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Table 1 Model averaged coefficients estimated to identify the effect size of rs6859 and other covariates in the multivariate linear regression model (n = 1310)

From: The SNP rs6859 in NECTIN2 gene is associated with underlying heterogeneous trajectories of cognitive changes in older adults

Variable

Coefficient

95% CI

p

Age (Years)

-0.34

-0.51, -0.18

< 0.001***

Education (Years)

1.77

1.37, 2.18

< 0.001***

Gender (Male)

-4.46

-6.81, -2.10

< 0.001***

Marriage (Never)

4.36

-0.73, 11.30

0.08

rs6859 (A allele)

-2.23

-3.83, -0.62

< 0.01**

Smoking (Yes)

-4.60

-7.11, -2.09

< 0.001***

Race (White)

0.16

-3.15, 5.76

0.56

Alcohol (Yes)

0.05

-5.20, 6.27

0.85

Hypertension (Yes)

-0.001

-2.38, 2.35

0.98

Diabetes (Yes)

4.05

0.37, 7.73

< 0.05*

CVD (Yes)

0.01

-2.23, 2.47

0.92

Dyslipidemia (Yes)

0.02

-2.11, 2.55

0.85

  1. Note. *p < 0.05; **p < 0.01; ***p < 0.001 Note. Hypertension, CVD, diabetes and dyslipidemia identified from the medication data