From: Neuromyelitis optica spectrum disorders without and with autoimmune diseases
NMOSD | NMOSD with autoimmune diseases | |||||
---|---|---|---|---|---|---|
Without autoimmune diseases (n = 115) | With autoimmune diseases (n = 40) | P | Non-organ-specific (n = 22) | Organ-specific (n = 18) | P | |
Gender, F: M | 91: 24 | 37: 3 | 0.055 | 22: 0 | 15: 3 | 0.165 |
Age, years | 37.63 ± 14.33 | 40.71 ± 13.80 | 0.240 | 40.90 ± 14.86 | 40.47 ± 12.80 | 0.924 |
Age at onset, years | 34.20 ± 13.70 | 37.37 ± 13.50 | 0.207 | 36.91 ± 14.63 | 37.94 ± 12.37 | 0.814 |
Disease duration, years | 1.83 (0.08, 30.00) | 1.33 (0.08, 31.08) | 0.219 | 1.25 (0.08, 31.08) | 2.67 (0.08, 7.00) | 0.414 |
Annualized relapse rate | 0.66 (0, 12.00) | 0.89 (0, 6.00) | 0.183 | 0.80 (0, 3.43) | 0.95 (0, 6.00) | 0.784 |
EDSS at last visit | 2.0 (0, 23.0) | 2.5 (0, 10.0) | 0.067 | 2.5 (1.0, 8.5) | 3.0 (0, 10.0) | 0.529 |
Clinical features, n (%) | ||||||
Headache | 18 (15.7%) | 8 (20.0%) | 0.526 | 3 (13.6%) | 5 (27.8%) | 0.475 |
Nystagmus | 6 (5.2%) | 4 (10.0%) | 0.289 | 2 (9.1%) | 2 (11.1%) | 0.832 |
IHN | 26 (22.6%) | 12 (30.0%) | 0.349 | 4 (18.2%) | 8 (44.4%) | 0.071 |
Bulbar paralysis | 9 (7.8%) | 2 (5.0%) | 0.549 | 1 (4.5%) | 1 (5.6%) | 1.000 |
Bowel or bladder dysfunction | 49 (42.6%) | 18 (45.0%) | 0.793 | 7 (31.8%) | 11 (61.1%) | 0.064 |
Visual impairment | 98 (85.2%) | 33 (82.5%) | 0.682 | 18 (81.8%) | 15 (83.3%) | 0.900 |
Motor deficit | 68 (59.1%) | 21 (52.5%) | 0.465 | 8 (36.4%) | 13 (72.2%) | 0.024* |
Sensory deficit | 83 (72.2%) | 25 (62.5%) | 0.252 | 14 (63.6%) | 11 (61.1%) | 0.870 |
Neuropathic pain | 29 (25.4%) | 13 (32.5%) | 0.388 | 6 (27.3%) | 7 (38.9%) | 0.435 |