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Table 1 Main effects of the models predicting functional outcome and long-term durability of treatment

From: Personalized decision-making for aneurysm treatment of aneurysmal subarachnoid hemorrhage: development and validation of a clinical prediction tool

Variable

Ordinal model (n = 2143)

Cox model (n = 2108)

Univariable

Multivariable

Univariable

Multivariable

cOR (95% CI)

cOR (95% CI)a

HR (95% CI)

HR (95% CI)b

Treatment

 Endovascular

Ref

Ref

Ref

Ref

 Neurosurgical

1.5 (1.3–1.7)

1.5 (1.3–1.7)

0.3 (0.2–0.4)

0.3 (0.2–0.4)

 Time-to-aneurysm-treatment (days)

1.05 (1.03–1.08)

1.02 (1.00–1.04)

0.96 (0.93–1.00)

Not included

Age (per decade)

 Linear

1.2 (1.18–1.35)

1.20 (1.12–1.28)

0.88 (0.78–0.99)

NA

  ≤ 52

 

NA

 

0.7 (0.6–0.9)

  > 52

 

NA

 

1.2 (0.9–1.5)

WFNS grade

 I

Ref

Ref

Ref

Not included

 II

2.1 (1.8–2.5)

1.9 (1.6–2.3)

1.1 (0.8–1.5)

 

 III

3.5 (2.6–4.8)

2.5 (1.8–3.5)

0.6 (0.3–1.3)

 

 IV

7.6 (4.9–11.5)

6.6 (4.3–10.1)

1.3 (0.6–2.9)

 

 V

10.6 (4.8–23.7)

9.4 (4.1–21.5)

0.8 (0.1–5.6)

 

CT Fisher grade

 1

Ref

Ref

Ref

Not included

 2

1.0 (0.7–1.5)

1.2 (0.8–1.8)

1.1 (0.5–2.2)

 

 3

1.6 (1.1–2.2)

1.6 (1.1–2.3)

1.2 (0.6–2.4)

 

 4

2.6 (1.8–3.6)

1.9 (1.3–2.7)

1.2 (0.6–2.3)

 

Aneurysm lumen size (mm)

1.05 (1.03–1.08)

1.05 (1.02–1.07)

1.06 (1.02–1.10)

1.06 (1.01–1.10)

Aneurysm neck size

  ≤ 4 mm

Ref

Not included

Ref

Not included

  > 4 mm

1.2 (1.0–1.4)

 

0.8 (0.6–1.1)

 

Aneurysm location

 ACA

Ref

Ref

Ref

Ref

 ACOM

1.0 (0.8–1.2)

0.9 (0.8–1.2)

1.6 (1.1–2.4)

1.6 (1.1–2.4)

 ICA

1.2 (0.9–1.5)

1.3 (1.0–1.6)

1.5 (1.0–2.3)

1.4 (0.9–2.1)

 MCA

1.0 (0.8–1.3)

0.9 (0.7–1.2)

1.3 (0.8–2.1)

1.2 (0.8–2.0)

 PCOM

1.1 (0.8–1.4)

1.0 (0.8–1.4)

1.2 (0.7–2.1)

1.1 (0.6–1.9)

 Posteriorc

1.1 (0.7–1.8)

1.0 (0.6–1.7)

1.3 (0.5–3.3)

1.5 (0.6–3.7)

Vasospasm at presentation

 Absent

Ref

Ref

Ref

Not included

 Present

1.6 (1.4–2.0)

1.2 (1.0–1.5)

0.9 (0.7–1.3)

 
  1. Abbreviations: ACA Anterior circulation artery, ACOM Anterior communicating artery, CT Computed tomography, CI Confidence interval, HR Hazard ratio, ICA Internal carotid artery, MCA Middle cerebral artery, mm milimeter, PCOM Posterior communicating artery, Post Posterior circulation, ref Reference category, WFNS World Federation of Neurological Surgeons grade
  2. aAn hazard ratio > 1 corresponds with a lower probability of no rebleed or retreatment
  3. bA common odds ratio > 1 corresponds with a worse outcome
  4. cLocations of aneurysms of the posterior circulation include: basilar artery, vertebral artery, superior cerebellar artery, anterior inferior cerebellar artery, posterior inferior cerebellar artery, and internal auditory artery