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  1. Fabry patients have symptoms and signs compatible with autonomic dysfunction. These symptoms and signs are considered to be due to impairment of the peripheral nervous system, but findings indicative of autono...

    Authors: Marieke Biegstraaten, Ivo N van Schaik, Wouter Wieling, Frits A Wijburg and Carla EM Hollak

    Citation: BMC Neurology 2010 10:38

    Content type: Research article

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  2. Holmes tremor is a rare symptomatic movement disorder. Currently suggested pathophysiological mechanisms of the disease are mostly derived from stroke cases. Although rare, cerebral toxoplasmosis may strengthe...

    Authors: Alain Lekoubou, Rodrigue Njouoguep, Callixte Kuate and André Pascal Kengne

    Citation: BMC Neurology 2010 10:37

    Content type: Case report

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  3. Animal models of focal cerebral ischemia are widely used in stroke research. The purpose of our study was to evaluate and compare the cerebral macro- and microvascular architecture of rats in two different mod...

    Authors: Alexander C Langheinrich, Mesut Yeniguen, Anne Ostendorf, Simone Marhoffer, Marian Kampschulte, Georg Bachmann, Erwin Stolz and Tibo Gerriets

    Citation: BMC Neurology 2010 10:36

    Content type: Research article

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  4. Assessment of visual fixation is commonly used in the clinical examination of patients with disorders of consciousness. However, different international guidelines seem to disagree whether fixation is compatib...

    Authors: Marie-Aurélie Bruno, Audrey Vanhaudenhuyse, Caroline Schnakers, Mélanie Boly, Olivia Gosseries, Athena Demertzi, Steve Majerus, Gustave Moonen, Roland Hustinx and Steven Laureys

    Citation: BMC Neurology 2010 10:35

    Content type: Research article

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  5. Spontaneous intracerebral hemorrhage (ICH) accounts for a high mortality and morbidity. Early prediction of outcome is crucial for optimized care and treatment decision. Copeptin, the C-terminal part of provas...

    Authors: Christian Zweifel, Mira Katan, Philipp Schuetz, Martin Siegemund, Nils G Morgenthaler, Adrian Merlo, Beat Mueller and Mirjam Christ-Crain

    Citation: BMC Neurology 2010 10:34

    Content type: Research article

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  6. In patients with Duchenne Muscular Dystrophy (DMD), the absent or diminished dystrophin leads to progressive skeletal muscle and heart failure. We evaluated the role of myocardial inflammation as a precipitati...

    Authors: Sophie Mavrogeni, Antigoni Papavasiliou, Kostas Spargias, Pantelis Constandoulakis, George Papadopoulos, Evangelos Karanasios, Dimitris Georgakopoulos, Genovefa Kolovou, Eftichia Demerouti, Spyridon Polymeros, Loukas Kaklamanis, Anastasios Magoutas, Evangelia Papadopoulou, Vyron Markussis and Dennis V Cokkinos

    Citation: BMC Neurology 2010 10:33

    Content type: Research article

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  7. Lacunar syndrome not due to lacunar infarct is poorly characterised. This single centre, retrospective study was conducted to describe the clinical characteristics of patients with lacunar syndrome not due to ...

    Authors: Adrià Arboix, Joan Massons, Luis García-Eroles, Cecilia Targa, Emili Comes and Olga Parra

    Citation: BMC Neurology 2010 10:31

    Content type: Research article

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  8. The c.2447G>A (p.R722H) mutation in the gene POLG1 of the catalytic subunit of human mitochondrial polymerase gamma has been previously found in a few occasions but its pathogenicity has remained uncertain. We se...

    Authors: Tuomas Komulainen, Reetta Hinttala, Mikko Kärppä, Leila Pajunen, Saara Finnilä, Hannu Tuominen, Heikki Rantala, Ilmo Hassinen, Kari Majamaa and Johanna Uusimaa

    Citation: BMC Neurology 2010 10:29

    Content type: Research article

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  9. Multiple sclerosis (MS) currently requires long-term treatment with disease-modifying drugs, administered parenterally up to once daily. The need for regular self-injection can be a barrier to treatment for ma...

    Authors: Virginia Devonshire, Txomin Arbizu, Björn Borre, Michael Lang, Alessandra Lugaresi, Barry Singer, Elisabetta Verdun di Cantogno and Peter Cornelisse

    Citation: BMC Neurology 2010 10:28

    Content type: Research article

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  10. The encephalopathy associated with autoimmune thyroid disease (EAATD) is characterized by neurological/psychiatric symptoms, high levels of anti-thyroid antibodies, increased cerebrospinal fluid protein concen...

    Authors: Gianluca Tamagno, Yahya Celik, Rafael Simó, Marcel Dihné, Kazumi Kimura, Giorgio Gelosa, Byung I Lee, Caroline Hommet and Giovanni Murialdo

    Citation: BMC Neurology 2010 10:27

    Content type: Research article

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  11. Short and valid measures of the impact of a stroke on integration are required in health and social settings. The Subjective Index of Physical and Social Outcome (SIPSO) is one such measure. However, there are...

    Authors: Paula Kersten, Ann Ashburn, Steve George and Joseph Low

    Citation: BMC Neurology 2010 10:26

    Content type: Research article

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  12. Conflicting data exists regarding the effect of hemispheric lateralization on acute ischemic stroke outcome. Some of this variability may be related to heterogeneous study populations, particularly with respec...

    Authors: Albert J Yoo, Javier Romero, Reza Hakimelahi, Raul G Nogueira, James D Rabinov, Johnny C Pryor, R Gilberto González, Joshua A Hirsch and Pamela W Schaefer

    Citation: BMC Neurology 2010 10:25

    Content type: Research article

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  13. The present investigation was designed to elucidate the use of dynamic contrast enhanced perfusion MR imaging (DCE pMRI) in characterizing hyperemia, including microvessel changes, and to examine whether DCE p...

    Authors: Haitao Lu, Jungong Zhao, Minghua Li, Yingsheng Cheng, Yongdong Li, Xiaofang You and Yuwu Zhao

    Citation: BMC Neurology 2010 10:24

    Content type: Research article

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  14. Women have a reduced risk of developing Parkinson's disease (PD) compared with age-matched men. Neuro-protective effects of estrogen potentially explain this difference. Tamoxifen, commonly used in breast canc...

    Authors: Jeanne C Latourelle, Merete Dybdahl, Anita L Destefano, Richard H Myers and Timothy L Lash

    Citation: BMC Neurology 2010 10:23

    Content type: Research article

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  15. In the setting of an acute stroke, anemia has the potential to worsen brain ischemia, however, the relationship between the entire range of hemoglobin to long-term outcome is not well understood.

    Authors: David Tanne, Noa Molshatzki, Oleg Merzeliak, Rakefet Tsabari, Maya Toashi and Yvonne Schwammenthal

    Citation: BMC Neurology 2010 10:22

    Content type: Research article

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  16. Alexander disease (ALX) is a rare neurological disorder characterized by white matter degeneration and cytoplasmic inclusions in astrocytes called Rosenthal fibers, labeled by antibodies against glial fibrilla...

    Authors: Michito Namekawa, Yoshihisa Takiyama, Junko Honda, Haruo Shimazaki, Kumi Sakoe and Imaharu Nakano

    Citation: BMC Neurology 2010 10:21

    Content type: Case report

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  17. Treatment of complex regional pain syndrome type I (CRPS-I) is subject to discussion. The purpose of this study was to develop multidisciplinary guidelines for treatment of CRPS-I.

    Authors: Roberto S Perez, Paul E Zollinger, Pieter U Dijkstra, Ilona L Thomassen-Hilgersom, Wouter W Zuurmond, Kitty CJ Rosenbrand and Jan H Geertzen

    Citation: BMC Neurology 2010 10:20

    Content type: Research article

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  18. Patients suffering from intracerebral haemorrhage have a poor prognosis, especially if they are using antiplatelet therapy. Currently, no effective acute treatment option for intracerebral haemorrhage exists. ...

    Authors: Koen de Gans, Rob J de Haan, Charles B Majoie, Maria M Koopman, Anneke Brand, Marcel G Dijkgraaf, Marinus Vermeulen and Yvo B Roos

    Citation: BMC Neurology 2010 10:19

    Content type: Study protocol

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  19. Endothelium-derived nitric oxide (NO) mediates the arterial dilation following a flow increase (i.e. flow-mediated dilation, FMD), easily assessed in the brachial artery. NO is also involved in cerebral hemody...

    Authors: Fabrizio Vernieri, Leo Moro, Claudia Altamura, Paola Palazzo, Raffaele Antonelli Incalzi, Paolo Maria Rossini and Claudio Pedone

    Citation: BMC Neurology 2010 10:18

    Content type: Research article

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  20. Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous disorder that can be an autosomal-dominant, autosomal-recessive, or X-linked disease. The most common autosomal-dominant form o...

    Authors: Mark Braschinsky, Riin Tamm, Christian Beetz, Elena Sachez-Ferrero, Elve Raukas, Siiri-Merike Lüüs, Katrin Gross-Paju, Catherine Boillot, Federico Canzian, Andres Metspalu and Sulev Haldre

    Citation: BMC Neurology 2010 10:17

    Content type: Research article

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  21. Neurocysticercosis (NC) is one of the most frequent parasitic diseases of the central nervous system. Cysticidal drugs, albendazole and praziquantel, are generally effective when parasites localize in the pare...

    Authors: Graciela Cárdenas, Roger Carrillo-Mezo, Helgi Jung, Edda Sciutto, Jose Luis Soto Hernandez and Agnès Fleury

    Citation: BMC Neurology 2010 10:16

    Content type: Case report

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  22. Adherence to therapies is a primary determinant of treatment success, yet the World Health Organisation estimate that only 50% of patients who suffer from chronic diseases adhere to treatment recommendations. ...

    Authors: Ronan O'Carroll, Martin Dennis, Marie Johnston and Cathie Sudlow

    Citation: BMC Neurology 2010 10:15

    Content type: Study protocol

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  23. Sub-cortical vascular ischaemia is the second most common etiology contributing to cognitive impairment in older adults, and is frequently under-diagnosed and under-treated. Although evidence is mounting that ...

    Authors: Teresa Liu-Ambrose, Janice J Eng, Lara A Boyd, Claudia Jacova, Jennifer C Davis, Stirling Bryan, Philip Lee, Penny Brasher and Ging-Yuek R Hsiung

    Citation: BMC Neurology 2010 10:14

    Content type: Study protocol

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  24. The stability of hypoperfused brain tissue in stroke patients with major artery occlusions is unknown. The purpose of this study was to determine the persistence of a diffusion/perfusion mismatch in patients w...

    Authors: R Gilberto González, Reza Hakimelahi, Pamela W Schaefer, Luca Roccatagliata, A Gregory Sorensen and Aneesh B Singhal

    Citation: BMC Neurology 2010 10:13

    Content type: Research article

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  25. Use of electronic media, i.e. mobile phones, computers, television, game consoles or listening to music, is very common, especially amongst adolescents. There is currently a debate about whether frequent use o...

    Authors: Astrid Milde-Busch, Rüdiger von Kries, Silke Thomas, Sabine Heinrich, Andreas Straube and Katja Radon

    Citation: BMC Neurology 2010 10:12

    Content type: Research article

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  26. In clinical neurology, a comprehensive understanding of consciousness has been regarded as an abstract concept - best left to philosophers. However, times are changing and the need to clinically assess conscio...

    Authors: Jodie R Gawryluk, Ryan CN D'Arcy, John F Connolly and Donald F Weaver

    Citation: BMC Neurology 2010 10:11

    Content type: Review

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  27. Cyclic vomiting syndrome (CVS), which is defined by recurrent stereotypical episodes of nausea and vomiting, is a relatively-common disabling condition that is associated with migraine headache and mitochondri...

    Authors: Richard G Boles, Mary R Lovett-Barr, Amy Preston, B UK Li and Kathleen Adams

    Citation: BMC Neurology 2010 10:10

    Content type: Research article

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  28. In idiopathic Parkinson's disease (IPD) transcranial sonography (TCS) represents an alternative diagnostic method to verify clinical diagnosis. Although the phenomenon of an increased echogenicity of the Subst...

    Authors: Sabine Mehnert, Iris Reuter, Karsten Schepp, Peter Maaser, Erwin Stolz and Manfred Kaps

    Citation: BMC Neurology 2010 10:9

    Content type: Research article

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  29. Postpoliomyelitis Syndrome (PPS) is a complex of late onset neuromuscular symptoms with new or increased muscle weakness and muscle fatigability as key symptoms. Main clinical complaints are severe fatigue, de...

    Authors: Fieke S Koopman, Anita Beelen, Karin H Gerrits, Gijs Bleijenberg, Tineke A Abma, Marianne de Visser and Frans Nollet

    Citation: BMC Neurology 2010 10:8

    Content type: Study protocol

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  30. Migraine is a common disorder that is highly co-morbid with psychopathological conditions such as depression and anxiety. Despite the extensive research and availability of treatment, migraine remains under-re...

    Authors: Zainab Samaan, E Anne MacGregor, Dowson Andrew, Peter McGuffin and Anne Farmer

    Citation: BMC Neurology 2010 10:7

    Content type: Research article

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  31. Previous epidemiologic studies have examined the association of smoking with amyotrophic lateral sclerosis (ALS) incidence, but their results have been inconsistent. Moreover, limited information exists on the...

    Authors: Alvaro Alonso, Giancarlo Logroscino, Susan S Jick and Miguel A Hernán

    Citation: BMC Neurology 2010 10:6

    Content type: Research article

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  32. Surrogate pain models have been extensively tested in Normal Human Volunteers (NHV). There are few studies that examined pain models in chronic pain patients. Patients are likely to have altered pain mechanism...

    Authors: Remigiusz Lecybyl, Juan Acosta, Joydeep Ghoshdastidar, Kinga Stringfellow and Magdi Hanna

    Citation: BMC Neurology 2010 10:5

    Content type: Research article

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  33. Congenital hemiplegia is the most common form of cerebral palsy (CP) accounting for 1 in 1300 live births. These children have limitations in capacity to use the impaired upper limb and bimanual coordination d...

    Authors: Roslyn Boyd, Leanne Sakzewski, Jenny Ziviani, David F Abbott, Radwa Badawy, Rose Gilmore, Kerry Provan, Jacques-Donald Tournier, Richard AL Macdonell and Graeme D Jackson

    Citation: BMC Neurology 2010 10:4

    Content type: Study protocol

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  34. More than 60% of new strokes each year are "mild" in severity and this proportion is expected to rise in the years to come. Within our current health care system those with "mild" stroke are typically discharg...

    Authors: Annie Rochette, Nicol Korner-Bitensky, Duane Bishop, Robert Teasell, Carole White, Gina Bravo, Robert Côté, Jean Lachaine, Teri Green, Louise-Hélène Lebrun, Sylvain Lanthier, Moira Kapral and Sharon Wood-Dauphinee

    Citation: BMC Neurology 2010 10:3

    Content type: Study protocol

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  35. Because of the emerging intersections of HIV infection and Alzheimer's disease, we examined cerebrospinal fluid (CSF) biomarkers related of amyloid and tau metabolism in HIV-infected patients.

    Authors: Magnus Gisslén, Jan Krut, Ulf Andreasson, Kaj Blennow, Paola Cinque, Bruce J Brew, Serena Spudich, Lars Hagberg, Lars Rosengren, Richard W Price and Henrik Zetterberg

    Citation: BMC Neurology 2009 9:63

    Content type: Research article

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  36. Tetrabenazine (TBZ) selectively depletes central monoamines by reversibly binding to the type-2 vesicular monoamine transporter. A previous double blind study in Huntington disease (HD) demonstrated that TBZ e...

    Authors: Samuel Frank

    Citation: BMC Neurology 2009 9:62

    Content type: Research article

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    The Erratum to this article has been published in BMC Neurology 2011 11:18

  37. The mismatch between diffusion weighted imaging (DWI) lesion and perfusion imaging (PI) deficit volumes has been used as a surrogate of ischemic penumbra. This pathophysiology-orientated patient selection crit...

    Authors: Benjamin Hotter, Sandra Pittl, Martin Ebinger, Gabriele Oepen, Kati Jegzentis, Kohsuke Kudo, Michal Rozanski, Wolf U Schmidt, Peter Brunecker, Chao Xu, Peter Martus, Matthias Endres, Gerhard J Jungehülsing, Arno Villringer and Jochen B Fiebach

    Citation: BMC Neurology 2009 9:60

    Content type: Study protocol

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  38. The burden of cerebrovascular disease in developing countries is rising sharply. The prevalence of established risk factors of stroke is exceptionally high in Pakistan. However, there is limited data on the bu...

    Authors: Ayeesha Kamran Kamal, Ahmed Itrat, Muhammed Murtaza, Maria Khan, Asif Rasheed, Amin Ali, Amna Akber, Zainab Akber, Naved Iqbal, Sana Shoukat, Farzin Majeed and Danish Saleheen

    Citation: BMC Neurology 2009 9:58

    Content type: Research article

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  39. About 80% of all stroke survivors have an upper limb paresis immediately after stroke, only about a third of whom (30 to 40%) regain some dexterity within six months following conventional treatment programs. ...

    Authors: A (Lex) EQ van Delden, C (Lieke) E Peper, Jaap Harlaar, Andreas Daffertshofer, Nienke I Zijp, Kirsten Nienhuys, Peter Koppe, Gert Kwakkel and Peter J Beek

    Citation: BMC Neurology 2009 9:57

    Content type: Study protocol

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  40. Neuromyelitis optica (NMO) is an idiopathic, severe, inflammatory demyelinating disease of the central nervous system, that causes severe optic neuritis and myelitis attacks. Early discrimination between multi...

    Authors: Zeljka Petelin Gadze, Sanja Hajnsek, Silvio Basic, Davor Sporis, Goran Pavlisa and Sibila Nankovic

    Citation: BMC Neurology 2009 9:56

    Content type: Case report

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  41. This study describes the prevalence of dementia and major dementia subtypes in Spanish elderly.

    Authors: Jesús de Pedro-Cuesta, Javier Virués-Ortega, Saturio Vega, Manuel Seijo-Martínez, Pedro Saz, Fernanda Rodríguez, Angel Rodríguez-Laso, Ramón Reñé, Susana Pérez de las Heras, Raimundo Mateos, Pablo Martínez-Martín, José María Manubens, Ignacio Mahillo-Fernandez, Secundino López-Pousa, Antonio Lobo, Jordi Llinàs Reglà…

    Citation: BMC Neurology 2009 9:55

    Content type: Research article

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  42. Neutralizing antibodies (NAbs) against Interferon beta (IFNβ) are reported to be associated with poor clinical response to therapy in multiple sclerosis (MS) patients. We aimed to quantify the contribution of ...

    Authors: Emilia Sbardella, Valentina Tomassini, Claudio Gasperini, Francesca Bellomi, Luca Ausili Cefaro, Vincenzo Brescia Morra, Guido Antonelli and Carlo Pozzilli

    Citation: BMC Neurology 2009 9:54

    Content type: Research article

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  43. This study aimed to explore the value of extended motor nerve conduction studies in patients with ulnar nerve entrapment at the elbow (UNE) in order to find the most sensitive and least time-consuming method. ...

    Authors: Kari Todnem, Ralf Peter Michler, Tony Eugen Wader, Morten Engstrøm and Trond Sand

    Citation: BMC Neurology 2009 9:52

    Content type: Research article

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