n=30 | |||||||
---|---|---|---|---|---|---|---|
Male | 60% | ||||||
Age at disease onset (y) | 53.9 | (35-62) | ± 6.8 | ||||
Age at PEG-J placement | 69.4 | (51-80) | ± 6.4 | ||||
Age at LFV (y) | 724 | (61-82) | ± 5.6 | ||||
Disease duration (y) | 17.2 | (10-33) | ± 5.7 | ||||
Disease duration at PEG-J placement (y) | 14.9 | (6-28) | ± 6.3 | ||||
Follow-up duration (mo) | 61.3 | (3-119) | ± 32.6 | ||||
Active follow-up | 23 | ||||||
Patients acquired from other sites | 3 | ||||||
Deceased | 6 | ||||||
Discontinued | 1 | ||||||
Patients with 23 (11-38) ± 8.2 months of follow-up (n=20) | |||||||
baseline | LFV | ||||||
MDS-UPDRS pt. III score | 31.6 | (4-50) | ± 14 | 33.5 | (8-66) | ± 15.2 | |
mH&Y stage | 3 | (2.5-4) | ± 0.5 | 3 | (2.5-4) | ± 0.6 | |
Weight (kg) | 57.5 | (38-76) | ± 10.8 | 57 | (36-75) | ± 11.3 | |
Morning dose (ml) | 7.8 | (3.6-12.5) | ± 2.7 | 8.1 | (3.6-12.6) | ± 1.8 | |
Continuous infusion (ml/h) | 3.1 | (2-4.3) | ± 0.7 | 3.3 | (2-4.6) | ± 0.8 | |
Extra dose (ml) | 2.2 | (1.3-3.5) | ± 0.6 | 2.2 | (0.5-3.5) | ± 0.8 | |
Average extra doses per day | 1.2 | (0-3) | ± 1.0 | 1.2 | (0-5) | ± 1.1 | |
Daily DLI dose (mg) | 1072 | (710-1486) | ± 236.4 | 1152 | (708-1698) | ± 262 | |
PEG-J procedures (n=156) | |||||||
First implants | 30 | ||||||
Scheduled replacements | 53 | ||||||
Not scheduled (unexpected) replacements | 73 | ||||||
Complications related PEG-J replacements | Events | Patients | |||||
Device-related | |||||||
Accidental removal | 1 | 1 | |||||
Device coloring | 8 | 4 | |||||
Tube breaking/puncture | 16 | 6 | |||||
Ext./int. bumper dislocation | 21 | 9 | |||||
Candida colonization | 1 | 1 | |||||
Tube dislocation | 35 | 12 | |||||
Patient-related | |||||||
Abdominal discomfort | 9 | 5 | |||||
Granulation tissue | 4 | 4 | |||||
Buried bumper syndrome | 1 | 1 | |||||
Peristomal inflammation | 4 | 4 | |||||
Total | 100 | ||||||
Stoma complicationsa | |||||||
Candida infection | 1 | 1 | |||||
Granuloma | 9 | 3 | |||||
Erythema | 44 | 13 | |||||
Serous secretions | 20 | 3 | |||||
Sero-ematic secretions | 2 | 1 | |||||
Purulent secretions | 3 | 1 | |||||
Edema | 6 | 2 | |||||
Total | 85 |