Cerebral vein thrombosis: clinical manifestation and diagnosis

Tanislav, Christian; Siekmann, Ralf; Sieweke, Nicole; Allendörfer, Jens; Pabst, Wolfgang; Kaps, Manfred; Stolz, Erwin

doi:10.1186/1471-2377-11-69

BMC Neurology

Table 2 Positive (PPV) and negative predictive value (NPV), sensitivity (Sens), specificity (Spec), and effectivity (Effect) of symptoms and symptom combinations in diagnosis of cerebral venous thrombosis (CVT)

From: Cerebral vein thrombosis: clinical manifestation and diagnosis

Parameter	CVT vs. no CVT	PPV	NPV	Sens	Spec	Effect
Headaches (any form)	27/39 vs. 145/200	0.17	0.82	0.69	0.28	0.34
- plus seizure (focal or generalized)	4/39 vs. 3/200	0.57	0.85	0.10	0.99	0.84
- plus focal neurological deficit	12/39 vs. 39/200	0.23	0.86	0.31	0.81	0.72
- plus previous history of DVT or PE	5/39 vs. 24/200	0.33	0.84	0.07	0.97	0.82
- plus papilledema	4/39 vs. 3/200	0.57	0.85	0.10	0.99	0.84
- plus altered consciousness	0/39 vs. 1/200	0.00	0.84	0.00	0.99	0.83
- plus oral contraceptives*	6/27 vs. 26/143	0.19	0.85	0.22	0.82	0.72
- plus increased D-dimers§	14/29 vs. 7/69	0.67	0.81	0.48	0.89	0.78
Seizures (focal or generalized)	11/39 vs. 19/200	0.37	0.86	0.28	0.91	0.80
- plus focal neurological deficit	2/39 vs. 3/200	0.40	0.84	0.05	0.99	0.83
- plus previous history of DVT or PE	1/39 vs. 1/200	0.50	0.84	0.03	0.99	0.84
- plus papilledema	0/39 vs. 0/200	-	-	-	-	-
- plus altered consciousness	0/39 vs. 1/200	0.00	0.84	0.00	0.99	0.83
- plus oral contraceptives*	1/27 vs. 1/143	0.03	0.96	0.17	0.80	0.78
- plus increased D-dimers§	8/29 vs. 1/69	0.89	0.76	0.28	0.98	0.78
Focal neurological deficit	17/39 vs. 68/200	0.20	0.86	0.44	0.66	0.62
- plus previous history of DVT or PE	1/39 vs. 6/200	0.14	0.83	0.02	0.97	0.81
- plus papilledema	2/39 vs. 0/200	1.00	0.84	0.05	1.00	0.85
- plus altered consciousness	0/39 vs. 2/200	0.00	0.84	0.00	0.99	0.83
- plus oral contraceptives*	3/27 vs. 5/143	0.38	0.85	0.11	0.97	0.83
- plus increased D-dimers§	11/29 vs. 1/69	0.92	0.79	0.38	0.98	0.81
Altered consciousness	0/39 vs. 10/200	0.00	0.83	0.00	0.95	0.79
- plus previous history of DVT or PE	0/39 vs. 1/200	0.00	0.84	0.00	0.99	0.83
- plus papilledema	0/39 vs. 0/200	-	-	-	-	-
- plus oral contraceptives*	0/39 vs. 1/200	0.00	0.84	0.00	0.99	0.83
- plus increased D-dimers§	0/29 vs. 1/69	0.00	0.70	0.00	0.99	0.69
Papilledema	4/39 vs. 7/200	0.36	0.85	0.10	0.97	0.82
- plus previous history of DVT or PE	1/39 vs. 1/200	0.50	0.84	0.03	0.99	0.84
- plus oral contraceptives*	1/39 vs. 1/200	0.50	0.84	0.03	0.99	0.84
- plus increased D-dimers^§	3/29 vs. 1/69	0.75	0.72	0.10	0.99	0.72
Increased D-dimers§	22/29 vs. 6/69	0.79	0.90	0.76	0.91	0.87

DVT: deep vein thrombosis of the legs
PE: pulmonary embolism
*limited to females
^§limited to patients with D-dimer measurements

Back to article page

ISSN: 1471-2377

Contact us

General enquiries: journalsubmissions@springernature.com