SNP/Haplotype | MAF | OR (95% CI) |
P
|
P
corr
|
---|
| Case | Control | | | |
---|
| (n = 98) | (n = 237) | | | |
---|
rs17426456
| 0.046 | 0.051 | 0.92 (0.45-1.88) | 0.79 | NS |
rs2300747
| 0.490 | 0.354 | 1.73 (1.23-2.43) |
0.007
|
0.03
|
rs1335532
| 0.520 | 0.367 | 1.87 (1.33-2.63) |
0.002
|
0.01
|
rs12044852
| 0.454 | 0.601 | 1.80 (1.28-2.53) |
0.004
|
0.02
|
rs1016140
| 0.535 | 0.395 | 1.76 (1.25-2.47) |
0.005
|
0.02
|
rs12025416
| 0.412 | 0.312 | 1.55 (1.09-2.20) | 0.06 | NS |
CD58_ht1
| 0.456 | 0.451 | 1.69 (1.22-2.34) |
0.006
|
0.03
|
CD58_ht2
| 0.234 | 0.281 | 1.52 (1.06-2.17) | 0.12 | NS |
CD58_ht3
| 0.089 | 0.063 | 2.13 (1.19-3.84) |
0.008
|
0.04
|
- Logistic regression analyses were performed for calculating odds ratio (95% confidential interval) and P-values for SNP sites and haplotypes. Age (continuous value) and sex (male = 0, female = 1) were adjusted by inclusion in logistic analysis as covariates. To obtain the optimal correction for multiple testing of single-nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD) with each other, the effective number of independent marker loci (4.5055) in CD58 was calculated using the web based software SNPSpD (http://genepi.qimr.edu.au/general/daleN/SNPSpD), on the basis of the spectral decomposition (SpD) of matrices of pairwise LD between SNPs. Significant associations (<0.05) are italicized. MAF, minor allele frequency; P
corr, corrected P-value using multiple testing corrections; OR, odds ratio; CI, confidence interval; NMO, neuromyelitis optica.