Table 1 Baseline characteristics

Age (years)

69 (9)

68 (9)

Sex (male)

72 (75%)

10 (63%)

Education*

5.0 [4.0–6.0]

4.0 [3.3–4.8]

Vascular risk factors

Treated hypertension

71 (75%)

10 (65%)

Systolic blood pressure (mm Hg)

168 (27)

174 (28)

Diastolic blood pressure (mm Hg)

86 (13)

87 (13)

Cardiac failure

3 (3%)

1 (6%)

Angina pectoris in past 6 months

7 (7%)

0 (0%)

Previous myocardial infarction

19 (20%)

3 (19%)

Previous CABG

17 (18%)

2 (13%)

Atrial fibrillation

4 (4%)

0 (0%)

Other cardiac embolic source

4 (4%)

0 (0%)

Type 2 diabetes mellitus

16 (17%)

2 (13%)

Type 1 diabetes mellitus

4 (4%)

1 (6%)

Peripheral arterial disease

17 (18%)

3 (19%)

Current smoker

32 (34%)

3 (19%)

Ex-smoker

55 (59%)

9 (56%)

Treated hyperlipidaemia

72 (76%)

13 (81%)

Cholesterol (mmol/L)

4.7 (1.1)

4.9 (1.4)

Imaging

MRA

68 (71%)

11 (69%)

CTA

28 (29%)

5 (31%)

Treatment

CEA

44 (46%)

10 (63%)

CAS

52 (54%)

6 (38%)

Symptomatic side

Left carotid artery

44 (46%)

10 (63%)

Degree of symptomatic carotid artery stenosis†

50–69%

13 (14%)

2 (13%)

70–99%

83 (87%)

14 (88%)

Degree of contralateral carotid artery stenosis^†

<50%

58 (60%)

13 (81%)

50–69%

12 (13%)

0 (0%)

70–99%

15 (16%)

2 (13%)

Occluded

7 (7%)

1 (6%)

Unknown

4 (4%)

0 (0%)

Anatomy anterior part circle of Willis

Ipsilateral A1 present

80 (83%)

15 (94%)

Anterior communicating artery present

95 (99%)

15 (94%)

Contralateral A1 present

86 (90%)

15 (94%)

Most recent ipsilateral event^‡

Amaurosis fugax

24 (26%)

2 (13%)

Transient ischaemic attack

34 (37%)

4 (25%)

Ischaemic stroke

29 (32%)

9 (56%)

Retinal infarction

3 (3%)

1 (6%)

Unknown

2 (2%)

0 (0%)

NIHSS at randomization

0 (0–1)

0.5(0–1)

Modified Rankin score at randomization

0–2

85 (90%)

15 (94%)

3–5§

10 (11%)

1 (6%)

Unknown

1 (0%)

0 (0%)