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  1. Prophylaxis to prevent relapses in the central nervous system after childhood acute lymphoblastic leukemia (ALL) used to consist of both intrathecal chemotherapy (CT) and cranial irradiation (CRT). CRT was mos...

    Authors: Marita Daams, Ilse Schuitema, Bob W van Dijk, Eline van Dulmen-den Broeder, Anjo JP Veerman, Cor van den Bos and Leo MJ de Sonneville
    Citation: BMC Neurology 2012 12:84
  2. To test the hypothesis that white matter lesions (WML) are primarily associated with regional frontal cortical volumes, and to determine the mediating effects of these regional frontal cortices on the associat...

    Authors: Jun-Young Lee, Philip Insel, R Scott Mackin, Norbert Schuff, Helena Chui, Charles DeCarli, Kee Hyung Park, Susanne G Mueller and Michael W Weiner
    Citation: BMC Neurology 2012 12:83
  3. Neuroprotective strategies after cardiopulmonary resuscitation are currently the focus of experimental and clinical research. Levosimendan has been proposed as a promising drug candidate because of its cardiop...

    Authors: Anna B Roehl, Norbert Zoremba, Markus Kipp, Johannes Schiefer, Andreas Goetzenich, Christian Bleilevens, Nikolaus Kuehn-Velten, Rene Tolba, Rolf Rossaint and Marc Hein
    Citation: BMC Neurology 2012 12:81
  4. The prognostic value of evoked potentials (EPs) in multiple sclerosis (MS) has not been fully established. The correlations between the Expanded Disability Status Scale (EDSS) at First Neurological Evaluation ...

    Authors: Nicolò Margaritella, Laura Mendozzi, Massimo Garegnani, Raffaello Nemni, Elena Colicino, Elisabetta Gilardi and Luigi Pugnetti
    Citation: BMC Neurology 2012 12:80
  5. Vertebral artery dissection (VAD) is often associated with trauma or occurs spontaneously, inevitably causing some neurological deficits. Even though acute infection can be related to the development of sponta...

    Authors: Xudong Pan, Aijun Ma, Kun Wang, Shumin Nie and Mei Wu
    Citation: BMC Neurology 2012 12:79
  6. CADASIL is an autosomal dominant genetic leukoencephalopathy linked to mutations in the Notch3 gene. In rare cases, widespread brain lesions on T2 MRI mimicking multiple sclerosis are observed. From a national re...

    Authors: Nicolas Collongues, Nathalie Derache, Frédéric Blanc, Pierre Labauge, Jérôme de Seze and Gilles Defer
    Citation: BMC Neurology 2012 12:78
  7. Acquired Brain Injury (ABI) from traumatic and non traumatic causes is a leading cause of disability worldwide yet there is limited research summarizing the health system economic burden associated with ABI. T...

    Authors: Amy Chen, Ksenia Bushmeneva, Brandon Zagorski, Angela Colantonio, Daria Parsons and Walter P Wodchis
    Citation: BMC Neurology 2012 12:76
  8. Although the development of early-onset dementia is a radical and invalidating experience for both patient and family there are hardly any non-pharmacological studies that focus on this group of patients. One ...

    Authors: Astrid M Hooghiemstra, Laura HP Eggermont, Philip Scheltens, Wiesje M van der Flier, Jet Bakker, Mathieu HG de Greef, Peter A Koppe and Erik JA Scherder
    Citation: BMC Neurology 2012 12:75
  9. Motor neurone disease (MND) is a devastating illness which leads to muscle weakness and death, usually within 2-3 years of symptom onset. Respiratory insufficiency is a common cause of morbidity, particularly ...

    Authors: Christopher J McDermott, Chin Maguire, Cindy L Cooper, Roger Ackroyd, Wendy O Baird, Simon Baudouin, Andrew Bentley, Stephen Bianchi, Stephen Bourke, Mike J Bradburn, Simon Dixon, John Ealing, Simon Galloway, Dayalan Karat, Nick Maynard, Karen Morrison…
    Citation: BMC Neurology 2012 12:74
  10. The autosomal dominant spinocerebellar ataxias (SCAs) confine a group of rare and heterogeneous disorders, which present with progressive ataxia and numerous other features e.g. peripheral neuropathy, macular ...

    Authors: Troels Tolstrup Nielsen, Skirmante Mardosiene, Annemette Løkkegaard, Jette Stokholm, Susanne Ehrenfels, Sara Bech, Lars Friberg, Jens Kellberg Nielsen and Jørgen E Nielsen
    Citation: BMC Neurology 2012 12:73
  11. New research criteria for the diagnosis of Alzheimer’s disease (AD) have recently been developed to enable an early diagnosis of AD pathophysiology by relying on emerging biomarkers. To enable efficient alloca...

    Authors: Ron LH Handels, Pauline Aalten, Claire AG Wolfs, Marcel OldeRikkert, Philip Scheltens, Pieter Jelle Visser, Manuela A Joore, Johan L Severens and Frans RJ Verhey
    Citation: BMC Neurology 2012 12:72
  12. Chronic headache (headache ≥ 15 days/month for at least 3 months) affects 2–5% of the general population. Medication overuse contributes to the problem. Medication-overuse headache (MOH) can be identified by u...

    Authors: Espen Saxhaug Kristoffersen, Jørund Straand, Jūratė Saltytė Benth, Michael Bjørn Russell and Christofer Lundqvist
    Citation: BMC Neurology 2012 12:70
  13. Post-traumatic amnesia (PTA) is a key symptom of traumatic brain injury (TBI). Accurate assessment of PTA is imperative in guiding clinical decision making. Our aim was to develop and externally validate a sho...

    Authors: Bram Jacobs, Janneke van Ekert, Lotje PL Vernooy, Peter Dieperink, Teuntje MJC Andriessen, Marc PH Hendriks, Arie B van Vugt, Marjolein AA Emons, George F Borm and Pieter E Vos
    Citation: BMC Neurology 2012 12:69
  14. Previous studies have suggested that pre-stroke treatment with low-dose aspirin (A) could reduce the severity of acute ischaemic stroke, but less is known on the effect of pre-stroke treatment with a combinati...

    Authors: Lola Arnarsdottir, Clara Hjalmarsson, Lena Bokemark and Björn Andersson
    Citation: BMC Neurology 2012 12:67
  15. The correlation between intracranial pressure (ICP) and intraocular pressure (IOP) is still controversial in literature and hence whether IOP can be used as a non-invasive surrogate of ICP remains unknown. The...

    Authors: Zhen Li, Yingxin Yang, Yan Lu, Dachuan Liu, Erhe Xu, Jianping Jia, Diya Yang, Xiaojun Zhang, Huiqing Yang, Daqing Ma and Ningli Wang
    Citation: BMC Neurology 2012 12:66
  16. Since atherogenesis is related to oxidative stress, our objective was to study the association of oxidative stress markers with the vascular recurrence in non-cardioembolic stroke.

    Authors: David Brea, Jaume Roquer, Joaquín Serena, Tomás Segura and José Castillo
    Citation: BMC Neurology 2012 12:65
  17. Lymphocyte-depleted Hodgkin’s lymphoma is the rarest form of classical Hodgkin’s lymphoma, accounting for < 1% of all cases. Patients often have advanced-stage disease at the time of presentation with an aggre...

    Authors: Ekkehard M Kasper, Fred C Lam, Markus M Luedi, Pascal O Zinn and German A Pihan
    Citation: BMC Neurology 2012 12:64
  18. Acute posthypoxic myoclonus (PHM) can occur in patients admitted after cardiopulmonary resuscitation (CPR) and is considered to have a poor prognosis. The origin can be cortical and/or subcortical and this mig...

    Authors: Aline Bouwes, Daniël van Poppelen, Johannes HTM Koelman, Michael A Kuiper, Durk F Zandstra, Henry C Weinstein, Selma C Tromp, Eveline GJ Zandbergen, Marina AJ Tijssen and Janneke Horn
    Citation: BMC Neurology 2012 12:63
  19. A recent meta-analysis on the UCHL1 S18Y variant and Parkinson’s disease (PD) showed a significant inverse association between the Y allele and PD; the individual studies included in that meta-analysis, however, ...

    Authors: Yoshihiro Miyake, Keiko Tanaka, Wakaba Fukushima, Chikako Kiyohara, Satoshi Sasaki, Yoshio Tsuboi, Tatsuo Yamada, Tomoko Oeda, Hiroyuki Shimada, Nobutoshi Kawamura, Nobutaka Sakae, Hidenao Fukuyama, Yoshio Hirota and Masaki Nagai
    Citation: BMC Neurology 2012 12:62
  20. An observational study to examine whether thrombolytic therapy in stroke patients realizes better quality of life outcomes compared to patients without thrombolytic therapy one year after stroke. We also exami...

    Authors: Leonie de Weerd, Gert-Jan R Luijckx, Klaas H Groenier and Klaas van der Meer
    Citation: BMC Neurology 2012 12:61
  21. Hashimoto’s encephalopathy is a poorly understood syndrome consisting of heterogeneous neurological symptoms and high serum antithyroid antibody titers, typically responding to steroids. More clinical series s...

    Authors: Yi Tang, Yi Xing, Michael T Lin, Jin Zhang and Jianping Jia
    Citation: BMC Neurology 2012 12:60
  22. Progressive neurodegeneration in Alzheimer’s disease (AD) induces cognitive deterioration, and there is controversy regarding the optimal treatment strategy in early AD. Stimulation therapy, including physical...

    Authors: Fred Andersen, Matti Viitanen, Dag S Halvorsen, Bjørn Straume, Tom Wilsgaard and Torgeir A Engstad
    Citation: BMC Neurology 2012 12:59
  23. Cardiac troponin-I (cTNI) is highly specific biomarker to prove myocardial damage, e.g. in acute coronary syndrome (ACS). However, it occurs in other conditions as well. We therefore analysed cTNI increase in ...

    Authors: Nicole Sieweke, Jens Allendörfer, Wolfgang Franzen, Andreas Feustel, Frank Reichenberger, Wolfgang Pabst, Heidrun Heidi Krämer, Manfred Kaps and Christian Tanislav
    Citation: BMC Neurology 2012 12:58
  24. The relationship between health-related quality of life (HRQoL) in people with Parkinson’s disease and their caregivers is little understood and any effects on caregiver strain remain unclear. This paper exami...

    Authors: David H Kelly, Jennifer L McGinley, Frances E Huxham, Hylton B Menz, Jennifer J Watts, Robert Iansek, Anna T Murphy, Mary Danoudis, Brooke Adair and Meg E Morris
    Citation: BMC Neurology 2012 12:57
  25. The International Classification of Functioning, Disability and Health (ICF) defines participation as a person’s performance in life situations, including the size of social networks, and satisfaction with soc...

    Authors: Clare L Scott, Louise H Phillips, Marie Johnston, Maggie M Whyte and Mary J MacLeod
    Citation: BMC Neurology 2012 12:56
  26. An international expert consensus committee recently recommended a brief battery of tests for cognitive evaluation in multiple sclerosis. The Brief International Cognitive Assessment for MS (BICAMS) battery in...

    Authors: Ralph HB Benedict, Maria Pia Amato, Jan Boringa, Bruno Brochet, Fred Foley, Stan Fredrikson, Paivi Hamalainen, Hans Hartung, Lauren Krupp, Iris Penner, Anthony T Reder and Dawn Langdon
    Citation: BMC Neurology 2012 12:55
  27. The high incidence of falls associated with Parkinson’s disease (PD) increases the risk of injuries and immobility and compromises quality of life. Although falls education and strengthening programs have show...

    Authors: Meg E Morris, Clarissa Martin, Jennifer L McGinley, Frances E Huxham, Hylton B Menz, Nicholas F Taylor, Mary Danoudis, Jennifer J Watts, Sze-Ee Soh, Andrew H Evans, Malcolm Horne and Peter Kempster
    Citation: BMC Neurology 2012 12:54
  28. The occupational therapy (OT) in care homes study (OTCH) aims to investigate the effect of a targeted course of individual OT (with task training, provision of adaptive equipment, minor environmental adaptatio...

    Authors: Cath M Sackley, Chris R Burton, Sandy Herron-Marx, Karen Lett, Jonathan Mant, Andrea K Roalfe, Leslie J Sharp, Bart Sheehan, Katie E Stant, Marion F Walker, Caroline L Watkins, Keith Wheatley, Jane Williams, Guiqing L Yao and Max G Feltham
    Citation: BMC Neurology 2012 12:52
  29. Post-Stroke Depression with or without Anxiety (PSDA) is a common disorder in the chronic phase of stroke. Neuropsychiatric problems, such as PSDA, have a negative impact on social reintegration and quality of...

    Authors: Joyce A Kootker, Luciano Fasotti, Sascha MC Rasquin, Caroline M van Heugten and Alexander CH Geurts
    Citation: BMC Neurology 2012 12:51
  30. The upper extremity plays an important role in daily functioning of patients with Multiple Sclerosis (MS) and strongly influences their quality of life. However, an explicit overview of arm-hand training progr...

    Authors: Annemie IF Spooren, Annick AA Timmermans and Henk AM Seelen
    Citation: BMC Neurology 2012 12:49
  31. Huntington’s disease (HD) is a fatal progressive neurodegenerative disorder caused by the expansion of the polyglutamine repeat region in the huntingtin gene. Although the disease is triggered by the mutation of ...

    Authors: Ravi Kiran Reddy Kalathur, Miguel A Hernández-Prieto and Matthias E Futschik
    Citation: BMC Neurology 2012 12:47
  32. Patients with Mild Cognitive Impairment (MCI) are at high risk of progression to Alzheimer’s dementia. Identifying MCI individuals with high likelihood of conversion to dementia and the associated biosignature...

    Authors: Jieping Ye, Michael Farnum, Eric Yang, Rudi Verbeeck, Victor Lobanov, Nandini Raghavan, Gerald Novak, Allitia DiBernardo and Vaibhav A Narayan
    Citation: BMC Neurology 2012 12:46
  33. Amitriptyline, a tricyclic antidepressant and potent use-dependent blocker of sodium channels, has been shown to attenuate acute and chronic pain in several preclinical modes. The purpose of this study was to ...

    Authors: Kuang-I Cheng, Hung-Chen Wang, Lin-Li Chang, Fu-Yen Wang, Chung-Sheng Lai, Chao-Wen Chou, Hung-Pei Tsai and Aij-Lie Kwan
    Citation: BMC Neurology 2012 12:44
  34. Cerebral venous sinus thrombosis (CVST) is a relatively rare cerebrovascular condition which accounts for 0.5% of all strokes. Risk of CVST has been documented in patients with numerous conditions including ce...

    Authors: Min Jia, Nian Xiong, Jinsha Huang, Youpei Wang, Xiaowei Zhang, Zhentao Zhang, Xuebing Cao, Zhicheng Lin and Tao Wang
    Citation: BMC Neurology 2012 12:43
  35. Evidence exist that motor observation activates the same cortical motor areas that are involved in the performance of the observed actions. The so called “mirror neuron system” has been proposed to be responsi...

    Authors: Denis Ertelt, Claudia Hemmelmann, Christian Dettmers, Andreas Ziegler and Ferdinand Binkofski
    Citation: BMC Neurology 2012 12:42
  36. Certain immune-mediated diseases (IMDs) have been associated with increased risk for cardiovascular disorders. The aim of the present study was to examine whether there is an association between 32 different I...

    Authors: Bengt Zöller, Xinjun Li, Jan Sundquist and Kristina Sundquist
    Citation: BMC Neurology 2012 12:41
  37. People who have suffered a stroke commonly report unfulfilled need for rehabilitation. Using a model of patient satisfaction, we examined characteristics in individuals that at 3 months after stroke predicted,...

    Authors: Malin Tistad, Kerstin Tham, Lena von Koch and Charlotte Ytterberg
    Citation: BMC Neurology 2012 12:40
  38. Hyperintense putaminal rim (HPR) is an important magnetic resonance imaging (MRI) sign for multiple system atrophy (MSA). Recent studies have suggested that it can also be observed in normal subjects at 3 T. W...

    Authors: Khin K Tha, Satoshi Terae, Akiko Tsukahara, Hiroyuki Soma, Ryo Morita, Ichiro Yabe, Yoichi M Ito, Hidenao Sasaki and Hiroki Shirato
    Citation: BMC Neurology 2012 12:39
  39. Alzheimer’s disease (AD) is the most common form of dementia. Mutations in genes such as those encoding amyloid precursor protein (APP), presenilin 1 and presenilin 2, are responsible for early-onset familial AD.

    Authors: Masao Abe, Naomi Sonobe, Ryuji Fukuhara, Yoko Mori, Shinichiro Ochi, Teruhisa Matsumoto, Takaaki Mori, Satoshi Tanimukai and Shu-ichi Ueno
    Citation: BMC Neurology 2012 12:38
  40. Treatment options for patients suffering from progressive forms of multiple sclerosis (MS) remain inadequate. Mast cells actively participate in the pathogenesis of MS, in part because they release large amoun...

    Authors: Patrick Vermersch, Rabah Benrabah, Nicolas Schmidt, Hélène Zéphir, Pierre Clavelou, Cyrille Vongsouthi, Patrice Dubreuil, Alain Moussy and Olivier Hermine
    Citation: BMC Neurology 2012 12:36
  41. We report the case of a chronic stroke patient (62 months after injury) showing total absence of motor activity evoked by transcranial magnetic stimulation (TMS) of spared regions of the left motor cortex, but...

    Authors: Julià L Amengual, Antoni Valero-Cabré, Misericordia Veciana de las Heras, Nurja Rojo, Seán Froudist-Walsh, Pablo Ripollés, Nils Bodammer, Bahram Mohammadi, Jordi Montero, Carles Grau, Thomas F Münte and Antoni Rodríguez-Fornells
    Citation: BMC Neurology 2012 12:35

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