Articles
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Citation: BMC Neurology 2017 17:35
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Clinical features and outcome in patients with osseomuscular type of Wilson’s disease
Wilson's disease with osseomuscular type is a rare condition, which often lacks typical hepatic and neurological symptoms and causes misdiagnoses easily. During the past 10 years, eight Chinese patients of ...
Citation: BMC Neurology 2017 17:34 -
Stroke caused by an inflammatory thrombus: a case report
Stroke is the leading cause of mortality and disability worldwide. Several definite risk factors have been identified for stroke, although infectious factors might also contribute to stroke episodes through in...
Citation: BMC Neurology 2017 17:33 -
Relationship between ABCB1 3435TT genotype and antiepileptic drugs resistance in Epilepsy: updated systematic review and meta-analysis
Antiepileptic drugs (AEDs) are effective medications available for epilepsy. However, many patients do not respond to this treatment and become resistant. Genetic polymorphisms may be involved in the variation...
Citation: BMC Neurology 2017 17:32 -
Case report: subacute tetraplegia in an immunocompromised patient
Clinical reasoning in Neurology is based on general associations which help to deduce the site of the lesion. However, even “golden principles” may occasionally be deceptive. Here, we describe the case of suba...
Citation: BMC Neurology 2017 17:31 -
Long noncoding RNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) inhibits proliferation and invasion of glioma cells by suppressing the Wnt/β-catenin signaling pathway
The dysregulation of long noncoding RNAs (lncRNAs) has been identified in a variety of cancers. An increasing number of studies have found the critical role of lncRNAs in the regulation of cellular processes, ...
Citation: BMC Neurology 2017 17:30 -
Peginterferon beta-1a improves MRI measures and increases the proportion of patients with no evidence of disease activity in relapsing-remitting multiple sclerosis: 2-year results from the ADVANCE randomized controlled trial
Subcutaneous peginterferon beta-1a has previously been shown to reduce the number of T2-hyperintense and gadolinium-enhancing (Gd+) lesions over 2 years in patients with relapsing-remitting multiple sclerosis ...
Citation: BMC Neurology 2017 17:29 -
Non-neuronal cholinergic activity is potentiated in myasthenia gravis
Non–neuronal acetylcholine (ACh) restricts autoimmune responses and attenuates inflammation by cholinergic anti-inflammation pathway. To date, the implication of ACh in myasthenia gravis (MG) remained unexplor...
Citation: BMC Neurology 2017 17:28 -
Evaluation and implementation of highly challenging balance training in clinical practice for people with Parkinson’s disease: protocol for the HiBalance effectiveness-implementation trial
If people with progressive neurological diseases are to avail of evidence-based rehabilitation, programs found effective in randomized controlled trials (RCT’s) must firstly be adapted and tested in clinical e...
Citation: BMC Neurology 2017 17:27 -
A rare case of bilateral cervical vagal neurofibromas: role of high-resolution ultrasound
Neurofibromas originating from vagus nerves are rarely reported in the literature. In particular, plexiform neurofibromas of the bilateral cervical vagus nerve are extremely rare.
Citation: BMC Neurology 2017 17:26 -
A comparison of central nervous system involvement in patients with classical Fabry disease or the later-onset subtype with the IVS4+919G>A mutation
Patients with the later-onset IVS4+919G>A (IVS4) Fabry mutation are known to have positive central nervous system involvement compared with age- and sex-matched controls. This study compares central nervous sy...
Citation: BMC Neurology 2017 17:25 -
Randomized controlled trial of a coordinated care intervention to improve risk factor control after stroke or transient ischemic attack in the safety net: Secondary stroke prevention by Uniting Community and Chronic care model teams Early to End Disparities (SUCCEED)
Recurrent strokes are preventable through awareness and control of risk factors such as hypertension, and through lifestyle changes such as healthier diets, greater physical activity, and smoking cessation. Ho...
Citation: BMC Neurology 2017 17:24 -
Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson’s disease
Our study was aimed to evaluate the risk of a selected non-motor symptom, namely rapid eye movement behavior disorder (RBD) symptoms, among patients with newly diagnosed Parkinson disease compared with health ...
Citation: BMC Neurology 2017 17:23 -
Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis) with atypical encephalitis and painful testitis: a case report
Kikuchi-Fujimoto disease is a self-limited clinicopathologic entity that is increasingly recognized worldwide. Kikuchi-Fujimoto disease is characterized by cervical lymphadenopathy occurring in young adults. N...
Citation: BMC Neurology 2017 17:22 -
Lower serum uric acid level strongly predict short-term poor functional outcome in acute stroke with normoglycaemia: a cohort study in China
Conflicting results on the correlation between hyperuricemia and the prognosis of stroke had been reported and the close association between serum uric acid (SUA) and abnormal glycomatabolism might further com...
Citation: BMC Neurology 2017 17:21 -
Elevated blood viscosity is associated with cerebral small vessel disease in patients with acute ischemic stroke
Increased level of blood viscosity, which is one of the major factors that determine blood rheology, has been reported as a risk factor or predictor for cerebrovascular events. We investigated how blood viscos...
Citation: BMC Neurology 2017 17:20 -
Monitoring training activity during gait-related balance exercise in individuals with Parkinson’s disease: a proof-of-concept-study
Despite the benefits of balance exercise in clinical populations, balance training programs tend to be poorly described, which in turn makes it difficult to evaluate important training components and compare b...
Citation: BMC Neurology 2017 17:19 -
Functional outcome and complications after the microsurgical removal of giant vestibular schwannomas via the retrosigmoid approach: a retrospective review of 16-year experience in a single hospital
Intracranial vestibular schwannoma still remain to be difficulty for its unique microsurgical technique and preservation of neuro-function, as well as reducing common complications that may arise in surgery.
Citation: BMC Neurology 2017 17:18 -
Long-term efficacy and safety of fingolimod in Japanese patients with relapsing multiple sclerosis: 3-year results of the phase 2 extension study
The low level of disease activity and manageable safety profile seen with fingolimod versus placebo in a 6-month, phase 2, randomized controlled trial in Japanese patients with relapsing multiple sclerosis (MS...
Citation: BMC Neurology 2017 17:17 -
Dancing with a seizure, a case report
Dancing is a very rare seizure semiology, and has only few case reports so far. Moreover, no case regarded as dancing with both description and video was presented.
Citation: BMC Neurology 2017 17:16 -
Monetary costs of Alzheimer’s disease in China: protocol for a cluster-randomised observational study
Alzheimer’s disease (AD) is the most common type of dementia. International multilateral cost-of-illness (COI) studies have revealed that the cost of treating this disease is huge, which places a significant b...
Citation: BMC Neurology 2017 17:15 -
Why use a mirror to assess visual pursuit in prolonged disorders of consciousness? Evidence from healthy control participants
Evidence of reliable smooth visual pursuit is crucial for both diagnosis and prognosis in prolonged disorders of consciousness (PDOC). However, a mirror is more likely than an object to elicit evidence of smoo...
Citation: BMC Neurology 2017 17:14 -
LETM presented with causalgia and ensued by sudden death
Longitudinally Extensive Transverse Myelitis LETM is a specific pattern of myelitis wherein at least three continuous vertebral segments are involved. Characteristically, it is a defining feature of neuromyeli...
Citation: BMC Neurology 2017 17:13 -
Management, prognosis and predictors of unfavourable outcomes in patients newly hospitalized for transient ischemic attack: a real-world investigation from Italy
Understanding the gap between evidence-based recommendations and real-world management is important to inform priority setting and health service planning.
Citation: BMC Neurology 2017 17:12 -
Electrocardiographic assessments and cardiac events after fingolimod first dose – a comprehensive monitoring study
First dose observation for cardiac effects is required for fingolimod, but recommendations on the extent vary. This study aims to assess cardiac safety of fingolimod first dose. Individual bradyarrhythmic epis...
Citation: BMC Neurology 2017 17:11 -
Subjective and objective assessment of physical activity in multiple sclerosis and their relation to health-related quality of life
Physical activity (PA) is frequently restricted in people with multiple sclerosis (PwMS) and aiming to enhance PA is considered beneficial in this population. We here aimed to explore two standard methods (sub...
Citation: BMC Neurology 2017 17:10 -
Factors associated with improvement or decline in cognitive function after an ischemic stroke in Korea: the Korean stroke cohort for functioning and rehabilitation (KOSCO) study
We conducted a prospective cohort study to investigate prevalence of poststroke cognitive impairment at 3 and 12 months after stroke onset and identify clinical and demographic factors associated with improvem...
Citation: BMC Neurology 2017 17:9 -
Plaque distribution of low-grade basilar artery atherosclerosis and its clinical relevance
The underlying pathophysiology of BA distribution is unclear and intriguing. Using high-resolution magnetic resonance imaging (HR-MRI), we sought to explore the plaque distribution of low-grade basilar artery ...
Citation: BMC Neurology 2017 17:8 -
Effects of acetyl-DL-leucine on cerebellar ataxia (ALCAT trial): study protocol for a multicenter, multinational, randomized, double-blind, placebo-controlled, crossover phase III trial
Cerebellar ataxia (CA) is a frequent and often disabling condition that impairs motor functioning and impacts on quality of life (QoL). No medication has yet been proven effective for the symptomatic or even c...
Citation: BMC Neurology 2017 17:7 -
Looking beyond the brain to improve the pathogenic understanding of Parkinson’s disease: implications of whole transcriptome profiling of Patients’ skin
Parkinson’s Disease is a progressive neurodegenerative disease, characterized by symptoms of motor impairment, resulting from the loss of dopaminergic neurons in the midbrain, however non-neuronal symptoms are...
Citation: BMC Neurology 2017 17:6 -
Screening for onconeural antibodies in neuromyelitis optica spectrum disorders
Some so-called “non-classical” paraneoplastic neurological syndromes (PNS), namely optic neuritis and myelitis, clinically overlap with neuromyelitis optica spectrum disorders (NMOSD), and conversely, in cance...
Citation: BMC Neurology 2017 17:5 -
Interaction among COX-2, P2Y1 and GPIIIa gene variants is associated with aspirin resistance and early neurological deterioration in Chinese stroke patients
The effect of genetic variants on aspirin resistance (AR) remains controversial. We sought to assess the association of genetic variants with AR and early clinical outcomes in patients with acute ischemic stro...
Citation: BMC Neurology 2017 17:4 -
Circadian course of the P300 ERP in patients with amyotrophic lateral sclerosis - implications for brain-computer interfaces (BCI)
Accidents or neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) can lead to progressing, extensive, and complete paralysis leaving patients aware but unable to communicate (locked-in state). B...
Citation: BMC Neurology 2017 17:3 -
A limb-girdle myopathy phenotype of RUNX2 mutation in a patient with cleidocranial dysplasia: a case study and literature review
Cleidocranial dysplasia (CCD) is a rare hereditary disorder that arises from heterozygous loss of function mutations in the runt-related transcription factor 2 (RUNX2) gene. As RUNX2 is mainly expressed in osteob...
Citation: BMC Neurology 2017 17:2 -
Anti-N-methyl-D-aspartate receptor(NMDAR) antibody encephalitis presents in atypical types and coexists with neuromyelitis optica spectrum disorder or neurosyphilis
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a clinically heterogeneous disorder characterized by epileptic seizures, psychosis, dyskinesia, consciousness impairments, and autonomic instability. ...
Citation: BMC Neurology 2017 17:1 -
Critical illness polyneuropathy (CIP) in neurological early rehabilitation: clinical and neurophysiological features
Critical illness polyneuropathy (CIP) is a complex disease affecting 30–70% of critically ill patients.
Citation: BMC Neurology 2016 16:256 -
A case report: Becker muscular dystrophy presenting with epilepsy and dysgnosia induced by duplication mutation of Dystrophin gene
Becker muscular dystrophy (BMD), a genetic disorder of X-linked recessive inheritance, typically presents with gradually progressive muscle weakness. The condition is caused by mutations of Dystrophin gene loc...
Citation: BMC Neurology 2016 16:255 -
Assessment of platelet function in patients with stroke using multiple electrode platelet aggregometry: a prospective observational study
There is a link between high on-treatment platelet reactivity (HPR) and adverse vascular events in stroke. This study aimed to compare multiple electrode platelet aggregometry (MEA), in healthy subjects and is...
Citation: BMC Neurology 2016 16:254 -
Serum albumin to globulin ratio is related to cognitive decline via reflection of homeostasis: a nested case-control study
Recent research suggests that several pathogenetic factors, including aging, genetics, inflammation, dyslipidemia, diabetes, and infectious diseases, influence cognitive decline (CD) risk. However, no definiti...
Citation: BMC Neurology 2016 16:253 -
Capsaicin 8% patch repeat treatment plus standard of care (SOC) versus SOC alone in painful diabetic peripheral neuropathy: a randomised, 52-week, open-label, safety study
This 52-week study evaluated the long-term safety and tolerability of capsaicin 8% w/w (179 mg) patch repeat treatment plus standard of care (SOC) versus SOC alone in painful diabetic peripheral neuropathy (PD...
Citation: BMC Neurology 2016 16:251 -
Bone mineral density in patients with multiple sclerosis, hereditary ataxia or hereditary spastic paraplegia after at least 10 years of disease - a case control study
Although disability is considered the main cause of low bone mineral density (BMD) in multiple sclerosis (MS), other factors related to the disease process or treatment could also be involved. The aim of this ...
Citation: BMC Neurology 2016 16:252 -
Quality of life after stroke in Pakistan
There is very little information about the quality of life (QOL) of stroke survivors in LMIC countries with underdeveloped non communicable health infrastructures, who bear two thirds of the global stroke burden.
Citation: BMC Neurology 2016 16:250 -
Presynaptic neuromuscular transmission defect in the stiff person syndrome
The stiff person syndrome (SPS) is a rare disorder characterized by muscular rigidity and stiffness.
Citation: BMC Neurology 2016 16:249 -
miR-491 regulates glioma cells proliferation by targeting TRIM28 in vitro
MicroRNAs are significantly involved in tumorigenesis and progression of glioma. However, the critical part they play in glioma have not been fully elaborated. miR-491 and Tripartite motif containing 28 (TRIM2...
Citation: BMC Neurology 2016 16:248 -
Endoscopic endonasal pituitary adenomas surgery: the surgical experience of 178 consecutive patients and learning curve of two neurosurgeons
We aim to study surgical technique and analyze the related factors affecting tumor total removal and postoperative endocrinological remission for endoscopic endonasal pituitary adenomas surgery.
Citation: BMC Neurology 2016 16:247 -
Health-related quality of life in stroke patients questionnaire, short version (HRQOLISP-40): validation for its use in Colombia
The health-related quality of life in stroke patients (HRQOLISP-40, short version) survey was developed in Nigeria and constitutes a 40-item, multidimensional, self-administrated questionnaire. We assessed the...
Citation: BMC Neurology 2016 16:246 -
Prevalence of non-febrile seizures in children with idiopathic autism spectrum disorder and their unaffected siblings: a retrospective cohort study
Autism spectrum disorder (ASD) is a heterogeneous disorder characterized not only by deficits in communication and social interactions but also a high rate of co-occurring disorders, including metabolic abnorm...
Citation: BMC Neurology 2016 16:245 -
Ratio of apoB/LDL: a potential clinical index for vascular cognitive impairment
Vascular cognitive impairment (VCI), compared to vascular dementia (VD), has a broader definition and highlights the effect of vascular disease in dementia, and stroke seems play an important role in the devel...
Citation: BMC Neurology 2016 16:243 -
A profile of The Clinical Course of Cognition and Comorbidity in Mild Cognitive Impairment and Dementia Study (The 4C study): two complementary longitudinal, clinical cohorts in the Netherlands
Heterogeneous disease trajectories of mild cognitive impairment (MCI) and dementia are frequently encountered in clinical practice, but there is still insufficient knowledge to understand the reasons and mecha...
Citation: BMC Neurology 2016 16:242 -
Help seeking behavior and onset-to-alarm time in patients with acute stroke: sub-study of the preventive antibiotics in stroke study
Patients with acute stroke often do not seek immediate medical help, which is assumed to be driven by lack of knowledge of stroke symptoms. We explored the process of help seeking behavior in patients with acu...
Citation: BMC Neurology 2016 16:241
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