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  1. Traditionally, tinnitus accompanied by hemifacial spasm has been considered a type of hyperactive neurovascular compression syndrome that is similar to hemifacial spasm alone because of the anatomically close ...

    Authors: Won Seok Chang, Bong Soo Kim, Ji Eun Lee, Hyun Ho Jung, Kiwoong Kim, Hyuk Chan Kwon, Yong Ho Lee and Jin Woo Chang
    Citation: BMC Neurology 2013 13:42
  2. Spinocerebellar ataxias (SCA) are a group of hereditary neurodegenerative disorders. Prevalence of SCA subtypes differ worldwide. Autosomal dominant ataxias are the commonest types of inherited ataxias seen in...

    Authors: Dulika S Sumathipala, Gayan S Abeysekera, Rohan W Jayasekara, Chantal ME Tallaksen and Vajira HW Dissanayake
    Citation: BMC Neurology 2013 13:39
  3. Eukaryotic translation initiation factor 4-gamma 1 (EIF4G1) gene mutations have recently been reported in autosomal dominant, late-onset Parkinson’s disease (LOPD). We carried out genetic analysis to determine th...

    Authors: Kai Li, Bei-sha Tang, Ji-feng Guo, Ming-xing Lou, Zhan-yun Lv, Zhen-hua Liu, Yun Tian, Cheng-yuan Song, Kun Xia and Xin-xiang Yan
    Citation: BMC Neurology 2013 13:38
  4. The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, des...

    Authors: Yvonne C Learmonth, Robert W Motl, Brian M Sandroff, John H Pula and Diego Cadavid
    Citation: BMC Neurology 2013 13:37
  5. This study describes a new method for determining site-specific vascular shear stress using dynamic measures of shear rate and blood viscosity (BV) in the carotid arteries, and examines characteristics of caro...

    Authors: Seul-Ki Jeong and Robert S Rosenson
    Citation: BMC Neurology 2013 13:36
  6. Using surrogate biomarkers for disease progression as endpoints in neuroprotective clinical trials may help differentiate symptomatic effects of potential neuroprotective agents from true disease-modifying eff...

    Authors: David JM McGhee, Pamela L Royle, Paul A Thompson, David E Wright, John P Zajicek and Carl E Counsell
    Citation: BMC Neurology 2013 13:35
  7. Some recent experimental data suggest a possible role of LINGO-1 in the pathogenesis of multiple sclerosis (MS). In an attempt to identify genetic biomarkers related to MS susceptibility, we genotyped two comm...

    Authors: Elena García-Martín, Oswaldo Lorenzo-Betancor, Carmen Martínez, Pau Pastor, Julián Benito-León, Jorge Millán-Pascual, Patricia Calleja, María Díaz-Sánchez, Diana Pisa, Laura Turpín-Fenoll, Hortensia Alonso-Navarro, Lucía Ayuso-Peralta, Dolores Torrecillas, Elena Lorenzo, José Francisco Plaza-Nieto, José A G Agúndez…
    Citation: BMC Neurology 2013 13:34
  8. The editors of BMC Neurology would like to thank all our reviewers who have contributed to the journal in Volume 12 (2012).

    Authors: Deesha A Majithia
    Citation: BMC Neurology 2013 13:25
  9. Neuromyelitis optica (NMO) includes transverse myelitis, optic neuritis and brain lesions. Recent studies have indicated that the brainstem is an important site of attack in NMO. Longitudinally extensive trans...

    Authors: Nasrin Asgari, Hanne Pernille Bro Skejoe, Soeren Thue Lillevang, Troels Steenstrup, Egon Stenager and Kirsten Ohm Kyvik
    Citation: BMC Neurology 2013 13:33
  10. Vascular endothelial growth factor (VEGF) is a well-known molecule mediating neuronal survival and angiogenesis. However, its clinical significance in ischemic stroke is still controversial. The goal of this s...

    Authors: Ryu Matsuo, Tetsuro Ago, Masahiro Kamouchi, Junya Kuroda, Takahiro Kuwashiro, Jun Hata, Hiroshi Sugimori, Kenji Fukuda, Seiji Gotoh, Noriko Makihara, Masayo Fukuhara, Hideto Awano, Tetsu Isomura, Kazuo Suzuki, Masahiro Yasaka, Yasushi Okada…
    Citation: BMC Neurology 2013 13:32
  11. The impact of neurological conditions on individuals, families and society is increasing and having a significant economic impact in Canada. While some economic data is known, the human costs of living with a ...

    Authors: Joan Versnel, Tanya Packer, Lori E Weeks, Jocelyn Brown, Marshall Godwin, Susan Hutchinson, George Kephart, Diane MacKenzie, Kerstin Roger, Robin Stadnyk, Michelle Villeneuve and Grace Warner
    Citation: BMC Neurology 2013 13:30
  12. Hereditary myopathy with early respiratory failure (HMERF) was described in several North European families and recently linked to a titin gene (TTN) mutation. We independently studied HMERF-like diseases with th...

    Authors: Camilo Toro, Montse Olivé, Marinos C Dalakas, Kumaraswami Sivakumar, Juan M Bilbao, Felix Tyndel, Noemí Vidal, Eva Farrero, Nyamkhishig Sambuughin and Lev G Goldfarb
    Citation: BMC Neurology 2013 13:29
  13. The partial form of the complex regional pain syndrome of the hand type 1 (CRPS 1), involving only 1 to 3 fingers, is a rare condition first described in 1972. The aim of the study is to define more precisely ...

    Authors: Michel Konzelmann, Olivier Deriaz and François Luthi
    Citation: BMC Neurology 2013 13:28
  14. At present, there is no consensus on how to clinically assess localisation to sound in patients recovering from coma. We here studied auditory localisation using the patient’s own name as compared to a meaning...

    Authors: Lijuan Cheng, Olivia Gosseries, Limei Ying, Xiaohua Hu, Dan Yu, Hongxing Gao, Minhui He, Caroline Schnakers, Steven Laureys and Haibo Di
    Citation: BMC Neurology 2013 13:27
  15. Worldwide, millions of people are suffering from dementia and this number is rising. An index of quality of life (QoL) can describe the impact a disease or treatment has on a person’s wellbeing. QoL comprises ...

    Authors: Roxane Anthea Francesca Weijenberg, Frank Lobbezoo, Dirk Lucas Knol, Jori Tomassen and Erik Johan Anton Scherder
    Citation: BMC Neurology 2013 13:26
  16. Mutations of the UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine-kinase (GNE)-gene are causally related to GNE myopathy. Yet, underlying pathomechanisms of muscle fibre damage have remained elusive. In...

    Authors: Charlotte Fischer, Konstanze Kleinschnitz, Arne Wrede, Ingrid Muth, Niels Kruse, Ichizo Nishino and Jens Schmidt
    Citation: BMC Neurology 2013 13:24
  17. The aim of this study were to describe acute care of ischemic stroke patients and adherence to performance measures, as well as the outcomes of these events, in a sample of patients treated in public hospitals...

    Authors: Lorena Hoffmeister, Pablo M Lavados, Merce Comas, Carolina Vidal, Rodrigo Cabello and Xavier Castells
    Citation: BMC Neurology 2013 13:23
  18. The social and medical impact of rare diseases is increasingly recognized. Amyotrophic lateral sclerosis (ALS) is the most prevalent of the motor neuron diseases. It is characterized by rapidly progressive dam...

    Authors: Gabriele Nagel, Hatice Ünal, Angela Rosenbohm, Albert C Ludolph and Dietrich Rothenbacher
    Citation: BMC Neurology 2013 13:22
  19. Fibromyalgia has a plethorae of symptoms, which can be confusing and even misleading. Accurate evaluation is necessary when patients with fibromyalgia are treated. Different types of instruments are available ...

    Authors: Jarno Gauffin, Tiina Hankama, Hannu Kautiainen, Pekka Hannonen and Maija Haanpää
    Citation: BMC Neurology 2013 13:21
  20. This study aimed to investigate the prevalence and clinical relevance of chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis (MS) patients and healthy controls using extra- and intracrania...

    Authors: Roberta Lanzillo, Marcello Mancini, Raffaele Liuzzi, Orlando Di Donato, Elena Salvatore, Valentina Maglio, Giovanni Vacca, Luca Amato, Gennaro D’Anna, Arturo Brunetti and Vincenzo Brescia Morra
    Citation: BMC Neurology 2013 13:20
  21. There have been several reports concerning the survival time after symptom onset in patients with amyotrophic lateral sclerosis (ALS). However, little is known about how the choice of physician (i.e., general ...

    Authors: Osamu Kano, Konosuke Iwamoto, Hirono Ito, Yuji Kawase, Derek Cridebring, Ken Ikeda and Yasuo Iwasaki
    Citation: BMC Neurology 2013 13:19
  22. Increasing evidence provides a clear association between rapid eye movement sleep behavior disorders (RBD) and Parkinson’s disease (PD), but the clinical features that determine the co-morbidity of RBD and PD ...

    Authors: Keisuke Suzuki, Tomoyuki Miyamoto, Masayuki Miyamoto, Yuka Watanabe, Shiho Suzuki, Muneto Tatsumoto, Masaoki Iwanami, Tsubasa Sada, Taro Kadowaki, Ayaka Numao, Kenichi Hashimoto, Hideki Sakuta and Koichi Hirata
    Citation: BMC Neurology 2013 13:18
  23. Deep-vein thrombosis (DVT) and pulmonary embolism (PE) are frequent and life-threatening complications of ischemic stroke. We evaluated rates of symptomatic DVT/PE, and of in-hospital and post-discharge thromb...

    Authors: Alpesh N Amin, Jay Lin, Stephen Thompson and Daniel Wiederkehr
    Citation: BMC Neurology 2013 13:17
  24. While mental comorbidity is considered common in multiple sclerosis (MS), its impact is poorly defined; methods are needed to support studies of mental comorbidity. We validated and applied administrative case...

    Authors: Ruth Ann Marrie, John D Fisk, Bo Nancy Yu, Stella Leung, Lawrence Elliott, Patricia Caetano, Sharon Warren, Charity Evans, Christina Wolfson, Lawrence W Svenson, Helen Tremlett, James F Blanchard and Scott B Patten
    Citation: BMC Neurology 2013 13:16
  25. Recent work has demonstrated that fall risk can be attributed to cognitive as well as motor deficits. Indeed, everyday walking in complex environments utilizes executive function, dual tasking, planning and sc...

    Authors: Anat Mirelman, Lynn Rochester, Miriam Reelick, Freek Nieuwhof, Elisa Pelosin, Giovanni Abbruzzese, Kim Dockx, Alice Nieuwboer and Jeffrey M Hausdorff
    Citation: BMC Neurology 2013 13:15
  26. Although intima-media thickness (IMT) was increased in several inflammatory diseases, studies investigating whether the inflammatory processes lead to macrovascular alteration with increased IMT in complex reg...

    Authors: Nicola Derenthal, Tim Maecken, Elena Krumova, Alfried Germing and Christoph Maier
    Citation: BMC Neurology 2013 13:14
  27. ‘Neuromarketing’ is a term that has often been used in the media in recent years. These public discussions have generally centered around potential ethical aspects and the public fear of negative consequences ...

    Authors: Andrija Javor, Monika Koller, Nick Lee, Laura Chamberlain and Gerhard Ransmayr
    Citation: BMC Neurology 2013 13:13
  28. Language comprehension requires decoding of complex, rapidly changing speech streams. Detecting changes of frequency modulation (FM) within speech is hypothesized as essential for accurate phoneme detection, a...

    Authors: Frank H Duffy, Yaman Z Eksioglu, Alexander Rotenberg, Joseph R Madsen, Aditi Shankardass and Heidelise Als
    Citation: BMC Neurology 2013 13:12
  29. Patients with recent stroke or TIA are at high risk for new vascular events. Several evidence based strategies in secondary prevention of stroke are available but frequently underused. Support programs with mu...

    Authors: Stefanie Leistner, Georg Michelson, Inga Laumeier, Michael Ahmadi, Maureen Smyth, Gabriele Nieweler, Wolfram Doehner, Jan Sobesky, Jochen B Fiebach, Peter Marx, Otto Busse, Friedrich Köhler, Holger Poppert, Martin LJ Wimmer, Thomas Knoll, Paul Von Weitzel-Mudersbach…
    Citation: BMC Neurology 2013 13:11
  30. To improve quality of life (QOL) in patients with multiple sclerosis (MS), it is important to decrease disability and prevent relapse. The aim of this study was to examine the causal and mutual relationships c...

    Authors: Hiromi Kikuchi, Nobuhiro Mifune, Masaaki Niino, Jun-ichi Kira, Tatsuo Kohriyama, Kohei Ota, Masami Tanaka, Hirofumi Ochi, Shunya Nakane and Seiji Kikuchi
    Citation: BMC Neurology 2013 13:10
  31. Jugular venous reflux (JVR) has been reported to cause cough syncope via retrograde-transmitted venous hypertension and consequently decreased cerebral blood flow (CBF). Unmatched frequencies of JVR and cough ...

    Authors: Chih-Ping Chung, Chun-Yu Cheng, Robert Zivadinov, Wei-Chih Chen, Wen-Yung Sheng, Yu-Chin Lee, Han-Hwa Hu, Hung-Yi Hsu and Kuang-Yao Yang
    Citation: BMC Neurology 2013 13:9
  32. POLG1 mutations have been associated with MELAS-like phenotypes. However given several clinical differences it is unknown whether POLG1 mutations are possible causes of MELAS or give raise to a distinct clinical...

    Authors: Antonella Cheldi, Dario Ronchi, Andreina Bordoni, Bianca Bordo, Silvia Lanfranconi, Maria Grazia Bellotti, Stefania Corti, Valeria Lucchini, Monica Sciacco, Maurizio Moggio, Pierluigi Baron, Giacomo Pietro Comi, Antonio Colombo and Anna Bersano
    Citation: BMC Neurology 2013 13:8
  33. Evidence about whether white blood cell (WBC) or its subtypes can act as a biomarker to predict the ischemic stroke events in the general population is scanty, particularly in Asian populations. The aim of thi...

    Authors: Tzy-Haw Wu, Kuo-Liong Chien, Hung-Ju Lin, Hsiu-Ching Hsu, Ta-Chen Su, Ming-Fong Chen and Yuan-Teh Lee
    Citation: BMC Neurology 2013 13:7
  34. Residual disability after stroke is substantial; 65% of patients at 6 months are unable to incorporate the impaired upper extremity into daily activities. Task-oriented training programs are rapidly being adop...

    Authors: Carolee J Winstein, Steven L Wolf, Alexander W Dromerick, Christianne J Lane, Monica A Nelsen, Rebecca Lewthwaite, Sarah Blanton, Charro Scott, Aimee Reiss, Steven Yong Cen, Rahsaan Holley and Stanley P Azen
    Citation: BMC Neurology 2013 13:5
  35. Responsiveness refers to a measurement tool’s ability to detect change in performance over time. The aim of the review was to summarise studies of responsiveness of lower limb physical performance measures dur...

    Authors: Katharine Scrivener, Catherine Sherrington and Karl Schurr
    Citation: BMC Neurology 2013 13:4
  36. A strong inverse relationship of functional limitation and socioeconomic status has been established in western ageing society. Functional limitation can be related to chronic diseases, disuse, cognitive decli...

    Authors: Vorapun Senanarong, Kamolthip Harnphadungkit, Niphon Poungvarin, Sathit Vannasaeng, Samut Chongwisal, Tipa Chakorn, Piyanuch Jamjumrus, Atthapon Raksthaput, Sinisa Chaichanettee, Nattapol Aoonkaew, Suthipol Udompunthurak, Rachelle S Doody and Jeffrey L Cummings
    Citation: BMC Neurology 2013 13:3
  37. It has been suggested that cerebrospinal fluid (CSF) CXCL13 is a diagnostic marker of Lyme neuroborreliosis (LNB), as its levels have been shown to be significantly higher in LNB than in several other CNS infe...

    Authors: Daniel Bremell, Niklas Mattsson, Mikael Edsbagge, Kaj Blennow, Ulf Andreasson, Carsten Wikkelsö, Henrik Zetterberg and Lars Hagberg
    Citation: BMC Neurology 2013 13:2
  38. Fibrates has been extensively used to improve plasma lipid levels and prevent adverse cardiovascular outcomes. However, the effect of fibrates on stroke is unclear at the present time. We therefore carried out...

    Authors: Yu-Hao Zhou, Xiao-Fei Ye, Fei-Fei Yu, Xiao Zhang, Ying-Yi Qin, Jian Lu and Jia He
    Citation: BMC Neurology 2013 13:1
  39. Few studies have systematically addressed the role of epidural analgesia and caesarean delivery in predicting the post-partum disease activity in women with Multiple Sclerosis (MS).

    Authors: Luisa Pastò, Emilio Portaccio, Angelo Ghezzi, Bahia Hakiki, Marta Giannini, Lorenzo Razzolini, Elisa Piscolla, Laura De Giglio, Carlo Pozzilli, Damiano Paolicelli, Maria Trojano, Maria Giovanna Marrosu, Francesco Patti, Loredana La Mantia, Gian Luigi Mancardi, Claudio Solaro…
    Citation: BMC Neurology 2012 12:165
  40. Stroke is one of the major causes of loss of independence, decreased quality of life and mortality among elderly people. About half of the elderly stroke patients discharged after rehabilitation in a nursing h...

    Authors: Tom PMM Vluggen, Jolanda CM van Haastregt, Jeanine A Verbunt, Elly JM Keijsers and Jos MGA Schols
    Citation: BMC Neurology 2012 12:164
  41. Based upon the acquainted loss of dopaminergic neurons in the substantia nigra in Parkinson’s disease (PD), we hypothesised changes in magnetic resonance imaging signal intensities of the basal ganglia to be u...

    Authors: Sarah Jesse, Jan Kassubek, Hans-Peter Müller, Albert C Ludolph and Alexander Unrath
    Citation: BMC Neurology 2012 12:163
  42. Reduced upper extremity function is one of the most common impairments after stroke and has previously been reported in approximately 70-80% of patients in the acute stage. Acute care for stroke has changes ov...

    Authors: Hanna C Persson, Marina Parziali, Anna Danielsson and Katharina S Sunnerhagen
    Citation: BMC Neurology 2012 12:162
  43. Physical disability in multiple sclerosis (MS) is frequently characterized by impaired ambulation. Although walking tests have been successfully employed to assess walking ability in MS patients, data analytic...

    Authors: Janina M Burschka, Philipp M Keune, Uwe Menge, Ulrich Hofstadt-van Oy, Patrick Oschmann and Olaf Hoos
    Citation: BMC Neurology 2012 12:161
  44. This paper provides a strategy to obtain a reliable estimate of the incidence rate for Amyotrophic lateral sclerosis based on data from the National Registry of Rare Diseases (NRRD). In fact, unobserved cases ...

    Authors: Irene Rocchetti, Domenica Taruscio and Daniela Pierannunzio
    Citation: BMC Neurology 2012 12:160
  45. Nerve damage in leprosy often causes disabilities and deformities. Prednisolone is used to treat nerve function impairment (NFI). However, optimal dose and duration of prednisolone treatment has not been estab...

    Authors: Inge Wagenaar, Wim Brandsma, Erik Post, Wim van Brakel, Diana Lockwood, Peter Nicholls, Paul Saunderson, Cairns Smith, Einar Wilder-Smith and Jan Hendrik Richardus
    Citation: BMC Neurology 2012 12:159
  46. Recombinant factor VIIa (rFVIIa) may be used for rapid hemostasis in life-threatening hemorrhage. In warfarin-associated intracerebral hemorrhage (wICH), FVIIa use is controversial and may carry significant th...

    Authors: Chou Sherry H-Y, Cai Xuemei, Konigsberg Rachael G, Bresette Linda M, Henderson Galen V, Sorond Farzaneh A and Feske Steven K
    Citation: BMC Neurology 2012 12:158

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