Inclusion criteria | |
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(1) | Patients with acute isolated spinal cord injury (AIS A-D) planned for surgical stabilization and decompression, lesion may include more than 1 segment |
(2) | Patients with acute isolated spinal fracture planned for surgical stabilization, lesion may include more than 1 segment |
(3) | ≥ 2 spinal cord or vertebral lesions definable one from another |
(4) | Legal age of the patient |
(5) | Documented informed consent of the patient |
Exclusion criteria | |
(1) | Non-traumatic spinal cord injury |
(2) | 2 or more spinal cord or vertebral lesions definable one from another |
(3) | Severe polytrauma (definition: patients with severe injuries of life-sustaining organ systems, which per se and in the acute phase are life-threatening (e.g., severe pelvic trauma, severe body cavity injuries) |
(4) | Concomitant traumatic brain injury (TBI) (definition: i) Patients with persisting neurological deficit in consequence of the TBI, ii) patient with severe TBI (Glasgow Coma Scale ≤ 8), and iii) patients with intracranial pressure monitoring sensors.) |
(5) | Neoplasia and/or antineoplastic therapy |
(6) | Rheumatic disease, collagenosis, vasculitis or other autoimmune disease |
(7) | Preexisting chronic infectious disease (before the injury) |
(8) | Preexisting systemic steroid treatment |
(9) | Severe alcohol or drug addiction |
(10) | Pregnancy, lactation |