian Schöberl and Andreas Straube

Right-to-left shunt and subclinical ischemic brain lesions in Chinese migraineurs: a multicentre MRI study

Migraine is considered as a risk factor for subclinical brain ischemic lesions, and right-to-left shunt (RLS) is more common among migraineurs. This cross-sectional study assessed the association of RLS with t...

Authors: Xiao-han Jiang, Si-bo Wang, Qian Tian, Chi Zhong, Guan-ling Zhang, Ya-jie Li, Pan Lin, Yong You, Rong Guo, Ying-hua Cui and Ying-qi Xing

Headache symptoms from migraine patients with and without aura through structure-validated self-reports

Headache symptoms self-reported by migraine patients are largely congruent with the clinician-used diagnostic criteria, but not always so. Patients’ self-reports of headache symptoms might offer additional clu...

Authors: Jiawei Wang, Bingren Zhang, Chanchan Shen, Jinhua Zhang and Wei Wang

Low threshold unmyelinated mechanoafferents can modulate pain

Human, hairy skin contains a subgroup of C-fibers, the C-low threshold mechanoreceptive afferents ((C-LTMR) C-tactile or C-touch (CT) fibers) that are linked with the signaling of affective aspects of human to...

Authors: Kathrin Habig, Anne Schänzer, Wolfgang Schirner, Gothje Lautenschläger, Benjamin Dassinger, Håkan Olausson, Frank Birklein, Elke R. Gizewski and Heidrun H. Krämer

Clinical experience with transcutaneous supraorbital nerve stimulation in patients with refractory migraine or with migraine and intolerance to topiramate: a prospective exploratory clinical study

Migraine is included in the top-ten disabling diseases and conditions among the Western populations. Non-invasive neurostimulation, including the Cefaly® device, for the treatment of various types of pain is a...

Authors: Michail Vikelis, Emmanouil V. Dermitzakis, Konstantinos C. Spingos, Georgios G. Vasiliadis, George S. Vlachos and Evaggelia Kararizou

Sex differences underlying orofacial varicella zoster associated pain in rats

Most people are initially infected with varicella zoster virus (VZV) at a young age and this infection results in chickenpox. VZV then becomes latent and reactivates later in life resulting in herpes zoster (H...

Authors: Crystal Stinson, Mohong Deng, Michael B Yee, Larry L. Bellinger, Paul R. Kinchington and Phillip R. Kramer

A diagnostic biomarker profile for fibromyalgia syndrome based on an NMR metabolomics study of selected patients and controls

Fibromyalgia syndrome (FMS) is a chronic pain syndrome. A plausible pathogenesis of the disease is uncertain and the pursuit of measurable biomarkers for objective identification of affected individuals is a c...

Authors: Bontle G. Malatji, Helgard Meyer, Shayne Mason, Udo F.H. Engelke, Ron A. Wevers, Mari van Reenen and Carolus J. Reinecke