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Pain

Section edited by Marina De Tommaso, Ke Ma and Zhi-Qi Zhao

This section focuses on neuropathic pain. Topics of interest include, but are not limited to, migraine, cluster headaches, analgesia, headache genetics and pain management.

  1. Migraine is a primary headache disorder, which cause significant disability in adolescence. This double blind, randomized clinical trial assessed the immediate effects of suction of paranasal sinus air during ...

    Authors: S. M. R. Bandara, S. Samita, A. M. Kiridana, D. M. P. U. K. Ralapanawa and H. M. M. T. B. Herath

    Citation: BMC Neurology 2019 19:248

    Content type: Research article

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  2. Medication Overuse Headache (MOH) is a prevalent and disabling disorder resulting from the overuse of analgesic drugs, triptans or other acute headache medications. In previous proteomic studies, several prote...

    Authors: Lanfranco Pellesi, Elisa Bellei, Simona Guerzoni, Maria Michela Cainazzo, Carlo Baraldi, Emanuela Monari and Luigi Alberto Pini

    Citation: BMC Neurology 2019 19:239

    Content type: Research article

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  3. The anterior cingulate cortex (ACC) is a key structure of the pain processing network. Several structural and functional alterations of this brain area have been found in migraine. In addition, altered seroton...

    Authors: Andrea Edit Edes, Shane McKie, Edina Szabo, Gyongyi Kokonyei, Dorottya Pap, Terezia Zsombok, Mate Magyar, Eva Csepany, Gabor Hullam, Adam Gyorgy Szabo, Lajos Rudolf Kozak, Gyorgy Bagdy and Gabriella Juhasz

    Citation: BMC Neurology 2019 19:237

    Content type: Research article

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  4. Increased high sensitivity C- reactive protein (hs-CRP) levels have been found in many earlier studies on migraine, and recently also in persons with migraine and insomnia. The aim of this study was to see whe...

    Authors: Knut Hagen, Lars Jacob Stovner, Kristian Bernhard Nilsen, Espen Saxhaug Kristoffersen and Bendik Slagsvold Winsvold

    Citation: BMC Neurology 2019 19:229

    Content type: Research article

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  5. Amongst the most challenging diagnostic dilemmas managing patients with vestibular symptoms (i.e. vertigo, nausea, imbalance) is differentiating dangerous central vestibular disorders from benign causes. Migra...

    Authors: Tzu-Pu Chang, Ariel A. Winnick, Yung-Chu Hsu, Pi-Yu Sung and Michael C. Schubert

    Citation: BMC Neurology 2019 19:219

    Content type: Research article

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  6. Microvascular decompression (MVD) is a type of neurosurgery used to treat trigeminal neuralgia (TN) caused by the vertebrobasilar contact/compression. The surgery is not risk-free, however; it may cause recurr...

    Authors: Xuhui Wang, Hong Wang, Sha Chen, Hong Liang, Hao Wang, Minhui Xu and Lunshan Xu

    Citation: BMC Neurology 2019 19:217

    Content type: Research article

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  7. Sciatica is a condition that is characterised by radicular pain in the leg and primarily caused by a herniated lumbar intervertebral disk. In addition to leg pain, patients can experience back pain, leg numbne...

    Authors: Eduard Verheijen, Alexander G. Munts, Oscar van Haagen, Dirk de Vries, Olaf Dekkers, Wilbert van den Hout and Carmen Vleggeert-Lankamp

    Citation: BMC Neurology 2019 19:216

    Content type: Study protocol

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  8. Cytokines in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) patients compared with healthy controls have been extensively studied. However, the evidence ...

    Authors: Matthew Corbitt, Natalie Eaton-Fitch, Donald Staines, Hélène Cabanas and Sonya Marshall-Gradisnik

    Citation: BMC Neurology 2019 19:207

    Content type: Research article

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  9. We studied the efficacy and safety of a second dose of lasmiditan for acute treatment of migraine.

    Authors: Li Shen Loo, Brian M. Plato, Ira M. Turner, Michael G. Case, Joel Raskin, Sherie A. Dowsett and John H. Krege

    Citation: BMC Neurology 2019 19:191

    Content type: Research article

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  10. Vestibular migraine (VM) has been recognized as a diagnostic entity over the past three decades. It affects up to 1% of the general population and 7% of patients seen in dizziness clinics. It is still underdia...

    Authors: Alice A. Takeuti, Mariana L. Fávero, Erica Helena Zaia and Fernando F. Ganança

    Citation: BMC Neurology 2019 19:144

    Content type: Research article

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  11. Visual disorders are common in Parkinson’s disease (PD) but their exact frequency and severity are unknown. Good visual functioning is crucial for patients with PD, because of their need to compensate for loss...

    Authors: Carlijn D. J. M. Borm, Mario Werkmann, Femke Visser, Marina Peball, Diana Putz, Klaus Seppi, Werner Poewe, Irene C. Notting, Annemarie Vlaar, Thomas Theelen, Carel Hoyng, Bastiaan R. Bloem and Nienke M. de Vries

    Citation: BMC Neurology 2019 19:141

    Content type: Study protocol

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  12. A short ketogenic diet (KD) treatment can prevent migraine attacks and correct excessive cortical response. Here, we aim to prove if the KD-related changes of cortical excitability are primarily due to cerebra...

    Authors: Cherubino Di Lorenzo, Gianluca Coppola, Martina Bracaglia, Davide Di Lenola, Giulio Sirianni, Paolo Rossi, Giorgio Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Mackenzie C. Cervenka and Francesco Pierelli

    Citation: BMC Neurology 2019 19:136

    Content type: Research article

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  13. Several studies have suggested that migraineurs suffer from neurocognitive abnormalities, but this phenomenon and exact mechanisms remain controversial. In this study, we aimed to reevaluate visual spatial att...

    Authors: Yunliang Guo, Qiang Tian, Song Xu, Mimi Han, Yue Sun, Yan Hong, Xunyao Hou and Xueping Liu

    Citation: BMC Neurology 2019 19:73

    Content type: Research article

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  14. Trigeminal neuralgia (TN) is characterized by facial pain that may be sudden, intense, and recurrent. Neurosurgical interventions, such as radiofrequency rhizotomy, can relieve TN pain, but their mechanisms an...

    Authors: Shu-Tian Chen, Jen-Tsung Yang, Hsu-Huei Weng, Hsueh-Lin Wang, Mei-Yu Yeh and Yuan-Hsiung Tsai

    Citation: BMC Neurology 2019 19:62

    Content type: Research article

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  15. In persons with migraine, severity of migraine is an important determinant of several health outcomes (e.g., patient quality of life and health care resource utilization). This study investigated how migraine ...

    Authors: Tolulope T. Sajobi, Farnaz Amoozegar, Meng Wang, Natalie Wiebe, Kirsten M. Fiest, Scott B. Patten and Nathalie Jette

    Citation: BMC Neurology 2019 19:53

    Content type: Research article

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  16. Fibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory, and mood problems. Recently, occipital nerve field stimulation (ONS) has been proposed...

    Authors: Shaheen Ahmed, Mark Plazier, Jan Ost, Gaetane Stassijns, Steven Deleye, Sarah Ceyssens, Patrick Dupont, Sigrid Stroobants, Steven Staelens, Dirk De Ridder and Sven Vanneste

    Citation: BMC Neurology 2018 18:191

    Content type: Research article

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  17. Galcanezumab, a humanized monoclonal antibody that selectively binds to the calcitonin gene-related peptide, has demonstrated in previous Phase 2 and Phase 3 clinical studies (≤6-month of treatment) a reductio...

    Authors: Angelo Camporeale, David Kudrow, Ryan Sides, Shufang Wang, Annelies Van Dycke, Katherine J. Selzler and Virginia L. Stauffer

    Citation: BMC Neurology 2018 18:188

    Content type: Research article

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  18. Headache management is common within chiropractic clinical settings; however, little is yet known about how this provider group manage headache sufferers. The aim of this study is to report on the prevalence o...

    Authors: Craig Moore, Andrew Leaver, David Sibbritt and Jon Adams

    Citation: BMC Neurology 2018 18:171

    Content type: Research article

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  19. Migraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy ...

    Authors: Thomas Folkmann Hansen, Louise K. Hoeffding, Lisette Kogelman, Thilde Marie Haspang, Henrik Ullum, Erik Sørensen, Christian Erikstrup, Ole Birger Pedersen, Kaspar René Nielsen, Henrik Hjalgrim, Helene M. Paarup, Thomas Werge and Kristoffer Burgdorf

    Citation: BMC Neurology 2018 18:147

    Content type: Research article

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  20. Post-translational modifications (PTMs) generate a tremendous protein diversity from the ~ 20,000 protein-coding genes of the human genome. In chronic pain conditions, exposure to pathological processes in the...

    Authors: Emmanuel Bäckryd, Sofia Edström, Björn Gerdle and Bijar Ghafouri

    Citation: BMC Neurology 2018 18:116

    Content type: Research article

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  21. Migraine is considered a disease with diurnal and 24 h pattern, though the existence of a prevalent circadian rhythm associated to migraine frequency and severity is still not clear. This observational cross-s...

    Authors: Marina de Tommaso and Marianna Delussi

    Citation: BMC Neurology 2018 18:94

    Content type: Research article

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  22. White matter hyperintensities (WMHs) are frequently detected in migraine patients. However, their significance and correlation to migraine disease burden remain unclear. This study aims to examine the correlat...

    Authors: Hui Xie, Qiang Zhang, Kang Huo, Rui Liu, Zhi-Jie Jian, Yi-Tong Bian, Guo-Liang Li, Dan Zhu, Li-Hui Zhang, Jian Yang and Guo-Gang Luo

    Citation: BMC Neurology 2018 18:93

    Content type: Research article

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  23. Neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory nervous system and is a major therapeutic challenge. Several screening tools have been developed to help physicians detect...

    Authors: Hans Timmerman, André P. Wolff, Ewald M. Bronkhorst, Oliver H. G. Wilder-Smith, Marcel J. Schenkels, Nick T. van Dasselaar, Frank J. P. M. Huygen, Monique A. H. Steegers and Kris C. P. Vissers

    Citation: BMC Neurology 2018 18:91

    Content type: Research article

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  24. The objective of this study was to compare the changes in the electroencephalogram (EEG) in response to noxious stimuli with tail flick and hot plate responses of rats administered opiorphin.

    Authors: Preet Singh, Kavitha Kongara, David Harding, Neil Ward, Venkata Sayoji Rao Dukkipati, Craig Johnson and Paul Chambers

    Citation: BMC Neurology 2018 18:43

    Content type: Research article

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  25. Data on autonomic nervous system (ANS) activations in migraine patients are quite controversial, with previous studies reporting over- and underactivation of the sympathetic as well as parasympathetic nervous ...

    Authors: Ozan E. Eren, Ruth Ruscheweyh, Christoph Schankin, Florian Schöberl and Andreas Straube

    Citation: BMC Neurology 2018 18:41

    Content type: Research article

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  26. Migraine is considered as a risk factor for subclinical brain ischemic lesions, and right-to-left shunt (RLS) is more common among migraineurs. This cross-sectional study assessed the association of RLS with t...

    Authors: Xiao-han Jiang, Si-bo Wang, Qian Tian, Chi Zhong, Guan-ling Zhang, Ya-jie Li, Pan Lin, Yong You, Rong Guo, Ying-hua Cui and Ying-qi Xing

    Citation: BMC Neurology 2018 18:18

    Content type: Research article

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  27. Headache symptoms self-reported by migraine patients are largely congruent with the clinician-used diagnostic criteria, but not always so. Patients’ self-reports of headache symptoms might offer additional clu...

    Authors: Jiawei Wang, Bingren Zhang, Chanchan Shen, Jinhua Zhang and Wei Wang

    Citation: BMC Neurology 2017 17:193

    Content type: Research article

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  28. Human, hairy skin contains a subgroup of C-fibers, the C-low threshold mechanoreceptive afferents ((C-LTMR) C-tactile or C-touch (CT) fibers) that are linked with the signaling of affective aspects of human to...

    Authors: Kathrin Habig, Anne Schänzer, Wolfgang Schirner, Gothje Lautenschläger, Benjamin Dassinger, Håkan Olausson, Frank Birklein, Elke R. Gizewski and Heidrun H. Krämer

    Citation: BMC Neurology 2017 17:184

    Content type: Research article

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  29. Migraine is included in the top-ten disabling diseases and conditions among the Western populations. Non-invasive neurostimulation, including the Cefaly® device, for the treatment of various types of pain is a...

    Authors: Michail Vikelis, Emmanouil V. Dermitzakis, Konstantinos C. Spingos, Georgios G. Vasiliadis, George S. Vlachos and Evaggelia Kararizou

    Citation: BMC Neurology 2017 17:97

    Content type: Research article

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  30. Most people are initially infected with varicella zoster virus (VZV) at a young age and this infection results in chickenpox. VZV then becomes latent and reactivates later in life resulting in herpes zoster (H...

    Authors: Crystal Stinson, Mohong Deng, Michael B Yee, Larry L. Bellinger, Paul R. Kinchington and Phillip R. Kramer

    Citation: BMC Neurology 2017 17:95

    Content type: Research article

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  31. Fibromyalgia syndrome (FMS) is a chronic pain syndrome. A plausible pathogenesis of the disease is uncertain and the pursuit of measurable biomarkers for objective identification of affected individuals is a c...

    Authors: Bontle G. Malatji, Helgard Meyer, Shayne Mason, Udo F.H. Engelke, Ron A. Wevers, Mari van Reenen and Carolus J. Reinecke

    Citation: BMC Neurology 2017 17:88

    Content type: Research article

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  32. In randomised studies, the capsaicin 8% patch has demonstrated effective pain relief in patients with peripheral neuropathic pain (PNP) arising from different aetiologies.

    Authors: Colette Mankowski, Chris D. Poole, Etienne Ernault, Roger Thomas, Ellen Berni, Craig J. Currie, Cecil Treadwell, José I. Calvo, Christina Plastira, Eirini Zafeiropoulou and Isaac Odeyemi

    Citation: BMC Neurology 2017 17:80

    Content type: Research article

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  33. Despite the expansion of conventional medical treatments for headache, many sufferers of common recurrent headache disorders seek help outside of medical settings. The aim of this paper is to evaluate research...

    Authors: Craig S. Moore, David W. Sibbritt and Jon Adams

    Citation: BMC Neurology 2017 17:61

    Content type: Research article

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  34. In unilateral neuropathic pain. e.g. after peripheral nerve injury, both positive and negative sensory signs occur often, accompanied by minor but equally directed contralateral sensory changes. To mimic this ...

    Authors: Elena K. Enax-Krumova, Stephanie Pohl, Andrea Westermann and Christoph Maier

    Citation: BMC Neurology 2017 17:60

    Content type: Research article

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  35. painDETECT (PD-Q) is a self-reported assessment of pain qualities developed as a screening tool for pain of neuropathic origin. Rasch analysis is a strategy for examining the measurement characteristics of a s...

    Authors: Tara L. Packham, Joseph C. Cappelleri, Alesia Sadosky, Joy C. MacDermid and Florian Brunner

    Citation: BMC Neurology 2017 17:48

    Content type: Research article

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  36. This 52-week study evaluated the long-term safety and tolerability of capsaicin 8% w/w (179 mg) patch repeat treatment plus standard of care (SOC) versus SOC alone in painful diabetic peripheral neuropathy (PD...

    Authors: Aaron I. Vinik, Serge Perrot, Etta J. Vinik, Ladislav Pazdera, Hélène Jacobs, Malcolm Stoker, Stephen K. Long, Robert J. Snijder, Marjolijne van der Stoep, Enrique Ortega and Nathaniel Katz

    Citation: BMC Neurology 2016 16:251

    Content type: Research article

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  37. Type 2 trigeminal neuralgia (TN) is an intractable neuropathic pain syndrome compared with type 1 TN because of the difficulty of diagnosis as well as the unsatisfactory prognosis. Neurovascular compression (N...

    Authors: Fanfan Chen, Lei Chen, Wei Li, Ling Li, Xiangdong Xu, Weimin Li, Wuhua Le, Wei Xie, Hua He and Peng Li

    Citation: BMC Neurology 2016 16:106

    Content type: Research article

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  38. Orbital inflammatory pseudotumor is a rare inflammatory condition of unknown cause that may extend intracranially, usually as a dural-based infiltrate. Here we report the first case of orbital pseudotumor pres...

    Authors: Enrico Tedeschi, Lorenzo Ugga, Ferdinando Caranci, Francesca Califano, Sirio Cocozza, Giacomo Lus and Arturo Brunetti

    Citation: BMC Neurology 2016 16:29

    Content type: Case report

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  39. Neuropathic pain is one of the key features of (classical) Fabry disease (FD). No randomized clinical trials comparing effectiveness of different pain management strategies have been performed. This review aim...

    Authors: Y. Schuller, G. E. Linthorst, C. E. M. Hollak, I. N. Van Schaik and M. Biegstraaten

    Citation: BMC Neurology 2016 16:25

    Content type: Research article

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    The Erratum to this article has been published in BMC Neurology 2016 16:67