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Table 2 Sensitivity, specificity, and odds ratios of single colour Doppler sonography criteria in MS patients and HCs

From: Chronic cerebrospinal venous insufficiency in multiple sclerosis: a highly prevalent age-dependent phenomenon

 

Sensitivity, % (95% CI)

Specificity, % (95% CI)

Odds ratio, (95% CI)

Reflux of the IJV and/or VV (Cr 1)

63,0

78,9

6,4

(55,0-70,5)

(64,2-89,5)

(2,7-14,9)

Intracranial reflux (Cr 2)

28,1

84,2

2,1

(21,3-35,8)

(70,3-93,1)

(0,8-5,4)

IJV stenosis B-mode anomalies (Cr 3)

80,8

52,6

4,7

(73,9-86,6)

(37,1-67,8)

(2,2-10,0)

No flow in the IJV and/or VV (Cr 4)

26,7

97,4

13,5

(20,0-34,3)

(88,4-99,6)

(1,8-101,6)

Negative CSA (Cr 5)

6,2

97,4

2,4

(3,1-10,9)

(88,4-99,6)

(0,3-19,8)

CCSVI

76,0

84,2

16,9

 

(68,6-82,4)

(70,3-93,1)

(6,5-43,8)

  1. An odds ratio greater than 1.0 indicates an increased likelihood of a diagnosis of CCSVI in MS patients versus controls.
  2. Abbreviations: MS: multiple sclerosis; HCs: healthy controls; CCSVI: chronic cerebrospinal venous insufficiency; Cr: criterion; IJV: internal jugular vein; VV: vertebral vein; CSA: cross sectional area; CI: confidence interval.