The clinical and neuroimaging differences between vascular parkinsonism and Parkinson’s disease: a case-control study

George, Peter; Roushdy, Tamer; Fathy, Mai; Hamid, Eman; Ibrahim, Yosra Abdelzaher; El-Belkimy, Mahmoud; Abdulghani, Mohamed Ossama; Shalash, Ali

doi:10.1186/s12883-024-03556-9

Table 5 Correlations of clinical characteristics and quality of life of Parkinson’s disease and vascular parkinsonism

From: The clinical and neuroimaging differences between vascular parkinsonism and Parkinson’s disease: a case-control study

		MDS -UPDRS III Off	MoCA	NMSS	PDQ
Vascular Parkinsonism
Age	Spearman	0.417	-0.159	0.412	0.141
Age	P-value	0.031	0.427	0.033	0.482
AOO	Spearman	0.366	-0.181	0.311	0.061
AOO	P-value	0.061	0.365	0.114	0.764
DOI	Spearman	0.406	-0.082	0.362	0.179
DOI	P-value	0.036	0.684	0.064	0.372
BDI	Spearman	0.362	-0.382	0.791	0.529
BDI	P-value	0.064	0.049	< 0.001	0.005
MDS-UPDRS III OFF	Spearman		-0.252	0.442	0.429
MDS-UPDRS III OFF	P-value		0.205	0.021	0.025
H&Y OFF	Spearman	0.136	-0.314	0.357	0.477
H&Y OFF	P-value	0.499	0.111	0.067	0.012
FAB	Spearman	-0.261	0.659	-0.397	-0.328
FAB	P-value	0.189	< 0.001	0.041	0.095
Number of vascular risk factors	Spearman	0.514	-0.360	0.225	0.232
Number of vascular risk factors	P-value	0.006	0.065	0.259	0.245
Fazekas total score	Spearman	-0.040	0.136	0.088	0.054
Fazekas total score	P-value	0.842	0.500	0.662	0.787
Schelten total score	Spearman	-0.143	0.007	-0.161	0.057
Schelten total score	P-value	0.477	0.973	0.424	0.776
Parkinson’s disease
Age	Spearman	-0.031	-0.134	0.060	-0.071
Age	P-value	0.836	0.362	0.683	0.634
AOO	Spearman	-0.203	-0.02	-0.041	-0.259
AOO	P-value	0.166	0.893	0.780	0.075
DOI	Spearman	0.470	-0.063	0.320	0.472
DOI	P-value	< 0.001	0.675	0.028	0.001
BDI	Spearman	0.587	-0.334	0.673	0.723
BDI	P-value	< 0.001	0.020	< 0.001	< 0.001
MDS-UPDRS III OFF	Spearman		-0.318	0.604	0.778
MDS-UPDRS III OFF	P-value		0.028	< 0.001	< 0.001
H&Y OFF	Spearman	0.843	-0.33	0.433	0.688
H&Y OFF	P-value	< 0.001	0.022	0.002	< 0.001
FAB	Spearman	-0.353	0.7	-0.243	-0.309
FAB	P-value	0.015	< 0.001	0.099	0.034
Number of vascular risk factors	Spearman	-0.016	0.041	0.274	0.164
Number of vascular risk factors	P-value	0.914	0.78	0.059	0.265
Fazekas total score	Spearman	0.007	-0.113	0.085	-0.158
Fazekas total score	P-value	0.962	0.445	0.566	0.283
Schelten total score	Spearman	-0.099	-0.028	0.083	-0.169
Schelten total score	P-value	0.502	0.852	0.575	0.250

AOO: age of onset; DOI: duration of illness; BDI: Beck depression inventory; MDS-UPDRS: movement disorder society – unified Parkinson’s disease rating scale; H&Y: Hoehn, and Yahr scale; NMSS: non-motor symptoms scale; PIGD = postural instability and gait disorder; FAB: Frontal Assessment Battery; MOCA: Montreal cognitive assessment; SN: Substantia Nigra, WMS: Wechsler memory scale; PDQ-39: Parkinson’s disease questionnaire-39. BHI: breath holding index
After Bonferroni correction, the p-value is significant if < 0.004

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