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Pain

Section edited by Marina De Tommaso

This section focuses on neuropathic pain. Topics of interest include, but are not limited to, migraine, cluster headaches, analgesia, headache genetics and pain management.

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  1. Persistent first intersegmental artery (PFIA) is a rare anatomical variation of vertebral arteries and is an asymptomatic finding in most cases. Here we report a rare case of cervical myelopathy caused by spin...

    Authors: Takuro Endo, Taku Sugawara and Naoki Higashiyama

    Citation: BMC Neurology 2020 20:402

    Content type: Case report

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  2. Acute neck pain (ANP) has recently been demonstrated to be a predictor of persistent posttraumatic complaints after mild traumatic brain injury (mTBI). The aim of this study was to determine specific character...

    Authors: Sophie M. Coffeng, Bram Jacobs, Myrthe E. de Koning, Gerard Hageman, Gerwin Roks and Joukje van der Naalt

    Citation: BMC Neurology 2020 20:315

    Content type: Research article

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  3. Prefrontal repetitive transcranial magnetic stimulation is an established add-on treatment for major depressive disorder and is increasingly feasible with protocols of short duration, such as intermittent thet...

    Authors: Erika Malm, Wiebke Struckmann, Jonas Persson and Robert Bodén

    Citation: BMC Neurology 2020 20:311

    Content type: Research article

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  4. Central sensitization is thought to be an important contributing factor in many chronic pain disorders. The Central Sensitization Inventory (CSI) is a patient-reported measure frequently used to assess symptom...

    Authors: Saurab Sharma, Jyoti Jha, Anupa Pathak and Randy Neblett

    Citation: BMC Neurology 2020 20:286

    Content type: Research article

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  5. Balanced Steady State Free Precession (b-SSFP) sequences and the newly developed Fast-Spin-Echo (FSE)-sequences enable an optimized visualization of neurovascular compression (NVC) in patients with trigeminal ...

    Authors: Sebastian Müller, Eya Khadhraoui, Ali Khanafer, Marios Psychogios, Veit Rohde and Levent Tanrikulu

    Citation: BMC Neurology 2020 20:279

    Content type: Research article

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  6. Real-world data on sufficient/insufficient response, and predictors of insufficient response, to acute treatments for migraine are limited in Japan. This study aimed to identify factors associated with insuffi...

    Authors: Koichi Hirata, Kaname Ueda, Wenyu Ye, Yongin Kim, Mika Komori, James Jackson, Sarah Cotton, Narayan Rajan and Tamas Treuer

    Citation: BMC Neurology 2020 20:274

    Content type: Research article

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  7. Although the criteria for acute migraine treatment and prevention have been well described, there are still unmet needs, general underuse and low benefits of preventive drugs.

    Authors: Marianna Delussi, Eleonora Vecchio, Giuseppe Libro, Silvia Quitadamo and Marina de Tommaso

    Citation: BMC Neurology 2020 20:256

    Content type: Research article

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  8. Injection-site reactions have been reported with biologicals. In this post hoc analysis of Phase 3 studies in participants with migraine, we provide a comprehensive overview and detailed summary of injection-s...

    Authors: Virginia L. Stauffer, Shufang Wang, Jo Bonner, ByungKun Kim, Rohit Bhandari, Kathleen A. Day and Angelo Camporeale

    Citation: BMC Neurology 2020 20:194

    Content type: Research article

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  9. To describe the clinical phenotype of paroxysmal extreme pain disorder, an autosomal dominant condition in four members in one family with the mutation NM_002977.3:c.3892G > T (p.Val1298Phe) in the SCN9A gene. Cl...

    Authors: Adam Stępień, Daria Sałacińska, Jacek Staszewski, Marta Durka-Kęsy and Jan Dobrogowski

    Citation: BMC Neurology 2020 20:182

    Content type: Case report

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  10. We propose two new concepts, the Filum Disease (FD) and the Neuro-cranio-vertebral syndrome (NCVS), that group together conditions thus far considered idiopathic, such as Arnold-Chiari Syndrome Type I (ACSI), ...

    Authors: Miguel B. Royo-Salvador, Marco V. Fiallos-Rivera, Horia C. Salca and Gabriel Ollé-Fortuny

    Citation: BMC Neurology 2020 20:175

    Content type: Research article

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  11. Spinal cerebrospinal fluid (CSF) leak can lead to intracranial hypotension and is an important differential diagnosis to consider in patients with sudden-onset chronic daily headaches. Pars interarticularis (P...

    Authors: Tommy Lik Hang Chan, Robert Cowan, Nada Hindiyeh, Syed Hashmi, Bryan Lanzman and Ian Carroll

    Citation: BMC Neurology 2020 20:162

    Content type: Research article

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  12. The Migraine Disability Assessment (MIDAS) questionnaire is widely used to determine the degree of migraine-related disability of subjects. So far, and to the best of our knowledge, no Spanish version of this ...

    Authors: Daniel Rodríguez-Almagro, Alexander Achalandabaso, Alma Rus, Esteban Obrero-Gaitán, Noelia Zagalaz-Anula and Rafael Lomas-Vega

    Citation: BMC Neurology 2020 20:67

    Content type: Research article

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  13. Complex Regional Pain Syndrome (CRPS) presents as chronic, continuous pain and sensory, autonomic, and motor abnormalities affecting one or more extremities. People with CRPS can also show changes in their per...

    Authors: Monika Halicka, Axel D. Vittersø, Michael J. Proulx and Janet H. Bultitude

    Citation: BMC Neurology 2020 20:62

    Content type: Study protocol

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  14. Migraine is one of the most common neurological disorders that leads to disabilities. However, the conventional drug therapy for migraine might be unsatisfactory at times. Therefore, this meta-analysis aimed t...

    Authors: Hong Deng, Gai-gai Li, Hao Nie, Yang-yang Feng, Guang-yu Guo, Wen-liang Guo and Zhou-ping Tang

    Citation: BMC Neurology 2020 20:57

    Content type: Review

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  15. Pharmacological treatment of patients with tension-type headache (TTH) includes symptomatic (acute) and prophylactic (preventive) medication. No previous study has investigated variables associated to symptoma...

    Authors: César Fernández-de-las-Peñas, Maria Palacios-Ceña, Matteo Castaldo, Kelun Wang, Ángel Guerrero-Peral, Antonella Catena and Lars Arendt-Nielsen

    Citation: BMC Neurology 2020 20:43

    Content type: Research article

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  16. Galcanezumab, a humanized monoclonal antibody that selectively binds to calcitonin gene-related peptide, has demonstrated a significant reduction in monthly migraine headache days in phase 2 and 3 trials. In t...

    Authors: Mark E. Bangs, David Kudrow, Shufang Wang, Tina M. Oakes, Gisela M. Terwindt, Delphine Magis, Laura Yunes-Medina and Virginia L. Stauffer

    Citation: BMC Neurology 2020 20:25

    Content type: Research article

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    The Correction to this article has been published in BMC Neurology 2020 20:90

  17. In recent years, the role of neuroinflammation and oxidative stress in migraine pathogenesis has achieved considerable interest; however, to date findings are equivocal. Thus, the objective of this study was t...

    Authors: Mansoureh Togha, Soodeh Razeghi Jahromi, Zeinab Ghorbani, Amir Ghaemi and Pegah Rafiee

    Citation: BMC Neurology 2019 19:323

    Content type: Research article

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  18. Authors: Priscila Mara Lorencini Selingardi, Antonia Lilian de Lima Rodrigues, Valquíria Aparecida da Silva, Diego Toledo Reis Mendes Fernandes, Jefferson Rosí Jr, Marco Antônio Marcolin, Lin T. Yeng, André R. Brunoni, Manoel J. Teixeira, Ricardo Galhardoni and Daniel Ciampi de Andrade

    Citation: BMC Neurology 2019 19:319

    Content type: Research article

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  19. Migraine is a primary headache disorder, which cause significant disability in adolescence. This double blind, randomized clinical trial assessed the immediate effects of suction of paranasal sinus air during ...

    Authors: S. M. R. Bandara, S. Samita, A. M. Kiridana, D. M. P. U. K. Ralapanawa and H. M. M. T. B. Herath

    Citation: BMC Neurology 2019 19:248

    Content type: Research article

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  20. Medication Overuse Headache (MOH) is a prevalent and disabling disorder resulting from the overuse of analgesic drugs, triptans or other acute headache medications. In previous proteomic studies, several prote...

    Authors: Lanfranco Pellesi, Elisa Bellei, Simona Guerzoni, Maria Michela Cainazzo, Carlo Baraldi, Emanuela Monari and Luigi Alberto Pini

    Citation: BMC Neurology 2019 19:239

    Content type: Research article

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  21. The anterior cingulate cortex (ACC) is a key structure of the pain processing network. Several structural and functional alterations of this brain area have been found in migraine. In addition, altered seroton...

    Authors: Andrea Edit Edes, Shane McKie, Edina Szabo, Gyongyi Kokonyei, Dorottya Pap, Terezia Zsombok, Mate Magyar, Eva Csepany, Gabor Hullam, Adam Gyorgy Szabo, Lajos Rudolf Kozak, Gyorgy Bagdy and Gabriella Juhasz

    Citation: BMC Neurology 2019 19:237

    Content type: Research article

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  22. Increased high sensitivity C- reactive protein (hs-CRP) levels have been found in many earlier studies on migraine, and recently also in persons with migraine and insomnia. The aim of this study was to see whe...

    Authors: Knut Hagen, Lars Jacob Stovner, Kristian Bernhard Nilsen, Espen Saxhaug Kristoffersen and Bendik Slagsvold Winsvold

    Citation: BMC Neurology 2019 19:229

    Content type: Research article

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  23. Amongst the most challenging diagnostic dilemmas managing patients with vestibular symptoms (i.e. vertigo, nausea, imbalance) is differentiating dangerous central vestibular disorders from benign causes. Migra...

    Authors: Tzu-Pu Chang, Ariel A. Winnick, Yung-Chu Hsu, Pi-Yu Sung and Michael C. Schubert

    Citation: BMC Neurology 2019 19:219

    Content type: Research article

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  24. Microvascular decompression (MVD) is a type of neurosurgery used to treat trigeminal neuralgia (TN) caused by the vertebrobasilar contact/compression. The surgery is not risk-free, however; it may cause recurr...

    Authors: Xuhui Wang, Hong Wang, Sha Chen, Hong Liang, Hao Wang, Minhui Xu and Lunshan Xu

    Citation: BMC Neurology 2019 19:217

    Content type: Research article

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  25. Sciatica is a condition that is characterised by radicular pain in the leg and primarily caused by a herniated lumbar intervertebral disk. In addition to leg pain, patients can experience back pain, leg numbne...

    Authors: Eduard Verheijen, Alexander G. Munts, Oscar van Haagen, Dirk de Vries, Olaf Dekkers, Wilbert van den Hout and Carmen Vleggeert-Lankamp

    Citation: BMC Neurology 2019 19:216

    Content type: Study protocol

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  26. Cytokines in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) patients compared with healthy controls have been extensively studied. However, the evidence ...

    Authors: Matthew Corbitt, Natalie Eaton-Fitch, Donald Staines, Hélène Cabanas and Sonya Marshall-Gradisnik

    Citation: BMC Neurology 2019 19:207

    Content type: Research article

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  27. We studied the efficacy and safety of a second dose of lasmiditan for acute treatment of migraine.

    Authors: Li Shen Loo, Brian M. Plato, Ira M. Turner, Michael G. Case, Joel Raskin, Sherie A. Dowsett and John H. Krege

    Citation: BMC Neurology 2019 19:191

    Content type: Research article

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  28. Vestibular migraine (VM) has been recognized as a diagnostic entity over the past three decades. It affects up to 1% of the general population and 7% of patients seen in dizziness clinics. It is still underdia...

    Authors: Alice A. Takeuti, Mariana L. Fávero, Erica Helena Zaia and Fernando F. Ganança

    Citation: BMC Neurology 2019 19:144

    Content type: Research article

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  29. Visual disorders are common in Parkinson’s disease (PD) but their exact frequency and severity are unknown. Good visual functioning is crucial for patients with PD, because of their need to compensate for loss...

    Authors: Carlijn D. J. M. Borm, Mario Werkmann, Femke Visser, Marina Peball, Diana Putz, Klaus Seppi, Werner Poewe, Irene C. Notting, Annemarie Vlaar, Thomas Theelen, Carel Hoyng, Bastiaan R. Bloem and Nienke M. de Vries

    Citation: BMC Neurology 2019 19:141

    Content type: Study protocol

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  30. A short ketogenic diet (KD) treatment can prevent migraine attacks and correct excessive cortical response. Here, we aim to prove if the KD-related changes of cortical excitability are primarily due to cerebra...

    Authors: Cherubino Di Lorenzo, Gianluca Coppola, Martina Bracaglia, Davide Di Lenola, Giulio Sirianni, Paolo Rossi, Giorgio Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Mackenzie C. Cervenka and Francesco Pierelli

    Citation: BMC Neurology 2019 19:136

    Content type: Research article

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  31. Several studies have suggested that migraineurs suffer from neurocognitive abnormalities, but this phenomenon and exact mechanisms remain controversial. In this study, we aimed to reevaluate visual spatial att...

    Authors: Yunliang Guo, Qiang Tian, Song Xu, Mimi Han, Yue Sun, Yan Hong, Xunyao Hou and Xueping Liu

    Citation: BMC Neurology 2019 19:73

    Content type: Research article

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  32. Trigeminal neuralgia (TN) is characterized by facial pain that may be sudden, intense, and recurrent. Neurosurgical interventions, such as radiofrequency rhizotomy, can relieve TN pain, but their mechanisms an...

    Authors: Shu-Tian Chen, Jen-Tsung Yang, Hsu-Huei Weng, Hsueh-Lin Wang, Mei-Yu Yeh and Yuan-Hsiung Tsai

    Citation: BMC Neurology 2019 19:62

    Content type: Research article

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  33. In persons with migraine, severity of migraine is an important determinant of several health outcomes (e.g., patient quality of life and health care resource utilization). This study investigated how migraine ...

    Authors: Tolulope T. Sajobi, Farnaz Amoozegar, Meng Wang, Natalie Wiebe, Kirsten M. Fiest, Scott B. Patten and Nathalie Jette

    Citation: BMC Neurology 2019 19:53

    Content type: Research article

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  34. Fibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory, and mood problems. Recently, occipital nerve field stimulation (ONS) has been proposed...

    Authors: Shaheen Ahmed, Mark Plazier, Jan Ost, Gaetane Stassijns, Steven Deleye, Sarah Ceyssens, Patrick Dupont, Sigrid Stroobants, Steven Staelens, Dirk De Ridder and Sven Vanneste

    Citation: BMC Neurology 2018 18:191

    Content type: Research article

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  35. Galcanezumab, a humanized monoclonal antibody that selectively binds to the calcitonin gene-related peptide, has demonstrated in previous Phase 2 and Phase 3 clinical studies (≤6-month of treatment) a reductio...

    Authors: Angelo Camporeale, David Kudrow, Ryan Sides, Shufang Wang, Annelies Van Dycke, Katherine J. Selzler and Virginia L. Stauffer

    Citation: BMC Neurology 2018 18:188

    Content type: Research article

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  36. Headache management is common within chiropractic clinical settings; however, little is yet known about how this provider group manage headache sufferers. The aim of this study is to report on the prevalence o...

    Authors: Craig Moore, Andrew Leaver, David Sibbritt and Jon Adams

    Citation: BMC Neurology 2018 18:171

    Content type: Research article

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  37. Migraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy ...

    Authors: Thomas Folkmann Hansen, Louise K. Hoeffding, Lisette Kogelman, Thilde Marie Haspang, Henrik Ullum, Erik Sørensen, Christian Erikstrup, Ole Birger Pedersen, Kaspar René Nielsen, Henrik Hjalgrim, Helene M. Paarup, Thomas Werge and Kristoffer Burgdorf

    Citation: BMC Neurology 2018 18:147

    Content type: Research article

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  38. Post-translational modifications (PTMs) generate a tremendous protein diversity from the ~ 20,000 protein-coding genes of the human genome. In chronic pain conditions, exposure to pathological processes in the...

    Authors: Emmanuel Bäckryd, Sofia Edström, Björn Gerdle and Bijar Ghafouri

    Citation: BMC Neurology 2018 18:116

    Content type: Research article

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  39. Migraine is considered a disease with diurnal and 24 h pattern, though the existence of a prevalent circadian rhythm associated to migraine frequency and severity is still not clear. This observational cross-s...

    Authors: Marina de Tommaso and Marianna Delussi

    Citation: BMC Neurology 2018 18:94

    Content type: Research article

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  40. White matter hyperintensities (WMHs) are frequently detected in migraine patients. However, their significance and correlation to migraine disease burden remain unclear. This study aims to examine the correlat...

    Authors: Hui Xie, Qiang Zhang, Kang Huo, Rui Liu, Zhi-Jie Jian, Yi-Tong Bian, Guo-Liang Li, Dan Zhu, Li-Hui Zhang, Jian Yang and Guo-Gang Luo

    Citation: BMC Neurology 2018 18:93

    Content type: Research article

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