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  1. Glioma metastasis, invasion, epithelial-mesenchymal transition (EMT) and chemoresistance indicate poor prognosis. Accumulating evidence reveals that Notch1 is an important factor in tumour progression. However...

    Authors: Jianlong Li, Qingbin Li, Lin Lin, Rui Wang, Lingchao Chen, Wenzhong Du, Chuanlu Jiang and Ruiyan Li
    Citation: BMC Neurology 2018 18:133
  2. Down syndrome (DS) is a common developmental disorder resulting from the presence of an additional copy of chromosome 21. Abnormalities in dopamine signaling are suggested to be involved in cognitive dysfuncti...

    Authors: Thanh Thi Mai Pham, Hiroki Kato, Haruyoshi Yamaza, Keiji Masuda, Yuta Hirofuji, Hiroshi Sato, Huong Thi Nguyen Nguyen, Xu Han, Yu Zhang, Tomoaki Taguchi and Kazuaki Nonaka
    Citation: BMC Neurology 2018 18:132
  3. The SPAN-100 index adds patient age and baseline NIHSS-score and was introduced to predict clinical outcome after acute ischemic stroke (AIS). Even with high NIHSS-scores younger patients cannot reach a SPAN-1...

    Authors: Cornelia Möbius, Christian Blinzler, Stefan Schwab, Martin Köhrmann and Lorenz Breuer
    Citation: BMC Neurology 2018 18:129
  4. Our aim was to compare the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) in during carotid endarterectomy (CEA) and carotid artery stenting (CAS).

    Authors: Ákos Mérei, Bálint Nagy, Gábor Woth, János Lantos, Ferenc Kövér, Lajos Bogár and Diána Mühl
    Citation: BMC Neurology 2018 18:128
  5. Critical care covers multiple disciplines. However, the causes of critical illness in the ICU, particularly the most common causes, remain unclear. We aimed to investigate the incidence and the most common cau...

    Authors: Ye-Ting Zhou, Dao-Ming Tong, Shao-Dan Wang, Song Ye, Ben-Wen Xu and Chen-Xi Yang
    Citation: BMC Neurology 2018 18:127
  6. Cardiac autonomic neuropathy (CAN) in diabetes is among the strongest risk markers for future global and cardiovascular mortality. The aim of this study was to analyse CAN prevalence and to compare the associatio...

    Authors: Anca Moţăţăianu, Smaranda Maier, Zoltan Bajko, Septimiu Voidazan, Rodica Bălaşa and Adina Stoian
    Citation: BMC Neurology 2018 18:126
  7. Neurogenic orthostatic hypotension (nOH) results from impaired vasoconstriction due to dysfunction of the autonomic nervous system and is commonly associated with Parkinson disease (PD), multiple system atroph...

    Authors: Daniel O. Claassen, Charles H. Adler, L. Arthur Hewitt and Christopher Gibbons
    Citation: BMC Neurology 2018 18:125
  8. Respiratory system elastance (ERS) is an important determinant of the responsiveness of intracranial pressure (ICP) to positive end-expiratory pressure (PEEP). However, lung elastance (EL) and chest wall elastanc...

    Authors: Han Chen, Kai Chen, Jing-Qing Xu, Ying-Rui Zhang, Rong-Guo Yu and Jian-Xin Zhou
    Citation: BMC Neurology 2018 18:124
  9. Sleep disorders and fatigue are common in multiple sclerosis (MS). The underlying causes are not fully understood, and prospective studies are lacking. Therefore, we conducted a prospective, observational coho...

    Authors: Sylvia Kotterba, Thomas Neusser, Christiane Norenberg, Patrick Bussfeld, Thomas Glaser, Martin Dörner and Markus Schürks
    Citation: BMC Neurology 2018 18:123
  10. Chinese guidelines for management of Parkinson’s disease (PD) have been issued and updated regularly since 2006. We undertook a cross-sectional survey to evaluate the impact of the latest edition (2014) on cur...

    Authors: Gang Wang, Hai-Lun Cui, Jun Liu, Qin Xiao, Ying Wang, Jian-Fang Ma, Hai-Yan Zhou, Jing Pan, Yu-Yan Tan and Sheng-Di Chen
    Citation: BMC Neurology 2018 18:122
  11. Segmental zoster paresis (SZP) of limbs, characterized by focal weakness of extremity, is recognized as a rare complication of herpes zoster (HZ). The following study analyzes the clinical characteristics and ...

    Authors: Ying Liu, Bing-Yun Wu, Zhen-Shen Ma, Juan-Juan Xu, Bing Yang, Heng Li and Rui-Sheng Duan
    Citation: BMC Neurology 2018 18:121
  12. The motor and sensory symptoms caused by compressive radial neuropathy are well-known, but the involvement of the autonomic nervous system or the dermatologic symptoms are less well known. We report an unusual...

    Authors: Jong Hyeon Ahn, Dae Joong Kim, Jung-Joon Sung, Yoon-Ho Hong, Suk-Won Ahn, Jeong Jin Park and Byung-Nam Yoon
    Citation: BMC Neurology 2018 18:120
  13. Benign gynecologic tumor, such as uterine adenomyosis, has been suggested to develop hypercoagulability. Although some cases of cerebral infarction associated with adenomyosis have been reported, the mechanism...

    Authors: Yasuhiro Aso, Ryo Chikazawa, Yuki Kimura, Noriyuki Kimura and Etsuro Matsubara
    Citation: BMC Neurology 2018 18:119
  14. Niemann-Pick disease type C (NPC) is a lysosomal storage disorder with severe prognosis. Disease-specific therapy is crucial to prevent disease progression; however, diagnosing NPC is quite difficult because o...

    Authors: Tomoya Kawazoe, Toshiyuki Yamamoto, Aya Narita, Kousaku Ohno, Kaori Adachi, Eiji Nanba, Atsuko Noguchi, Tsutomu Takahashi, Masamitsu Maekawa, Yoshikatsu Eto, Masafumi Ogawa, Miho Murata and Yuji Takahashi
    Citation: BMC Neurology 2018 18:117
  15. Post-translational modifications (PTMs) generate a tremendous protein diversity from the ~ 20,000 protein-coding genes of the human genome. In chronic pain conditions, exposure to pathological processes in the...

    Authors: Emmanuel Bäckryd, Sofia Edström, Björn Gerdle and Bijar Ghafouri
    Citation: BMC Neurology 2018 18:116
  16. Dysphagia and other eating and drinking difficulties are common in progressive neurological diseases. Mealtimes can become a major source of difficulty and anxiety for patients and their families. Decisions ab...

    Authors: Gemma Clarke, Elizabeth Fistein, Anthony Holland, Jake Tobin, Sam Barclay and Stephen Barclay
    Citation: BMC Neurology 2018 18:115
  17. Deficits in gait and balance are common among neurological inpatients. Currently, assessment of these patients is mainly subjective. New assessment options using wearables may provide complementary and more ob...

    Authors: Felix P. Bernhard, Jennifer Sartor, Kristina Bettecken, Markus A. Hobert, Carina Arnold, Yvonne G. Weber, Sven Poli, Nils G. Margraf, Christian Schlenstedt, Clint Hansen and Walter Maetzler
    Citation: BMC Neurology 2018 18:114
  18. We present a patient fulfilling the electrophysiological criteria for definite chronic inflammatory demyelinating polyneuropathy (CIDP), antibody-positive myasthenia gravis (MG), and membranous glomerulonephri...

    Authors: Saskia Bolz, Andreas Totzeck, Kerstin Amann, Mark Stettner, Christoph Kleinschnitz and Tim Hagenacker
    Citation: BMC Neurology 2018 18:113
  19. Cutaneous and systemic plasmacytosis are skin disorders characterized by cutaneous polyclonal plasma cell infiltration accompanied by polyclonal hypergammaglobulinemia. Cutaneous plasmacytosis involvement is l...

    Authors: Taku Hatano, Masashi Takanashi, Hitoshi Tsuchihashi, Shin-Ichi Ueno, Arisa Hayashida, Yutaka Tsukune, Kazuaki Kanai, Yasushi Shimo and Nobutaka Hattori
    Citation: BMC Neurology 2018 18:112
  20. Multiple sclerosis (MS) is one of the most frequently observed neurological conditions in Switzerland, but data sources for country-wide epidemiological trend monitoring are lacking. Moreover, while clinical a...

    Authors: Nina Steinemann, Jens Kuhle, Pasquale Calabrese, Jürg Kesselring, Giulio Disanto, Doron Merkler, Caroline Pot, Vladeta Ajdacic-Gross, Stephanie Rodgers, Milo Alan Puhan and Viktor von Wyl
    Citation: BMC Neurology 2018 18:111
  21. Seizures arising from the precuneus are rare, and few studies have aimed at characterizing the clinical presentation of such seizures within the anatomic context of the frontoparietal circuits. We aimed to cha...

    Authors: Yanfeng Yang, Haixiang Wang, Wenjing Zhou, Tianyi Qian, Wei Sun and Guoguang Zhao
    Citation: BMC Neurology 2018 18:110
  22. Semantic variant primary progressive aphasia (svPPA) is a subtype of primary progressive aphasia characterized by two-way anomia and disturbance in word comprehension, with focal atrophy in the left temporal l...

    Authors: Ryota Kobayashi, Hiroshi Hayashi, Shinobu Kawakatsu, Aiko Ishiki, Nobuyuki Okamura, Hiroyuki Arai and Koichi Otani
    Citation: BMC Neurology 2018 18:109
  23. Diffusion kurtosis imaging (DKI) has the potential to provide microstructural insights into myelin and axonal pathology with additional kurtosis parameters. To our knowledge, few studies are available in the c...

    Authors: Hai Qing Li, Bo Yin, Chao Quan, Dao Ying Geng, Hai Yu, Yi Fang Bao, Jun Liu and Yu Xin Li
    Citation: BMC Neurology 2018 18:108
  24. Nocturia is a common urinary symptom of multiple sclerosis (MS) which can affect quality of life (QoL) adversely. Melatonin is a hormone known to regulate circadian rhythm and reduce smooth muscle activity suc...

    Authors: Marcus J. Drake, Luke Canham, Nikki Cotterill, Debbie Delgado, Jenny Homewood, Kirsty Inglis, Lyndsey Johnson, Mary C. Kisanga, Denise Owen, Paul White and David Cottrell
    Citation: BMC Neurology 2018 18:107
  25. Insulin-like growth factor I (IGF-I) has neuroprotective effects in experimental ischemic stroke (IS). However, in patients who have suffered IS, various associations between the levels of serum IGF-I (s-IGF-I...

    Authors: N. David Åberg, Daniel Åberg, Katarina Jood, Michael Nilsson, Christian Blomstrand, H. Georg Kuhn, Johan Svensson, Christina Jern and Jörgen Isgaard
    Citation: BMC Neurology 2018 18:106
  26. After stroke, spasticity of the rectus femoris (RF) and triceps surae (TS) muscles frequently alters the gait pattern. Knee flexion and ankle dorsiflexion in swing are often reduced, respectively called Stiff ...

    Authors: Anthony Supiot, Maxime Geiger, Djamel Bensmail, Phillippe Aegerter, Didier Pradon and Nicolas Roche
    Citation: BMC Neurology 2018 18:104
  27. Mild cognitive impairment is an early stage of Alzheimer’s disease. Increasing evidence has indicated that cognitive training could improve cognitive abilities of MCI patients in multiple cognitive domains, ma...

    Authors: Yiqi Lin, Binyin Li, Huidong Tang, Qun Xu, Yuncheng Wu, Qi Cheng, Chunbo Li, Shifu Xiao, Lu Shen, Weiguo Tang, Hui Yu, Naying He, Huawei Lin, Fuhua Yan, Wenwei Cao, Shilin Yang…
    Citation: BMC Neurology 2018 18:103
  28. Perinatal stroke (PS) affects up to 1/2300 infants and frequently leads to unilateral cerebral palsy (UCP). Preterm-born infants affected by unilateral haemorrhagic parenchymal infarction (HPI) are also at ris...

    Authors: Anna Purna Basu, Janice Pearse, Rose Watson, Pat Dulson, Jessica Baggaley, Blythe Wright, Denise Howel, Luke Vale, Dipayan Mitra, Nick Embleton and Tim Rapley
    Citation: BMC Neurology 2018 18:102
  29. Miller Fisher syndrome (MFS) and Bickerstaff’s Brainstem Encephalitis (BBE) share some clinical features and a common immunological profile characterized by anti-GQ1b antibodies. Some MFS patients overlap with...

    Authors: Angela Puma, Jeanne Benoit, Sabrina Sacconi and Antonino Uncini
    Citation: BMC Neurology 2018 18:101
  30. Epileptic seizures can lead to cardiac arrhythmias. The arrhythmias may be in the form of tachycardia, bradycardia or asystole. Ictal bradycardia and asystole can lead to sudden unexpected death.

    Authors: Nirmeen Kishk, Amani Nawito, Ahmed El-Damaty and Amany Ragab
    Citation: BMC Neurology 2018 18:100
  31. Leigh Syndrome (LS, OMIM 256000) is an early-onset, progressive neurodegenerative disorder characterized by broad clinical and genetic heterogeneity; it is the most frequent disorder of mitochondrial energy pr...

    Authors: Paolo Aretini, Chiara Maria Mazzanti, Marco La Ferla, Sara Franceschi, Francesca Lessi, Veronica De Gregorio, Claudia Nesti, Angelo Valetto, Veronica Bertini, Benedetta Toschi, Roberta Battini and Maria Adelaide Caligo
    Citation: BMC Neurology 2018 18:99
  32. Brief measures of health-related quality of life (HRQOL) that assess both patient-reported functioning and well-being after stroke are scarce. The objective of this study was to examine reliability and validit...

    Authors: Guri Heiberg, Synne Garder Pedersen, Oddgeir Friborg, Jørgen Feldbæk Nielsen, Henriette Stabel Holm, Nicole Steinbüchel von, Cathrine Arntzen and Audny Anke
    Citation: BMC Neurology 2018 18:98
  33. Immunoglobulin associated meningitis is a rare disease that mimics infectious meningitis. This is, to our knowledge, the first case of Immunoglobulin-associated meningitis described in a patient with Systemic ...

    Authors: Luísa Graça, Joana Alves, João Nuak and António Sarmento
    Citation: BMC Neurology 2018 18:97
  34. Recently, most reports of Leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis are from Europe and the US, while the short term outcome and clinical characteristics of Chinese patients are rarely rep...

    Authors: Weishuai Li, Si Wu, Qingping Meng, Xiaotian Zhang, Yang Guo, Lin Cong, Shuyan Cong and Dongming Zheng
    Citation: BMC Neurology 2018 18:96
  35. Migraine is considered a disease with diurnal and 24 h pattern, though the existence of a prevalent circadian rhythm associated to migraine frequency and severity is still not clear. This observational cross-s...

    Authors: Marina de Tommaso and Marianna Delussi
    Citation: BMC Neurology 2018 18:94
  36. White matter hyperintensities (WMHs) are frequently detected in migraine patients. However, their significance and correlation to migraine disease burden remain unclear. This study aims to examine the correlat...

    Authors: Hui Xie, Qiang Zhang, Kang Huo, Rui Liu, Zhi-Jie Jian, Yi-Tong Bian, Guo-Liang Li, Dan Zhu, Li-Hui Zhang, Jian Yang and Guo-Gang Luo
    Citation: BMC Neurology 2018 18:93
  37. Neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory nervous system and is a major therapeutic challenge. Several screening tools have been developed to help physicians detect...

    Authors: Hans Timmerman, André P. Wolff, Ewald M. Bronkhorst, Oliver H. G. Wilder-Smith, Marcel J. Schenkels, Nick T. van Dasselaar, Frank J. P. M. Huygen, Monique A. H. Steegers and Kris C. P. Vissers
    Citation: BMC Neurology 2018 18:91
  38. Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are incurable, progressive and fatal neurodegenerative diseases with patients variably affected clinically by motor, behavior, and cognitiv...

    Authors: Vivek Majumder, Jenna M. Gregory, Marcelo A. Barria, Alison Green and Suvankar Pal
    Citation: BMC Neurology 2018 18:90
  39. Brain autoimmunity has been reported in patients with preceding infection of the central nervous system by herpesviridae. It has been hypothesized that neuronal damage releasing antigens might trigger secondary i...

    Authors: Harald Hegen, Raimund Helbok, Mario Kofler, Bettina Pfausler, Alois Schiefecker, Erich Schmutzhard and Ronny Beer
    Citation: BMC Neurology 2018 18:89
  40. Sleep disturbances are common in patients with advanced Parkinson disease (PD). The aim of this study was to evaluate a possible association of cortical thickness, cortical and subcortical volume with sleep di...

    Authors: Andrius Radziunas, Vytenis Pranas Deltuva, Arimantas Tamasauskas, Rymante Gleizniene, Aiste Pranckeviciene, Kestutis Petrikonis and Adomas Bunevicius
    Citation: BMC Neurology 2018 18:88
  41. Young ischemic stroke patients are common while classification and analysis based upon imaging characteristics are rarely reported. We intend to compare the clinical and MRI characteristics of cerebral stroke ...

    Authors: Zhang-Ning Zhao, Xiao-Lin Li, Jin-Zhi Liu, Zhi-Ming Jiang and Ai-Hua Wang
    Citation: BMC Neurology 2018 18:87
  42. Multiple sclerosis (MS) is the most common non-traumatic condition that leads to disability among young individuals. It is associated with demyelination, inflammation, and neurodegeneration within the central ...

    Authors: Osama Al Wutayd, Ashri Gad Mohamed, Jameelah Saeedi, Hessa Al Otaibi and Mohammed Al Jumah
    Citation: BMC Neurology 2018 18:86
  43. Following publication of the original article [1], Andrés Damián Ortega Heredia requested that his name be corrected from

    Authors: Germaine Eleanor Torres Herrán, Andrés Damián Ortega Heredia, Braulio Martinez Burbano, Marcos Serrano-Dueñas, María Angélica Ortiz Yepez, Raúl Alberto Barrera Madera, Luis Alfredo Masabanda Campaña, Guillermo David Baño Jiménez, Denny Maritza Santos Saltos and Edgar Patricio Correa Díaz
    Citation: BMC Neurology 2018 18:84

    The original article was published in BMC Neurology 2018 18:55

  44. The plaques at the dorsal or lateral wall of basilar artery (BA) are associated with pontine infarcts. We sought to explore the correlations between vertebrobasilar artery geometry and BA plaque locations.

    Authors: Jin Yu, Shu Zhang, Ming-Li Li, Yi Ma, Yu-Ru Dong, Min Lou, Feng Feng, Shan Gao, Shi-Wen Wu and Wei-Hai Xu
    Citation: BMC Neurology 2018 18:83

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