Pain

A phase 3, long-term, open-label safety study of Galcanezumab in patients with migraine

Galcanezumab, a humanized monoclonal antibody that selectively binds to the calcitonin gene-related peptide, has demonstrated in previous Phase 2 and Phase 3 clinical studies (≤6-month of treatment) a reductio...

Authors: Angelo Camporeale, David Kudrow, Ryan Sides, Shufang Wang, Annelies Van Dycke, Katherine J. Selzler and Virginia L. Stauffer

The management of common recurrent headaches by chiropractors: a descriptive analysis of a nationally representative survey

Headache management is common within chiropractic clinical settings; however, little is yet known about how this provider group manage headache sufferers. The aim of this study is to report on the prevalence o...

Authors: Craig Moore, Andrew Leaver, David Sibbritt and Jon Adams

Comorbidity of migraine with ADHD in adults

Migraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy ...

Authors: Thomas Folkmann Hansen, Louise K. Hoeffding, Lisette Kogelman, Thilde Marie Haspang, Henrik Ullum, Erik Sørensen, Christian Erikstrup, Ole Birger Pedersen, Kaspar René Nielsen, Henrik Hjalgrim, Helene M. Paarup, Thomas Werge and Kristoffer Burgdorf

Do fragments and glycosylated isoforms of alpha-1-antitrypsin in CSF mirror spinal pathophysiological mechanisms in chronic peripheral neuropathic pain? An exploratory, discovery phase study

Post-translational modifications (PTMs) generate a tremendous protein diversity from the ~ 20,000 protein-coding genes of the human genome. In chronic pain conditions, exposure to pathological processes in the...

Authors: Emmanuel Bäckryd, Sofia Edström, Björn Gerdle and Bijar Ghafouri

Migraine-related disability and co-morbid depression among migraineurs in Ethiopia: a cross-sectional study

Migraine headache is a neurologic disorder which mainly affects younger and productive segment of population. Migraine not only causes pain; but also affects quality of life in terms of low productivity and ec...

Authors: Biniyam Alemayehu Ayele and Yared Mamushet Yifru

Circadian rhythms of migraine attacks in episodic and chronic patients: a cross sectional study in a headache center population

Migraine is considered a disease with diurnal and 24 h pattern, though the existence of a prevalent circadian rhythm associated to migraine frequency and severity is still not clear. This observational cross-s...

Authors: Marina de Tommaso and Marianna Delussi

Association of white matter hyperintensities with migraine features and prognosis

White matter hyperintensities (WMHs) are frequently detected in migraine patients. However, their significance and correlation to migraine disease burden remain unclear. This study aims to examine the correlat...

Authors: Hui Xie, Qiang Zhang, Kang Huo, Rui Liu, Zhi-Jie Jian, Yi-Tong Bian, Guo-Liang Li, Dan Zhu, Li-Hui Zhang, Jian Yang and Guo-Gang Luo

Avoiding Catch-22: validating the PainDETECT in a population of patients with chronic pain

Neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory nervous system and is a major therapeutic challenge. Several screening tools have been developed to help physicians detect...

Authors: Hans Timmerman, André P. Wolff, Ewald M. Bronkhorst, Oliver H. G. Wilder-Smith, Marcel J. Schenkels, Nick T. van Dasselaar, Frank J. P. M. Huygen, Monique A. H. Steegers and Kris C. P. Vissers

Comparison of electroencephalographic changes in response to acute electrical and thermal stimuli with the tail flick and hot plate test in rats administered with opiorphin

The objective of this study was to compare the changes in the electroencephalogram (EEG) in response to noxious stimuli with tail flick and hot plate responses of rats administered opiorphin.

Authors: Preet Singh, Kavitha Kongara, David Harding, Neil Ward, Venkata Sayoji Rao Dukkipati, Craig Johnson and Paul Chambers

The cold pressor test in interictal migraine patients – different parasympathetic pupillary response indicates dysbalance of the cranial autonomic nervous system

Data on autonomic nervous system (ANS) activations in migraine patients are quite controversial, with previous studies reporting over- and underactivation of the sympathetic as well as parasympathetic nervous ...

Authors: Ozan E. Eren, Ruth Ruscheweyh, Christoph Schankin, Florian Schöberl and Andreas Straube

Right-to-left shunt and subclinical ischemic brain lesions in Chinese migraineurs: a multicentre MRI study

Migraine is considered as a risk factor for subclinical brain ischemic lesions, and right-to-left shunt (RLS) is more common among migraineurs. This cross-sectional study assessed the association of RLS with t...

Authors: Xiao-han Jiang, Si-bo Wang, Qian Tian, Chi Zhong, Guan-ling Zhang, Ya-jie Li, Pan Lin, Yong You, Rong Guo, Ying-hua Cui and Ying-qi Xing

Headache symptoms from migraine patients with and without aura through structure-validated self-reports

Headache symptoms self-reported by migraine patients are largely congruent with the clinician-used diagnostic criteria, but not always so. Patients’ self-reports of headache symptoms might offer additional clu...

Authors: Jiawei Wang, Bingren Zhang, Chanchan Shen, Jinhua Zhang and Wei Wang

Low threshold unmyelinated mechanoafferents can modulate pain

Human, hairy skin contains a subgroup of C-fibers, the C-low threshold mechanoreceptive afferents ((C-LTMR) C-tactile or C-touch (CT) fibers) that are linked with the signaling of affective aspects of human to...

Authors: Kathrin Habig, Anne Schänzer, Wolfgang Schirner, Gothje Lautenschläger, Benjamin Dassinger, Håkan Olausson, Frank Birklein, Elke R. Gizewski and Heidrun H. Krämer

Clinical experience with transcutaneous supraorbital nerve stimulation in patients with refractory migraine or with migraine and intolerance to topiramate: a prospective exploratory clinical study

Migraine is included in the top-ten disabling diseases and conditions among the Western populations. Non-invasive neurostimulation, including the Cefaly® device, for the treatment of various types of pain is a...

Authors: Michail Vikelis, Emmanouil V. Dermitzakis, Konstantinos C. Spingos, Georgios G. Vasiliadis, George S. Vlachos and Evaggelia Kararizou

Sex differences underlying orofacial varicella zoster associated pain in rats

Most people are initially infected with varicella zoster virus (VZV) at a young age and this infection results in chickenpox. VZV then becomes latent and reactivates later in life resulting in herpes zoster (H...

Authors: Crystal Stinson, Mohong Deng, Michael B Yee, Larry L. Bellinger, Paul R. Kinchington and Phillip R. Kramer

A diagnostic biomarker profile for fibromyalgia syndrome based on an NMR metabolomics study of selected patients and controls

Fibromyalgia syndrome (FMS) is a chronic pain syndrome. A plausible pathogenesis of the disease is uncertain and the pursuit of measurable biomarkers for objective identification of affected individuals is a c...

Authors: Bontle G. Malatji, Helgard Meyer, Shayne Mason, Udo F.H. Engelke, Ron A. Wevers, Mari van Reenen and Carolus J. Reinecke

Effectiveness of the capsaicin 8% patch in the management of peripheral neuropathic pain in European clinical practice: the ASCEND study

In randomised studies, the capsaicin 8% patch has demonstrated effective pain relief in patients with peripheral neuropathic pain (PNP) arising from different aetiologies.

Authors: Colette Mankowski, Chris D. Poole, Etienne Ernault, Roger Thomas, Ellen Berni, Craig J. Currie, Cecil Treadwell, José I. Calvo, Christina Plastira, Eirini Zafeiropoulou and Isaac Odeyemi

A critical review of manual therapy use for headache disorders: prevalence, profiles, motivations, communication and self-reported effectiveness

Despite the expansion of conventional medical treatments for headache, many sufferers of common recurrent headache disorders seek help outside of medical settings. The aim of this paper is to evaluate research...

Authors: Craig S. Moore, David W. Sibbritt and Jon Adams

Ipsilateral and contralateral sensory changes in healthy subjects after experimentally induced concomitant sensitization and hypoesthesia

In unilateral neuropathic pain. e.g. after peripheral nerve injury, both positive and negative sensory signs occur often, accompanied by minor but equally directed contralateral sensory changes. To mimic this ...

Authors: Elena K. Enax-Krumova, Stephanie Pohl, Andrea Westermann and Christoph Maier

Measurement properties of painDETECT: Rasch analysis of responses from community-dwelling adults with neuropathic pain

painDETECT (PD-Q) is a self-reported assessment of pain qualities developed as a screening tool for pain of neuropathic origin. Rasch analysis is a strategy for examining the measurement characteristics of a s...

Authors: Tara L. Packham, Joseph C. Cappelleri, Alesia Sadosky, Joy C. MacDermid and Florian Brunner

Capsaicin 8% patch repeat treatment plus standard of care (SOC) versus SOC alone in painful diabetic peripheral neuropathy: a randomised, 52-week, open-label, safety study

This 52-week study evaluated the long-term safety and tolerability of capsaicin 8% w/w (179 mg) patch repeat treatment plus standard of care (SOC) versus SOC alone in painful diabetic peripheral neuropathy (PD...

Authors: Aaron I. Vinik, Serge Perrot, Etta J. Vinik, Ladislav Pazdera, Hélène Jacobs, Malcolm Stoker, Stephen K. Long, Robert J. Snijder, Marjolijne van der Stoep, Enrique Ortega and Nathaniel Katz

Pre-operative declining proportion of fractional anisotropy of trigeminal nerve is correlated with the outcome of micro-vascular decompression surgery

Type 2 trigeminal neuralgia (TN) is an intractable neuropathic pain syndrome compared with type 1 TN because of the difficulty of diagnosis as well as the unsatisfactory prognosis. Neurovascular compression (N...

Authors: Fanfan Chen, Lei Chen, Wei Li, Ling Li, Xiangdong Xu, Weimin Li, Wuhua Le, Wei Xie, Hua He and Peng Li

Erratum to: Pain management strategies for neuropathic pain in Fabry disease - a systematic review

Authors: Y. Schuller, G.E. Linthorst, C.E.M. Hollak, I.N. Van Schaik and M. Biegstraaten

Intracranial extension of orbital inflammatory pseudotumor: a case report and literature review

Orbital inflammatory pseudotumor is a rare inflammatory condition of unknown cause that may extend intracranially, usually as a dural-based infiltrate. Here we report the first case of orbital pseudotumor pres...

Authors: Enrico Tedeschi, Lorenzo Ugga, Ferdinando Caranci, Francesca Califano, Sirio Cocozza, Giacomo Lus and Arturo Brunetti

Pain management strategies for neuropathic pain in Fabry disease - a systematic review

Neuropathic pain is one of the key features of (classical) Fabry disease (FD). No randomized clinical trials comparing effectiveness of different pain management strategies have been performed. This review aim...

Authors: Y. Schuller, G. E. Linthorst, C. E. M. Hollak, I. N. Van Schaik and M. Biegstraaten