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Table 4 Laboratory adverse events according to treatment groups, and action taken

From: A single-blinded trial of methotrexate versus azathioprine as steroid-sparing agents in generalized myasthenia gravis

 

AZA n = 4/15

MTX

N = 3/16

 

Amylase > 2 × ULN

1

0

Resolved on dose reduction

AST > 2 × ULN

1

1

Resolved on dose reduction

ALT > 2 × ULN

2

1

1 resolved on dose reduction; 2 no action & stable

ALT > 3 × ULN

0

1

Improved on dose reduction- stable

GGT ≥2 × ULN

1

1

1 resolved on dose reduction; 1 no action & stable/resolved

  1. AZA- azathioprine; MTX- methotrexate. ULN refers to upper limit of normal.
  2. ALT refers to alanine aminotransferase, normal range 5-40 U/L, AST to aspartate amintransferase, normal 5-40 U/L, GGT to gamma-glutamyl transpeptidase, normal 0-35 U/l.
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BMC Neurology

ISSN: 1471-2377

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