Figure 3

Superimposed structures of presenilin 2 with native Val 214 residue and Leu mutation. The structures of presenilin 2 with native Val 214 residue and Leu mutation were generated by RaptorX 3D prediction program. The side-chains of Val and Leu 214 residues reveal noticeable changes of extending towards opposite direction (a). Green color CPK (Corey, Pauling, Koltun) indicates the side-chain of native Val residue and the red color indicated the Leu mutation. Other proceeding residues, Ile 219 and His220, revealed significant changes in their side-chains (b). Green colored side-chains indicated the Ile and His residues from the native form and red colored side-chains indicated the mutant presenilin 2.