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  1. Content type: Research article

    Obstructive Sleep Apnea (OSA) is associated with many cardiovascular and psychiatric diseases. Day-time sleepiness is a common consequence of sleep apnea and correlates with road-traffic accidents (RTA). Pakis...

    Authors: Fawad Taj, Zarmeneh Aly, Mahwash Kassi and Mansoor Ahmed

    Citation: BMC Neurology 2008 8:50

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  2. Content type: Study protocol

    Main claims of the literature are that functional recovery of the paretic upper limb is mainly defined within the first month post stroke and that rehabilitation services should preferably be applied intensive...

    Authors: Gert Kwakkel, Carel GM Meskers, Erwin E van Wegen, Guus J Lankhorst, Alexander CH Geurts, Annet A van Kuijk, Eline Lindeman, Anne Visser-Meily, Erwin de Vlugt and J Hans Arendzen

    Citation: BMC Neurology 2008 8:49

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  3. Content type: Research article

    Frontotemporal lobar degeneration (FTLD) consists of a clinically and neuropathologically heterogeneous group of syndromes affecting the frontal and temporal lobes of the brain. Mutations in microtubule-associ...

    Authors: Anna-Lotta Kaivorinne, Johanna Krüger, Katja Kuivaniemi, Hannu Tuominen, Virpi Moilanen, Kari Majamaa and Anne M Remes

    Citation: BMC Neurology 2008 8:48

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  4. Content type: Research article

    Parkinson's disease is a progressive neurodegenerative disorder, where most cases are sporadic with a late onset. In rare incidences familial forms of early-onset parkinsonism occur, and when recessively inher...

    Authors: Ronny Myhre, Stina Steinkjer, Alice Stormyr, Gina L Nilsen, Hiba Abu Zayyad, Khalid Horany, Mohamad K Nusier and Helge Klungland

    Citation: BMC Neurology 2008 8:47

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  5. Content type: Study protocol

    Parkinson's disease is a progressive neurological disorder resulting from a degeneration of dopamine producing cells in the substantia nigra. Clinical symptoms typically affect gait pattern and motor performan...

    Authors: Sean Ledger, Rose Galvin, Deirdre Lynch and Emma K Stokes

    Citation: BMC Neurology 2008 8:46

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  6. Content type: Research article

    Cardioembolic stroke generally results in more severe disability, since it typically has a larger ischemic area than the other types of ischemic stroke. However, it is difficult to differentiate cardioembolic ...

    Authors: Kazushi Yukiiri, Naohisa Hosomi, Takayuki Naya, Tsutomu Takahashi, Hiroyuki Ohkita, Mao Mukai, Hisashi Masugata, Koji Murao, Masaki Ueno, Takehiro Nakamura, Hiroaki Dobashi, Takanori Miki, Yasuhiro Kuroda and Masakazu Kohno

    Citation: BMC Neurology 2008 8:45

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  7. Content type: Research article

    A possible method of finding physiological markers of multiple sclerosis (MS) is the application of EEG quantification (QEEG) of brain activity when the subject is stressed by the demands of a cognitive task. ...

    Authors: Manuel Vazquez-Marrufo, Javier J Gonzalez-Rosa, Encarnacion Vaquero, Pablo Duque, Monica Borges, Carlos Gomez and Guillermo Izquierdo

    Citation: BMC Neurology 2008 8:44

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  8. Content type: Research article

    Deep brain stimulation of the subthalamic nucleus significantly improves motor function in patients with severe Parkinson's disease. However, the effects on nonmotor aspects remain uncertain. The present study...

    Authors: Iris Kaiser, Ilse Kryspin-Exner, Thomas Brücke, Dieter Volc and François Alesch

    Citation: BMC Neurology 2008 8:43

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  9. Content type: Research article

    Transcranial duplex sonography (TCD) of the substantia nigra has emerged as a promising, non-invasive tool to diagnose idiopathic Parkinson's disease (IPD). However, its diagnostic accuracy in patients with un...

    Authors: Annemarie MM Vlaar, Tjerk de Nijs, Marinus JPG van Kroonenburgh, Werner H Mess, Ania Winogrodzka, Selma C Tromp and Wim EJ Weber

    Citation: BMC Neurology 2008 8:42

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  10. Content type: Research article

    We previously demonstrated improved sweating after enzyme replacement therapy (ERT) in Fabry disease using the thermo-regularity sweat and quantitative sudomotor axon reflex tests. Skin-impedance, a measure sk...

    Authors: Surya N Gupta, Markus Ries, Gary J Murray, Jane M Quirk, Roscoe O Brady, Jeffrey R Lidicker, Raphael Schiffmann and David F Moore

    Citation: BMC Neurology 2008 8:41

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  11. Content type: Study protocol

    The treatment of Herpes-simplex-virus-encephalitis (HSVE) remains a major unsolved problem in Neurology. Current gold standard for therapy is acyclovir, a drug that inhibits viral replication. Despite antivira...

    Authors: Francisco Martinez-Torres, Sanjay Menon, Maria Pritsch, Norbert Victor, Ekkehart Jenetzky, Katrin Jensen, Eva Schielke, Erich Schmutzhard, Jan de Gans, Chin-Hee Chung, Steffen Luntz, Werner Hacke and Uta Meyding-Lamadé

    Citation: BMC Neurology 2008 8:40

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  12. Content type: Research article

    Prevalence of degenerative dementias and dementias associated with cerebrovascular disease is increasing. Dementia is one of the most significant public health problem. In recent years, the role of vascular ri...

    Authors: Manuel Fernández Martínez, Jessica Castro Flores, Susana Pérez de las Heras, Aitziber Mandaluniz Lekumberri, María Gordejuela Menocal and Juan José Zarranz Imirizaldu

    Citation: BMC Neurology 2008 8:39

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  13. Content type: Technical advance

    To reduce injection pain and improve satisfaction, a thinner (29-gauge [29G]), sharper (5-bevel) needle than the 27G/3-bevel needle used previously to inject interferon (IFN) beta-1a, 44 or 22 mcg subcutaneous...

    Authors: Amer Jaber, Gian B Bozzato, Lionel Vedrine, Wes A Prais, Julie Berube and Philippe E Laurent

    Citation: BMC Neurology 2008 8:38

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  14. Content type: Research article

    Detecting malingering or exaggeration of impairments in brain function after traumatic brain injury is of increasing importance in neuropsychological assessment. Lawyers involved in brain injury litigation cas...

    Authors: Jascha Rüsseler, Alexandra Brett, Ulrike Klaue, Michael Sailer and Thomas F Münte

    Citation: BMC Neurology 2008 8:37

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  15. Content type: Research article

    Considering the costs of multiple sclerosis (MS), it is crucial that the health-related services supplied are in accordance with needs as they are perceived by people with MS (PwMS). Satisfaction with care is ...

    Authors: Charlotte Ytterberg, Sverker Johansson, Kristina Gottberg, Lotta Widén Holmqvist and Lena von Koch

    Citation: BMC Neurology 2008 8:36

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  16. Content type: Research article

    Processing stimuli in one sensory modality is known to result in suppression of other sensory-specific cortices. Additionally, behavioral experiments suggest that the primary consequence of paying attention to...

    Authors: Jennifer L Mozolic, David Joyner, Christina E Hugenschmidt, Ann M Peiffer, Robert A Kraft, Joseph A Maldjian and Paul J Laurienti

    Citation: BMC Neurology 2008 8:35

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  17. Content type: Research article

    Delirium is a common disorder in the early phase of stroke. Given the presumed cholinergic deficiency in delirium, we tested treatment with the acetylcholinesterase inhibitor rivastigmine.

    Authors: Annemarie W Oldenbeuving, Paul LM de Kort, Ben PW Jansen, L Jaap Kappelle and Gerwin Roks

    Citation: BMC Neurology 2008 8:34

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  18. Content type: Research article

    Recent consensus guidelines recommend pregabalin as a first-tier treatment for painful diabetic peripheral neuropathy (DPN). We evaluated the efficacy of pregabalin 600 mg/d (300 mg dosed BID) versus placebo f...

    Authors: Joseph C Arezzo, Julio Rosenstock, Linda LaMoreaux and Lynne Pauer

    Citation: BMC Neurology 2008 8:33

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  19. Content type: Research article

    Frontotemporal lobar degeneration (FTLD) represents a clinically, pathologically and genetically heterogenous neurodegenerative disorder, often complicated by neurological signs such as motor neuron-related li...

    Authors: Agnes A Luty, John BJ Kwok, Elizabeth M Thompson, Peter Blumbergs, William S Brooks, Clement T Loy, Carol Dobson-Stone, Peter K Panegyres, Jane Hecker, Garth A Nicholson, Glenda M Halliday and Peter R Schofield

    Citation: BMC Neurology 2008 8:32

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  20. Content type: Research article

    Several studies have suggested that the specific stroke subtype may influence the presence of leukoaraiosis in patients with ischemic stroke. We investigated the association between stroke subtype and leukoara...

    Authors: Seung-Jae Lee, Joong-Seok Kim, Kwang-Soo Lee, Jae-Young An, Woojun Kim, Yeong-In Kim, Bum-Soo Kim and So-Lyung Jung

    Citation: BMC Neurology 2008 8:31

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  21. Content type: Research article

    Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. A clear parent of origin effect has been shown in several populations, perhaps resulting from factors operating...

    Authors: Sreeram V Ramagopalan, William Valdar, David A Dyment, Gabriele C DeLuca, Sarah-Michelle Orton, Irene M Yee, Maria Criscuoli, George C Ebers and A Dessa Sadovnick

    Citation: BMC Neurology 2008 8:30

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  22. Content type: Research article

    Duloxetine hydrochloride is a reuptake inhibitor of 5-hydroxytryptamine and norepinephrine used to treat depression, generalized anxiety disorder, neuropathic pain, and stress incontinence in women. We investi...

    Authors: Asquad Sultan, Helen Gaskell, Sheena Derry and R Andrew Moore

    Citation: BMC Neurology 2008 8:29

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  23. Content type: Research article

    Early feeding via a nasogastric tube (NGT) is recommended as safe way of supplying nutrition in patients with acute dysphagic stroke. However, preliminary evidence suggests that NGTs themselves may interfere w...

    Authors: Rainer Dziewas, Tobias Warnecke, Christina Hamacher, Stefan Oelenberg, Inga Teismann, Christopher Kraemer, Martin Ritter, Erich B Ringelstein and Wolf R Schaebitz

    Citation: BMC Neurology 2008 8:28

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  24. Content type: Research article

    Hyperhomocysteinemia is a potentially modifiable risk factor for stroke, and may have a negative impact on the course of ischaemic stroke. The role of hyperhomocysteinemia as it relates to stroke in Africans i...

    Authors: Njideka U Okubadejo, Olajumoke O Oladipo, Adekunle A Adeyomoye, Gbolahan O Awosanya and Mustapha A Danesi

    Citation: BMC Neurology 2008 8:26

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  25. Content type: Research article

    Medication nonadherence can be as high as 50% and results in suboptimal patient outcomes. Stroke patients in particular can benefit from pharmacotherapy for thrombosis, hypertension, and dyslipidemia but are a...

    Authors: Heather L Lummis, Ingrid S Sketris, Gordon J Gubitz, Michel R Joffres and Gordon J Flowerdew

    Citation: BMC Neurology 2008 8:25

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  26. Content type: Research article

    This study evaluated the benefits and impact of ICU therapeutic interventions on the survival and functional ability of severe cerebrovascular accident (CVA) patients.

    Authors: Moussa Riachy, Frida Sfeir, Ghassan Sleilaty, Samer Hage-Chahine, Georges Dabar, Taha Bazerbachi, Zeina Aoun-Bacha, Georges Khayat and Salam Koussa

    Citation: BMC Neurology 2008 8:24

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  27. Content type: Research article

    Hallucinations occur in 20–40% of PD patients and have been associated with unfavorable clinical outcomes (i.e., nursing home placement, increased mortality). Hallucinations, like other non-motor features of P...

    Authors: Spiridon Papapetropoulos, Heather Katzen, Anette Schrag, Carlos Singer, Blake K Scanlon, Daniel Nation, Alexandra Guevara and Bonnie Levin

    Citation: BMC Neurology 2008 8:21

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  28. Content type: Research article

    The Paul Coverdell National Acute Stroke Registry (PCNASR) is a U.S. based national registry designed to monitor and improve the quality of acute stroke care delivered by hospitals. The registry monitors care ...

    Authors: Mathew J Reeves, Andrew J Mullard and Susan Wehner

    Citation: BMC Neurology 2008 8:19

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  29. Content type: Research article

    Although stroke is a leading cause of morbidity and mortality in Nigeria, there is no information on awareness of its warning signs. This study was designed to assess awareness of stroke warning signs in Niger...

    Authors: Kolawole W Wahab, Peter O Okokhere, Asuwemhe J Ugheoke, Ojeh Oziegbe, Adedayo F Asalu and Taofeek A Salami

    Citation: BMC Neurology 2008 8:18

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  30. Content type: Research article

    Cognitive decline is a major threat to well being in later life. Change scores and regression based models have often been used for its investigation. Most methods used to describe cognitive decline assume ind...

    Authors: Graciela Muniz Terrera, Fiona Matthews and Carol Brayne

    Citation: BMC Neurology 2008 8:16

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  31. Content type: Research article

    Many individuals afflicted with multiple sclerosis (MS) experience a transient worsening of symptoms when body temperature increases due to ambient conditions or physical activity. Resulting symptom exacerbati...

    Authors: Dennis A Grahn, Julie vLS Murray and H Craig Heller

    Citation: BMC Neurology 2008 8:14

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  32. Content type: Research article

    Botulism is a rare disease caused by intoxication leading to muscle weakness and rapidly progressive dysphagia. With adequate therapy signs of recovery can be observed within several days. In the last few year...

    Authors: Inga K Teismann, Olaf Steinstraeter, Tobias Warnecke, Julian Zimmermann, Erich B Ringelstein, Christo Pantev and Rainer Dziewas

    Citation: BMC Neurology 2008 8:13

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  33. Content type: Research article

    The relationship between stroke risk and cognitive function has not previously been examined in a large community living sample other than the Framingham cohort. The objective of this study was to examine the ...

    Authors: David J Llewellyn, Iain A Lang, Jing Xie, Felicia A Huppert, David Melzer and Kenneth M Langa

    Citation: BMC Neurology 2008 8:12

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  34. Content type: Research article

    The EVIDENCE (EVidence of Interferon Dose-response: European North American Comparative Efficacy) study was an international, randomized, open-label, assessor-blinded, parallel-group study assessing the effica...

    Authors: A Traboulsee, A AL-Sabbagh, R Bennett, P Chang and DKB Li

    Citation: BMC Neurology 2008 8:11

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  35. Content type: Research article

    Neuroleptic-induced movement disorders (NIMDs) have overlapping co-morbidity. Earlier studies have described typical clinical movement patterns for individual NIMDs. This study aimed to identify specific movem...

    Authors: Sven Janno, Matti M Holi, Katinka Tuisku and Kristian Wahlbeck

    Citation: BMC Neurology 2008 8:10

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  36. Content type: Research article

    The objective of this study was to analyze factors influencing the risk and timing of Alzheimer's disease (AD) in central Norway. The APOE ε4 allele is the only consistently identified risk factor for late onset ...

    Authors: Sigrid B Sando, Stacey Melquist, Ashley Cannon, Michael L Hutton, Olav Sletvold, Ingvild Saltvedt, Linda R White, Stian Lydersen and Jan O Aasly

    Citation: BMC Neurology 2008 8:9

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  37. Content type: Research article

    Recent pathological studies have suggested that thalamic degeneration may represent a site of non-dopaminergic degeneration in Parkinson's Disease (PD). Our objective was to determine if changes in the thalami...

    Authors: Martin J McKeown, Ashish Uthama, Rafeef Abugharbieh, Samantha Palmer, Mechelle Lewis and Xuemei Huang

    Citation: BMC Neurology 2008 8:8

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  38. Content type: Study protocol

    Over 50% of patients with upper limb paresis resulting from stroke face long-term impaired arm function and ensuing disability in daily life. Unfortunately, the number of effective treatments aimed at improvin...

    Authors: Jeanine A Verbunt, Henk AM Seelen, Feljandro P Ramos, Bernard HM Michielsen, Wim L Wetzelaer and Martine Moennekens

    Citation: BMC Neurology 2008 8:7

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  39. Content type: Research article

    Pesticides and correlated lifestyle factors (e.g., exposure to well-water and farming) are repeatedly reported risk factors for Parkinson's disease (PD), but few family-based studies have examined these relati...

    Authors: Dana B Hancock, Eden R Martin, Gregory M Mayhew, Jeffrey M Stajich, Rita Jewett, Mark A Stacy, Burton L Scott, Jeffery M Vance and William K Scott

    Citation: BMC Neurology 2008 8:6

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  40. Content type: Research article

    In Spain, stroke is one of the major causes of death and the main cause of severe disability in people over 65 years. We analyzed the incidence of ischemic stroke, stroke subtypes, case fatality and disability...

    Authors: María Teresa Alzamora, Marta Sorribes, Antonio Heras, Nicolás Vila, Marisa Vicheto, Rosa Forés, José Sánchez-Ojanguren, Amparo Sancho and Guillem Pera

    Citation: BMC Neurology 2008 8:5

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  41. Content type: Research article

    The main objective of this study was to investigate the angiotensin converting enzyme (ACE) genotype as a possible risk factor for migraine (both with and without aura) compared to controls. We also wanted to exa...

    Authors: Erling Tronvik, Lars J Stovner, Gunnar Bovim, Linda R White, Amanda J Gladwin, Kathryn Owen and Harald Schrader

    Citation: BMC Neurology 2008 8:4

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  42. Content type: Research article

    A software based tool has been developed (Optem) to allow automatize the recommendations of the Canadian Multiple Sclerosis Working Group for optimizing MS treatment in order to avoid subjective interpretation.

    Authors: Juan Luís Ruiz-Peña, Pablo Duque and Guillermo Izquierdo

    Citation: BMC Neurology 2008 8:3

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  43. Content type: Research article

    The use of self-report measurements in clinical settings is increasing. However, in patients with limitations that interfere with reliable self-assessment such as cognitive impairment or mood disturbances, as ...

    Authors: Femke AH van der Linden, Jolijn J Kragt, Margarethe van Bon, Martin Klein, Alan J Thompson, Henk M van der Ploeg, Chris H Polman and Bernard MJ Uitdehaag

    Citation: BMC Neurology 2008 8:2

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  44. Content type: Research article

    Mutations in the genes PRKN and LRRK2 are the most frequent known genetic lesions among Parkinson's disease patients. We have previously reported that in the Portuguese population the LRRK2 c.6055G > A; p.G2019S ...

    Authors: Jose Bras, Rita Guerreiro, Maria Ribeiro, Ana Morgadinho, Cristina Januario, Margarida Dias, Ana Calado, Cristina Semedo, Catarina Oliveira, John Hardy and Andrew Singleton

    Citation: BMC Neurology 2008 8:1

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