The size of the treatment effect: do patients and proxies agree?

BMC Neurology

Table 2 Overall mean MSIS-29 scores at baseline and after treatment

	Patients Mean ± SD (n = 42)	Proxy respondents Mean ± SD (n = 42)
MSIS-29 physical scale baseline	48.8 ± 18.4	48.2 ± 18.0
MSIS-29 physical scale after treatment	42.0 ± 20.3	44.6 ± 20.8
Change on MSIS-29 physical scale^a	-6.8 ± 16.3	-3.6 ± 16.2
Effect size	0.4	0.2
Difference between change scores^b:	-3.2 ± 14.8 (p = 0.367)
95% CI of the difference	(-10.3 – 3.8)
ICC	0.58
MSIS-29 psychological scale baseline	31.4 ± 19.6	34.7 ± 20.4
MSIS-29 psychological scale after treatment	27.7 ± 17.8	34.6 ± 21.1
Change on MSIS-29 psychological scale^a	-3.7 ± 15.2	-0.1 ± 20.2
Effect size	0.2	0.0
Difference between change scores^b:	-3.6 ± 20.5 (p = 0.353)
95% CI of the difference	(-11.4 – 4.1)
ICC	0.34

^a mean MSIS-29 scores after treatment minus mean MSIS-29 scores at baseline; negative values indicate improvement
^b Patient mean change score minus proxy mean change score
CI = Confidence Interval ICC = Intraclass correlation coefficient

ISSN: 1471-2377