From: Treatment of multiple system atrophy using intravenous immunoglobulin
Type | No | Subjects | R | Comments | |
---|---|---|---|---|---|
1 | Elevated BP | 7 | 7 | I | Transient, responding to adjusting the infusion rate |
2 | Accidental injury | 1 | 1 | N | After It4, nose fracture |
3 | UTI | 1 | 1 | N | After It5, treated with antibiotics |
4 | Pruritic skin rash | 4 | 3 | I | 2 subjects withdrew from the study. In these subjects, one subject experienced rash after It1 and second after It2. 1 subject experienced rash after I4 and I5 and was treated with Diphenhydramine, Acetaminophen and oral Prednisone |
5 | Increased temperature and/or skin flushing | 5 | 1 | I | Treated with Diphenhydramine, Acetaminophen, and slowing the infusion rate |
6 | RLS | 1 | 1 | N | Diagnosed after It4, treated with iron supplements |
8 | Decreased GFR | 1 | 2 | N | After It5 and It6, resolved |
9 | Ankle edema | 1 | N | After It5, treated with diazide diuretics | |
10 | Elevated BUN | 1 | 1 | N | After It5, started trial with elevated BUN at screening visit, resolved |
11 | Worsening of allergies | 2 | 1 | N | Worsening of running nose and cough after It5 and It6, also associated with cold and fever after It6, treated with Acetaminophen, Pseudoephedrine, and Diphenhydramine. |
13 | Nodular lung abnormality | 1 | 1 | N | Later determined to be abnormal tangle of veins, probably since birth |
14 | Low potassium | 1 | 1 | P | After It1, treated with increased dose of potassium |
15 | GI viral infection | 1 | 1 | N | After It5, treated with fluids, antiemetics and anti-diarrheal agents |
16 | Elevated PSA | 1 | 1 | N | Before It1, resolved |
17 | Wrist strain | 1 | 1 | N | After It1, resolved |
18 | Worsening of sleep apnea | 1 | 1 | N | After It2, prrescribed CPAP |