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  1. Primary diffuse leptomeningeal gliomatosis (PDLG) is a lethal neoplasm that is characterized by glioma cells exclusively infiltrating into cerebral and spinal meninges. Intraventricular hemorrhage as an initia...

    Authors: Min Zhu, JunJun Zheng, Yuanzhao Zhu, Hui Wan, Yuchen Wu and Daojun Hong
    Citation: BMC Neurology 2015 15:77
  2. Home-based training is becoming ever more important with increasing demands on the public health systems. We investigated whether individualized and supervised interactive home-based training delivered through...

    Authors: Jakob Lorentzen, Line Z. Greve, Mette Kliim-Due, Betina Rasmussen, P. E. Bilde and Jens B. Nielsen
    Citation: BMC Neurology 2015 15:75
  3. Growing body of evidence suggests that Parkinson’s disease (PD) is associated with oxidative damage via iron accumulation in the substantia nigra (SN). Low ceruloplasmin (CP)-ferroxidase activity has been iden...

    Authors: Guillaume Grolez, Caroline Moreau, Bernard Sablonnière, Guillaume Garçon, Jean-Christophe Devedjian, Sayah Meguig, Patrick Gelé, Christine Delmaire, Regis Bordet, Luc Defebvre, Ioav Z Cabantchik and David Devos
    Citation: BMC Neurology 2015 15:74
  4. The pain that commonly occurs after brachial plexus avulsion poses an additional burden on the quality of life of patients already impaired by motor, sensory and autonomic deficits. Evidence-based treatments f...

    Authors: Manoel Jacobsen Teixeira, Matheus Gomes da S da Paz, Mauro Tupiniquim Bina, Scheila Nogueira Santos, Irina Raicher, Ricardo Galhardoni, Diego Toledo Fernandes, Lin T Yeng, Abrahão F Baptista and Daniel Ciampi de Andrade
    Citation: BMC Neurology 2015 15:73
  5. Epidemiological studies describe a latitude gradient for increased MS prevalence and a preponderance of disease in Caucasian individuals. However, individuals from other ethnic backgrounds and low-risk regions...

    Authors: Richard S Nicholas, Vassiliki Kostadima, Maya Hanspal, Benjamin R Wakerley, Ruhena Sergeant, Saskia Decuypere, Omar Malik, Rosemary J Boyton and Daniel M Altmann
    Citation: BMC Neurology 2015 15:72
  6. Cerebral amyloid angiopathy (CAA) refers to the deposition of β-amyloid (Aβ) peptides in the wall of brain vasculature, commonly involving capillaries and arterioles. Also being considered a part of CAA is the...

    Authors: Zhi-Qin Xue, Zheng-Wen He, Jian-Jun Yu, Yan Cai, Wen-Ying Qiu, Aihua Pan, Wei-Ping Gai, Huaibin Cai, Xue-Gang Luo, Chao Ma and Xiao-Xin Yan
    Citation: BMC Neurology 2015 15:71
  7. Data estimating the recurrence and risk of death are lacking in low and middle income countries, where two thirds of the stroke burden occurs. Previously we had shown that the incidence and mortality have been...

    Authors: Norberto Luiz Cabral, Milena Muller, Selma Cristina Franco, Alexandre Longo, Carla Moro, Vivian Nagel, Rafaela B Liberato, Adriana C Garcia, Vanessa G Venancio and Anderson RR Gonçalves
    Citation: BMC Neurology 2015 15:70
  8. Large intracranial occlusive vascular disease is a major contributor to the incidence of stroke worldwide, especially when it involves the middle cerebral artery (MCA). The data on the prognosis of symptomatic...

    Authors: Lili Tian, Xuanye Yue, Gangming Xi, Youmeng Wang, Zongyou Li, Ying Zhou and Xiaobing Fan
    Citation: BMC Neurology 2015 15:68
  9. Cholinesterase inhibitors are used to treat the symptoms of dementia and can theoretically cause bradycardia. Previous studies suggest that patients taking these medications have an increased risk of undergoin...

    Authors: Allen R Huang, Calum J Redpath and Carl van Walraven
    Citation: BMC Neurology 2015 15:66
  10. The relationship between central obesity and stroke is inconsistent in diabetic and non-diabetic populations. This indicates an interaction between diabetes and central obesity on stroke risk. The present stud...

    Authors: Jennifer Olofindayo, Hao Peng, Yan Liu, Hongmei Li, Mingzhi Zhang, Aili Wang and Yonghong Zhang
    Citation: BMC Neurology 2015 15:65
  11. A visual field defect (VFD) is a common consequence of stroke with a detrimental effect upon the survivors’ functional ability and quality of life. The identification of effective treatments for VFD is a key p...

    Authors: Tobias Loetscher, Celia Chen, Sophie Wignall, Andreas Bulling, Sabrina Hoppe, Owen Churches, Nicole A Thomas, Michael E R Nicholls and Andrew Lee
    Citation: BMC Neurology 2015 15:64
  12. Motor and non-motor impairments affect quality of life in individuals with Parkinson’s disease. Our preliminary research indicates that forced exercise cycling, a mode of exercise in which a participant’s volu...

    Authors: Anson B Rosenfeldt, Matthew Rasanow, Amanda L Penko, Erik B Beall and Jay L Alberts
    Citation: BMC Neurology 2015 15:63
  13. The treatment option for acute ischaemic stroke depends on the duration of symptoms, the dynamics of neurological condition changes, the aetiology, type of stroke, as well as the results of angiographic and ne...

    Authors: Anetta Lasek-Bal, Tomasz Urbanek, Damian Ziaja, Aldona Warsz-Wianecka, Przemysław Puz and Krzysztof Ziaja
    Citation: BMC Neurology 2015 15:62
  14. Decision-making is an essential function of everyday life. Decision-making under explicit risk requires developing advantageous decision strategies based on fixed outcomes (e.g., probabilities of winning or lo...

    Authors: Ashley D Radomski, Christopher Power, Scot E Purdon, Derek J Emery, Gregg Blevins, Kenneth G Warren and Esther Fujiwara
    Citation: BMC Neurology 2015 15:61
  15. Both apathy and suicide are common in poststroke patients. However, the association between poststroke apathy and suicide-related ideation (SI) in Chinese stroke patients is not clear and poorly understood. Th...

    Authors: Wai Kwong Tang, Lara Caeiro, Chieh Grace Lau, Huajun Liang, Vincent Mok, Gabor S Ungvari and Ka Sing Wong
    Citation: BMC Neurology 2015 15:60
  16. Impulse control disorder (ICD) and behaviours (ICB) represent a group of behavioural disorders that have become increasingly recognised in Parkinson’s disease (PD) patients who previously used dopaminergic med...

    Authors: Shahidee Zainal Abidin, Eng Liang Tan, Soon-Choy Chan, Ameerah Jaafar, Alex Xuen Lee, Mohd Hamdi Noor Abd Hamid, Nor Azian Abdul Murad, Nur Fadlina Pakarul Razy, Shahrul Azmin, Azlina Ahmad Annuar, Shen Yang Lim, Pike-See Cheah, King-Hwa Ling and Norlinah Mohamed Ibrahim
    Citation: BMC Neurology 2015 15:59
  17. Chronic fatigue is present in more than 60% of the patients with a neuromuscular disease and can be their most disabling symptom. In combination with other impairments, fatigue often results in low levels of p...

    Authors: Yvonne Veenhuizen, Edith HC Cup, Jan T Groothuis, Jan CM Hendriks, Eddy MM Adang, Baziel GM van Engelen and Alexander CH Geurts
    Citation: BMC Neurology 2015 15:58
  18. One of the usual problems psychologists and clinicians face in clinical practice is differential diagnostics of Alzheimer’s disease and depression. It has been reported that the ACE and ACE-R could discriminat...

    Authors: Augustinas Rotomskis, Ramunė Margevičiūtė, Arūnas Germanavičius, Gintaras Kaubrys, Valmantas Budrys and Albinas Bagdonas
    Citation: BMC Neurology 2015 15:57
  19. Parkinson’s disease (PD) is a neurodegenerative disorder with a wide range of motor and non-motor symptoms. Despite optimal medical management, PD still results in a high disability rate and secondary complica...

    Authors: Nicolien M van der Kolk, Sebastiaan Overeem, Nienke M de Vries, Roy PC Kessels, Rogier Donders, Marc Brouwer, Daniela Berg, Bart Post and Bas R Bloem
    Citation: BMC Neurology 2015 15:56
  20. LEOPARD syndrome (LS) belongs to the family of neuro-cardio-facio-cutaneous syndromes, which include Neurofibromatosis-1 (NF1), Noonan syndrome, Costello Syndrome, cardio-facio-cutaneous syndrome, Noonan-like ...

    Authors: Marianna Spatola, Christian Wider, Thierry Kuntzer and Alexandre Croquelois
    Citation: BMC Neurology 2015 15:55
  21. In the context of an epidemiologic transition in South Africa, in which cardiovascular disease is increasing, little is known about the stroke burden, particularly morbidity in rural populations. Risk factors ...

    Authors: Mandy Maredza, Melanie Y Bertram and Stephen M Tollman
    Citation: BMC Neurology 2015 15:54
  22. Since chronic fatigue syndrome (CFS) and fibromyalgia (FM) often co-exist, some believe they reflect the same process, somatization. Against that hypothesis are data suggesting FM but not CFS was common in pat...

    Authors: Slobodanka Pejovic, Benjamin H Natelson, Maria Basta, Julio Fernandez-Mendoza, Fauzia Mahr and Alexandros N Vgontzas
    Citation: BMC Neurology 2015 15:53
  23. Impaired dominant hand function in stroke patients is a common clinical problem. Functional improvement after focal spasticity therapy is well documented but knowledge about central correlates is sparse. Brain...

    Authors: Ulla Bergfeldt, Tomas Jonsson, Lennart Bergfeldt and Per Julin
    Citation: BMC Neurology 2015 15:52
  24. Cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau and p-tau have a characteristic pattern in Alzheimer’s Disease (AD). Their roles in HIV-associated neurocognitive disorder (HAND) remains unclear.

    Authors: Lucette A Cysique, Timothy Hewitt, Juliana Croitoru-Lamoury, Kevin Taddei, Ralph N Martins, Constance SN Chew, Nicholas NWS Davies, Patricia Price and Bruce J Brew
    Citation: BMC Neurology 2015 15:51
  25. Proteinase-activated receptor 2 (PAR-2) has been shown to promote both neurotoxic and neuroprotective effects. Similarly, other routinely used nonspecific markers of neuronal damage can be found in cerebrospin...

    Authors: Zdenek Rohan, Magdalena Smetakova, Jaromir Kukal, Robert Rusina and Radoslav Matej
    Citation: BMC Neurology 2015 15:50
  26. We describe a case of a very unusual complication following a coiling procedure in which the patient developed transient unique cerebral and cerebellar lesions. Lesions were examined not only by magnetic reson...

    Authors: Kentaro Deguchi, Yuko Kawahara, Shoko Deguchi, Nobutoshi Morimoto, Tomoko Kurata, Yoshio Ikeda, Tomotsugu Ichikawa, Koji Tokunaga, Nobuyuki Kawai, Kenji Sugiu and Koji Abe
    Citation: BMC Neurology 2015 15:49
  27. Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare complication of Crohn's disease (CD), and it is uncertain whether it is associated with CD itself or with its treatment. We describe a case of...

    Authors: Suji Kim, Seok-Jae Kang, Ki-Wook Oh, Byung Kyu Ahn, Hang Lak Lee, Dong Soo Han, Kiseok Jang and Young Seo Kim
    Citation: BMC Neurology 2015 15:48
  28. Heritability of Alzheimer’s disease (AD) is estimated at 74% and genetic contributors have been widely sought. The ε4 allele of apolipoprotein E (APOE) remains the strongest common risk factor for AD, with numero...

    Authors: Jennifer S Yokoyama, Luke W Bonham, Renee L Sears, Eric Klein, Anna Karydas, Joel H Kramer, Bruce L Miller and Giovanni Coppola
    Citation: BMC Neurology 2015 15:47
  29. Eslicarbazepine acetate (ESL, Aptiom®) is a once-daily (QD) anticonvulsant, approved as adjunctive treatment of partial-onset seizures (POS). It is extensively converted after oral administration to eslicarbaz...

    Authors: Mercedes P Jacobson, Ladislav Pazdera, Perminder Bhatia, Todd Grinnell, Hailong Cheng and David Blum
    Citation: BMC Neurology 2015 15:46
  30. Although hyperlipidemia is known as a risk factor of stroke, its effects on the outcome are unknown. The aim of the study is to clarify the influences of hyperlipidemia on the stroke early outcome by estimatin...

    Authors: Kazuo Shigematsu, Yoshiyuki Watanabe and Hiromi Nakano
    Citation: BMC Neurology 2015 15:44
  31. To obtain evidence for the clinical and cost-effectiveness of treatments for patients with rare diseases is a challenge. Non-dystrophic myotonia (NDM) is a group of inherited, rare muscle diseases characterize...

    Authors: Bas C Stunnenberg, Willem Woertman, Joost Raaphorst, Jeffrey M Statland, Robert C Griggs, Janneke Timmermans, Christiaan G Saris, Bas J Schouwenberg, Hans M Groenewoud, Dick F Stegeman, Baziel G M van Engelen, Gea Drost and Gert Jan van der Wilt
    Citation: BMC Neurology 2015 15:43
  32. Development of a long-term stroke care plan requires serial assessment of long-term patient function and consideration of caregiver mood. However, to date, few comprehensive cohort studies have included both s...

    Authors: Won Hyuk Chang, Min Kyun Sohn, Jongmin Lee, Deog Young Kim, Sam-Gyu Lee, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, Eun Young Han and Yun-Hee Kim
    Citation: BMC Neurology 2015 15:42
  33. Neuropsychological batteries are infrequently used to assess cognitive impairment in multiple sclerosis because they are time-consuming and require trained personnel. The Symbol Digit Modalities Test (SDMT) is...

    Authors: Mariana López-Góngora, Luis Querol and Antonio Escartín
    Citation: BMC Neurology 2015 15:40
  34. Postpolio syndrome (PPS) is characterized by progressive disabilities that develop decades after prior paralytic poliomyelitis. Because chronic inflammation may be the process underlying the development of PPS...

    Authors: Yao-Hsien Huang, Hung-Chou Chen, Kuang-Wei Huang, Po-Chih Chen, Chaur-Jong Hu, Chin-Piao Tsai, Ka-Wai Tam and Yi-Chun Kuan
    Citation: BMC Neurology 2015 15:39
  35. Thyrotoxic periodic paralysis (TPP) is a life-threatening channelopathy manifesting as recurrent episodes of hypokalemia and muscle weakness in the presence of hyperthyroidism. Recent findings indicate defects...

    Authors: Xiaobing Li, Sheng Yao, Yining Xiang, Xiaolei Zhang, Xiangbing Wu, Laimin Luo, Haihua Huang, Min Zhu, Hui Wan and Daojun Hong
    Citation: BMC Neurology 2015 15:38
  36. The objective of this study was to investigate the effects of Rosiglitazone (RSG) infusion therapy following minimally invasive surgery (MIS) for intracerebral hemorrhage(ICH) evacuation on perihematomal secon...

    Authors: Guofeng Wu, Junjie Wu, Yu Jiao, Likun Wang, Fan Wang and Yingjun Zhang
    Citation: BMC Neurology 2015 15:37
  37. Transient ischemic attacks (TIA) are characterized by acute onset focal neurological symptoms and complete recovery within 24 hours. Attacks of nonfocal symptoms not fulfilling the criteria for TIA but lacking...

    Authors: Frank G van Rooij, Anil M Tuladhar, Roy PC Kessels, Sarah E Vermeer, Bozena M Góraj, Peter J Koudstaal, David G Norris, Frank-Erik de Leeuw and Ewoud J van Dijk
    Citation: BMC Neurology 2015 15:36
  38. Stroke is the second largest cause of death worldwide. Hypercoagulability is a key feature in ischaemic stroke due to the development of an abnormally dense clot structure but techniques assessing the mechanic...

    Authors: Sophia N Stanford, Ahmed Sabra, Lindsay D’Silva, Matthew Lawrence, Roger HK Morris, Sharon Storton, Martyn Rowan Brown, Vanessa Evans, Karl Hawkins, Phylip Rhodri Williams, Simon J Davidson, Mushtaq Wani, John F Potter and Phillip A Evans
    Citation: BMC Neurology 2015 15:35
  39. Clinical studies have tested the use of an engineered herpes virus to treat pain. We hypothesized that subcutaneous injections of an engineered herpes virus that expresses enkephalin would attenuate orofacial ...

    Authors: Phillip R Kramer, Mikhail Umorin and Larry L Bellinger
    Citation: BMC Neurology 2015 15:34
  40. Hyperechogenicity of the substantia nigra was recently reported in patients with sporadic ALS with a frequency similar to PD. Data on the diagnostic utility compared to key differential diagnoses of ALS do not...

    Authors: Andreas Hermann, Ulrike Reuner, Jochen Schaefer, Panteha Fathinia, Tordis Leimert, Jan Kassubek, Mario Leimert, Albert C Ludolph and Alexander Storch
    Citation: BMC Neurology 2015 15:33
  41. Because our previous study showed disparate voxel based morphometry (VBM) results between SPM and FSL softwares in the brain of amyotrophic lateral sclerosis patients with frontotemporal dementia (ALS-FTD), we...

    Authors: Venkateswaran Rajagopalan and Erik P Pioro
    Citation: BMC Neurology 2015 15:32
  42. Cognitive impairment commonly occurs in the acute phase post-stroke, but may persist with over half of all stroke survivors experiencing some form of long-term cognitive deficit. Recent evidence suggests that ...

    Authors: Lisa Mellon, Linda Brewer, Patricia Hall, Frances Horgan, David Williams and Anne Hickey
    Citation: BMC Neurology 2015 15:31
  43. Family history (FH) is a risk factor for cardiovascular disease, especially coronary artery disease (CAD). The impact on risk of stroke is less clear. This study investigated young and middle-aged ischemic str...

    Authors: Halvor Øygarden, Annette Fromm, Kristin Modalsli Sand, Geir Egil Eide, Lars Thomassen, Halvor Naess and Ulrike Waje-Andreassen
    Citation: BMC Neurology 2015 15:30
  44. About 20% of patients with a first ischaemic stroke will experience a new vascular event within the first year. The atherosclerotic burden, an indicator of the extension of atherosclerosis in a patient, has be...

    Authors: Joaquín Serena, Tomás Segura, Jaume Roquer, María García-Gil and José Castillo
    Citation: BMC Neurology 2015 15:28
  45. Chronic inflammatory demyelinating polyneuropathy (CIDP) as a pure sensory variant is rarely encountered. Therefore the best treatment option is hard to define.

    Authors: Elisabeth Chroni, Dimitra Veltsista, Evangelia Gavanozi, Tavitha Vlachou, Panagiotis Polychronopoulos and Panagiotis Papathanasopoulos
    Citation: BMC Neurology 2015 15:27
  46. We peformed a ventral intermediate nucleus (Vim) thalamotomy in a patient with Holmes’ tremor and palatal tremor. The frequencies of these movement disorders were 4 Hz and 3 Hz, respectively. Vim thalamotomy s...

    Authors: Futaba Maki, Sumito Sato, Katsushige Watanabe, Toshiyuki Yanagisawa, Yuta Hagiwara, Takahiro Shimizu and Yasuhiro Hasegawa
    Citation: BMC Neurology 2015 15:26

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