Table 1 Demographic and clinical characteristics of patients stratified according to cognitive dysfunction

Demographic Features and Clinical Diseases

Age (y)

72 (67, 76)

73 (68, 76)

0.932

0.351

Gender, male, n (%)

94 (70.68%)

152 (69.09%)

0.099

0.753

Area, rural, n (%)

28 (21.05%)

71 (32.27%)

5.171

0.023^*

Alcohol comsumption, n (%)

21 (15.79%)

54 (24.55%)

3.798

0.051

Smoking, n (%)

53 (39.85%)

87 (39.55%)

0.003

0.955

Education level

−0.353

0.724

Illiteracy, n (%)

3 (2.25%)

13 (5.91%)

Elementary school, n (%)

31 (23.31%)

45 (20.45%)

Junior high school & above, n (%)

99 (74.44%)

162 (73.64%)

Hypertension, n (%)

101 (75.94%)

162 (73.64%)

0.232

0.630

Coronary Artery Disease, n (%)

26 (19.55%)

43 (19.55%)

0.000

0.999

Cerebral Arterial Stenosis, n (%)

19 (14.29%)

23 (10.45%)

1.161

0.281

Scale Tests

MMSE score

25 (25, 27)

19 (15, 22)

−14.595

0.000^*

HAMA score

9 (7,13)

11 (7, 15)

1.588

0.112

HAMD score

10 (6, 15)

10 (7, 16)

0.366

0.714

Severity of dependence (BI)

−4.117

0.000^*

Independent, n(%)

60 (45.11%)

54 (24.55%)

Mildly dependent, n(%)

60 (45.11%)

125 (56.82%)

Moderately dependent, n(%)

12 (9.23%)

32 (14.54%)

Severely dependent, n(%)

1 (0.75%)

9 (4.09%)

Peripheral Blood Cells & Coagulation Function

White blood cell (×10⁹/L)

5.78 (4.83, 7.18)

5.77 (4.88, 6.90)

−0.438

0.662

Neutrophil %

0.613 ± 0.098

0.605 ± 0.099

0.288

0.462

Lymphocyte %

0.289 ± 0.091

0.290 ± 0.090

0.262

0.905

Neutrophil (×10⁹/L)

3.60 (2.77, 4.56)

3.54 (2.65, 4.35)

−0.719

0.472

Lymphocyte (×10⁹/L)

1.65 (1.28, 2.02)

1.61 (1.28, 2.09)

−0.304

0.761

Blood platelet (×10⁹/L)

181 (149, 207)

184 (152, 218)

0.935

0.350

PT (s)

11.00 (10.40, 11.40)

11.00 (10.50, 11.50)

0.196

0.845

APTT (s)

25.80 (23.00, 28.40)

25.90 (23.40, 28.75)

0.499

0.617

Fibrinogen (g/L)

2.73 (2.35, 3.23)

2.90 (2.39, 3.40)

1.297

0.195

Thrombin time (s)

18.20 (17.30, 19.00)

18.10 (17.25, 19.00)

−0.354

0.724

D-dimer (mg/L)

0.36 (0.24, 0.70)

0.40 (0.24, 0.66)

0.719

0.472

FDP (µg/ml)

1.85 (1.40, 2.76)

1.95 (1.43, 2.52)

0.285

0.775

PT% (%)

94.40 (85.60, 100.00)

94.30 (85.65, 104.00)

0.846

0.398

INR

0.97 (0.92, 1.03)

0.97 (0.92, 1.02)

−0.019

0.985

Hepatorenal Function

ALT (IU/L)

20 (15, 28)

19 (14, 25)

−1.793

0.073

AST (IU/L)

20 (16, 25)

19 (15, 23)

−1.906

0.057

γ-GGT (IU/L)

20 (15, 30)

23 (16, 35)

1.673

0.094

Totel protein (g/L)

66.0 ± 5.8

64.8 ± 5.5

0.345

0.054

Globulin (g/L)

26.1 ± 4.3

26.1 ± 4.1

0.224

0.921

Albumin (g/L)

39.9 ± 3.4

38.7 ± 3.5

0.349

0.003^*

Total bilirubin (µmol/L)

13.1 (10.1, 15.9)

11.1 (8.8, 14.9)

−2.993

0.003^*

Direct bilirubin (µmol/L)

4.7 (3.4, 6.3)

4.0 (3.1, 5.4)

−2.307

0.021^*

Indirect bilirubin (µmol/L)

8.5 (6.3, 10.0)

7.1 (5.5, 9.4)

−2.863

0.004^*

Alkaline phosphatase (IU/L)

73 (61, 86)

76 (65, 92)

1.792

0.073

Cystatin-C (mg/L)

1.11 (0.98, 1.22)

1.10 (0.98, 1.28)

0.325

0.745

Blood urea nitrogen (mmol/L)

5.09 (4.29, 6.51)

5.30 (4.35, 6.73)

0.922

0.357

Serum creatinine (µmol/L)

87 (74, 100)

87 (72, 100)

−0.051

0.959

Serum uric acid (µmol/L)

288 (228, 345)

270 (230, 323)

−1.775

0.076

BP, lipid, weight and glycemic management

BMI (kg/m²)

24.3 (23.1, 26.1)

24.0 (22.6, 26.0)

−0.745

0.456

Systolic blood pressure (mmHg)

139 (131, 156)

140 (130, 151)

−0.599

0.549

Diastolic blood pressure (mmHg)

80 (72, 87)

79 (72, 85)

−0.596

0.551

T2D, n (%)

45 (33.83%)

108 (49.09%)

7.856

0.005^*

HbA_1c (%)

6.4 (5.6, 7.4)

6.6 (5.9, 7.9)

1.796

0.073

Blood glucose (mmol/L)

7.4 (6.1, 9.4)

7.4 (6.0, 10.8)

0.403

0.687

Total cholesterol (mmol/L)

3.67 (3.05, 4.26)

3.65 (3.07, 4.43)

0.138

0.890

Triglyceride (mmol/L)

1.15 (0.90, 1.60)

1.18 (0.92, 1.69)

0.744

0.457

HDL-C (mmol/L)

1.07 (0.89, 1.28)

1.06 (0.90, 1.22)

−0.340

0.734

LDL-C (mmol/L)

2.00 (1.49, 2.60)

2.11 (1.56, 1.76)

0.647

0.518

Apolipoprotein-A1 (g/L)

1.08 (0.93, 1.29)

1.08 (0.96, 1.22)

−0.160

0.873

Apolipoprotein-B (g/L)

0.66 (0.51, 0.79)

0.65 (0.54, 0.84)

1.018

0.309

HCY (µmol/L)

13.33 (10.37, 17.48)

12.85 (10.50, 17.24)

−0.022

0.983

Vit B₁₂ (pmol/L)

262 (176, 510)

331 (211, 549)

1.926

0.054

Folic Acid (nmol/L)

13.99 (8.62, 22.32)

12.65 (8.39, 19.60)

−0.988

0.323