| End-points | A% (SD) | S % | Sp % | NPV % | AUC% (SD) | PPV % | Kappa |
---|
| Change EDSS | 80 (14) | 92 | 61 | 80 | 76 (25) | 80 | 0.54 |
NNets | Disability progression | 75 (17) | 87 | 52 | 61 | 74 (31) | 80 | 0.37 |
| Relapse-free | 67 (21) | 53 | 77 | 70 | 65 (22) | 61 | 0.33 |
- The results are expressed as the percentage (SD). The attributes selected for the different classifiers (see Table S4) were: 1) Clinical variables: disease subtype, age, sex, EDSS, motor score of the EDSS, MSFC, NHPT, TWT; 2) MRI variables: T1 lesion volume, Gad+ lesion volume, GM volume, WM volume; 3) MEP variables: presence of pathological MEP, MEP score, CMCT.
- SD: Standard Deviation; AUC: Area under ROC curve; A: Accuracy; S: sensitivity; Sp: specificity; PPV: positive predictive value; NPV: negative predictive value.