Figure 8
From: POLG1 p.R722H mutation associated with multiple mtDNA deletions and a neurological phenotype
Cartoon of a tentative structure of a segment of the spacer region of human pol γA. Stereo views of the region from residue #700 to #770 of the normal (red/gray) and p.R722H/p.W748S double mutant (blue) protein is shown. The structure was predicted with homology modeling by using 1kln.pdb as a template. p.R722 (red), p.W748 (red), p.H722 (blue) and p.S748 (blue) are highlighted.