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  1. Sexual dysfunction (SD) is very common in people with multiple sclerosis (PwMS) and contributes a significant burden of disease, particularly for young people. SD has direct neurological contributions from dep...

    Authors: Claudia H. Marck, Pia L. Jelinek, Tracey J. Weiland, Jane S. Hocking, Alysha M. De Livera, Keryn L. Taylor, Sandra L. Neate, Naresh G. Pereira and George A. Jelinek
    Citation: BMC Neurology 2016 16:210
  2. In Parkinson’s disease (PD), cognitive impairment is an important non-motor symptom heralding the development of dementia. Effective treatments to slow down the rate of cognitive decline in PD patients with mi...

    Authors: Sjors C. F. van de Weijer, Annelien A. Duits, Bastiaan R. Bloem, Roy P. Kessels, Jacobus F. A. Jansen, Sebastian Köhler, Gerrit Tissingh and Mark L. Kuijf
    Citation: BMC Neurology 2016 16:209
  3. Despite that disability of the upper extremity is common after stroke, there is limited knowledge how it influences self-perceived ability to perform daily hand activities. The aim of this study was to describ...

    Authors: Elisabeth Ekstrand, Lars Rylander, Jan Lexell and Christina Brogårdh
    Citation: BMC Neurology 2016 16:208
  4. The Qatari law, as in many other countries, uses brain death as the main criteria for organ donation and cessation of medical support. By contrast, most of the public in Qatar do not agree with the limitation ...

    Authors: Saibu George, Merlin Thomas, Wanis H. Ibrahim, Ahmed Abdussalam, Prem Chandra, Husain Shabbir Ali and Tasleem Raza
    Citation: BMC Neurology 2016 16:207
  5. Acute ischemic stroke (AIS) is a common neurological event that causes varying degrees of disability. AIS outcome varies considerably, from complete recovery to complete loss of tissue and function. This diver...

    Authors: Estelle Seyman, Hilla Shaim, Shani Shenhar-Tsarfaty, Tali Jonash-Kimchi, Natan M. Bornstein and Hen Hallevi
    Citation: BMC Neurology 2016 16:206
  6. Assessing primary rehabilitation needs in patients with acquired brain injury is a challenge due to case complexity and the heterogeneity of symptoms after brain injury. The Rehabilitation Complexity Scale-Ext...

    Authors: Thomas Maribo, Asger R. Pedersen, Jim Jensen and Jørgen F. Nielsen
    Citation: BMC Neurology 2016 16:205
  7. Recent studies suggest that cortical lesions in multiple sclerosis (MS) substantially contribute to clinical disease severity. The present study aimed at investigating clinical, neuroanatomical, and cognitive ...

    Authors: Olivia Geisseler, Tobias Pflugshaupt, Ladina Bezzola, Katja Reuter, David Weller, Bernhard Schuknecht, Peter Brugger and Michael Linnebank
    Citation: BMC Neurology 2016 16:204
  8. Acute brainstem syndrome (ABS) may herald multiple sclerosis (MS), neuromyelitis optica (NMO), or occur as an isolated syndrome. The aquaporin 4 (AQP4)-specific serum autoantibody, NMO-IgG, is a biomarker for ...

    Authors: Chen Cheng, Ying Jiang, Xiaodong Lu, Fu Gu, Zhuang Kang, Yongqiang Dai, Zhengqi Lu and Xueqiang Hu
    Citation: BMC Neurology 2016 16:203
  9. Clobazam (CLB) is a well characterized antiepileptic drug (AED) that differs from other benzodiazepines by its basic chemical structure and pharmacodynamic properties. Only one previous study examined the effi...

    Authors: Dominik Madžar, Anna Geyer, Ruben U. Knappe, Stephanie Gollwitzer, Joji B. Kuramatsu, Stefan T. Gerner, Hajo M. Hamer and Hagen B. Huttner
    Citation: BMC Neurology 2016 16:202
  10. Hereditary sensory and autonomic neuropathy (HSAN) type II with WNK1/HSN2 gene mutation is a rare disease characterized by early-onset demyelination sensory loss and skin ulceration. To the best of our knowledge,...

    Authors: Keiko Yamada, Junhui Yuan, Tomoo Mano, Hiroshi Takashima and Masahiko Shibata
    Citation: BMC Neurology 2016 16:201
  11. The smell sense reduction was considered to represent the potentially warning of early stage of neurodegenerative disorders. The Shanghai Aging Study provided us a unique opportunity to explore the association...

    Authors: Xiaoniu Liang, Ding Ding, Qianhua Zhao, Qihao Guo, Jianfeng Luo and Zhen Hong
    Citation: BMC Neurology 2016 16:199
  12. Leber’s hereditary optic neuropathy (LHON) co-occuring with multiple sclerosis-like disease (LHON-MS) is suggested to be a separate disease entity denoted Harding’s disease. Little is known about the response ...

    Authors: Trygve Holmøy, Antonie G. Beiske, Svetozar Zarnovicky, Aija Zuleron Myro, Egil Røsjø and Emilia Kerty
    Citation: BMC Neurology 2016 16:197
  13. Congenital myasthenic syndromes (CMSs) occur as a result of genetic mutations that cause aberrations in structure and/or function of proteins involved in neuromuscular transmission. Acetylcholine receptor epsi...

    Authors: Thashi Chang, Judith Cossins and David Beeson
    Citation: BMC Neurology 2016 16:195
  14. Previous studies suggested the potential interactions between cerebrovascular diseases and impaired renal function. However, the relationship between renal function and white matter hyperintensity (WMH), marke...

    Authors: Lixia Zong, Ming Yao, Jun Ni, Lixin Zhou, Jing Yuan, Bin Peng, Yi-Cheng Zhu and Liying Cui
    Citation: BMC Neurology 2016 16:193
  15. Caregivers of care-recipients with mild cognitive impairment (MCI) or dementia experience high caregiver burden; however, the psychiatric burden of caregivers of care-recipients with subjective cognitive decli...

    Authors: Xiaoniu Liang, Qihao Guo, Jianfeng Luo, Fang Li, Ding Ding, Qianhua Zhao and Zhen Hong
    Citation: BMC Neurology 2016 16:191
  16. Paclitaxel-based regimens are frequently associated with the development of peripheral neuropathy. The autonomous nervous system (ANS) effects, however, of this chemotherapeutic agent remain unexplored.

    Authors: Emmanouil V. Dermitzakis, Vasilios K. Kimiskidis, George Lazaridis, Zoi Alexopoulou, Eleni Timotheadou, Alexandros Papanikolaou, Ourania Romanidou, George Georgiadis, Konstantine T. Kalogeras, Iakovos Tsiptsios, Basil Tarlatzis and George Fountzilas
    Citation: BMC Neurology 2016 16:190
  17. Many aspects of pharmacological treatment of Lyme neuroborreliosis in children, such as choice of drug, dosage, and duration are subject to intense debates, leading to uncertainties in patients’ parents and he...

    Authors: Rick Dersch, Tilman Hottenrott, Stefanie Schmidt, Harriet Sommer, Hans-Iko Huppertz, Sebastian Rauer and Joerg J. Meerpohl
    Citation: BMC Neurology 2016 16:189
  18. Older adults with dementia are at an increased risk of falls, however, little is known about risk factors for recurrent injurious falls (a subsequent fall after the first fall has occurred) among this group. T...

    Authors: Lynn B. Meuleners, Michelle L. Fraser, Max K. Bulsara, Kyle Chow and Jonathon Q. Ng
    Citation: BMC Neurology 2016 16:188
  19. In the US, the approved multiple sclerosis (MS) oral disease-modifying therapies (ODMTs) are fingolimod (FTY), teriflunomide (TFN), and dimethyl fumarate (DMF). FTY and TFN are recommended with once-daily dose...

    Authors: Tara Nazareth, Howard S. Friedman, Prakash Navaratnam, Denise A. Herriott, John J. Ko, Peri Barr and Rahul Sasane
    Citation: BMC Neurology 2016 16:187
  20. Sleep-wake disturbances are frequently reported following traumatic brain injury (TBI), but they remain poorly documented in the acute stage of injury. Little is known about their origin and evolution.

    Authors: Catherine Duclos, Marie Dumont, Marie-Julie Potvin, Alex Desautels, Danielle Gilbert, David K Menon, Francis Bernard and Nadia Gosselin
    Citation: BMC Neurology 2016 16:186
  21. It is widely accepted that neuroinflammatory processes play an important role in the pathogenesis of Alzheimer’s disease (AD) and high levels of cytokines and chemokines are detected around Aβ plaques.

    Authors: Raphael Hesse, Anke Wahler, Pauline Gummert, Stefanie Kirschmer, Markus Otto, Hayrettin Tumani, Jan Lewerenz, Cathrin Schnack and Christine A. F. von Arnim
    Citation: BMC Neurology 2016 16:185
  22. Since the application of MRI scanning to the diagnosis and treatment of multiple sclerosis, it has been recognized that only a small fraction of lesions seen on MRI scans produce recognizable symptoms or neuro...

    Authors: Stanley Cohan, Chiayi Chen, Elizabeth Baraban, Tamela Stuchiner and Lois Grote
    Citation: BMC Neurology 2016 16:184
  23. Past studies found that cerebral developmental venous anomaly (DVA) is often concurrent with cavernous malformation (CM). But the reason of the concurrency remains unknown. The purpose of this study was to con...

    Authors: Tengfei Yu, Xing Liu, Xiangjiang Lin, Chuanfeng Bai, Jizong Zhao, Junting Zhang, Liwei Zhang, Zhen Wu, Shuo Wang, Yuanli Zhao and Guolu Meng
    Citation: BMC Neurology 2016 16:183
  24. As little is known of association(s) between gut microbiota profiles and host immunological markers, we explored these in children with and without multiple sclerosis (MS).

    Authors: Helen Tremlett, Douglas W. Fadrosh, Ali A. Faruqi, Janace Hart, Shelly Roalstad, Jennifer Graves, Collin M. Spencer, Susan V. Lynch, Scott S. Zamvil and Emmanuelle Waubant
    Citation: BMC Neurology 2016 16:182
  25. Due to the preventive nature of disease-modifying therapies for multiple sclerosis, treatment success particularly depends on adherence to therapeutic regimens and patients’ perception of treatment efficacy. T...

    Authors: Uwe Klaus Zettl, Ulrike Bauer-Steinhusen, Thomas Glaser, Klaus Hechenbichler and Michael Hecker
    Citation: BMC Neurology 2016 16:181
  26. α-Synuclein has been proposed as a potential biomarker for Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI). However, results from α-synuclein measurements in cerebrospinal fluid (CSF) ha...

    Authors: Guro Berge, Sigrid B. Sando, Grethe Albrektsen, Camilla Lauridsen, Ina Møller, Gøril R. Grøntvedt, Geir Bråthen and Linda R. White
    Citation: BMC Neurology 2016 16:180
  27. Autosomal recessive cerebellar ataxias (ARCA) are a group of neurodegenerative disorders characterized by early onset of gait impairment, disturbed limb coordination, dysarthria, and eye movement abnormalities...

    Authors: Cong Lu, Yi-Cen Zheng, Yi Dong and Hong-Fu Li
    Citation: BMC Neurology 2016 16:179
  28. Glioblastoma is refractory to conventional treatment, which is combined of surgery, chemotherapy and radiotherapy. Recent studies have shown that glioma initiating cells (GICs) contribute to tumorigenesis and ...

    Authors: Hongxing Ye, Mantao Chen, Fei Cao, Hongguang Huang, Renya Zhan and Xiujue Zheng
    Citation: BMC Neurology 2016 16:178
  29. Hypertension is the prime risk factor for stroke, and primary aldosteronism (PA) is the most common cause of secondary hypertension. The prevalence of PA in stroke patients has never been reported. The aim of ...

    Authors: Yosuke Miyaji, Yuichi Kawabata, Hideto Joki, Shunsuke Seki, Kentaro Mori, Tomoya Kamide, Akira Tamase, Hiroshi Shima, Motohiro Nomura, Yoshihisa Kitamura, Hirotatsu Nakaguchi, Taichi Minami, Tetsuji Tsunoda, Mayuko Sasaki, Masayo Yamada and Fumiaki Tanaka
    Citation: BMC Neurology 2016 16:177
  30. Stroke is a major complication of sickle cell anaemia (SCA). It occurs commonly in childhood with about 10 % of children with sickle cell anaemia getting affected by this complication. In Uganda, there is pauc...

    Authors: Deogratias Munube, Elly Katabira, Grace Ndeezi, Moses Joloba, Samden Lhatoo, Martha Sajatovic and James K. Tumwine
    Citation: BMC Neurology 2016 16:175
  31. Alternating hemiplegia of childhood (AHC) is a rare neurological disorder that manifests recurrent attacks of hemiplegia, oculogyric, and choreoathetotic involuntary movements. De novo mutations in ATP1A3 cause t...

    Authors: Hikaru Kanemasa, Ryoko Fukai, Yasunari Sakai, Michiko Torio, Noriko Miyake, Sooyoung Lee, Hiroaki Ono, Satoshi Akamine, Kei Nishiyama, Masafumi Sanefuji, Yoshito Ishizaki, Hiroyuki Torisu, Hirotomo Saitsu, Naomichi Matsumoto and Toshiro Hara
    Citation: BMC Neurology 2016 16:174
  32. Myasthenia gravis is an autoimmune neuromuscular disorder, which has only rarely been reported to co-manifest with myositis. The diagnosis of concomitant myositis in patients with myasthenia gravis is clinical...

    Authors: M. I. Stefanou, L. Komorowski, S. Kade, A. Bornemann, U. Ziemann and M. Synofzik
    Citation: BMC Neurology 2016 16:172
  33. Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) is a rare autosomal dominant disorder characterized by cerebral white matter degeneration and caused by mutations in the colony-stimulating fact...

    Authors: Yaqing Shu, Ling Long, Siyuan Liao, Jiezheng Yang, Jianfang Li, Wei Qiu, Yu Yang, Jian Bao, Aiming Wu, Xueqiang Hu and Zhengqi Lu
    Citation: BMC Neurology 2016 16:171
  34. Natural killer (NK) cells comprise the main components of lymphocyte-mediated nonspecific immunity. Through their effector function they play a crucial role combating bacterial and viral challenges. They are a...

    Authors: Inês Laginha, Marcel A. Kopp, Claudia Druschel, Klaus-Dieter Schaser, Benedikt Brommer, Rick C. Hellmann, Ralf Watzlawick, Ramin-Raul Ossami-Saidi, Harald Prüss, Vieri Failli, Christian Meisel, Thomas Liebscher, Erik Prilipp, Andreas Niedeggen, Axel Ekkernkamp, Ulrike Grittner…
    Citation: BMC Neurology 2016 16:170
  35. Patients who experience severe brain injuries are at risk of secondary brain damage, because of delayed vasospasm and edema. Traditionally, many of these patients are kept on prolonged bed rest in order to mai...

    Authors: A. Rocca, J.-M. Pignat, L. Berney, J. Jöhr, D. Van de Ville, R. T. Daniel, M. Levivier, L. Hirt, A. R. Luft, E. Grouzmann and K. Diserens
    Citation: BMC Neurology 2016 16:169
  36. Early identification of stroke is crucial to maximize early management benefits in emergency departments. This study aimed to develop and validate a new stroke recognition instrument for differentiating acute ...

    Authors: Haifeng Mao, Peiyi Lin, Junrong Mo, Yunmei Li, Xiaohui Chen, Timothy H. Rainer and Huilin Jiang
    Citation: BMC Neurology 2016 16:168
  37. In Ethiopia where the burden of epilepsy is highest among school age children and teenagers, and where people with epilepsy (PWE) and their relatives suffers from high level of perceived stigma, there had not ...

    Authors: Meron Awraris Gebrewold, Fikre Enquselassie, Redda Teklehaimanot and Seid Ali Gugssa
    Citation: BMC Neurology 2016 16:167
  38. Parkinson’s disease (PD) is the second commonest neurodegenerative disease in developed countries. Current treatment for PD is pharmacologically focused and can have significant side-effects. There is increasi...

    Authors: Jenny Advocat, Joanne Enticott, Brooke Vandenberg, Craig Hassed, Jennifer Hester and Grant Russell
    Citation: BMC Neurology 2016 16:166
  39. Fahr’s disease is rare a neurodegenerative idiopathic condition characterized by symmetric and bilateral calcifications of basal ganglia, usually associated with progressive neuropsychiatric dysfunctions and m...

    Authors: Elisabetta Savino, Cecilia Soavi, Eleonora Capatti, Massimo Borrelli, Giovanni B. Vigna, Angelina Passaro and Giovanni Zuliani
    Citation: BMC Neurology 2016 16:165
  40. Exercise testing devices for evaluating cardiopulmonary fitness in patients with severe disability after stroke are lacking, but we have adapted a robotics-assisted tilt table (RATT) for cardiopulmonary exerci...

    Authors: Jittima Saengsuwan, Lucia Berger, Corina Schuster-Amft, Tobias Nef and Kenneth J. Hunt
    Citation: BMC Neurology 2016 16:163
  41. The underlying causes of minor stroke are difficult to assess. Here, we evaluate the reliability of the Chinese Ischemic Stroke Subclassification (CISS) system in patients with minor stroke, and compare it to ...

    Authors: Sha Tan, Lei Zhang, Xiaoyu Chen, Yanqiang Wang, Yinyao Lin, Wei Cai, Yilong Shan, Wei Qiu, Xueqiang Hu and Zhengqi Lu
    Citation: BMC Neurology 2016 16:162

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