From: Functional correlates of Apolipoprotein E genotype in Frontotemporal Lobar Degeneration
Variable | ApoE ε4- (n = 35) | ApoE ε4+ (n = 17) | Normal data^ | p ‡ |
---|---|---|---|---|
Age, years | 67.1 ± 9.3 | 68.0 ± 6.9 | - | .73 |
Gender, female% | 51.4% | 64.7% | - | .37† |
Education, years | 7.7 ± 4.2 | 6.9 ± 2.7 | - | .99 |
Family History, % | 17.1 | 17.6 | - | .88 |
Age at onset, years | 64.6 ± 8.8 | 65.0 ± 6.9 | - | .96 |
Estimated disease duration, years | 2.6 ± 2.2 | 2.3 ± 1.2 | - | .94 |
MMSE | 25.3 ± 3.9 | 24.4 ± 4.5 | 24 | .54 |
UPDRS-III | 14.7 ± 11.4 | 10.6 ± 10.9 | 0 | .15 |
IADL, lost functions | 1.2 ± 1.9 | 2.2 ± 2.2 | 0 | .16 |
BADL, lost functions | 0.6 ± 1.1 | 0.7 ± 1.1 | 0 | .33 |
Short Story | 10.1 ± 4.2 | 6.3 ± 3.9 | 7.5 | .004 |
Rey Figure, copy | 27.3 ± 6.7 | 23.7 ± 9.2 | 29 | .15 |
Rey Figure, recall | 12.5 ± 5.5 | 10.9 ± 7.5 | 15 | .21 |
Raven Coloured Matrices | 24.6 ± 5.5 | 19.0 ± 7.0 | 17.5 | .003 |
Verbal Fluency | 25.1 ± 10.7 | 20.6 ± 10.4 | 16 | .13 |
Set Test | 31.0 ± 9.3 | 26.6 ± 9.6 | 24 | .13 |
Digit Span | 5.6 ± 1.4 | 5.4 ± 1.7 | 3.75 | .70 |
Token Test | 30.2 ± 4.3 | 27.1 ± 5.4 | 29 | .06 |
Trail Making A, ES = 0 or 1 | 41.0% | 66.0% | >1 | .48† |
Trail Making B, ES = 0 or 1 | 50.0% | 73.0% | >1 | .44† |
De Renzi Imitation Test | 64.3 ± 12.2 | 66.1 ± 9.0 | 62 | .94 |