Table 2 Clinical characterisation and MRI follow-up of NMO patients with longitudinally extensive transverse myelitis (LETM) (n = 23)
Clinical manifestations | F/M | Anti-AQP4 antibodies positive | F/M | Anti-AQP4 antibodies negative | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Number of patients = 17 | Number of patients = 6 | |||||||||||||
Duration of disease | EDSS Score | Duration of disease | EDSS Score | |||||||||||
2-4 y | 5-10 y | 2-4 | 5-7 | 8-9 | 2-4 y | 5-10 y | 2-4 | 5-7 | 8-9 | |||||
MRI of the spinal cord | ||||||||||||||
Single LETM | 14/3 | 17 | 10 | 7 | 5 | 5 | 7 | 3/3 | 6 | 3 | 3 | 1 | 4 | 1 |
Brainstem involvement | 7/0 | 7 | 5 | 2 | 0 | 1 | 6 | 1/0 | 1 | 0 | 1 | 0 | 0 | 1 |
Relapsing LETM | 4/0 | 4 | 3 | 1 | 0 | 1 | 3 | 1/0 | 1 | 1 | 0 | 0 | 1 | 0 |
Multiple shorter TM | 5/1 | 6 | 4 | 2 | 0 | 1 | 5 | 1/2 | 3 | 2 | 1 | 0 | 2 | 1 |
Normal SC | 2/1 | 3 | 3 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Focal atrophy of SC | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3/2 | 5 | 5 | 0 | 0 | 5 | 0 |
General atrophy of SC | 4/1 | 5 | 4 | 1 | 0 | 0 | 5 | 1/1 | 2 | 1 | 1 | 0 | 0 | 2 |