Figure 2

Non-inflammatory cortical demyelination is prominent in chronic MS. (A) Cortical demyelination in the cingulate gyrus (PLP, scale bar = 5 mm); (B) Cortical demyelination in the frontal lobe (PLP, scale bar = 5 mm); (C) Cortical demyelination in the hippocampus (PLP, scale bar = 2.5 mm); (D) Although the occipital lobe is less frequently affected, cortical demyelination can be very extensive in the occipital lobe of some MS patients (PLP, scale bar = 5 mm).